Thompson, MA
Alicia Thompson, Danvers, MA US
Patent application number | Description | Published |
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20110269690 | WATER-MEDIATED CONTROL OF DEPOLYMERIZATION STEP OF GLATIRAMER ACETATE SYNTHESIS - Methods of making copolymers are described. | 11-03-2011 |
20110319643 | Synthesis of an Azido Energetic Alcohol - A method of forming an azido energetic alcohol includes converting an energetic diol to a cyclic sulfite, oxidizing the cyclic sulfite to a cyclic sulfate, and opening the cyclic sulfate. The cyclic sulfate is opened, followed by hydrolysis, to form an azido energetic alcohol. | 12-29-2011 |
20150105535 | CONTROL OF COPOLYMER COMPOSITIONS - Methods of making copolymers are described. | 04-16-2015 |
Allen J. Thompson, Norwell, MA US
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20150161373 | SECURE CONNECTION BETWEEN A DATA REPOSITORY AND AN INTELLIGENCE APPLICATION - Embodiments of the invention are directed to systems, methods and computer program products for establishing a secure connection between a data repository and an intelligence application. In one embodiment, a method includes receiving, from a user device and using a processing device, a request from the intelligence application, the request communicated from the intelligence application through a data virtualization application and for obtaining access to the data repository; responding, using the processing device, to the request comprising preparing and sending an authentication request through the data virtualization application to the intelligence application; receiving authentication credentials from the intelligence application through the data virtualization application, the authentication credentials associated with one or more users of a plurality of users authorized to access the data repository; determining that the authentication credentials are valid; and providing device, access to the data repository in response to validating the authentication credentials. | 06-11-2015 |
20150193783 | Assessing Client Impact - Methods and systems for assessing client impact are presented. In particular, some aspects of the disclosure provide ways of assessing the effects of various projects and deployments on different clients of an organization. In some embodiments, a computer system may gather project data associated with one or more projects. Subsequently, the computer system may identify one or more client impacts based on the gathered project data. The computer system then may publish an inventory based on the one or more identified client impacts. In some instances, in publishing the inventory, the computer system may analyze a volume of change activity for at least one client, and may determine, based on this analysis, that at least one deployment event of at least one project should be delayed for the at least one client. | 07-09-2015 |
Benjamin B. Thompson, Framingham, MA US
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20160115380 | POLYMER INTERLAYERS COMPRISING STABILIZED FLUORESCENT PARTICLES - An interlayer comprised of a thermoplastic resin, at least one luminescent pigment and a carboxylic acid additive. The use of a thermoplastic resin, at least one luminescent pigment and a carboxylic acid additive reduces or minimizes the optical defects (such as high color or yellowness and increased haze) caused by discoloration of the pigment without sacrificing other characteristics of the interlayer. | 04-28-2016 |
Benjamin Bristol Thompson, Framingham, MA US
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20150158276 | POLYMER INTERLAYERS COMPRISING UV ABSORBERS - A UV stable polymer composition comprising a poly(vinyl acetal) resin, a plasticizer and at least one UV absorber, wherein the ultraviolet absorber comprises structure (1) | 06-11-2015 |
Brian Thompson, Lakeville, MA US
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20120109589 | METHODS AND SYSTEMS FOR DIRECT-PARAMETRIC INTEROPERABILITY IN COMPUTER-AIDED DESIGN - The present disclosure features methods and systems for direct-parametric interoperability in computer-aided design. Two approaches for developing three-dimensional designs are currently widely used: direct and parametric computer-aided design (CAD) modeling. To combine advantages of both approaches, in one aspect of the present invention, a direct modeling user interface is used for editing a model, allowing intuitive and easy manipulation of geometry, and a parametric geometry engine interprets these manipulations as history-based features to create a construction recipe. Thus, the underlying architecture of the model remains parametric, even though the user may not realize that history and associative relationships are being created and modified during every manipulation. Accordingly, the present invention provides the intuitive WYSIWYG editing of direct CAD modeling, while retaining the powerful features and regenerative capabilities of parametric modelers. | 05-03-2012 |
20120109591 | METHODS AND SYSTEMS FOR ENFORCING PARAMETRIC CONSTRAINTS IN A DIRECT MODELING INTERFACE IN COMPUTER-AIDED DESIGN - The present disclosure features methods and systems for enforcing parametric constraints in a direct modeling interface in computer-aided design (CAD). A parametric geometry engine of a CAD application may compare an attempted edit to a feature in a direct modeling user interface of the CAD application to an existing constraint created in a parametric modeling user interface, and, in one embodiment, prevent the user from completing the edit. In other embodiments, the parametric geometry engine may present a dialog box to the user and allow them to reject the edit, override or delete the constraint, modify the constraint, or take other actions as appropriate. In still other embodiments, the parametric geometry engine may allow one user to edit the feature, but not another user. Thus, parametric constraints and permissions-based ownership of entities may be enforced in a direct modeling user interface. | 05-03-2012 |
Caitlin A. Thompson, Cambridge, MA US
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20140182094 | LOCK MOUNTING ASSEMBLIES FOR TRANSPORTATION DEVICES - Lock mounting assemblies are disclosed for storing and mounting a locking apparatus to a transportation device. The mounting assemblies include one or more straps or connectors for securing the mounting assembly to the transportation device. The mounting assemblies having a structure to securely retain the locking apparatus on the transportation device and provide easy access to and release of the locking apparatus from the mounting assembly. | 07-03-2014 |
Carl V. Thompson, Acton, MA US
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20120125203 | Water purification and enhancement systems - Water purification system comprising filtration media sized with respect to each other to allow a first contaminant in the water to saturate the first medium with a delay prior to saturation of the second medium with a second contaminant. | 05-24-2012 |
Chris Thompson, Boston, MA US
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20090012544 | GASTROINTESTINAL BYPASS SLEEVE AS AN ADJUNCT TO BARIATRIC SURGERY - Disclosed herein are systems and methods for treating a patient that has undergone a bariatric surgical procedure, to promote weight loss in the patient. The systems and methods can involve positioning a gastrointestinal bypass sleeve within a portion of the altered GI anatomy to create or restore a restriction, and/or create a malabsorptive effect via a gastric and partial intestinal bypass. The bypass sleeve can include a proximal attachment element for attaching the proximal end of the sleeve in a penetrating or non-penetrating manner at the gastroesophageal junction, stomach, neo-stomach, or other locations. The bypass can be placed during the same operative session as the bariatric surgical procedure, or alternatively at a later date. | 01-08-2009 |
Chris Thompson, Needham, MA US
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20110307070 | STENT FOR REPAIR OF ANASTOMASIS SURGERY LEAKS - A stent for repairing post-anastomasis (e.g., bariatric) surgery leaks is formed by an elongated tube having a proximal flare-shaped flange, an enlarged middle section, and a distal flare-shaped flange, where an exterior surface of the elongated tube is substantially covered with a polymer. | 12-15-2011 |
20150126983 | Incisionless Endoluminal Gastric Tissue Approximation for the Treatment Of Obesity - An incisionless fully endoscopic method of reducing the capacity of the stomach is provided to surgically treat obesity. The method is directed to endoluminal tissue approximation of a portion of the stomach, including at least a portion of the greater curvature thereof. The method includes a pattern of stitching in which a portion of the stomach is closed off. One stitching pattern causes the lateral portion of the stomach to be drawn to reduce the usable volume of the stomach while maintaining a pathway from the esophagus to the pylorus. As the stitching pattern advances, the fundus is automatically drawn downward so that it may be endoscopically approached for stitching in a facilitated manner. According to another aspect of the invention, another stitching pattern extends from the antrum to the fundus between the anterior and posterior portions of the stomach. | 05-07-2015 |
Christopher C. Thompson, Needham, MA US
Patent application number | Description | Published |
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20080319258 | Sterile Access Conduit - An elongate flexible conduit including a sealing membrane is positioned through a natural body orifice and along the gastrointestinal (GI) tract of a patient. The sealing membrane is advanced along the GI tract until proximate a target wall segment of an inner wall of the GI tract. The sealing membrane is then permanently or releasably attached to the target wall segment thereby sealing off and isolating the target wall segment from the rest of the GI tract establishing a sterile pathway from the target wall to the natural body orifice. An incision is made through both the sealing membrane and the wall of the GI tract to gain access to the peritoneum to perform surgical techniques without allowing bacteria, stomach acids, and other contaminants in the GI tract to enter the peritoneum. An instrument can then be introduced into the peritoneal cavity through the incision along the sterile pathway. | 12-25-2008 |
20100268022 | ENDOSCOPIC GASTRIC BYPASS DEFECT REPAIR - The invention relates to systems or kits and methods for repairing defects in gastric bypass operations, e.g., methods of closing intragastric fistulas ( | 10-21-2010 |
20130018235 | SYSTEM AND METHOD FOR WIRELESS BIOSENSOR MONITORING - A system and method for monitoring a physical parameter of a subject is provided. The system may include a casing with a sensor coupled to the casing. The sensor may be configured to detect a physical parameter of the subject. The physical parameter may include a chemical parameter of the subject. The system includes an endoscopic clip coupled to the casing and may include a wireless transmitter for transmitting a signal via a wireless medium. The signal encodes the physical parameter of the subject detected by the sensor and the wireless transmitter is electronically connected to the endoscopic clip. The system may further include a monitor configured to communicate with the wireless transmitter for receiving the signal encoding the physical parameter of the subject. | 01-17-2013 |
20140370474 | SYSTEM AND METHOD FOR PART-TASK TRAINING BOX FOR FLEXIBLE ENDOSCOPY - Embodiments of the invention provide an endoscopic training system and method for the development of endoscopic procedure skills and technical competency of an endoscopist. The system includes a portable part-task enclosure with a plurality of walls defining an internal chamber. One of the walls includes an access port coupling the internal chamber to an external environment and the access port can be configured to facilitate the passage of a flexible endoscope insertion member. The system further includes a plurality of objects disposed within the internal chamber. Each of the plurality of objects is configured for manipulation by a medical tool that extends through the flexible endoscope insertion member. | 12-18-2014 |
Christopher C. Thompson, Danvers, MA US
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20110295285 | METHODS AND APPARATUS FOR MAGNET-INDUCED COMPRESSION ANASTOMOSIS BETWEEN ADJACENT ORGANS - Methods and apparatus for creating an anastomosis or fistula between the gallbladder and an adjacent organ are disclosed. First, a parent magnet, typically a permanent magnet, is deployed in the stomach, small intestine, or another organ adjacent to the gallbladder, and a mating daughter material is deployed in the gallbladder in order to create a magnet-compression anastomosis. The gallbladder may then be ablated or otherwise functionally inactivated through the anastomosis. Another aspect of the invention relates to an all-in-one surgical kit that contains all the necessary specialized tools for a surgeon to perform the procedure. | 12-01-2011 |
Christopher E. Thompson, Danvers, MA US
Patent application number | Description | Published |
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20080210741 | WELD REPAIR AS A COMBINED HEAT TREATMENT BRAZING PROCESS FOR METALLIC COMPONENTS - A method for welding and brazing a metallic component, such as, for example, a metallic component in a turbine, such as a bucket or blade. The method includes the steps of welding the metallic component to create a welded component; covering the welded component with a braze material to create a braze-covered welded component; and subjecting the braze-covered welded component to stress relief treatment. | 09-04-2008 |
20090064520 | Inspection tool for measuring bucket Z notch position - An inspection tool for a turbine bucket shroud includes: a clamp device for clamping a dovetail portion of a turbine bucket; a template plate provided with an aperture defined by a edge shaped to conform to a specified shape of the turbine bucket shroud, wherein the template is moveable to a location over the turbine bucket shroud in a direction toward the clamp device, and wherein, at the location, the aperture represents a design specification location for the turbine bucket shroud relative to the dovetail portion of the bucket. A measurement gauge is provided for measuring gaps between edges of the shroud and edges of the template aperture. | 03-12-2009 |
20090116533 | Method and apparatus for testing and evaluating machine components under simulated in-situ thermal operating conditions - A method and apparatus is described for enabling the testing and evaluation of industrial machine components and, in particular, gas turbine engine components, under simulated in-situ thermal operating conditions for effectively evaluating new component designs and repair techniques. A specimen machine component/part is placed in a test chamber and cyclically heated and cooled while being monitored to obtain information regarding the initiation and propagation of a crack within the structure of the component. Information regarding the number of heating and cooling cycles sustained by the component until crack initiation and information indicating the rate of crack propagation are acquired and compared over multiple heating-cooling cycles to evaluate components and repair techniques. In one example implementation, the component is monitored during cyclic heating-cooling for spontaneous acoustic emissions and acoustic emission waveform data is recorded and analyzed to determine crack initiation and/or propagation. | 05-07-2009 |
20100028143 | Split doublet power nozzle and related method - A vane doublet for a turbine nozzle includes a radially inner band; a radially outer band; and a pair of airfoils extending between the inner band and the outer band. One of the inner and outer bands is split in a generally axial direction along a split line passing between the pair of airfoils, and a seal is secured between or adjacent to facing edges of the split line. | 02-04-2010 |
Christopher F. Thompson, Arlington, MA US
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20120225886 | NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS - The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor. | 09-06-2012 |
20130331372 | Cyclic Amine Substituted Oxazolidinone CETP Inhibitor - Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compound of Formula I, A | 12-12-2013 |
20140221383 | CETP INHIBITORS - Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis: | 08-07-2014 |
20160075724 | CETP Inhibitors - Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis: | 03-17-2016 |
Christopher Francis Thompson, Boston, MA US
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20150329548 | SUBSTITUTED PYRROLOPYRIMIDINES AS HDM2 INHIBITORS - The present invention provides substituted pyrrolopyrimidines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. | 11-19-2015 |
Christopher Francis Thompson, Arlington, MA US
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20140179680 | Substituted Imidazopyridines as HDM2 Inhibitors - The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. | 06-26-2014 |
20140357618 | SUBSTITUTED IMIDAZOPYRIDINES AS HDM2 INHIBITORS - The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. | 12-04-2014 |
20150353553 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS - The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. | 12-10-2015 |
20150368247 | 2,6,7 SUBSTITUTED PURINES AS HDM2 INHIBITORS - The present invention provides 2,6,7 substituted purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same. | 12-24-2015 |
Craig Thompson, Sudbury, MA US
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20110097678 | Method of heating and heating apparatus - Method of heating and heating apparatus. According to one embodiment, the heating apparatus is designed for warming infusion fluids and includes a pair of catalytic heaters positioned around a cartridge containing the infusion fluid. Each catalytic heater includes a pair of frames jointly defining a cavity. One of the frames per heater is positioned proximate to the cartridge and includes an input port for receiving a liquid solution of methanol. The other frame per heater is positioned distal to the cartridge and includes an input port for receiving oxygen gas and an output port for exhaust gases. A first fluid diffusion medium is positioned within the methanol frame, and a second fluid diffusion medium is positioned within the oxygen frame. Sandwiched between the two diffusion media are a pervaporation membrane facing the first diffusion medium and a porous metal catalyst facing the second diffusion medium. Methanol in liquid form is supplied to the pervaporation membrane, which then transports the methanol in vapor form to the catalyst, where combustion occurs. Heat from the combustion reaction is then conducted through the heater to the cartridge containing the infusion fluid. | 04-28-2011 |
David Andrew Thompson, Westborough, MA US
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20100306412 | Method and apparatus for content-aware and adaptive deduplication - A method, a system, an apparatus, and a computer readable medium for transmission of data across a network are disclosed. The method includes receiving a data stream, analyzing the received data stream to determine a starting location and an ending location of each zone within the received data stream, based on the starting and ending locations, generating a zone stamp identifying the zone, the zone stamp includes a sequence of contiguous characters representing at least a portion of data in the zone, wherein the order of characters in the zone stamp corresponds to the order of data in the zone, comparing the zone stamp with another zone stamp of another zone in any data stream received, determining whether the zone is substantially similar to another zone by detecting that the zone stamp is substantially similar to another zone stamp, delta-compressing zones within any data stream received that have been determined to have substantially similar zone stamps, thereby deduplicating zones having substantially similar zone stamps within any data stream received, and transmitting the deduplicated zones across the network from one storage location to another storage location. | 12-02-2010 |
David B. Thompson, Cambridge, MA US
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20110112040 | SUPERCHARGED PROTEINS FOR CELL PENETRATION - Compositions, systems and related methods for delivering a supercharged protein or a complex of a supercharged protein and therapeutic agent (e g, nucleic acid, peptide, small molecule) to cells are disclosed. Superpositively charged proteins may be associated with nucleic acids (which typically have a net negative charge) via electrostatic interactions. The systems and methods may involve altering the primary sequence of a protein in order to “supercharge” the protein (e g, to generate a superpositively-charged protein). The compositions may be used to treat proliferative diseases, infectious diseases, cardiovascular diseases, inborn errors in metabolism, genetic diseases, etc. | 05-12-2011 |
20120100569 | SUPERCHARGED PROTEINS FOR CELL PENETRATION - Compositions, preparations, systems, and related methods for delivering a supercharged protein, or a complex of a supercharged protein and an agent (e.g., nucleic acids, peptides, proteins, small molecules) to cells are provided. Such systems and methods include the use of supercharged proteins. For example, superpositively charged proteins may be associated with nucleic acids (which typically have a net negative charge) via electrostatic interactions. In some embodiments, such systems and methods involve altering the primary sequence of a protein in order to “supercharge” the protein (e.g., to generate a superpositively-charged protein). In some embodiments, complexes comprising supercharged proteins and one or more agents to be delivered are useful as therapeutic agents. In some embodiments, complexes and/or pharmaceutical compositions thereof are administered to a subject in need thereof. The inventive complexes or pharmaceutical compositions thereof may be used to treat proliferative diseases, infectious diseases, cardiovascular diseases, inborn errors in metabolism, genetic diseases, etc. | 04-26-2012 |
20150071898 | CAS9-RECOMBINASE FUSION PROTEINS AND USES THEREOF - Some aspects of this disclosure provide compositions, methods, and kits for improving the specificity of RNA-programmable endonucleases, such as Cas9. Also provided are variants of Cas9, e.g., Cas9 dimers and fusion proteins, engineered to have improved specificity for cleaving nucleic acid targets. Also provided are compositions, methods, and kits for site-specific recombination, using Cas9 fusion proteins (e.g., nuclease-inactivated Cas9 fused to a recombinase catalytic domain). Such Cas9 variants are useful in clinical and research settings involving site-specific modification of DNA, for example, genomic modifications. | 03-12-2015 |
20150071899 | CAS9-FOKI FUSION PROTEINS AND USES THEREOF - Some aspects of this disclosure provide compositions, methods, and kits for improving the specificity of RNA-programmable endonucleases, such as Cas9. Also provided are variants of Cas9, e.g., Cas9 dimers and fusion proteins, engineered to have improved specificity for cleaving nucleic acid targets. Also provided are compositions, methods, and kits for site-specific nucleic acid modification using Cas9 fusion proteins (e.g., nuclease-inactivated Cas9 fused to a nuclease catalytic domain). Such Cas9 variants are useful in clinical and research settings involving site-specific modification of DNA, for example, genomic modifications. | 03-12-2015 |
20150071903 | USE OF CATIONIC LIPIDS TO DELIVER CAS9 - Compositions, methods, strategies, kits, and systems for the supercharged protein-mediated delivery of functional effector proteins into cells in vivo, ex vivo, or in vitro are provided. Compositions, methods, strategies, kits, and systems for delivery of functional effector proteins using cationic lipids and cationic polymers are also provided. Functional effector proteins include, without limitation, transcriptional modulators (e.g., repressors or activators), recombinases, nucleases (e.g., RNA-programmable nucleases, such as Cas9 proteins; TALE nuclease, and zinc finger nucleases), deaminases, and other gene modifying/editing enzymes. Functional effector proteins include TALE effector proteins, e.g., TALE transcriptional activators and repressors, as well as TALE nucleases. Compositions, methods, strategies, and systems for the delivery of functional effector proteins into cells is useful for therapeutic and research purposes, including, but not limited to, the targeted manipulation of a gene associated with disease, the modulation of the expression level of a gene associated with disease, and the programming of cell fate. | 03-12-2015 |
20150071906 | DELIVERY SYSTEM FOR FUNCTIONAL NUCLEASES - Compositions, methods, strategies, kits, and systems for the supercharged protein-mediated delivery of functional effector proteins into cells in vivo, ex vivo, or in vitro are provided. Compositions, methods, strategies, kits, and systems for delivery of funcational effector proteins using cationic lipids and cationic polymers are also provided. Functional effector proteins include, without limitation, transcriptional modulators (e.g., repressors or activators), recombinases, nucleases (e.g., RNA-programmable nucleases, such as Cas9 proteins; TALE nuclease, and zinc finger nucleases), deaminases, and other gene modifying/editing enzymes. Functional effector proteins include TALE effector proteins, e.g., TALE transcriptional activators and repressors, as well as TALE nucleases. Compositions, methods, strategies, and systems for the delivery of functional effector proteins into cells is useful for therapeutic and research purposes, including, but not limited to, the targeted manipulation of a gene associated with disease, the modulation of the expression level of a gene associated with disease, and the programming of cell fate. | 03-12-2015 |
20150118216 | DELIVERY OF NEGATIVELY CHARGED PROTEINS USING CATIONIC LIPIDS - Compositions, methods, strategies, kits, and systems for the delivery of negatively charged proteins, protein complexes, and fusion proteins, using cationic polymers or lipids are provided. Delivery of proteins into cells can be effected in vivo, ex vivo, or in vitro. Proteins that can be delivered using the compositions, methods, strategies, kits, and systems provided herein include, without limitation, enzymes, transcription factors, genome editing proteins, Cas9 proteins, TALEs, TALENs, nucleases, binding proteins (e.g., ligands, receptors, antibodies, antibody fragments; nucleic acid binding proteins, etc.), structural proteins, and therapeutic proteins (e.g., tumor suppressor proteins, therapeutic enzymes, growth factors, growth factor receptors, transcription factors, proteases, etc.), as well as variants and fusions of such proteins. | 04-30-2015 |
Edmund Thompson, Burlington, MA US
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20120033739 | Error Concealment In A Video Decoder - The error concealment technique disclosed herein relates to the use of existing information by the decoder to conceal bitstream errors regardless of what the encoder does. Examples of existing information include, for example, the previous reference frame, macroblock information for the previous reference frames, etc. Another aspect of the system described herein relates to the steps that the encoder can take to enhance the decoder's ability to recover gracefully from a transmission error. Exemplary steps that can be taken by the encoder include intra walk around and sending GOB headers. Although these encoder techniques can provide greatly enhanced results, they are not strictly necessary to the system described herein. | 02-09-2012 |
Greg A. Thompson, Arlington, MA US
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20150015210 | VOLTAGE-ENHANCED ENERGY STORAGE DEVICES - The present disclosure provides an energy storage device comprising at least one electrochemical cell comprising a negative current collector, a negative electrode in electrical communication with the negative current collector, an electrolyte in electrical communication with the negative electrode, a positive electrode in electrical communication with the electrolyte and a positive current collector in electrical communication with the positive electrode. The negative electrode comprises an alkali metal. Upon discharge, the electrolyte provides charged species of the alkali metal. The positive electrode can include a Group IIIA, IVA, VA and VIA of the periodic table of the elements, or a transition metal (e.g., Group 12 element). | 01-15-2015 |
20150132627 | VOLTAGE-ENHANCED ENERGY STORAGE DEVICES - The present disclosure provides an energy storage device comprising at least one electrochemical cell comprising a negative current collector, a negative electrode in electrical communication with the negative current collector, an electrolyte in electrical communication with the negative electrode, a positive electrode in electrical communication with the electrolyte and a positive current collector in electrical communication with the positive electrode. The negative electrode comprises an alkali metal. Upon discharge, the electrolyte provides charged species of the alkali metal. The positive electrode can include a Group IIIA, IVA, VA and VIA of the periodic table of the elements, or a transition metal (e.g., Group 12 element). | 05-14-2015 |
Guy Thompson, Watertown, MA US
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20150306596 | MEMBRANE-BASED FLUID-FLOW CONTROL DEVICES - Described herein are fluid-flow control devices for transferring a fluid from a place to another and/or controlling a fluid flow. In some embodiments, fluid-flow control devices described herein can be used as pumping devices to transfer a fluid by peristaltic motion and/or as valve devices to control fluid flow for various applications, e.g., in a microfluidic platform. | 10-29-2015 |
Jacob Thompson, Westborough, MA US
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20090157835 | Presence Enabled Instance Messaging for Distributed Energy Management Solutions - A method and system is described for real time communication in a network of distributed energy resource management devices (EMDs). Presence-based real time communications are established between at least one distributed energy resource management device (EMD) connected to an electric utility grid and a network operations center (NOC) application. | 06-18-2009 |
Jeffrey Thompson, Stoneham, MA US
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20100184951 | Truncated BAFF Receptors - The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered O-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders. | 07-22-2010 |
20110311530 | TRUNCATED BAFF RECEPTORS - The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered 0-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders. | 12-22-2011 |
20120189634 | TACI AS AN ANTI-TUMOR AGENT - A method of treating a mammal for a condition associated with undesired cell proliferation comprising administering to said mammal an effective amount of a TACI reagent, wherein said reagent extends mean survival time of said mammal by about 10% or more as compared to the absence of administering the TACI reagent. | 07-26-2012 |
20130177558 | Method of Treating Immunological Disorders by Administering Truncated BAFF Receptors - The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered O-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders. | 07-11-2013 |
20150023961 | METHODS OF MODULATING IMMUNOLOGICAL RESPONSES BY ADMINISTERING TRUNCATED BAFF RECEPTORS - The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered O-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders. | 01-22-2015 |
20150139992 | BAFF RECEPTOR (BCMA), AN IMMUNOREGULATORY AGENT - A novel receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided. | 05-21-2015 |
20150218247 | TACI AS AN ANTI-TUMOR AGENT - A method of treating a mammal for a condition associated with undesired cell proliferation comprising administering to said mammal an effective amount of a TACI reagent, wherein said reagent extends mean survival time of said mammal by about 10% or more as compared to the absence of administering the TACI reagent. | 08-06-2015 |
Jeffrey C. Thompson, Charlestown, MA US
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20090250249 | INTERPOSERS, ELECTRONIC MODULES, AND METHODS FOR FORMING THE SAME - Electronic modules and interposers are formed by encapsulating microelectronic dies and/or posts within cavities in a substrate. | 10-08-2009 |
20090250823 | Electronic Modules and Methods for Forming the Same - Electronic modules are formed by encapsulating microelectronic dies within cavities in a substrate. | 10-08-2009 |
20090251879 | DIE THINNING PROCESSES AND STRUCTURES - Microelectronic dies are thinned according to a variety of approaches, which may include bonding the dies to a substrate under vacuum, disposing a film over the dies and the substrate, and/or changing a center of pressure during thinning. | 10-08-2009 |
20110309528 | Electronic Modules and Methods for Forming the Same - Electronic modules are formed by encapsulating microelectronic dies within cavities in a substrate. | 12-22-2011 |
20120086135 | INTERPOSERS, ELECTRONIC MODULES, AND METHODS FOR FORMING THE SAME - In various embodiments, an electronic module features a first cavity in a first side of a substrate, a fill hole extending from the first cavity, and a second cavity in a second side of the substrate. The second cavity is in fluidic communication with the fill hole, and a die is encapsulated within the second cavity. | 04-12-2012 |
20130329376 | ELECTRONIC MODULES - Electronic modules are formed by encapsulating microelectronic dies within cavities in a substrate. | 12-12-2013 |
20150181709 | ELECTRONIC MODULE SUBASSEMBLIES AND METHODS FOR FABRICATING THE SAME - An electronic module subassembly including a substrate. The substrate includes a bottom laminate, a middle laminate coupled to the bottom laminate, and a top laminate coupled to the middle laminate. The middle laminate has a plurality of web areas, each web area defining at least one hole. The defines a planar top surface and a plurality of open areas corresponding to and aligned with the plurality of web areas. First components have a first thickness. At least one first component is in each of the open areas. Second components have a second thickness relatively larger than the first thickness. At least one second component is in each of the open areas. The second components extend into the respective at least one hole of the web areas. Encapsulant fills in the open areas and the web areas. | 06-25-2015 |
Jeffrey K. Thompson, Woburn, MA US
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20150186566 | INJECTION OF SIMULATED SOURCES IN A SYSTEM OF NETWORKED SENSORS - Simulated sources can be injected into a networked system for use in training and/or testing. | 07-02-2015 |
Jeffrey S. Thompson, Stoneham, MA US
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20100166741 | ALTERED BR-3 BINDING POLYPEPTIDES - The present invention relates to novel BR3 binding antibodies having altered Fc effector function and/or having a mature core carbohydrate structure in the Fc region which lacks fiicose. The present invention also relates to the use of those BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods. | 07-01-2010 |
20100280227 | POLYPEPTIDES THAT BIND BR3 AND USES THEREOF - The present invention relates to novel BR3 binding antibodies and polypeptides, including antagonist and agonist polypeptides. The present invention also relates to the use of the BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods. | 11-04-2010 |
20100311189 | Novel Receptor Nucleic Acids and Polypeptides - Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided. | 12-09-2010 |
20120070437 | METHOD OF IDENTIFYING COMPOUNDS THAT BIND BAFF-R - Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided. | 03-22-2012 |
20140187485 | NOVEL RECEPTOR NUCLEIC ACIDS AND POLYPEPTIDES - Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided. | 07-03-2014 |
Katherine Thompson, Andover, MA US
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20130095184 | Metal-Containing Materials for Treatment of Bacterial Conditions - Metal-containing materials, as well as their preparation, formulations, and use are disclosed. | 04-18-2013 |
Kevin M. Thompson, Framingham, MA US
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20160089121 | BIOPSY DEVICE - A biopsy system driver includes a motor having a rotatable output shaft, a support structure, a drive shaft, an elongate lead screw and a biopsy instrument drive member. The drive shaft is rotatably coupled to the support structure and includes or is otherwise operatively connected to the motor output shaft such that activation of the motor rotates the drive shaft. The elongate lead screw is coupled to the drive shaft such that rotation of the drive shaft rotates the lead screw about an axis of the lead screw. The lead screw is axially translatable relative to the drive shaft and to the support structure. The biopsy instrument drive member is threadably coupled to the lead screw such that rotation of the lead screw causes axial translation of one of the lead screw and biopsy instrument drive member relative to the other one and to the support structure. | 03-31-2016 |
Kristin Thompson, Arlington, MA US
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20090075342 | Metabolic profile directed aptamer medicinal chemistry - The present invention provides materials and methods for enhancing aptamers. More specifically, the materials and methods of the present invention are directed toward the modification of aptamers by the identification of one or more cleavage sites, and introduction of a chemical substitution at a position proximal to the cleavage site(s). Such aptamers are useful for the treatment of disease, in diagnostic and detection applications, and/or research, e.g., target validation. | 03-19-2009 |
20090082555 | Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics - The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics. | 03-26-2009 |
20090258425 | GENE KNOCK-DOWN BY INTRACELLULAR EXPRESSION OF APTAMERS - Materials and Methods are provided for target validation by gene knock-down with intracellularly expressed aptamers and siRNAs. The aptamers produced by the materials and methods of the invention are useful in target validation for therapeutics development. | 10-15-2009 |
20100120024 | Materials and methods for the generation of transcripts comprising modified nucleotides - Materials and Methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence. | 05-13-2010 |
Lori A. Thompson, Beverly, MA US
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20110072685 | INTEGRAL INSOLE WITH MULTIPLE AREAS OF DIFFERENT RESILIENCY AND METHOD OF MAKING THE INSOLE - An insole for a shoe includes a body that is configured to fit within the shoe. A heel recess in a heel area of the insole extends partially through the body. A metatarsal opening in a metatarsal area of the insole extends completely through the body. A heel insert is secured in the heel recess, and a metatarsal insert is secured in the metatarsal opening. A method is disclosed for making an insole by mixing a reactive resin with a quantity of cork particles to form a body mixture. The mixture is injected into an injection mold to form a body portion of the insole that includes a heel recess and metatarsal opening. A heel insert and metatarsal insert are molded and provided in the heel recess and metatarsal opening, respectively. | 03-31-2011 |
Marc Thompson, Harvard, MA US
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20130234706 | SYSTEM AND METHOD FOR PROCESSING MAGNETIC RESONANCE SIGNALS - A broadband magnetic resonance (MR) receiver is described herein. The MR receiver can be used to process nuclear magnetic resonance (NMR) signals. The MR receiver includes a transformer that amplifies the MR signals and a preamplifier that receives the MR signals from the transformer. The preamplifier includes a common-drain amplifier stage and a common-source amplifier stage. | 09-12-2013 |
Marc T. Thompson, Harvard, MA US
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20110043281 | DYNAMICALLY ADJUSTABLE LOW NOISE, LOW POWER INSTRUMENTATION AMPLIFIER - A circuit in accordance with an embodiment of the present invention includes an instrumentation amplifier, a dynamically adjustable low pass filter, at least one monitor and a controller. The instrumentation amplifier includes a pair of buffered operational amplifiers that accept a pair of input signals, and a differential operational amplifier that outputs an output signal indicative of a difference between the pair of input signals. The dynamically adjustable low pass filter is configured to provide band limiting of the output signal at frequencies greater than a cutoff frequency. The monitor, or monitors, is/are configured to monitor a signal upstream of the instrumentation amplifier and/or a signal downstream of the instrumentation amplifier and output a monitor signal. The controller is configured to receive the monitor signal, or signals, and to dynamically adjust output voltage noise at frequencies greater than the crossover frequency of the multipath amplifiers and/or the cutoff frequency of the low pass filter based on the monitor signal, or signals. | 02-24-2011 |
Maria Thompson, Cambridge, MA US
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20120056556 | LED-BASED LIGHT SOURCE HAVING DECORATIVE AND ILLUMINATION FUNCTIONS - A light source that generally includes multiple light emitting diode (LED) sources emitting light at different colors. A controller energizes the LED sources for establishing a changing pattern of the light colors to provide a decorative effect while simultaneously establishing white light illumination of a target area. | 03-08-2012 |
20130056765 | LIGHT EMITTING DIODE LIGHT SOURCE INCLUDING ALL NITRIDE LIGHT EMITTING DIODES - A light source including at least two phosphor converted (pc) light emitting diodes (LEDs), each of the pc LEDs including an associated blue-emitting LED as an excitation source for a phosphor containing element. | 03-07-2013 |
Michael Thompson, Boston, MA US
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20140234987 | METHODS FOR PREDICTING TIME-TO-DELIVERY IN PREGNANT WOMEN - The present disclosure relates to methods for predicting time-to-delivery in pregnant women. The methods include predicting that a pregnant woman will deliver within a predetermined time frame if PAMG-1 is determined to be present at a level above a predetermined detection threshold in a vaginal fluid sample obtained from the pregnant woman. Also provided are methods for determining a patient's risk of preterm labor and/or spontaneous rupture of the chorioamniotic membrane. | 08-21-2014 |
Raymond Thompson, Southborough, MA US
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20120027379 | VIDEO PROCESSING METHODS AND SYSTEMS - Video processing methods include correlating a video frame in a video stream with event data in a data stream based on a video frame time stamp and an event data time stamp, the time stamps being based on a time scale that is independent, and recording the correlation in a database. Other video processing methods include receiving a query for a video frame and searching for event data in a database. The database has an event data table and a video data table used in locating the video frame. Further video processing methods include receiving a query to retrieve a video clip for each of a plurality of plays, searching for event data in a database, locating the video clip for each of the plurality of plays, and compiling the video clips into a compiled video stream lacking video frames that do not satisfy the query. | 02-02-2012 |
Robert Delano Thompson, Milford, MA US
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20100138979 | Ergonomically shaped water blocking face screen - An ergonomically shaped water blocking face screen which provides a new and improved protective device for use in separating the facial portion of the head from the portion of the head bearing hair whereas to create a physical division between the two and thus allow work to be done on either side without reciprocal contamination or interference. A preferred embodiment comprises the use of a protective visor with a skin contacting seal and a means to affix the visor to the user's head and face. | 06-10-2010 |
Robert F. Thompson, Weston, MA US
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20120109054 | DEVICES WITH AN ERODIBLE SURFACE FOR DELIVERING AT LEAST ONE ACTIVE AGENT TO TISSUE OVER A PROLONGED PERIOD OF TIME - A device is disclosed for delivering an active agent to target tissue at a site that includes a bodily fluid. The device includes a body that has an erodible member that releases the active agent over a prescribed period of time. | 05-03-2012 |
20120109082 | DEVICES FOR DELIVERING AT LEAST ONE ACTIVE AGENT TO TISSUE - A device for delivering an active agent to target tissue at a site that includes a bodily fluid includes a body having a first exterior surface including a first section having a local, discrete recessed area formed in the body for holding the active agent. The body includes a surface flow feature in the form of a canal that is formed in the body and is recessed relative to the exterior surface. The surface flow feature interfaces with the first section and the local recessed area and is configured so as to guide or modify flow of the bodily fluid relative to the body such that fluid communication is provided between the bodily fluid and the local recessed area. The local recessed area is recessed relative to at least a portion of the canal. | 05-03-2012 |
Robert W. Thompson, Holden, MA US
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20100276365 | System and method for removing organic contaminants from water - A method and system for removing organic contaminants from water by use of a panel of hydrophobic polymer membranes which resist degradation when exposed to aggressive oxidizing solutions and that can be used to decompose the organic contaminants while fostering selective-permeation by the organic contaminants are disclosed. | 11-04-2010 |
Roy A. Thompson, Dorchester, MA US
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20100126506 | MODULAR PRESSURE SUPPORT SYSTEM AND METHOD - A pressure support system that comprises a patient circuit, a docking assembly, and a tank. The patient circuit delivers a pressurized flow of breathable gas to a patient. The docking assembly has an inlet and an outlet that is adapted to receive the pressurized flow of breathable gas, and is also adapted to be connected with the patient circuit. The tank is constructed and arranged to be removably connected with the docking assembly, and enables the pressurized flow of breathable gas to pass therethrough. The tank is also adapted to contain a liquid such that a humidity level of the pressurized flow of breathable gas is elevated as the pressurized flow of breathable gas passes therethrough. | 05-27-2010 |
20130206140 | MODULAR PRESSURE SUPPORT SYSTEM AND METHOD - A pressure support system that comprises a patient circuit, a docking assembly, and a tank. The patient circuit delivers a pressurized flow of breathable gas to a patient. The docking assembly has an inlet and an outlet that is adapted to receive the pressurized flow of breathable gas, and is also adapted to be connected with the patient circuit. The tank is constructed and arranged to be removably connected with the docking assembly, and enables the pressurized flow of breathable gas to pass therethrough. The tank is also adapted to contain a liquid such that a humidity level of the pressurized flow of breathable gas is elevated as the pressurized flow of breathable gas passes therethrough. | 08-15-2013 |
Ryan Thompson, Needham, MA US
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20150297007 | SYSTEM AND METHOD FOR PROVIDING EATING ASSISTANCE TO THOSE WITH PHYSICAL LIMITATIONS - The present invention is directed to a system and method for method to facilitate self-feeding for those with physical limitations that can easily loaded with food and is usable anywhere. The system includes a specially designed utensil called a ploon, which is a hybrid of a spoon and a plate. The ploon is coupled to an actuation device for loading the ploon with food and for lifting the ploon to the person's mouth. A switch-based interface allows the user to control the movement of the ploon, the ploon loader, and the ploon lifter, and the switch-based interface is facilitated with a microcontroller. The system can be mounted to a wheelchair of the user or is easily packable, such that the system is with the user and ready to go, whenever the user may need it. | 10-22-2015 |
Stanley Thompson, Andover, MA US
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20150204699 | Clip for a Patient Monitoring Pod - Disclosed are clips for a patient monitoring pod that is used with portable patient monitoring devices and systems. A patient monitoring pod and clip can rotate relative to each other to accommodate a patient's environment. | 07-23-2015 |
Stephen Michael Thompson, Acton, MA US
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20150055708 | PARALLEL SYMBOL DECODING - A device for parallel symbol decoding may include a first and second block. The first block is configured to convert a bitstream into a stream of binary symbols corresponding to motion vector data and other compressed image data, insert length fields into the stream of binary symbols that are each indicative of a number of consecutive binary symbols that correspond to motion vector data, and store the stream of binary symbols in a buffer. The second block is configured to retrieve the stream of binary symbols from the buffer, determine, based at least in part on the inserted length fields, consecutive binary symbols that correspond to motion vector data, decode the consecutive binary symbols that correspond to motion vector data via a first decode path, and to decode binary symbols that correspond to other compressed image data via a second decode path that is independent of the first decode path. | 02-26-2015 |
Susan Thompson, Canton, MA US
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20140378946 | APPARATUS AND METHODS FOR COMPRESSING A WOMAN'S BREAST TO EXPRESS MILK IN A CONCEALABLE MANNER - Wearable breast pumps are provided which utilize compression to enhance milk expression. The breast milk expression systems herein can allow breastfeeding users to obtain milk discreetly and comfortably in the presence of others. These systems compress the breast at one or more locations, such as at a base of a breast and/or along inferior and lateral sides of a breast, to stimulate milk expression. Various components and methods for expressing milk can facilitate milk output. For example, vacuum can be used in conjunction with compression. For another example, one or more temperature sensitive components can be utilized to improve milk secretion. In some embodiments, milk can be collected in a sterile custom storage container located around or beneath the breasts to facilitate wearability. After expression is complete, a quick-release valve can be used to detach the storage container from the pump and can prevent leaks. | 12-25-2014 |
Timothy Thompson, Marlborough, MA US
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20100147138 | FLASH MEMORY BASED STORED SAMPLE ELECTRONIC MUSIC SYNTHESIZER - A flash-memory based stored-sample electronic music synthesizer enables the electronic reproduction of a large number of independent voices while accommodating the exacting demands of voice continuity, minimal note-start latency, and voice synchronicity. | 06-17-2010 |
20120325073 | FLASH MEMORY BASED STORED SAMPLE ELECTRONIC MUSIC SYNTHESIZER - A flash-memory based stored-sample electronic music synthesizer enables the electronic reproduction of a large number of independent voices while accommodating the exacting demands of voice continuity, minimal note-start latency, and voice synchronicity. Error correction code associated with each page of a sound sample is stored with the sound sample and is retrieved with the sound sample during playback to thereby increase the overall sample retrieval rate. | 12-27-2012 |
William Thompson, Westborough, MA US
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20150117751 | METHOD OF INSPECTING IMAGES OF CONNECTORS OF OPTICAL CABLES BY USING LIVE, STILL OR STORED IMAGES - A method for inspecting connectors of multi-fiber optical cables is disclosed. The method may include receiving a plurality of images of a plurality of areas of a connector and determining, via at least a processor, matching features in two or more images according to unique visual characteristics of the images. The method further may include aligning the images, according to unique matching features of the images, and combining the images such as to obtain a combined-image of the full connector or a desired area of the connector. The combined-image of the connector may be displayed on a monitor or a display. | 04-30-2015 |
William Henry Thompson, Westborough, MA US
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20140125798 | METHOD FOR PRE AND POST IMAGE ASSOCIATION IN FIBER OPTIC INSPECTION - A fiber optic connector inspection display system including: a input unit which receives fiber end-face images; a display mode selection unit which allows a user to select at least one of an image capture mode or an image review mode; a capturing unit which captures the fiber end-face images; a storing unit which stores the captured images as a first still image and a second still image; a display unit which displays the received fiber end-face images from the input unit or the stored first and second still images, and a control unit which stores each of the first and second still images with a user defined identification label, and the control unit may further label the each of the first and second still images with a preset image pair mode label if the user selects a preset image pair mode. | 05-08-2014 |
20150130849 | APPARATUS FOR IMAGE MANIPULATION AND ANALYSIS ON PAIRED IMAGES IN FIBER OPTIC TEST - An optical fiber inspection apparatus including a memory configured to store a pair of images of ends of optical fibers, a display, and a processor coupled to the memory and the display, wherein the processor controls the display to display the pair of images simultaneously. | 05-14-2015 |