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| 20090099523 | INFUSION PUMP ASSEMBLY - An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. | 04-16-2009 |
| 20100089475 | MEDIUM CONNECTOR - A medium connector including a passage configured to allow for the flow of medium, and a multi-portion engagement surface positioned about the passage. The multi-portion engagement surface includes a first surface portion, and a second surface portion. The first surface portion is configured to provide an interference fit with a corresponding sealing surface of a mating connector. The second surface portion is configured to provide a clearance fit with the corresponding sealing surface of the mating connector. The ratio of the first surface portion and the second surface portion is selected to regulate an engagement force between the medium connector and the mating connector. | 04-15-2010 |
| 20100094222 | INFUSION PUMP ASSEMBLY - An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. | 04-15-2010 |
| 20110208123 | Infusion Pump Assembly - A removable power supply cover assembly ( | 08-25-2011 |
| 20110230837 | INFUSION PUMP METHODS, SYSTEMS AND APPARATUS - A system for priming an infusion pump is disclosed. The system includes a priming cap including a septum and configured to matably connect with a male part comprising a needle and attached to a length of tubing for fluid, wherein when matably connected with the male part, the priming cap occludes the tubing. | 09-22-2011 |
| 20110313351 | INFUSION PUMP APPARATUS, METHOD AND SYSTEM - An infusion pump system is disclosed. The system includes a syringe having a plunger within the syringe barrel, the syringe having an exit end, at least one temperature determination device adjacent to the syringe, at least one device to determine the distance the plunger has moved with respect to the syringe barrel, and a pump processor in communication with the at least one temperature determination device and the at least one optical sensor, wherein when the controller determines a change in temperature and a corresponding plunger movement, the controller increases or decreases a preprogrammed basal rate of the infusion pump by a predetermined amount for a predetermined time. | 12-22-2011 |
| 20120083738 | INFUSION PUMP ASSEMBLY - An infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in movable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. | 04-05-2012 |
| 20120101440 | MEDICAL DEVICE INSERTION APPARATUS, SYSTEM AND METHOD - An insertion device is disclosed. The insertion device includes a base portion, a top portion slidably connected to the base portion, an introduction needle, a catheter in slidable relation to the introduction needle, and a substantially cylindrical flash chamber, the flash chamber having an inlet in fluid communication with the introduction needle. The flash chamber is connected to the base portion, the top portion slidably engages with the flash chamber, and the catheter and the top portion slidably advance with respect to the introduction needle and the base portion. | 04-26-2012 |
| 20120209196 | INFUSION PUMP ASSEMBLY - An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. | 08-16-2012 |
| 20120209197 | INFUSION PUMP ASSEMBLY - An infusion pump assembly is disclosed. The infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, where the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. | 08-16-2012 |
| 20130066265 | INFUSION PUMP ASSEMBLY - An infusion pump assembly includes a locking tab and a pump barrel inside a pump barrel housing, the pump barrel accommodates a reservoir assembly. The reservoir assembly includes a reservoir and a plunger rod. The infusion pump assembly also includes a locking disc at a terminus of the pump barrel. The locking disc includes a clearance hole for the plunger rod. The locking disc also includes at least one locking tab notch in close proximity with the locking tab. The locking tab is in moveable engagement with the locking tab notch, and the reservoir moves the locking tab from a locked position to an unlocked position when the plunger rod is inserted through clearance hole. The locking disc rotates upon torque being applied to the reservoir assembly, the locking disc rotating from a non-loaded position to a loaded position with respect to the plunger rod and a drive screw. | 03-14-2013 |
| 20130074959 | PUMPING CASSETTE - A pump cassette is disclosed. The pump cassette includes a housing having at least, one fluid inlet line and at least one fluid outlet line. The cassette also includes at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps a fluid from the fluid inlet line to the fluid outlet line. A hollow spike is also included on the housing as well as at least one metering pump The metering pump is fluidly connected to the hollow spike on the housing and to a metering pump fluid line. The metering pump fluid line is fluidly connected to the fluid outlet line. | 03-28-2013 |
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| 20080305114 | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 12-11-2008 |
| 20090175857 | Human Antibodies That Bind Human IL-12 And Methods For Producing - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 07-09-2009 |
| 20090269302 | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 10-29-2009 |
| 20120213792 | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 08-23-2012 |
| 20120244168 | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 09-27-2012 |
| 20120308514 | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 12-06-2012 |
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| 20090311241 | Human antibodies that bind human IL-12 and methods for producing - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 12-17-2009 |
| 20110123544 | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 05-26-2011 |
| 20120201831 | HUMAN ANTIBODIES THAT BIND HUMAN IL-12 AND METHODS FOR PRODUCING - Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention. | 08-09-2012 |
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| 20120099733 | AUDIO ADJUSTMENT SYSTEM - A stereo widening system and associated signal processing algorithms are described herein that can, in several embodiments, widen a stereo image with fewer processing resources than existing crosstalk cancellation systems. These system and algorithms can advantageously be implemented in a handheld device or other device with speakers placed close together, thereby improving the stereo effect produced with such devices at lower computational cost. However, the systems and algorithms described herein are not limited to handheld devices, but can more generally be implemented in any device with multiple speakers. | 04-26-2012 |
| 20120170756 | IMMERSIVE AUDIO RENDERING SYSTEM - A depth processing system can employ stereo speakers to achieve immersive effects. The depth processing system can advantageously manipulate phase and/or amplitude information to render audio along a listener's median plane, thereby rendering audio along varying depths. In one embodiment, the depth processing system analyzes left and right stereo input signals to infer depth, which may change over time. The depth processing system can then vary the phase and/or amplitude decorrelation between the audio signals over time to enhance the sense of depth already present in the audio signals, thereby creating an immersive depth effect. | 07-05-2012 |
| 20120170757 | IMMERSIVE AUDIO RENDERING SYSTEM - A depth processing system can employ stereo speakers to achieve immersive effects. The depth processing system can advantageously manipulate phase and/or amplitude information to render audio along a listener's median plane, thereby rendering audio along varying depths. In one embodiment, the depth processing system analyzes left and right stereo input signals to infer depth, which may change over time. The depth processing system can then vary the phase and/or amplitude decorrelation between the audio signals over time to enhance the sense of depth already present in the audio signals, thereby creating an immersive depth effect. | 07-05-2012 |
| 20130030800 | ADAPTIVE VOICE INTELLIGIBILITY PROCESSOR - Systems and methods for adaptively processing speech to improve voice intelligibility are described. These systems and methods can adaptively identify and track formant locations, thereby enabling formants to be emphasized as they change. As a result, these systems and methods can improve near-end intelligibility, even in noisy environments. The systems and methods can be implemented in Voice-over IP (VoIP) applications, telephone and/or video conference applications (including on cellular phones, smart phones, and the like), laptop and tablet communications, and the like. The systems and methods can also enhance non-voiced speech, which can include speech generated without the vocal track, such as transient speech. | 01-31-2013 |
| 20130096926 | AUDIO ADJUSTMENT SYSTEM - An audio adjustment system is provided that can output a user interface customized by the provider of the audio system instead of the electronic device manufacturer. Such an arrangement can save both field engineers and manufacturers a significant amount of time. Advantageously, in certain embodiments, such an audio adjustment system can be provided without knowledge of the electronic device's firmware. Instead, the audio adjustment system can communicate with the electronic device through an existing audio interface in the electronic device to enable a user to control audio enhancement parameters in the electronic device. For instance, the audio adjustment system can control the electronic device via an audio input jack on the electronic device. The electronic device can also include decoding features for decoding communications sent by the audio adjustment system. | 04-18-2013 |
| 20130097510 | AUDIO ADJUSTMENT SYSTEM - An audio adjustment system is provided that can output a user interface customized by the provider of the audio system instead of the electronic device manufacturer. Such an arrangement can save both field engineers and manufacturers a significant amount of time. Advantageously, in certain embodiments, such an audio adjustment system can be provided without knowledge of the electronic device's firmware. Instead, the audio adjustment system can communicate with the electronic device through an existing audio interface in the electronic device to enable a user to control audio enhancement parameters in the electronic device. For instance, the audio adjustment system can control the electronic device via an audio input jack on the electronic device. | 04-18-2013 |
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| 20110040395 | OBJECT-ORIENTED AUDIO STREAMING SYSTEM - Systems and methods for providing object-oriented audio are described. Audio objects can be created by associating sound sources with attributes of those sound sources, such as location, velocity, directivity, and the like. Audio objects can be used in place of or in addition to channels to distribute sound, for example, by streaming the audio objects over a network to a client device. The objects can define their locations in space with associated two or three dimensional coordinates. The objects can be adaptively streamed to the client device based on available network or client device resources. A renderer on the client device can use the attributes of the objects to determine how to render the objects. The renderer can further adapt the playback of the objects based on information about a rendering environment of the client device. Various examples of audio object creation techniques are also described. | 02-17-2011 |
| 20110040396 | SYSTEM FOR ADAPTIVELY STREAMING AUDIO OBJECTS - Systems and methods for providing object-oriented audio are described. Audio objects can be created by associating sound sources with attributes of those sound sources, such as location, velocity, directivity, and the like. Audio objects can be used in place of or in addition to channels to distribute sound, for example, by streaming the audio objects over a network to a client device. The objects can define their locations in space with associated two or three dimensional coordinates. The objects can be adaptively streamed to the client device based on available network or client device resources. A renderer on the client device can use the attributes of the objects to determine how to render the objects. The renderer can further adapt the playback of the objects based on information about a rendering environment of the client device. Various examples of audio object creation techniques are also described. | 02-17-2011 |
| 20110040397 | SYSTEM FOR CREATING AUDIO OBJECTS FOR STREAMING - Systems and methods for providing object-oriented audio are described. Audio objects can be created by associating sound sources with attributes of those sound sources, such as location, velocity, directivity, and the like. Audio objects can be used in place of or in addition to channels to distribute sound, for example, by streaming the audio objects over a network to a client device. The objects can define their locations in space with associated two or three dimensional coordinates. The objects can be adaptively streamed to the client device based on available network or client device resources. A renderer on the client device can use the attributes of the objects to determine how to render the objects. The renderer can further adapt the playback of the objects based on information about a rendering environment of the client device. Various examples of audio object creation techniques are also described. | 02-17-2011 |
| 20110066428 | SYSTEM FOR ADAPTIVE VOICE INTELLIGIBILITY PROCESSING - An adaptive audio system can be implemented in a communication device. The adaptive audio system can enhance voice in an audio signal received by the communication device to increase intelligibility of the voice. The audio system can adapt the audio enhancement based at least in part on levels of environmental content, such as noise, that are received by the communication device. For higher levels of environmental content, for example, the audio system might apply the audio enhancement more aggressively. Additionally, the adaptive audio system can detect substantially periodic content in the environmental content. The adaptive audio system can further adapt the audio enhancement responsive to the environmental content. | 03-17-2011 |
| 20120259625 | SYSTEM FOR PROCESSING AN AUDIO SIGNAL TO ENHANCE SPEECH INTELLIGIBILITY - An adaptive audio system can be implemented in a communication device. The adaptive audio system can enhance voice in an audio signal received by the communication device to increase intelligibility of the voice. The audio system can adapt the audio enhancement based at least in part on levels of environmental content, such as noise, that are received by the communication device. For higher levels of environmental content, for example, the audio system might apply the audio enhancement more aggressively. Additionally, the adaptive audio system can detect substantially periodic content in the environmental content. The adaptive audio system can further adapt the audio enhancement responsive to the environmental content. | 10-11-2012 |
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| 20090063638 | Method and Apparatus for Processing Messages in Messaging System - Techniques are disclosed for processing messages in a messaging system, particularly during an overload condition. For example, a method of processing messages of an instant messaging system includes the following steps. A message from a first instant messaging user is received during an overload condition. A message type associated with the received message is determined. The method then decides whether to send the message to a second instant messaging user based on the determined message type of the received message. In another method, processing messages in an instant messaging system includes the following steps. Presence information associated with a first instant messaging system user is received. The presence information is sent to a second instant messaging system user when the second messaging system user requests the presence information associated with the first instant messaging system user. | 03-05-2009 |
| 20090177779 | Methods and Apparatus for Randomization of Periodic Behavior in Communication Network - A technique for use in a client, wherein the client supports a state-based signaling protocol (e.g., Session Initiation Protocol or SIP), includes initiating a given session state between the client and a server that also supports the state-based signaling protocol, and refreshing the given session state in a randomized manner. Further, a technique for use in a server, wherein the server supports a state-based signaling protocol (again, e.g., SIP), includes randomly assigning an expiration time duration for a given session state between the server and a client that also supports the state-based signaling protocol, and reporting the randomly assigned expiration time for the given session state to the client. By randomizing various behaviors of the client, the server, or both, bursty traffic in the communication network is reduced or eliminated. | 07-09-2009 |
| 20090222564 | Apparatus and Method for Supporting Connection Establishment in an Offload of Network Protocol Processing - A number of improvements in network adapters that offload protocol processing from the host processor are provided. Specifically, a mechanism for improving connection establishment in a system utilizing an offload network adapter is provided. The connection establishment mechanism provides the ability to offload connection establishment and maintenance of connection state information to the offload network adapter. As a result of this offloading of connection establishment and state information maintenance, the number of communications needed between the host system and the offload network adapter may be reduced. In addition, offloading of these functions to the offload network adapter permits bulk notification of established connections and state information to the host system rather than piecemeal notifications as is present in known computing systems. | 09-03-2009 |
| 20110119367 | Methods and Apparatus for Randomization of Periodic Behavior in Communication Network - A technique for use in a client, wherein the client supports a state-based signaling protocol (e.g., Session Initiation Protocol or SIP), includes initiating a given session state between the client and a server that also supports the state-based signaling protocol, and refreshing the given session state in a randomized manner. Further, a technique for use in a server, wherein the server supports a state-based signaling protocol (again, e.g., SIP), includes randomly assigning an expiration time duration for a given session state between the server and a client that also supports the state-based signaling protocol, and reporting the randomly assigned expiration time for the given session state to the client. By randomizing various behaviors of the client, the server, or both, bursty traffic in the communication network is reduced or eliminated. | 05-19-2011 |
| 20110161456 | Apparatus and Method for Supporting Memory Management in an Offload of Network Protocol Processing - A number of improvements in network adapters that offload protocol processing from the host processor are provided. Specifically, mechanisms for handling memory management and optimization within a system utilizing an offload network adapter are provided. The memory management mechanism permits both buffered sending and receiving of data as well as zero-copy sending and receiving of data. In addition, the memory management mechanism permits grouping of DMA buffers that can be shared among specified connections based on any number of attributes. The memory management mechanism further permits partial send and receive buffer operation, delaying of DMA requests so that they may be communicated to the host system in bulk, and expedited transfer of data to the host system. | 06-30-2011 |
| 20110167134 | Apparatus and Method for Supporting Memory Management in an Offload of Network Protocol Processing - A number of improvements in network adapters that offload protocol processing from the host processor are provided. Specifically, mechanisms for handling memory management and optimization within a system utilizing an offload network adapter are provided. The memory management mechanism permits both buffered sending and receiving of data as well as zero-copy sending and receiving of data. In addition, the memory management mechanism permits grouping of DMA buffers that can be shared among specified connections based on any number of attributes. The memory management mechanism further permits partial send and receive buffer operation, delaying of DMA requests so that they may be communicated to the host system in bulk, and expedited transfer of data to the host system. | 07-07-2011 |
| 20120005652 | Method and System for Lazy Data Serialization in Computer Communications - A method of transmitting information to a receiving computer systems includes determining in a processing unit of a computer whether a receiving computer system can receive the information without converting a local format of the information into a canonical format of the information, if it is determined that the receiving computer system cannot receive the information without converting the local format into the canonical format, then converting the local format to the canonical format and transmitting the information to the receiving computer system, and if it is determined that the receiving computer system can receive the information without converting the local format into the canonical format, then transmitting the information to the receiving computer system. | 01-05-2012 |
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| 20080305120 | Immunogenic Compositions Comprising Hmgb 1 Polypeptides - The present invention relates to novel immunogenic compositions (e.g., vaccines), the production of such immunogenic compositions and methods of using such compositions. More specially, this invention provides unique immunogenic molecules comprising an HMGB1 polypeptide (e.g., an HMGB1 B-box polypeptide) and an antigen. Even more specifically, this invention provides novel fusion proteins comprising an isolated HMGB1 polypeptide and an antigen such that administration of these fusion proteins provides the two signals required for native T-cell activation. | 12-11-2008 |
| 20110236406 | IMMUNOGENIC COMPOSITIONS COMPRISING HMGB1 POLYPEPTIDES - The present invention relates to novel immunogenic compositions (e.g., vaccines), the production of such immunogenic compositions and methods of using such compositions. More specifically, this invention provides unique immunogenic molecules comprising an HMGB1 polypeptide (e.g., an HMGB1 B-box polypeptide) and an antigen. Even more specifically, this invention provides novel fusion proteins comprising an isolated HMGB1 polypeptide and an antigen such that administration of these fusion proteins provides the two signals required for native T-cell activation. | 09-29-2011 |
| 20120219546 | METHODS FOR TREATING CONDITIONS MEDIATED BY THE INFLAMMATORY CYTOKINE CASCADE USING GAPDH INHIBITORS - The present invention is directed to a method of treating a subject at risk for or having a condition mediated by an inflammatory cytokine cascade comprising administering to the subject an amount of a GAPDH inhibitor effective to treat the subject at risk for or having a condition mediated by an inflammatory cytokine cascade. | 08-30-2012 |
| 20130071389 | METHODS FOR TREATMENT OF INFLAMMATORY DISEASES - The present invention provides methods of treating inflammatory diseases in a subject comprising administering to the subject a therapeutically effective amount of an agent that inhibits pigment epithelium-derived factor (PEDF) and methods of screening for agents that inhibit PEDF. | 03-21-2013 |
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| 20090132018 | Nerve Stimulation Patches And Methods For Stimulating Selected Nerves - A selective nerve stimulation patch includes a substrate having a top surface and a bottom surface, integrated components overlying the top surface of the substrate and being electrically interconnected with one another for generating at least one nerve stimulating signal, electrodes integrated into the substrate and exposed at the bottom surface thereof for applying the at least one nerve stimulating signal to a target nerve, a waterproof, breathable cover overlying the substrate and the integrated components, and a support flange surrounding the substrate and coupling the cover and the substrate together. The support flange has a top surface that slopes downwardly toward an outer perimeter thereof, and at least a portion of the cover conforms to the sloping top surface of the support flange. In one embodiment, the patch generates a high frequency waveform with properties such as amplitude, frequency and the like chosen so as to overcome tissue impedance and the stimulation threshold of the target nerve. The modulated waveform is the waveform obtained by modulating the carrier waveform by a pulse envelope. | 05-21-2009 |
| 20090157149 | DERMATOME STIMULATION DEVICES AND METHODS - A nerve stimulation device includes a first waveform generator adapted to generate a first waveform having a first frequency capable of stimulating nerves within a dermatome, a second waveform generator adapted to generate a first carrier waveform having a second frequency capable of passing through tissue of a mammal, and a third waveform generator adapted to generate a second carrier waveform having a third frequency different than the second frequency and being capable of passing through the tissue of the mammal. The device includes a modulator electrically coupled to the first, second and third waveform generators and adapted to modulate the first waveform, the first carrier waveform, and the second carrier waveform to generate a modulated signal package capable of stimulating the nerves at different depths within the dermatome. The device also has an electrode electrically coupled to the modulator for applying the modulated waveform to the dermatomic region. | 06-18-2009 |
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| 20090149918 | IMPLANTABLE ANTENNA - An antenna implantable through minimally invasive techniques, preferably comprising a coil with conductive probes is provided. The antenna is preferably superelastic nickel-titanium having an insulative coating. The antenna may conduct a signal originating from a device external to the body of the implantee, or from another implanted device connected to the antenna depending on whether the antenna is employed for sending, receiving, or transceiving signals. Signals may contain data, operational commands, and may be used to transfer power. The implantable antenna may be connected to another implanted device, such as a blood pressure monitor, or may be implanted as a stand-alone device for purposes such as stimulating tissue. | 06-11-2009 |
| 20100161005 | Optimizing stimulation therapy of an external stimulating device based on firing of action potential in target nerve - A method and system for optimizing stimulation therapy of an external stimulating device. The stimulating signal for stimulation of a target nerve is produced using the external stimulating device. A magnetic field is induced in an implanted transmitting coil disposed proximate the target nerve when the action potential is fired along an axon of the target nerve. In turn, a feedback signal is generated in a receiving coil associated with the external stimulating device based on whether the target nerve fires an action potential. Stimulating signal parameters of the stimulating signal are adjusted based on the feedback signal. | 06-24-2010 |
| 20100249677 | Piezoelectric stimulation device - A method for stimulating a predetermined body part such as a nerve using a stimulation device including an external non-implantable transmitting device powered by a power source and generating an electrical waveform signal. A surface electrode applies the generated electrical waveform signal transcutaneously. An implantable piezoelectric element receives the applied electrical waveform signal generated transcutaneously and, in turn, causes mechanical deformation resulting in mechanical vibration of the implantable piezoelectric element sufficient to stimulate the predetermined body part. The electrical waveform signal may be either a high frequency continuous waveform or high frequency burst packets. | 09-30-2010 |
| 20110264163 | System and Method for Nerve Stimulation - A system and method for stimulating a nerve, wherein the system includes a first waveform generator adapted to generate a first waveform having a frequency capable of stimulating a predetermined nerve of the mammal, a second waveform generator adapted to generate a carrier waveform having a frequency capable of passing through tissue of the mammal, a modulation device electrically coupled to the first and second waveform generators and adapted to modulate the first and carrier waveforms to create a modulated waveform, and an electrode electrically coupled to the modulation device and positioned substantially adjacent to skin of the mammal, and adapted to apply the modulated waveform thereto. | 10-27-2011 |
