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| 20080201642 | PROBLEM DETERMINATION IN DISTRIBUTED ENTERPRISE APPLICATIONS - A method, system and computer program are provided for problem determination in an enterprise computer system in a distributed environment. In the method, information is obtained regarding the enterprise applications, and high-level information is presented to a user, with one or more prompts are provided to the user for more detailed information. In response to a request from a user for more detailed information about the application, more detailed information is provided to the user. Several levels of more detailed information about applications, including information as to individual threads, is available. The method also includes the steps of receiving instructions from an administrator to establish an account for a user, associating one or more servers with the account, and providing access to the corresponding user only to the associated servers. In the method, searches may be conducted for strings and requests, and identified strings and requests may be sorted by a variety of criteria. | 08-21-2008 |
| 20090019441 | METHOD, SYSTEM, AND COMPUTER PROGRAM FOR MONITORING PERFORMANCE OF APPLICATIONS IN A DISTRIBUTED ENVIRONMENT - A method, system, and computer program include receiving a request string, and mapping the received request string to a distinguishable request string and a collapsible request string. The received request string may be in the form of a JSP, a servlet, and remote Enterprise Java Bean calls. A user may be prompted to create rules for mapping of a received request string to a distinguishable request string and a collapsible request string. | 01-15-2009 |
| 20090070462 | SYSTEM AND COMPUTER PROGRAM FOR MONITORING PERFORMANCE OF APPLICATIONS IN A DISTRIBUTED ENVIRONMENT - A system and computer program for monitoring the performance of applications running on a server in a distributed computing environment includes prompting the user to select information for monitoring, monitoring application performance in accordance with the selected information, and making the monitored performance information available to the user. | 03-12-2009 |
| 20110276594 | METHOD, SYSTEM, AND COMPUTER PROGRAM FOR MONITORING PERFORMANCE OF APPLICATIONS IN A DISTRIBUTED ENVIRONMENT - A method, system, and computer program include receiving a request string, and mapping the received request string to a distinguishable request string and a collapsible request string. The received request string may be in the form of a JSP, a servlet, and remote Enterprise Java Bean calls. A user may be prompted to create rules for mapping of a received request string to a distinguishable request string and a collapsible request string. | 11-10-2011 |
| 20120047255 | PROBLEM DETERMINATION IN DISTRIBUTED ENTERPRISE APPLICATIONS - Problem determination in an enterprise computer system in a distributed environment is provided. Information is obtained regarding the enterprise applications, and high-level information is presented to a user, with one or more prompts provided to the user for more detailed information. In response to a request from a user for more detailed information about the application, more detailed information is provided to the user. Several levels of more detailed information about applications, including information as to individual threads, is available. The method also includes the steps of receiving instructions from an administrator to establish an account for a user, associating one or more servers with the account, and providing access to the corresponding user only to the associated servers. In the method, searches may be conducted for strings and requests, and identified strings and requests may be sorted by a variety of criteria. | 02-23-2012 |
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| 20080208973 | CONTEXTUAL MOBILE LOCAL SEARCH BASED ON SOCIAL NETWORK VITALITY INFORMATION - A system, apparatus, and method are directed to managing contextual based mobile searches. A context oriented user interface interprets inputs from a mobile user based on vitality information. In one embodiment, the input may be interpreted as a request to perform a context-based search over a network using at least some of the vitality information. Vitality information may include a location of the mobile device, a time of day, an event, information from the mobile user's calendar, past behavior of the mobile user, weather, social networking data, aggregate behaviors, or even information about proximity of a social contact. By employing vitality information to perform a mobile search, better search results and a richer user experience may be provided that includes a sense of community, a sense of presence (e.g., a sense of “here-ness.”). In one embodiment, the mobile user may provide comments to others regarding the search results. | 08-28-2008 |
| 20080256170 | SOCIAL NETWORKING FOR MOBILE DEVICES - A mobile device, system, and method are directed towards enabling an integrated display of live views. The integrated live views are generated by employing social networking information, including moods of a person, avatars, status of a member's activities including whether they are in an IM session, or the like. Integrated live views may include a live contact list, a group view, a friend view, an activity oriented view, a list of content, or the like, based on the mobile user's social networking information. By providing the mobile user with integrated live views of their social network, the mobile user may be able communicate with other members within the mobile social networking context, to obtain, and respond to invites from a social network member, provide opportunities for activities to other members, to grow their social network, and to consume content that is displayed relative to their social network. | 10-16-2008 |
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| 20080205116 | THREE-DIMENSIONAL MAGNETIC MEMORY - Magnetic memories and methods are disclosed. A magnetic memory as described herein includes a plurality of stacked data storage layers to form a three-dimensional magnetic memory. Bits may be written to a data storage layer in the form of magnetic domains. The bits can then be transferred between the stacked data storage layers by heating a neighboring data storage layer, which allows the magnetic fields from the magnetic domains to imprint the magnetic domains in the neighboring data storage layer. By imprinting the magnetic domains into the neighboring data storage layer, the bits are copied from one data storage layer to another. | 08-28-2008 |
| 20090168235 | ENHANCED CPP READ SENSORS WITH LATERAL SPIN TRANSPORT - CPP read sensors and associated methods of fabrication are described that provide lateral spreading of a sense current along the length of an AFM layer of the read sensor. Winged regions (i.e., extended portions) are added to the layers of a CPP sensor stack to induce lateral spreading of the sense current in the AFM layer. Particularly, the pinned layer and the AFM layer have widths greater than the other layers of the sensor stack. Further, the pinned layer comprises multiple layers of materials, with a first layer of material closer to the AFM layer having a lower conductivity and/or a lower spin dependent scattering asymmetry than the second layer of material. | 07-02-2009 |
| 20090168263 | READ TRANSDUCER AND MAGNETIC STORAGE SYSTEM IMPLEMENTING SAME - A transducer according to one embodiment comprises a first ferromagnetic layer; a second ferromagnetic layer; and an electrically conductive layer positioned between the ferromagnetic layers; wherein a length of the first ferromagnetic layer in a first direction parallel to a plane of deposition thereof is greater than a length of the electrically conductive layer in the first direction such that a first end of the first ferromagnetic layer extends beyond an end of the electrically conductive layer in the first direction, wherein an electrical current enters or exits the end of the first ferromagnetic layer that extends beyond the end of the electrically conductive layer in the first direction. Additional transducer structures, and systems implementing such transducers, are also disclosed. | 07-02-2009 |
| 20100002487 | THREE-DIMENSIONAL MAGNETIC MEMORY - Magnetic memories and methods are disclosed. A magnetic memory as described herein includes a plurality of stacked data storage layers to form a three-dimensional magnetic memory. Bits may be written to a data storage layer in the form of magnetic domains. The bits can then be transferred between the stacked data storage layers by heating a neighboring data storage layer, which allows the magnetic fields from the magnetic domains to imprint the magnetic domains in the neighboring data storage layer. By imprinting the magnetic domains into the neighboring data storage layer, the bits are copied from one data storage layer to another. | 01-07-2010 |
| 20100039849 | READ/WRITE ELEMENTS FOR A THREE-DIMENSIONAL MAGNETIC MEMORY - Read/write elements for three-dimensional magnetic memories are disclosed. One embodiment describes an array of integrated read/write elements. The array includes read conductors formed proximate to one of the layers (i.e., storage stacks) of the three-dimensional magnetic memory. The array also includes flux caps formed proximate to the read conductors, and read sensors formed proximate to the flux caps. The array also includes a magnetic pole having a first end contacting the read sensor and a second end opposite the first end. First write conductors are fabricated between the magnetic poles, and second write conductors are also fabricated between the magnetic poles orthogonal to the first write conductors. The first write conductors and the second write conductors form current loops around the magnetic poles. | 02-18-2010 |
| 20100142099 | LOW RESISTANCE TUNNEL MAGNETORESISTANCE (TMR) STRUCTURE - A magnetic structure in one embodiment includes a tunnel barrier layer; a free layer; and a buffer layer between the tunnel barrier layer and the free layer, wherein a cross sectional area of the tunnel barrier layer in a direction parallel to a plane of deposition thereof is greater than a cross sectional area of the free layer in a direction parallel to a plane of deposition thereof, wherein a cross sectional area of the buffer layer in a direction parallel to a plane of deposition thereof is greater than a cross sectional area of the free layer in the direction parallel to the plane of deposition thereof. Additional systems and methods are also presented. | 06-10-2010 |
| 20100214699 | MAGNETORESISTIVE SENSOR WITH OVERLAID COMBINED LEADS AND SHIELDS - A magnetic head according to one embodiment includes a first magnetic shield; a first insulation layer disposed above said first magnetic shield; a plurality of sensor layers disposed above said first insulation layer; two electrical leads overlying a majority of a surface of the sensor layers, the electrical leads being formed of a magnetic material and serving as a second magnetic shield; and a read width insulation member disposed above said sensor layers and between said two electrically conductive members, the read width insulation members lying in a common plane with the electrically conductive members, the common plane being oriented parallel to a plane of deposition of the read width insulation member. Other systems and methods are also presented. | 08-26-2010 |
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| 20090175326 | PARTIAL RESPONSE RECEIVER - A receive circuit for receiving a signal transmitted via an electric signal conductor. A first sampling circuit generates a first sample value that indicates whether the signal exceeds a first threshold level, and a second sampling circuit generates a second sample value that indicates whether the signal exceeds a second threshold level. A first select circuit receives the first and second sample values from the first and second sampling circuits and selects, according to a previously generated sample value, either the first sample value or the second sample value to be output as a selected sample value. | 07-09-2009 |
| 20090285272 | PARTIAL RESPONSE RECEIVER - An integrated circuit device having a receive circuit is disclosed. The receive circuit generates first and second sets of samples of incoming symbols during first and second time intervals, respectively. A select circuit selects, based at least in part on the first set of samples, at least one sample from the second set to be output as a received data value. The integrated circuit device further includes a transmit circuit to generate an output symbol during a third time interval. The output symbol has an amplitude based, at least in part, on a transmit data value for which an output symbol was generated during a time interval prior to the third time interval. | 11-19-2009 |
| 20100142610 | PARTIAL RESPONSE RECEIVER - A signaling system is described. The signaling system comprises a transmit device, a receive device including a partial response receive circuit, and a signaling path coupling the transmit device and the receive device. The receive device observes an equalized signal from the signaling path, and includes circuitry to use feedback from the most recent previously resolved symbol to sample a currently incoming symbol. The transmit device equalizes transmit data to transmit the equalized signal, by applying weighting based on one or more data values not associated with the most recent previously resolved symbol value. | 06-10-2010 |
| 20120213267 | PARTIAL RESPONSE RECEIVER - A signaling system is described. The signaling system comprises a transmit device, a receive device including a partial response receive circuit, and a signaling path coupling the transmit device and the receive device. The receive device observes an equalized signal from the signaling path, and includes circuitry to use feedback from the most recent previously resolved symbol to sample a currently incoming symbol. The transmit device equalizes transmit data to transmit the equalized signal, by applying weighting based on one or more data values not associated with the most recent previously resolved symbol value. | 08-23-2012 |
| 20120224621 | EQUALIZING RECEIVER - A signaling system is described. The signaling system comprises a transmit device, a receive device including a partial response receive circuit, and a signaling path coupling the transmit device and the receive device. The receive device observes an equalized signal from the signaling path, and includes circuitry to use feedback from the most recent previously resolved symbol to sample a currently incoming symbol. The transmit device equalizes transmit data to transmit the equalized signal, by applying weighting based on one or more data values not associated with the most recent previously resolved symbol value. | 09-06-2012 |
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| 20130024851 | Multiple Application Versions - In one aspect, this application describes a method for determining a version of a software application targeted for a computing device. The method includes receiving, at an application marketplace system and from a user associated with a computing device that operates remotely from the application marketplace system, a request that corresponds to a software application distributed by the application marketplace system, the software application having multiple versions on the application marketplace system. The method also includes determining one or more device attributes that are associated with the computing device, and identifying a particular version of the software application, from among the multiple versions on the application marketplace system, that is targeted for the computing device based on the device attributes. The method also includes providing, for display to the user and in response to the request, information related to the particular version of the software application. | 01-24-2013 |
| 20130024852 | Multiple Application Versions - In one aspect, this application describes a method for determining a version of a software application targeted for a computing device. The method includes receiving, at an application marketplace system and from a user associated with a computing device that operates remotely from the application marketplace system, a request that corresponds to a software application distributed by the application marketplace system, the software application having multiple versions on the application marketplace system. The method also includes determining one or more device attributes that are associated with the computing device, and identifying a particular version of the software application, from among the multiple versions on the application marketplace system, that is targeted for the computing device based on the device attributes. The method also includes providing, for display to the user and in response to the request, information related to the particular version of the software application. | 01-24-2013 |
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| 20090159785 | Optical sensing device - The present invention discloses an optical sensing device with multiple photodiode elements and multi-cavity Fabry-Perot ambient light filter structure to detect and convert light signal with different wavelength spectrum into electrical signal. In embodiment, the optical sensing device capable of sensing color information of ambient light or sunlight and provides blocking of infrared (IR) light within the wavelength ranging from 700 nm to 1100 nm. Preferably, the optical sensing device senses not just the ambient light brightness but also the fundamental red, green and blue color components of the ambient light. | 06-25-2009 |
| 20090237423 | Display apparatus of adjusting gamma and brightness based on ambient light and its display adjustment method - This invention discloses a display apparatus capable of adjusting gamma and brightness based on ambient light and its display adjustment method. The display apparatus is adjusted to display an image output signal based on an image input signal and the correlated color temperature and brightness of an ambient light. The display apparatus includes a plurality of light sensing circuits, a memory unit, an image processing module, and a display module. The light sensing circuit senses the ambient light to produce a digital ambient color temperature index value. The memory unit stores a lookup table of brightness expression rates and gamma adjustment parameters corresponding to different color temperature index values. The image processing module produces a gamma adjustment parameter by a lookup table based on the color temperature index value and generates the gamma expression rate of the image input signal. The image processing module adjusts the image input signal to generate the image output signal based on the gamma adjustment parameter. The display module displays the image output signal. | 09-24-2009 |
| 20110226952 | Reflection Sensing System - A reflection sensing system comprises a body, an illuming module and a detecting module. The body is made by low temperature co-fired ceramic (LTCC) technology or other plasticity colloids and disposed a plurality of electronic connecting points. The illuming module includes a first accommodating space and a light emitted diode (LED), and the detecting module includes a light detector. The first accommodating space is disposed on the body and having a first open at one side. The cross-section of the first accommodating space is parabolic. The LED is disposed at the site of the focus of the first accommodating space, connected to the electronic connecting points and facing to the first open. The light detector is disposed on the body, connected to the electronic connecting points and providing sensing signals after receiving light. | 09-22-2011 |
| 20120012966 | MULTI-CAVITY OPTICAL SENSING AND THERMOPILE INFRARED SENSING SYSTEM - The present invention discloses a multi-cavity optical sensing and thermopile infrared sensing system, which comprises an optical sensing part, a dielectric layer, a plurality of optical cavities, and a plurality of thermocouples. The dielectric layer covers on the top of the optical sensing part. The optical cavities are formed by a plurality of metal reflectors inside the dielectric layer. The thermocouples are laterally disposed near the bottom of the dielectric layer. In addition, a low temperature region is formed in an area which is the overlapping of vertical projections of such thermocouples and the optical sensing part; a high temperature region is formed by the overlapping of vertical projections of such thermocouples, but without the overlaying which belongs to the vertical projection of the optical sensing part. Therefore, the system can sense the ambient light brightness, color conditions and human blackbody infrared signals within the range of 8-12 micrometers wavelength. | 01-19-2012 |
| 20120019149 | Proximity Sensor, Control Method Thereof, and Electronic Apparatus Equipped with the Same - A proximity sensor, a control method thereof and an electronic apparatus equipped with the proximity sensor are disclosed. The proximity sensor connected to a light-emitting module includes a light source, a light receiver and a control module. The light source emits lights at predetermined time intervals. The light receiver receives reflected lights of the emitted lights that are reflected from an object. The control module determines whether an average value of intensity values of the reflected lights is larger than a threshold value. If yes, the control module further determines whether a difference between a highest and a lowest intensity value of the reflected lights falls in a preset range. If yes, the control module would control the light-emitting module to change to a different light mode thereof. When a user reacts to the different light mode, the system will be able to tell whether a real user is present. | 01-26-2012 |
| 20120298869 | PROXIMITY SENSING APPARATUS AND SENSING METHOD THEREOF - The present invention discloses a proximity sensing apparatus and a method thereof. The proximity sensing apparatus comprises a panel, a first light-emitting unit, a second light-emitting unit and a sensing unit. The panel comprises a plurality of transparent areas. The first light-emitting unit is located at one side of the panel and emits a plurality of first light signals through one of the transparent areas. The second light-emitting unit is located at the same side as the first light-emitting unit of the panel and emits a plurality of second light signals through one of the transparent areas. The sensing unit is located at the same side as the first light-emitting unit of the panel and senses the reflected first light signals or the reflected second light signals reflected by an object. Wherein, the sensing unit is closer to the first light-emitting unit than to the second light-emitting unit. | 11-29-2012 |
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| 20110143979 | Lubricating oil compositions - A lubricating oil composition is disclosed which comprises (a) a major amount of an oil of lubricating viscosity; (b) one or more non-halogen-containing oil-soluble titanium complexes comprising at least one ligand comprising an anion of a carboxylic acid; (c) one or more dispersants; and (d) one or more detergents, wherein the lubricating oil composition is free of any zinc dialkyldithiophosphate. | 06-16-2011 |
| 20110143980 | Lubricating oil compositions containing titanium complexes - A lubricating oil composition is disclosed which comprises (a) a major amount of an oil of lubricating viscosity; and (b) one or more non-halogen-containing oil-soluble titanium complexes comprising at least one ligand selected from the group consisting of (i) an anion of an α-, β- or γ-hydroxycarbonyl compound; (ii) an anion of an α-, β- or γ-hydroxycarboxylic acid, amide or ester; (iii) an anion of an α-, β- or γ-aminocarboxylic acid; and (iv) an anion of an α-, β- or γ-keto acid. | 06-16-2011 |
| 20120077719 | PREPARATION OF A MOLYBDENUM IMIDE ADDITIVE COMPOSITION AND LUBRICATING OIL COMPOSITIONS CONTAINING SAME - The invention is directed to oil soluble additive compositions, lubricating oil compositions, and additive concentrates. The oil soluble additive composition comprises a salt or complex of (i) a molybdenum component which comprises a molybdenum oxide, sulfide, or oxysulfide of the general formula MoO | 03-29-2012 |
| 20120149618 | Method for improving fluorocarbon elastomer seal compatibility - Disclosed is a method for improving compatibility of a fluorocarbon elastomer seal with a lubricating oil composition containing (a) a major amount of a base oil of lubricating viscosity; and (b) one or more dispersants containing one or more basic nitrogen atoms. The method involves adding to the lubricating oil composition an effective amount of one or more fluorocarbon elastomer compatibility improving agents comprising one or more non-halogen-containing oil-soluble titanium complexes comprising at least one ligand selected from the group consisting of (i) an anion of a saturated carboxylic acid, (ii) an anion of an α-, β- or γ-hydroxycarbonyl compound; (iii) an anion of an α-, β- or γ-hydroxycarboxylic acid, amide, or ester; (iv) an anion of an α-, β- or γ-aminocarboxylic acid; and (v) an anion of an α-, β- or γ-keto acid. | 06-14-2012 |
| 20120309654 | LUBRICATING OIL COMPOSITIONS CONTAINING TITANIUM COMPLEXES - A lubricating oil composition is disclosed which comprises (a) a major amount of an oil of lubricating viscosity; and (b) one or more non-halogen-containing oil-soluble titanium complexes comprising at least one ligand selected from the group consisting of (i) an anion of an α-, β- or γ-hydroxycarbonyl compound; (ii) an anion of an α-, β- or γ-hydroxycarboxylic acid, amide or ester; (iii) an anion of an α-, β- or γ-aminocarboxylic acid; and (iv) an anion of an α-, β- or γ-keto acid. | 12-06-2012 |
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| 20090010252 | Integrated Memory for Storing Egressing Packet Data, Replay Data and To-be Egressed Data - An integrated egress/replay memory structure is provided with split rate write and read ports and means for managing at least three types of data moving into, through and/or out of the integrated memory structure, namely: (1) currently egressing packet data; (2) replay data; and (3) to-be egressed data. Additionally, a shared free space (4) is managed between the storage areas of the (2) replay data and (3) the to-be egressed data. The to-be egressed data (PdBx) is allowed to enter into (to be written into) a front-end raceway portion of the integrated memory structure at a rate which can be substantially greater than that allowed for corresponding egressing packet data (PdUx). Thus, even when egressing packet data that is ahead in line is shifting out toward a slow rate egress port, this slowing factor does not slow the speed at which the to-be egressed data (PdBx) can be shifted into the front-end raceway portion. A shared free space memory area is maintained between the storage areas of the replay data (PdAx) and to-be-egressed data (PdBx). When a positive acknowledgement (ACK) is received from the destination of already-egressed data (of the After-Transmission Data, or PdAx), the corresponding replay storage area (the area storing the acknowledged PdAx data) can be reallocated for use as an empty part of the raceway portion. | 01-08-2009 |
| 20090010279 | Integrated Memory for Storing Egressing Packet Data, Replay Data and To-be Egressed Data - An integrated egress/replay memory structure is provided with split rate write and read ports and means for managing at least three types of data moving into, through and/or out of the integrated memory structure, namely: (1) currently egressing packet data; (2) replay data; and (3) to-be egressed data. Additionally, a shared free space (4) is managed between the storage areas of the (2) replay data and (3) the to-be egressed data. The to-be egressed data (PdBx) is allowed to enter into (to be written into) a front-end raceway portion of the integrated memory structure at a rate which can be substantially greater than that allowed for corresponding egressing packet data (PdUx). Thus, even when egressing packet data that is ahead in line is shifting out toward a slow rate egress port; this slowing factor does not slow the speed at which the to-be egressed data (PdBx) can be shifted into the front-end raceway portion. A shared free space memory area is maintained between the storage areas of the replay data (PdAx) and to-be-egressed data (PdBx). When a positive acknowledgement (ACK) is received from the destination of already-egressed data (of the After-Transmission Data, or PdAx), the corresponding replay storage area (the area storing the acknowledged PdAx data) can be reallocated for use as an empty part of the raceway portion. | 01-08-2009 |
| 20090086735 | Method of Skipping Nullified Packets During Mass Replay from Replay Buffer - In PCI-Express and alike network systems, back-up copies of recently sent packets are kept in a replay buffer for resending if the original packet is not well received by an intended destination device. A method for locating the back-up copy in the retry buffer comprises applying a less significant portion of the sequence number of a to-be-retrieved back-up copy to an index table to obtain a start address or other locater indicating where in the retry buffer the to-be-retrieved back-up copy resides. A method for skipping replay of late nullified packets includes deleting from the index table, references to late nullified packets. | 04-02-2009 |
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| 20090156576 | Azetidines as MEK Inhibitors for the Treatment of Proliferative Diseases - Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer. | 06-18-2009 |
| 20090163471 | Tropane compounds - A compound according to Formula I or II: | 06-25-2009 |
| 20090215803 | Pyrimidinones as Casein Kinase II (CK2) Modulators - A compound having Formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R | 08-27-2009 |
| 20090318373 | Receptor-type kinase modulators and methods of use - The present invention provides compounds for modulating receptor kinase activity, particularly ephrin and EGFR, and methods of treating diseases mediated by receptor kinase activity utilizing the compounds and pharmaceutical compositions thereof. Diseases mediated by receptor kinase activity include, but are not limited to, diseases characterized in part by abnormal levels of cell proliferation (i.e. tumor growth), programmed cell death (apoptosis), cell migration and invasion and angiogenesis associated with tumor growth. Compounds of the invention include “spectrum selective” kinase modulators, compounds that inhibit, regulate and/or modulate signal transduction across subfamilies of receptor-type tyrosine kinases, including ephrin and EGFR. | 12-24-2009 |
| 20100249096 | Azetidines as MEK Inhibitors for the Treatment of Proliferative Diseases - Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer. | 09-30-2010 |
| 20100298290 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture - The invention is directed to Compounds of Formula I: | 11-25-2010 |
| 20110071145 | Raf Modulators And Methods Of Use - The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention. | 03-24-2011 |
| 20110263558 | Azetidines as MEK Inhibitors for the Treatment of Proliferative Diseases - Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer. | 10-27-2011 |
| 20120258953 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture - The invention is directed to Compounds of Formula (I): the invention provides compounds that inhibit, regulate, and/or modulate P13K and/or mTOR that are useful in the treatment of hyperproliferative diseases, such as cancer, in mammals. This invention also provides methods of making the compound methods of using such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds. For example, cancer in which activity against PI3fC-alph mTOR, or both contributes to its pathology and/or symptomatology include breast cancer mantle cell lymphoma, renal cell carcinoma, acute myelogenous leukemia, chronic myelogenous leukemia, NPM/ALK-transformed anaplastic large cell lymphoma, diffu large B cell lymphoma, rhabdomyosarcoma, ovarian cancer, endometrial cancer, cervic cancer, non small cell lung carcinoma, small cell lung carcinoma, adenocarcinoma, col cancer, rectal cancer, gastric carcinoma, hepatocellular carcinoma, melanoma, pancreat cancer, prostate carcinoma, thyroid carcinoma, anaplastic large cell lymphoma, hemangiom glioblastoma, or head and neck cancer. | 10-11-2012 |
