Patent application number | Description | Published |
20120035241 | USE OF INHIBITORS OF PLAC8 ACTIVITY FOR THE MODULATION OF ADIPOGENESIS - The present invention concerns Plac8, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Plac8 activity in preadipocytes and adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of Plac8 activity as well screening test for identification of modulators as of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders. | 02-09-2012 |
20120101150 | USE OF VGII3 ACTIVITY MODULATOR FOR THE MODULATION OF ADIPOGENESIS - The present invention concerns Vgll3 a new target involved in adipogenesis modulation. Further, the present invention relates to methods to increase Vgll3 activity in adipocytes and preadipocytes. In addition, pharmaceutical composition comprising Vgll3 activity enhancing molecules in order to enhance the Vgll3 activity in a target tissue are also provided. These methods, compositions and molecules can be useful to modulate adipogenesis and thus treat obesity and related disorders. | 04-26-2012 |
20120165391 | USE OF INHIBITORS OF ZDHHC2 ACTIVITY FOR MODULATION OF ADIPOGENESIS - The present invention concerns Zdhhc2, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Zdhhc2 activity in adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of Zdhhc2 activity as well as screening test for identification of modulators of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders. | 06-28-2012 |
20130018083 | USE OF SIRNA TARGETTING SIPA1L1 FOR THE REDUCTION OF ADIPOGENESISAANM Hall; DianaAACI LausanneAACO CHAAGP Hall; Diana Lausanne CHAANM Jimenez; MariaAACI Chavannes-pres-RenensAACO CHAAGP Jimenez; Maria Chavannes-pres-Renens CHAANM Poussin; CarineAACI Evian-les-BainsAACO FRAAGP Poussin; Carine Evian-les-Bains FRAANM Thorens; BernardAACI EpalingesAACO CHAAGP Thorens; Bernard Epalinges CH - The present invention concerns Sipa1l1, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Sipa1l1 activity in preadipocytes and adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of Sipa1l1 activity as well as screening test for identification of modulators of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders. | 01-17-2013 |
20140178965 | TRANSIENTLY IMMORTALIZED CELLS FOR USE IN GENE THERAPY - The invention provides methods and compositions for expanding cells that are not abundant or are difficult to obtain in pure form in culture, are in short supply (e.g., human cells), or have brief lifetimes in culture, using fusion polypeptide. The fusion polypeptide has a first region having the transport function of herpesviral VP22 protein or human immunodeficiency virus (HIV) TAT protein, and a second region with a polypeptide having cell immortalization activity, a polypeptide having telomerase-specific activity, or a polypeptide having telomerase gene activation activity. The resulting cells of the invention are suitable for use in cell therapy. | 06-26-2014 |
20150057334 | USE OF INHIBITORS OF ZDHHC2 ACTIVITY FOR MODULATION OF ADIPOGENESIS - The present invention concerns Zdhhc2, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Zdhhc2 activity in adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of Zdhhc2 activity as well as screening test for identification of modulators of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders. | 02-26-2015 |
20150065563 | USE OF VGII3 ACTIVITY MODULATOR FOR THE MODULATION OF ADIPOGENESIS - The present invention concerns Vgll3 a new target involved in adipogenesis modulation. | 03-05-2015 |
Patent application number | Description | Published |
20090272379 | ELECTRICALLY HEATED SMOKING SYSTEM HAVING A LIQUID STORAGE PORTION - An electrically heated smoking system includes a shell and a replaceable mouthpiece. The shell includes an electric power supply and electric circuitry. The mouthpiece includes a liquid storage portion and a capillary wick having a first end and a second end. The first end of the wick extends into the liquid storage portion for contact with liquid therein. The mouthpiece also includes a heating element for heating the second end of the capillary wick, an air outlet, and an aerosol forming chamber between the second end of the capillary wick and the air outlet. When the shell and mouthpiece are engaged or connected, the heating element is in electrical connection with the power supply via the circuitry, and a flowpath for air is defined from at least one air inlet to the air outlet via the aerosol forming chamber. In use, liquid is transferred from the liquid storage portion towards the heating element by capillary action in the wick. Liquid at the second end of the capillary wick is vaporized by the heating element. The supersaturated vapor created, is mixed and carried in the air flow from the at least one air inlet to the aerosol forming chamber. In the aerosol forming chamber, the vapor condenses to form an aerosol, which is carried towards the air outlet. | 11-05-2009 |
20110094523 | SMOKING SYSTEM HAVING A LIQUID STORAGE PORTION - A smoking system includes a capillary wick for holding liquid, at least one air inlet, at least one air outlet and a chamber between the air inlet and air outlet. The air inlet, the air outlet and the chamber are arranged so as to define an air flow route from the air inlet to the air outlet via the capillary wick so as to convey aerosol formed from the liquid to the air outlet. The smoking system further includes at least one guide for channeling the air flow in the air flow route, so as to control particle size in the aerosol. The smoking system optionally includes at least one heater for heating the liquid in at least a portion of the capillary wick to form the aerosol. | 04-28-2011 |
20110155153 | HEATER FOR AN ELECTRICALLY HEATED AEROSOL GENERATING SYSTEM - An electrically heated aerosol generating system for receiving an aerosol-forming substrate includes at least one electric heater for heating the aerosol-forming substrate to form the aerosol. The heater includes a heating element of a first cross section electrically connected to a plurality of elongate support elements. Each support element has a cross section greater than the first cross section. At least one of the support elements is integrally formed with the heating element. | 06-30-2011 |
20130306064 | Aerosol Generating System with Prevention of Condensate Leakage - There is provided an aerosol generating system for heating a liquid aerosol-forming substrate. The system includes an aerosol-forming chamber, and a leakage preventer for preventing or reducing leakage of liquid aerosol condensate from the aerosol generating system. The leakage preventer may include one or more of: at least one cavity in a wall of the aerosol-forming chamber, for collecting droplets of condensed liquid aerosol-forming substrate; at least one hooked member for collecting droplets of condensed liquid aerosol-forming substrate; an impactor for disrupting airflow in the aerosol-forming chamber so as to collect liquid droplets; and a closure member for substantially sealing the aerosol-forming chamber when the aerosol generating system is not in use. | 11-21-2013 |
20130306065 | Aerosol Generating System With Leakage Prevention - There is provided an aerosol generating system for heating a liquid aerosol-forming substrate. The system includes a liquid storage portion for storing the liquid aerosol-forming substrate, and a leakage preventer for preventing or reducing leakage of the liquid aerosol forming substrate from the liquid storage portion. The leakage preventer may include one or more of a porous plug at least partially located within the liquid storage portion, a first sealer between the liquid storage portion and a capillary wick, and a second sealer between the liquid storage portion and an electrical connector of an electric heater. | 11-21-2013 |
20130340750 | Electrically Heated Aerosol Generating System Having Improved Heater Control - There is provided a method for controlling at least one electric heating element of an electrically heated aerosol generating system for heating an aerosol-forming substrate. The electrically heated aerosol generating system has a sensor for detecting airflow indicative of a user taking a puff having an airflow duration. The method includes the steps of: increasing the heating power for the at least one heating element from zero to power p1 when the sensor detects that the airflow rate has increased to a first threshold, maintaining the heating power at a power p1 for at least some of the airflow duration, and decreasing the heating power for the at least one heating element from power p1 to zero when the sensor detects that the airflow rate has decreased to a second threshold. | 12-26-2013 |
20140020693 | AEROSOL GENERATING SYSTEM HAVING MEANS FOR DETERMINING DEPLETION OF A LIQUID SUBSTRATE - There is provided an electrically operated aerosol generating system for receiving an aerosol-forming substrate. The system includes a liquid storage portion for storing liquid aerosol-forming substrate, an electric heater including at least one heating element for heating the liquid aerosol-forming substrate, and electric circuitry for determining depletion of liquid aerosol-forming substrate heated by the heater based on a relationship between a temperature of the heating element and power applied to the heating element. There is also provided a method in an electrically operated aerosol generating system including a liquid storage portion for storing liquid aerosol-forming substrate and an electric heater including at least one heating element for heating the liquid aerosol-forming substrate, the method including determining depletion of liquid aerosol-forming substrate heated by the heater based on a relationship between a temperature of the heating element and power applied to the heating element. | 01-23-2014 |
20140318559 | ELECTRICALLY HEATED SMOKING SYSTEM HAVING A LIQUID STORAGE PORTION - An electrically heated smoking system includes a shell and a replaceable mouthpiece. The shell includes an electric power supply and electric circuitry. The mouthpiece includes a liquid storage portion and a capillary wick having a first end and a second end. The first end of the wick extends into the liquid storage portion for contact with liquid therein. The mouthpiece also includes a heating element for heating the second end of the capillary wick, an air outlet, and an aerosol forming chamber between the second end of the capillary wick and the air outlet. When the shell and mouthpiece are engaged or connected, the heating element is in electrical connection with the power supply via the circuitry, and a flowpath for air is defined from at least one air inlet to the air outlet via the aerosol forming chamber. In use, liquid is transferred from the liquid storage portion towards the heating element by capillary action in the wick. Liquid at the second end of the capillary wick is vaporized by the heating element. The supersaturated vapor created, is mixed and carried in the air flow from the at least one air inlet to the aerosol forming chamber. In the aerosol forming chamber, the vapor condenses to form an aerosol, which is carried towards the air outlet. | 10-30-2014 |