| Patent application number | Description | Published |
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| 20080234257 | SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY - Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and/or premature ejaculation are described. | 09-25-2008 |
| 20080241289 | PREPARATION AND UTILITY OF NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS - Disclosed herein are non-nucleoside reverse transcriptase inhibitors having structural Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and the methods of their use thereof. | 10-02-2008 |
| 20080242687 | SUBSTITUTED PYRIMIDINES - Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 10-02-2008 |
| 20080255036 | SUBSTITUTED THIOPHENES - Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 10-16-2008 |
| 20080255200 | SUBSTITUTED BENZIMIDAZOLES - Disclosed herein are substituted benzimidazole-based proton pump modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 10-16-2008 |
| 20080262086 | SUBSTITUTED ANTHRANILIC ACIDS - Disclosed herein are substituted anthranilic acids, pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and medical use of such compounds for the treatment and/or management of hypertension, edema associated with congestive heart failure, hepatic disease, renal disease including nephrotic syndrome, or clearance of toxic substances from the body. | 10-23-2008 |
| 20080268071 | SUBSTITUTED CYCLOHEXANONES - Disclosed herein are substituted cyclohexanone-based NMDA receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 10-30-2008 |
| 20080280886 | SUBSTITUTED UREAS - Disclosed herein are urea-based 5-HT receptor modulators, pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and medical use of such compounds for the treatment and/or management of 5-HT receptor-mediated disorders. | 11-13-2008 |
| 20080280991 | SUBSTITUTED NAPHTHALENES - Disclosed herein are substituted naphthalene-based melatonin (MT) receptor modulators and/or 5-HT receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 11-13-2008 |
| 20080300316 | SUBSTITUTED PHENETHYLAMINES - Disclosed herein are substituted phenethylamine alpha adrenergic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 12-04-2008 |
| 20080312247 | SUBSTITUTED PIPERAZINES - Disclosed herein are substituted piperazine late Na | 12-18-2008 |
| 20080319026 | SUBSTITUTED N-ARYL PYRIDINONES - Disclosed herein are substituted N-Aryl pyridinone fibrotic inhibitors and/or collagen infiltration modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 12-25-2008 |
| 20090005309 | SUBSTITUTED PIPERIDINES - Disclosed herein are substituted piperidine-based muscarinic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 01-01-2009 |
| 20090005431 | SUBSTITUTED PYRROLIDINES - Disclosed herein are substituted pyrrolidine-based muscarinic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 01-01-2009 |
| 20090018207 | SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY - Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described. | 01-15-2009 |
| 20090022706 | SUBSTITUTED CYCLOHEXENES - Disclosed herein are substituted cyclohexene TLR4 signaling pathway modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 01-22-2009 |
| 20090023765 | SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY - Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described. | 01-22-2009 |
| 20090028873 | SUBSTITUTED CYCLOHEXANOLS - Disclosed herein are substituted cyclohexanol opioid receptor modulators and/or neurotransmitter reuptake modulators of Formula I or Formula II, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 01-29-2009 |
| 20090068168 | SUBSTITUTED AMINO ALCOHOLS - Disclosed herein are substituted amino alcohol anti-mycobacterial agents and/or chelation therapy agents of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 03-12-2009 |
| 20090176792 | SUBSTITUTED DIBENZHYDRYLPIPERAZINES - The present invention relates to new dibenzhydrylpiperazine modulators of histamine receptors, pharmaceutical compositions thereof, and methods of use thereof. | 07-09-2009 |
| 20090191183 | SUBSTITUTED INDOLES - Disclosed herein are substituted indole cysteinyl leukotriene receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 07-30-2009 |
| 20090202540 | SUBSTITUTED OXAZAPHOSPHORINES - The present invention relates to new oxazaphosphorine alkylating agents and/or immuno-suppressive agents, pharmaceutical compositions thereof, and methods of use thereof. | 08-13-2009 |
| 20090203763 | SUBSTITUTED BENZHYDRYLETHERS - Disclosed herein are substituted benzhydrylethers of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of their use thereof. | 08-13-2009 |
| 20090209550 | SUBSTITUTED TRIAZOLOPYRIDINES - Disclosed herein are substituted triazolopyridine serotonin reuptake modulators and/or 5-HT receptor modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 08-20-2009 |
| 20090209592 | INHIBITORS OF THE GASTRIC H+, K+-ATPASE WITH ENHANCED THERAPEUTIC PROPERTIES - Chemical syntheses and medical uses of novel inhibitors of the gastric H | 08-20-2009 |
| 20090215831 | INHIBITORS OF THE GASTRIC H+, K+-ATPASE WITH ENHANCED THERAPEUTIC PROPERTIES - Chemical syntheses and medical uses of novel inhibitors of the gastric H | 08-27-2009 |
| 20090247628 | SUBSTITUTED PHENYLCYCLOHEXYLGLYCOLATES - Disclosed herein are substituted phenylcyclohexylglycolate-based muscarinic acetylcholine receptor modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 10-01-2009 |
| 20090258897 | Substituted benzimidazoles - Disclosed herein are substituted benzimidazole-based proton pump modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 10-15-2009 |
| 20090270469 | SUBSTITUTED OXAZOLIDINONES - The present invention relates to new oxazolidinone modulators of skeletal muscle function and tone, pharmaceutical compositions thereof, and methods of use thereof. | 10-29-2009 |
| 20090285811 | ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE GLUCOCORTICOID STEROIDS - The present invention relates to new glucocorticoid steroid modulators of glucocorticoid receptor, pharmaceutical compositions thereof, and methods of use thereof. | 11-19-2009 |
| 20090291958 | Substituted PDE5 inhibitors - Provided herein are substituted PDE5 inhibitors of Formula 1, and processes of preparation and pharmaceutical compositions thereof. Also provided are methods of their use for the treatment and/or management of hypertension, erectile dysfunction, and/or the inability to maintain improved erectile function. | 11-26-2009 |
| 20090312435 | SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY - Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described. | 12-17-2009 |
| 20100009950 | SUBSTITUTED ETHANOLAMINES - The present invention relates to new substituted ethanolamine adrenergic receptor modulators, pharmaceutical compositions thereof, and methods of use thereof. | 01-14-2010 |
| 20100016365 | SUBSTITUTED 4-AMINO-PIPERIDINES - The present invention relates to new substituted 4-amino-piperidine opioid receptor modulators, pharmaceutical compositions thereof, and methods of use thereof. | 01-21-2010 |
| 20100055072 | 2-OXO-1,2-DIHYDRO-QUINOLINE MODULATORS OF IMMUNE FUNCTION - The present invention relates to new 2-oxo-1,2-dihydro-quinoline modulators of immune function, pharmaceutical compositions thereof, and methods of use thereof. | 03-04-2010 |
| 20100056546 | SULFONYLUREA INHIBITORS OF ATP-SENSITIVE POTASSIUM CHANNELS - The present invention relates to new sulfonylurea inhibitors of ATP-sensitive potassium channels, pharmaceutical compositions thereof, and methods of use thereof. | 03-04-2010 |
| 20100069356 | DIBENZOTHIAZEPINE MODULATORS OF DOPAMINE, ALPHA ADRENERGIC, AND SEROTONIN RECEPTORS - The present invention relates to new dibenzothiazepine modulators of D1 receptors, D2 receptors, alpha-1 adrenergic receptors, alpha-2 adrenergic receptors, H1 receptors, 5-HT1A receptors, and/or 5-HT2 receptors, pharmaceutical compositions thereof, and methods of use thereof. | 03-18-2010 |
| 20100069399 | ARYLPIPERAZINE MODULATORS OF D2 RECEPTORS, 5-HT1A RECEPTORS, AND/OR 5-HT2A RECEPTORS - The present invention relates to new arylpiperazine modulators of D2 receptors, 5-HT1A receptors, and/or 5-HT2A receptors, pharmaceutical compositions thereof, and methods of use thereof. | 03-18-2010 |
| 20100074973 | THIOXANTHENE MODULATORS OF DOPAMINE D2 RECEPTORS - The present invention relates to new thioxanthene modulators of dopamine D | 03-25-2010 |
| 20100075916 | SUBSTITUTED QUINAZOLINE INHIBITORS OF GROWTH FACTOR RECEPTOR TYROSINE KINASES - The present invention relates to new substituted quinazoline inhibitors of vascular endothelial growth factor receptor tyrosine kinase, epidermal growth factor receptor tyrosine kinase, and/or REarranged during Transfection tyrosine kinase, pharmaceutical compositions thereof, and methods of use thereof. | 03-25-2010 |
| 20100075935 | XANTHINE MODULATORS OF ADENOSINE A1 RECEPTOR - The present invention relates to new xanthine modulators of adenosine A | 03-25-2010 |
| 20100075950 | PHENYLPROPANONE MODULATORS OF DOPAMINE RECEPTOR - The present invention relates to new phenylpropanone modulators of dopamine receptors, serotonin receptors, and/or nicotinic acetylcholine receptors, pharmaceutical compositions thereof, and methods of use thereof. | 03-25-2010 |
| 20100076074 | CARBAMATE REDUCERS OF SKELETAL MUSCLE TENSION - The present invention relates to new carbamate skeletal muscle relaxants, pharmaceutical compositions thereof, and methods of use thereof. | 03-25-2010 |
| 20100076087 | METHODS OF REDUCTION OF INTERPATIENT VARIABILITY - Disclosed herein are methods for the reduction of inter-patient variability of a drug, such as in one or more parameters including half-life (t | 03-25-2010 |
| 20100087364 | TROPINE MODULATORS OF 5-HT3 RECEPTOR - The present invention relates to new tropine modulators of 5-HT3 receptor, pharmaceutical compositions thereof, and methods of use thereof. | 04-08-2010 |
| 20100087455 | SUBSTITUTED XANTHINE COMPOUNDS - The present invention relates to new substituted xanthine-based agents, pharmaceutical compositions thereof, and methods of use thereof. | 04-08-2010 |
| 20100093758 | PYRIDINE SULFONAMIDE MODULATORS OF ENDOTHELIN-A RECEPTOR - The present invention relates to new pyridine sulfonamide modulators of endothelin-A receptor, pharmaceutical compositions thereof, and methods of use thereof. | 04-15-2010 |
| 20100099666 | PHENOTHIAZINE MODULATORS OF H1 RECEPTOR AND D2 RECEPTOR - The present invention relates to new phenothiazine modulators of H1 receptors and/or D2 receptors, pharmaceutical compositions thereof, and methods of use thereof. | 04-22-2010 |
| 20100099701 | ISOQUINOLINONE MODULATORS OF 5-HT3 RECEPTORS - The present invention relates to new isoquinolinone modulators of 5-HT3 receptors, pharmaceutical compositions thereof, and methods of use thereof. | 04-22-2010 |
| 20100105720 | PREPARATION AND UTILITY OF SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS WITH HYPNOTIC EFFECTS - The present disclosure is directed to modulators of GABA | 04-29-2010 |
| 20100105755 | SUBSTITUTED BENZAMIDE MODULATORS OF DOPAMINE RECEPTOR - The present invention relates to new substituted benzamide modulators of dopamine receptor, pharmaceutical compositions thereof, and methods of use thereof. | 04-29-2010 |
| 20100111901 | TRIAZOLE INHIBITORS OF AROMATASE - The present invention relates to new triazole modulators of aromatase activity, pharmaceutical compositions thereof, and methods of use thereof. | 05-06-2010 |
| 20100113359 | DIMETHYLPHENOXY MODULATORS OF VIRAL PROTEASE ACTIVITY AND/OR PARASITIC ENZYME ACTIVITY - The present invention relates to new dimethylphenoxy inhibitors of viral protease or parasitic enzymes, pharmaceutical compositions thereof, and methods of use thereof. | 05-06-2010 |
| 20100113405 | METHYLINDAZOLE MODULATORS OF 5-HT3 RECEPTORS - The present invention relates to new methylindazole modulators of 5-HT3 receptor activity, pharmaceutical compositions thereof, and methods of use thereof. | 05-06-2010 |
| 20100113431 | N-METHYL PIPERAZINE MODULATORS OF H1 RECEPTOR - The present invention relates to new N-methyl piperazine modulators of H1 receptor activity, pharmaceutical compositions thereof, and methods of use thereof. | 05-06-2010 |
| 20100113432 | PHENOTHIAZINE MODULATORS OF D2 RECEPTORS AND 5-HT2 RECEPTORS - The present invention relates to new phenothiazine modulators of D2 receptor activity and/or 5-HT2 receptor activity, pharmaceutical compositions thereof, and methods of use thereof. | 05-06-2010 |
| 20100113478 | INDOLONE MODULATORS OF 5-HT3 RECEPTOR - The present invention relates to new indolone modulators of 5-HT3 receptor, pharmaceutical compositions thereof, and methods of use thereof. | 05-06-2010 |
| 20100113496 | PIPERIDINE MODULATORS OF VMAT2 - The present invention relates to new piperidine modulators of VMAT2, nicotinic acetylcholine receptors, and/or μ-opioid receptors, pharmaceutical compositions thereof, and methods of use thereof. | 05-06-2010 |
| 20100113606 | AMINOPROPANOL MODULATORS OF BETA-1 ADRENERGIC RECEPTOR - The present invention relates to new aminopropanol modulators of beta-1 adrenergic receptor activity, pharmaceutical compositions thereof, and methods of use thereof. | 05-06-2010 |
| 20100119508 | PHENYLACETIC ACID INHIBITORS OF CYCLOOXYGENASE - The present invention relates to new phenylacetic acid inhibitors of cyclooxygenase activity, pharmaceutical compositions thereof, and methods of use thereof. | 05-13-2010 |
| 20100119622 | 3H-BENZOOXAZOL-2-ONE MODULATORS OF D2 RECEPTOR AND/OR 5-HT1A RECEPTOR - The present invention relates to new 3H-benzooxazol-2-one modulators of D2 receptors and/or 5-HT1A receptors, pharmaceutical compositions thereof, and methods of use thereof. | 05-13-2010 |
| 20100119623 | IMIDAZOLYL MODULATORS OF 5-HT3 RECEPTORS - The present invention relates to new imidazolyl modulators of 5-HT3 receptors, pharmaceutical compositions thereof, and methods of use thereof. | 05-13-2010 |
| 20100119624 | BENZISOXAZOLE MODULATORS OF D2 RECEPTOR AND/OR 5-HT2A RECEPTOR - The present invention relates to new benzisoxazole modulators of D2 receptors and/or 5-HT2A receptors, pharmaceutical compositions thereof, and methods of use thereof. | 05-13-2010 |
| 20100120733 | STEROID MODULATORS OF GLUCOCORTICOID RECEPTOR - The present invention relates to new steroid modulators of glucocorticoid receptor activity, pharmaceutical compositions thereof, and methods of use thereof. | 05-13-2010 |
| 20100120744 | ACETAMIDOPROPANE MODULATORS OF NMDA RECEPTORS - The present invention relates to new acetamidopropane modulators of NMDA receptor, pharmaceutical compositions thereof, and methods of use thereof. | 05-13-2010 |
| 20100120756 | PHENOTHIAZINE MODULATORS OF H1 RECEPTORS - The present invention relates to new phenothiazine modulators of H1 receptors, pharmaceutical compositions thereof, and methods of use thereof. | 05-13-2010 |
| 20100120861 | BENZOIC ACID INHIBITORS OF ATP-SENSITIVE POTASSIUM CHANNELS - The present invention relates to new benzoic acid inhibitors of ATP-sensitive potassium channel activity, pharmaceutical compositions thereof, and methods of use thereof. | 05-13-2010 |
| 20100120917 | BUTYLAMMONIUM MODULATORS OF FATTY ACID TRANSPORT - The present invention relates to new butylammonium modulators of fatty acid transport, and/or removal of toxic acyl-CoA compounds, pharmaceutical compositions thereof, and methods of use thereof | 05-13-2010 |
| 20100121067 | PREPARATION AND UTILITY OF SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS WITH HYPNOTIC EFFECTS - The present disclosure is directed to modulators of GABA | 05-13-2010 |
| 20100124541 | HYDROXYADAMANTYL INHIBITORS OF DIPEPTIDYLPEPTIDASE IV - The present invention relates to new hydroxyadamantyl inhibitors of dipeptidylpeptidase IV activity, pharmaceutical compositions thereof, and methods of use thereof. | 05-20-2010 |
| 20100124550 | AMIDE INHIBITORS OF RENIN - The present invention relates to new amide inhibitors of renin, pharmaceutical compositions thereof, and methods of use thereof | 05-20-2010 |
| 20100125067 | SULFONAMIDE INHIBITORS OF CARBONIC ANHYDRASE II - The present invention relates to new sulfonamide inhibitors of carbonic anhydrase II, pharmaceutical compositions thereof, and methods of use thereof. | 05-20-2010 |
| 20100125085 | PYRIDOINDOLE MODULATORS OF NMDA RECEPTOR AND ACETYLCHOLINESTERASE - The present invention relates to new pyridoindole modulators of NMDA receptors, AMPA receptors, and/or L-type calcium channels, and/or inhibitors of acetylcholinesterase, pharmaceutical compositions thereof, and methods of use thereof. | 05-20-2010 |
| 20100125094 | PYRROLIDINYL MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS - The present invention relates to new pyrrolidinyl modulating nicotinic acetylcholine receptor compounds, pharmaceutical compositions thereof, and methods of use thereof. | 05-20-2010 |
| 20100129311 | PHENYLALANINE AMIDE INHIBITORS OF ATP-SENSITIVE POTASSIUM CHANNELS - The present invention relates to new phenylalanine amide inhibitors of ATP-sensitive potassium channels, pharmaceutical compositions thereof, and methods of use thereof. | 05-27-2010 |
| 20100129366 | THIAZOLE INHIBITORS OF CYCLOOXYGENASE - The present invention relates to new thiazole inhibitors of cyclooxygenase, pharmaceutical compositions thereof, and methods of use thereof. | 05-27-2010 |
| 20100130480 | BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2 - The present invention relates to new benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions thereof, and methods of use thereof. | 05-27-2010 |
| 20100130528 | ADAMANTANE MODULATORS OF NMDA RECEPTOR AND/OR 5HT3 RECEPTOR - The present invention relates to new adamantane modulators of NMDA receptors and/or 5HT3 receptors, pharmaceutical compositions thereof, and methods of use thereof. | 05-27-2010 |
| 20100130543 | PYRAZOLE CARBOXAMIDE INHIBITORS OF FACTOR XA - The present invention relates to new pyrazole carboxamide inhibitors of factor Xa, pharmaceutical compositions thereof, and methods of use thereof. | 05-27-2010 |
| 20100130582 | INDOLINONE MODULATORS OF DOPAMINE RECEPTOR - The present invention relates to new indolinone modulators of dopamine receptor, pharmaceutical compositions thereof, and methods of use thereof. | 05-27-2010 |
| 20100130615 | SULFONYLUREA INHIBITORS OF ATP-SENSITIVE POTASSIUM CHANNELS - The present invention relates to new sulfonylurea inhibitors of ATP-sensitive potassium channels, pharmaceutical compositions thereof, and methods of use thereof. | 05-27-2010 |
| 20100130617 | ETHANOLAMINE MODULATORS OF NMDA RECEPTOR AND MUSCARINIC ACETYLCHOLINE RECEPTOR - The present invention relates to new ethanolamine modulators of NMDA receptors and/or muscarinic acetylcholine receptors, pharmaceutical compositions thereof, and methods of use thereof. | 05-27-2010 |
| 20100135956 | STEROID MODULATORS OF PROGESTERONE RECEPTOR AND/OR GLUCOCORTICOID RECEPTOR - The present invention relates to new steroid modulators of progesterone receptor activity and/or glucocorticoid receptor activity, pharmaceutical compositions thereof, and methods of use thereof. | 06-03-2010 |
| 20100137244 | PREPARATION AND UTILITY OF HMG-COA REDUCTASE INHIBITORS - Chemical syntheses and medical uses of novel modulators of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and diastereomeric mixtures of isomers, individual diastereomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of hypercholesterolemia, dyslipidemia, coronary artery disease, atherosclerosis, metabolic syndrome, a hyperproliferative disease such as colorectal cancer, prostate cancer, and melanoma, a neurodegenerative disease such as cerebral ischemia, Alzheimer's disease, and Parkinson's disease are described. | 06-03-2010 |
| 20100137268 | PHTHALAZINONE MODULATORS OF H1 RECEPTORS AND/OR LTC4 RECEPTORS - The present invention relates to new phthalazinone modulators of H1 receptor activity and/or modulators of LTC4 production, pharmaceutical compositions thereof, and methods of use thereof. | 06-03-2010 |
| 20100137332 | PIPERAZINE MODULATORS OF NK-1 RECEPTORS - The present invention relates to new piperazine modulators of NK-1 receptors, pharmaceutical compositions thereof, and methods of use thereof. | 06-03-2010 |
| 20100143287 | TRIFLUOROMETHYLPHENYL MODULATORS OF CALCIUM-SENSING RECEPTOR - The present invention relates to new trifluoromethylphenyl modulators of calcium-sensing receptor, pharmaceutical compositions thereof, and methods of use thereof. | 06-10-2010 |
| 20100143295 | QUINAZOLINE INHIBITORS OF EGFR TYROSINE KINASE - The present invention relates to new quinazoline inhibitors of EGFR tyrosine kinase, pharmaceutical compositions thereof, and methods of use thereof. | 06-10-2010 |
| 20100143296 | PODOPHYLLOTOXIN INHIBITORS OF TOPOISOMERASE II - The present invention relates to new podophyllotoxin inhibitors of topoisomerase II, pharmaceutical compositions thereof, and methods of use thereof. | 06-10-2010 |
| 20100143354 | TRIAZINE DNA MODIFIERS - The present invention relates to new triazine DNA modifiers, pharmaceutical compositions thereof, and methods of use thereof | 06-10-2010 |
| 20100143505 | INDANONE INHIBITORS OF ACETYLCHOLINESTERASE - The present invention relates to new indanone inhibitors of acetylcholinesterase, pharmaceutical compositions thereof, and methods of use thereof. | 06-10-2010 |
| 20100143507 | CARBOXYLIC ACID INHIBITORS OF HISTONE DEACETYLASE, GABA TRANSAMINASE AND SODIUM CHANNEL - The present invention relates to new carboxylic acid inhibitors of histone deacetylase, GABA transaminase, and/or sodium channel activity, pharmaceutical compositions thereof, and methods of use thereof. | 06-10-2010 |
| 20100144657 | PHENYLPIPERIDINE MODULATORS OF mu-OPIOID RECEPTORS - The present invention relates to new phenylpiperidine modulators of opioid μ-receptors, pharmaceutical compositions thereof, and methods of use thereof. | 06-10-2010 |
| 20100144880 | AMINO ACID INHIBITORS OF PLASMIN - The present invention relates to new amino acid inhibitors of plasmin, pharmaceutical compositions thereof, and methods of use thereof | 06-10-2010 |
| 20100150896 | DIAMINOQUINAZOLINE INHIBITORS OF DIHYDROFOLATE REDUCTASE - The present invention relates to new diaminoquinazoline inhibitors of dihydrofolate reductase activity, pharmaceutical compositions thereof, and methods of use thereof. | 06-17-2010 |
| 20100150899 | PYRAZOLINONE SCAVENGERS OF FREE RADICAL - The present invention relates to new pyrazolinone scavengers of free radicals, pharmaceutical compositions thereof, and methods of use thereof. | 06-17-2010 |
| 20100152224 | SCOPINE MODULATORS OF MUSCARINIC ACETYLCHOLINE RECEPTOR - The present invention relates to new scopine modulators of muscarinic acetylcholine receptors, pharmaceutical compositions thereof, and methods of use thereof. | 06-17-2010 |
| 20100152283 | TETRAHYDROCANNABINOL MODULATORS OF CANNABINOID RECEPTORS - The present invention relates to new tetrahydrocannabinol modulators of cannabinoid receptors, pharmaceutical compositions thereof, and methods of use thereof. | 06-17-2010 |
| 20100159033 | BENZISOXAZOLE MODULATORS OF D2 RECEPTOR, AND/OR 5-HT2A RECEPTOR - The present invention relates to new benzisoxazole modulators of D2 receptors and/or 5-HT2A receptors, pharmaceutical compositions thereof, and methods of use thereof. | 06-24-2010 |
| 20100159034 | PYRROLIDINONE INHIBITORS OF PDE-4 - The present invention relates to new pyrrolidinone inhibitors of PDE-4 activity, pharmaceutical compositions thereof, and methods of use thereof. | 06-24-2010 |
| 20100160271 | BICYCLIC MODULATORS OF H1 RECEPTORS - The present invention relates to new bicyclic modulators of H1 receptor activity, pharmaceutical compositions thereof, and methods of use thereof | 06-24-2010 |
| 20100160272 | OXEPINE MODULATORS OF H1 RECEPTORS AND/OR INHIBITORS OF MAST CELL DEGRANULATION - The present invention relates to new oxepine modulators of H1 receptors and/or inhibitors of mast cell degranulation, pharmaceutical compositions thereof, and methods of use thereof. | 06-24-2010 |
| 20100160338 | BENZENESULFONAMIDE MODULATORS OF ALPHA-1A ADRENERGIC RECEPTORS - The present invention relates to new benzenesulfonamide modulators of alpha-1A adrenergic receptors, pharmaceutical compositions thereof, and methods of use thereof. | 06-24-2010 |
| 20100160347 | PYRIDO[1,2-a]PYRIMIDIN-4-ONE INHIBITORS OF MAST CELL DEGRANULATION - The present invention relates to new pyrido[1,2-a]pyrimidin-4-one inhibitors of mast cell degranulation, pharmaceutical compositions thereof, and methods of use thereof. | 06-24-2010 |
| 20100160446 | 3,4-DIMETHOXYPHENETHYLAMINE MODULATORS OF L-TYPE CALCIUM CHANNEL - The present invention relates to new 3,4-dimethoxyphenethylamine modulators of L-type calcium channel activity, pharmaceutical compositions thereof, and methods of use thereof. | 06-24-2010 |
| 20100166887 | DIBENZO[b,e][1,4]DIAZEPINE MODULATORS OF DOPAMINE RECEPTORS, SEROTONIN RECEPTORS, ADRENERGIC RECEPTORS, ACETYLCHOLINE RECEPTORS, AND/OR HISTAMINE RECEPTORS - The present invention relates to new dibenzo[b,e][1,4]diazepine modulators of dopamine receptors, serotonin receptors, adrenergic receptors, acetylcholine receptors, and/or histamine receptors, pharmaceutical compositions thereof, and methods of use thereof. | 07-01-2010 |
| 20100167988 | ETHOXYPHENYLMETHYL INHIBITORS OF SGLT2 - The present invention relates to new ethoxyphenylmethyl modulators of SGLT2, pharmaceutical compositions thereof, and methods of use thereof. | 07-01-2010 |
| 20100167989 | ISOPROPOXYPHENYLMETHYL INHIBITORS OF SGLT2 - The present invention relates to new isopropoxyphenylmethyl inhibitors of SGLT2, pharmaceutical compositions thereof, and methods of use thereof. | 07-01-2010 |
| 20100168086 | 7,8,10,10A-TETRAHYDRO-6H-BENZO[C]CHROMEN-9(6AH)-ONE MODULATORS OF CANNABINOID RECEPTORS - The present invention relates to new 7,8,10,10a-tetrahydro-6H-benzo[c]chromen-9(6aH)-one modulators of cannabinoid receptors, pharmaceutical compositions thereof, and methods of use thereof. | 07-01-2010 |
| 20100172916 | SUBSTITUTED HYDROXYPHENYLAMINE COMPOUNDS - The present invention relates to new substituted hydroxyphenylamine based modulators of hormone and/or pigment levels, pharmaceutical compositions thereof, and methods of use thereof. | 07-08-2010 |
| 20100222257 | SUBSTITUTED PHENETHYLAMINES - Disclosed herein are substituted phenethylamine alpha adrenergic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 09-02-2010 |
| 20100234388 | SUBSTITUTED PDE5 INHIBITORS - Provided herein are substituted PDE5 inhibitors of Formula (1), and processes of preparation and pharmaceutical compositions thereof. Also provided are methods of their use for the treatment and/or management of hypertension, erectile dysfunction, and/or the inability to maintain improved erectile function. The compounds are deuterated tadalafil derivatives. | 09-16-2010 |
| 20100266711 | THIENOBENZODIAZEPINE MODULATORS OF D1 RECEPTOR, D2 RECEPTOR, AND/OR 5-HT2 RECEPTOR - The present invention relates to new thienobenzodiazepine modulators of D1 receptors, D2 receptors, and/or 5-HT2 receptors, pharmaceutical compositions thereof, and methods of use thereof. | 10-21-2010 |
| 20100280086 | SUBSTITUTED THIOPHENES - Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 11-04-2010 |
| 20100286124 | PROP-2-YN-1-AMINE INHIBITORS OF MONOAMINE OXIDASE TYPE B - The present invention relates to new prop-2-yn-1-amine inhibitors of monoamine oxidase type B activity, pharmaceutical compositions thereof, and methods of use thereof. | 11-11-2010 |
| 20100291151 | 1-METHYLPYRAZOLE MODULATORS OF SUBSTANCE P, CALCITONIN GENE-RELATED PEPTIDE, ADRENERGIC RECEPTOR, AND/OR 5-HT RECEPTOR - The present invention relates to new 1-methylpyrazole modulators of substance P release, calcitonin gene-related peptide activity, adrenergic receptor activity, and/or 5-HT receptor activity, pharmaceutical compositions thereof, and methods of use thereof. | 11-18-2010 |
| 20110054020 | NAPTHYLENE INHIBITORS OF CYCLOOXYGENASE - The present invention relates to new napthylene inhibitors of cyclooxygenase activity, pharmaceutical compositions thereof, and methods of use thereof | 03-03-2011 |
| 20110091459 | IMIDAZOLE MODULATORS OF MUSCARINIC ACETYLCHOLINE RECEPTOR M3 - The present invention relates to new imidazole modulators of M3 muscarinic acetylcholine receptor activity, pharmaceutical compositions thereof, and methods of use thereof. | 04-21-2011 |
| 20110123555 | PREPARATION AND UTILITY OF CCR5 INHIBITORS - Disclosed herein are substituted 8-azabicyclo[3.2.1]octane-based anti-infective agents of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 05-26-2011 |
| 20110130424 | SUBSTITUTED PHENYLPIPERIDINES WITH SEROTONINERGIC ACTIVITY AND ENHANCED THERAPEUTIC PROPERTIES - Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described. | 06-02-2011 |
| 20110136834 | INHIBITORS OF E1 ACTIVATING ENZYMES - This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia. | 06-09-2011 |
| 20110136914 | SUBSTITUTED ARYLOXYPROPYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY - Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described. | 06-09-2011 |
| 20110160154 | SUBSTITUTED PIPERAZINES - Disclosed herein are substituted piperazine late Na | 06-30-2011 |
| 20110160244 | PHENYLPIPERIDINE MODULATORS OF MU-OPIOID RECEPTOR - The present invention relates to new phenylpiperidine modulators of μ-opioid receptors, pharmaceutical compositions thereof, and methods of use thereof. | 06-30-2011 |
