Patent application number | Description | Published |
20080269147 | RNA interference mediating small RNA molecules - Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a | 10-30-2008 |
20090186843 | RNA sequence-specific mediators of RNA interference - The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long dsRNA. Thus, these 21-23 nt fragments are the sequence-specific mediators of RNA degradation. A molecular signal, which may be their specific length, must be present in these 21-23 nt fragments to recruit cellular factors involved in RNAi. This present invention encompasses these 21-23 nt fragments and their use for specifically inactivating gene function. The use of these fragments (or chemically synthesized oligonucleotides of the same or similar nature) enables the targeting of specific mRNAs for degradation in mammalian cells, where the use of long dsRNAs to elicit RNAi is usually not practical, presumably because of the deleterious effects of the interferon response. This specific targeting of a particular gene function is useful in functional genomic and therapeutic applications. | 07-23-2009 |
20100010207 | RNA INTERFERENCE MEDIATING SMALL RNA MOLECULES - Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a | 01-14-2010 |
20100087512 | MICRORNA MOLECULES | 04-08-2010 |
20100087513 | MICRORNA MOLECULES | 04-08-2010 |
20100093837 | MICRORNA MOLECULES | 04-15-2010 |
20100099748 | MICRORNA MOLECULES | 04-22-2010 |
20100113561 | MICRORNA MOLECULES | 05-06-2010 |
20100273255 | Human micrornas and methods for inhibiting same - The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a microRNA shown in SEQ ID NOs: 1-94; 281-374; 467-481; 497-522; or 549, except that up to thirty percent of the bases may be wobble bases, and up to 10% of the contiguous bases may be non-complementary. The invention further relates to modified single stranded microRNA molecules, isolated single stranded anti-microRNA molecules and isolated microRNP molecules. In another embodiment, the invention relates to a method for inhibiting microRNP activity in a cell. | 10-28-2010 |
20100286245 | IDENTIFICATION OF NOVEL GENES CODING FOR SMALL TEMPORAL RNAS | 11-11-2010 |
20100286246 | IDENTIFICATION OF NOVEL GENES CODING FOR SMALL TEMPORAL RNAS | 11-11-2010 |
20100286385 | Anti-MicroRNA Oligonucleotide Molecules - The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell. | 11-11-2010 |
20100292308 | MICRORNA MOLECULES | 11-18-2010 |
20110054159 | RNA INTERFERENCE MEDIATING SMALL RNA MOLECULES - Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a | 03-03-2011 |
20110165669 | Anti-MicroRNA Oligonucleotide Molecules - The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell. | 07-07-2011 |
20120070892 | DNA Virus MicroRNA and Methods for Inhibiting Same - The invention relates to isolated nucleic acid molecules comprising the sequence of a human cytomegalovirus microRNA. In another embodiment, the invention relates to single stranded DNA virus microRNA molecules comprising the sequence of a human cytomegalovirus microRNA. The invention also relates to the anti-DNA virus microRNA molecules. | 03-22-2012 |
20120115220 | Anti-MicroRNA Oligonucleotide Molecules - The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell. | 05-10-2012 |
20120246747 | RNA-INTERFERENCE BY SINGLE-STRANDED RNA MOLECULES - The present invention relates to sequence and structural features of single-stranded (ss)RNA molecules required to mediate target-specific nucleic acid modifications by RNA-interference (RNAi), such as target mRNA degradation and/or DNA methylation. | 09-27-2012 |
20120255045 | INDUCIBLE SMALL RNA EXPRESSION CONSTRUCTS FOR TARGETED GENE SILENCING - The invention relates to vectors for the inducible expression of RNA molecules in eukaryotic, particularly mam | 10-04-2012 |
20130130322 | Modified RNA Ligase for Efficient 3` Modification of RNA - The invention provides a novel truncated mutated T4 RNA ligase 2. In addition, methods are provided for ligating pre-adenlylated donor molecules to the 3′ hydroxyl group of RNA in the absence of ATP using the ligase. | 05-23-2013 |
20130245090 | IDENTIFICATION OF NOVEL GENES CODING FOR SMALL TEMPORAL RNAS | 09-19-2013 |