Patent application number | Description | Published |
20100124533 | Large Animal Model for Human-Like Advanced Atherosclerotic Plaque - An animal model for cardiovascular disease comprising one or more vascular plaque lesions formed at selected sites within a vascular segment of a nonhuman mammal. The vascular plaque lesion is formed by administering a hypercholesterolemic diet to the nonhuman mammal, inflicting an injury to the vascular wall at the selected site after a predetermined exposure to the hypercholesterolemic diet, and applying a hydrogel to the injured vascular wall. Another aspect of the invention provides a method for evaluating a test compound for an effect on atherosclerotic lesion formation comprising administering to a nonhuman mammal a hypercholesterolemic diet, and, after a defined period of time, isolating a segment of a blood vessel using a balloon catheter, inflicting an injury to the vascular wall within the isolated segment, and applying a hydrogel within the vascular segment. The method further comprises forming a vascular plaque lesion on the vascular wall at the site of the injury, delivering the test compound to the nonhuman mammal, and monitoring atherosclerotic lesion size and composition at the injured site after a defined period of exposure to the test compound. | 05-20-2010 |
20110182964 | Vascular Stent Which Elutes Amino Acid-Methyl-Ester Derivatives for the Treatment of Vulnerable Plaque and Vascular Disease - This invention provides implantable medical devices that include delivery systems containing amino acid derivatives, and related methods for making and using. More specifically, this invention provides vascular stents with coatings containing methyl ester derivatives of amino acids, and related methods for making and using. | 07-28-2011 |
20110218606 | Methods for Stabilizing Femoral Vessels - The invention provides methods for stabilizing the femoral artery. | 09-08-2011 |
20120259314 | Apparatus and Methods for Recanalization of a Chronic Total Occlusion - A method of recanalizing a chronic total occlusion (CTO) is disclosed. A catheter with a guidewire slidingly received therein is positioned proximally adjacent to the CTO. An occlusion weakening therapy effective to quickly soften and/or loosen the CTO is delivered to the CTO via the catheter. The occlusion weakening therapy includes at least one enzyme and a chelating agent which are selectively deliverable either together or separately depending on the type of material encountered by the guidewire. According to various methods, the enzyme(s) may be delivered if tissue is encountered, the chelating agent may be delivered if calcification is encountered, and both enzyme(s) and chelating agent(s) may be delivered if a fibrous cap is encountered. The distal end of the guidewire may be advanced into the CTO shortly after delivery of the occlusion weakening therapy and is manipulated through the CTO until the guidewire successfully crosses the CTO. | 10-11-2012 |
20120315303 | METHODS AND INTRAVASCULAR TREATMENT DEVICES USING PACLITAXEL FOR TREATMENT OF ATHEROSCLEROSIS - Methods and intravascular treatment devices for treating atherosclerosis are provided. | 12-13-2012 |
20130046283 | METHODS AND INTRAVASCULAR TREATMENT DEVICES FOR TREATMENT OF ATHEROSCLEROSIS - Methods and intravascular treatment devices for treating atherosclerosis are provided. | 02-21-2013 |