Patent application number | Description | Published |
20110301500 | AUTOMATED VESSEL PUNCTURE DEVICE USING THREE-DIMENSIONAL(3D) NEAR INFRARED (NIR) IMAGING AND A ROBOTICALLY DRIVEN NEEDLE - The present invention is directed to an automated vessel puncture device, methods of mapping three-dimensional views of subcutaneous vessels and methods for providing simultaneous real-time diagnostic assay. | 12-08-2011 |
20120020931 | THERAPEUTIC ENCAPSULATED EMBRYONIC STEM CELLS AND MESENCHYMAL STROMAL CELLS - This application discloses alginate microencapsulation-mediated differentiation of embryonic stem cells and use of the stem cell differentiation method for the development of effective treatment of various diseases and disorders. The microencapsulation of embryonic stem (ES) cells results in decreased cell aggregation and enhanced neural lineage differentiation through incorporating the soluble inducer retinoic acid (RA) into the permeable microcapsule system. This application also discloses a micro-encapsulation system for immobilizing mesenchymal stromal cells (MSCs) while sustaining the molecular communication. Thus, the invention provides the use of encapsulated mesenchymal stromal cells in the cellular transplantation therapies. Moreover, the invention provides methods for delivery of encapsulated MSCs into the central nervous system and therapies derived therefrom, such as, the treatment of spinal cord injury (SCI) and other inflammatory conditions. | 01-26-2012 |
20130331293 | AUTOMATED HIGH-CONTENT IMAGE ANALYSIS SYSTEM AND METHODS AND USES THEREOF - This invention relates to algorithms, methods and products useful in assessing steatosis level of tissues, using an automated high-content image analysis framework. The algorithms, methods and products are particularly useful in liver transplantation by providing a fast, precise and reproducible steatosis level estimation pre-transplantation. The invention also enables in vitro high throughput screening of drug candidates for reducing intra-cellular triglyceride content in the form of lipid droplets from fatty livers. | 12-12-2013 |
20140212918 | IN VITRO MODEL OF MACROSTEATOTIC (FATTY) LIVER - The present invention relates to a system and methods for identifying a compound for de-fatting and functional recovery of macrosteatotic hepatocytes. | 07-31-2014 |
20140213466 | HIGH-THROUGHPUT ASSESSMENT METHOD FOR CONTACT HYPERSENSITIVITY - The present invention provides methods for high-throughput assessment of in vivo skin sensitizing activity of chemical compounds through detection of secretion levels of cytokine markers implicated in skin sensitization in combination with a multivariate analysis, using support vector machine (SVM) for feature selection. The invention includes a computational algorithm that will provide unbiased analysis on the skin cell secretome data and predict the level of skin sensitization. The invention allows accurate assessment of the level sensitizing potency of any chemicals in a high-throughput manner, which can eliminate the needs for animal experiments, potentially saving money and time. | 07-31-2014 |
20140336078 | HIGH THROUGHPUT SENSITIZATION DETECTION DEVICES AND METHODS - This invention discloses devices and methods for high throughput skin sensitization detection. The devices comprise a microfabricated chamber comprising a region having one or more input channels and an outlet, and a face suitable for mounting a skin tissue and in fluidic communication with the region. The devices can be used in the methods for determining a prognosis of sensitization in an animal subject and identifying compounds that do not cause sensitization and thus are suitable for preparing cosmetic compositions. | 11-13-2014 |
20150065916 | FULLY AUTOMATED VASCULAR IMAGING AND ACCESS SYSTEM - The present invention is directed to a self-contained, fully automated vascular imaging and access device, methods of imaging, mapping, and analyzing three-dimensional views of blood vessels, and methods for providing continuous and real-time communication with a robotically actuated needle and a computer interface. | 03-05-2015 |
20150374273 | AUTOMATED VESSEL PUNCTURE DEVICE USING THREE-DIMENSIONAL(3D) NEAR INFRARED (NIR) IMAGING AND A ROBOTICALLY DRIVEN NEEDLE - The present invention is directed to an automated vessel puncture device, methods of mapping three-dimensional views of subcutaneous vessels and methods for providing simultaneous real-time diagnostic assay. | 12-31-2015 |