Patent application number | Description | Published |
20130022685 | Topical Compositions and Methods of Detection and Treatment - A topical composition includes a nanoemulsion of a plurality of hydrophobic particles having a hydrophilic coating therein. The hydrophobic particles are derived from the same or different hydrophobic material and each hydrophobic particle has a melting point below the melting point of the respective hydrophobic material. The hydrophobic particles comprise a mean particle size of less than about 10 nm, and the nanoemulsion further includes one or more pharmaceutically active agents. | 01-24-2013 |
20130095114 | T Cell Regulation - Combinations of anti-cancer vaccines and inhibitory antibodies to CD223 overcome immune suppression in cancer patients. The vaccines may be isolated antigens, groups of antigens, or whole tumor cells. The inhibitory antibodies may be generated in an animal by injection of fragments of CD223. Antibodies may be monoclonal antibodies or single chain antibodies or humanized antibodies. | 04-18-2013 |
20130096477 | LOW PROFILE HAND-EXTENSION/FLEXION DEVICE - A movement device for flexing and/or straightening a joint of a user includes a first anchor element adapted to be positioned adjacent a jointed appendage of a user at a first position. A second anchor element is adapted to be positioned about the jointed appendage at a second position, wherein the jointed appendage is located between the first anchor element and the second anchor element. A spring member is positioned between the first and second anchor elements wherein the spring member is fixedly secured to the second anchor element and moveable through the first anchor element to thereby allow the spring member to bend about a joint of the appendage when said appendage is flexed. The spring member is configured to exert bending forces in opposition to working muscles of the user to straighten or flex the joint of the appendage. To minimize discomfort, an intermediary support device is disposed between the first anchor element and the second anchor element which prevents the spring member from contacting the joint of the user. | 04-18-2013 |
20130101073 | Adaptive Interference Canceller in a Digital Phase Array - A digital phased array may include a plurality of antenna elements forming a main array of the digital phased array, a plurality of mixers configured to down-convert data received at respective ones of the antenna elements, a plurality of analog-to-digital converters configured to digitize data provided by corresponding ones of the mixers, and a digital signal processor. The digital signal processor may be configured to receive digitized data including at least one interference signal and at least one desired signal, determine an angle of arrival of the at least one interference signal, steer a beam of the main array toward the at least one interference signal based on the determined angle of arrival, and perform interference cancelation relative to the at least one interference signal. | 04-25-2013 |
20130101657 | ANGIOGENESIS INHIBITORS - Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject. | 04-25-2013 |
20130116293 | High-Throughput Methods for Determining Pharmacological Levels of Plasma D-Serine - Described herein are high-throughput methods of monitoring D-serine levels in plasma. The assay involves the use of strong cation solid phase extraction (SPE) to isolate D-serine from plasma, followed by quantitation of D-serine using the D-amino acid oxidase-(DAAO-) catalyzed reaction. Also described are methods of screening for compounds that act as DAAO inhibitors. | 05-09-2013 |
20130121961 | TREATMENT MODALITIES TO PREVENT OR TREAT LOSS OF CARDIOVASCULAR FUNCTION IN AGING HUMANS - Provided herein are methods for treating, preventing or reducing age related vascular stiffness and impaired cardiovascular function in a subject comprising administering to the subject a therapeutic amount of IL-10 or an IL-10 agonist or pharmaceutical compositions comprising the same. Also included herein are methods for determining whether a biologically active agent can treat, prevent or reduce age related vascular stiffness and impaired cardiovascular function using an in vitro model in a IL-10 knockout IL-10(tm/tm) mouse which lacks IL-10 function. | 05-16-2013 |
20130131144 | GDE Compositions and Methods - The present invention relates to compositions to treat glycerophosphodiester phosphodiesterase (GDE) related disorders. The invention also relates to methods treating GDE related disorders. The invention further relates to kits for treating GDE related disorders in a subject. The invention further relates to methods of identifying novel treatments for treating GDE related disorders in a subject. | 05-23-2013 |
20130131867 | STEADY HAND MICROMANIPULATION ROBOT - A cooperative-control robot includes a base component, a mobile platform arranged proximate the base component, a translation assembly operatively connected to the base component and the mobile platform and configured to move the mobile platform with translational degrees of freedom substantially without rotation with respect to said the component, a tool assembly connected to the mobile platform, and a control system configured to communicate with the translation assembly to control motion of the mobile platform in response to forces by a user applied to at least a portion of the cooperative-control robot. The translation assembly includes at least three independently operable actuator arms, each connected to a separate position of the mobile platform. A robotic system includes two or more the cooperative-control robots. | 05-23-2013 |
20130141096 | SYSTEMS AND METHODS FOR MEASURING NUCLEAR MAGNETIC RESONANCE SPIN-LATTICE RELAXATION TIME T1 AND SPIN-SPIN RELAXATION TIME T2 - A system for measuring nuclear magnetic resonance spin-lattice relaxation time T | 06-06-2013 |
20130149785 | METHODS FOR MAKING AND USING MOLECULAR SWITCHES INVOLVING CIRCULAR PERMUTATION - The invention provides molecular switches which couple external signals to functionality, and combinatorial methods of making and using the same involving circular permutation of nucleic acid and amino acid sequences. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellularly, control drug release, provide conditionally active proteins, perform metabolic engineering, and modulate cell signaling pathways. Libraries comprising the switches, expression vectors and host cells for expressing the switches are also provided. | 06-13-2013 |
20130152949 | Blast Attenuating Earplug - An earplug includes a body, insertable into an ear canal, where the body defines a channel having at least two ends. The channel can house a movable structure configured to allow passage of sound around the movable structure in a rest position, and to block at least a portion of the channel in a deflected position. The movable structure moves from the rest position to the deflected position based on receiving, at one of the at least two ends of the channel, a pressure wave having at least a threshold amplitude pressure to block at least a portion of the pressure wave from reaching the other end of the channel. | 06-20-2013 |
20130157299 | Tyrosine Kinome - Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in −20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention. | 06-20-2013 |
20130161599 | ELECTRO-CHEMICAL SENSORS, SENSOR ARRAYS AND CIRCUITS - An electro-chemical sensor includes a first electrode, a second electrode spaced apart from the first electrode, and a semiconductor channel in electrical contact with the first and second electrodes. The semiconductor channel includes a trapping material. The trapping material reduces an ability of the semiconductor channel to conduct a current of charge carriers by trapping at least some of the charge carriers to localized regions within the semiconductor channel. The semiconductor channel includes at least a portion configured to be exposed to an analyte to be detected, and the trapping material, when exposed to the analyte, interacts with the analyte so as to at least partially restore the ability of the semiconductor channel to conduct the current of charge carriers. | 06-27-2013 |
20130164220 | COLLAGEN MIMETIC PEPTIDES FOR TARGETING COLLAGEN STRANDS FOR IN VITRO AND IN VIVO IMAGING AND THERAPEUTIC USE - The present invention provides both a caged collagen mimetic peptide (CCMP) having the formula: L-S-Z | 06-27-2013 |
20130164343 | COMPOSITIONS AND METHODS FOR ENHANCING TRANSPORT THROUGH MUCUS - The invention generally relates to compositions and methods for transporting substances across mucosal barriers. The invention also relates to methods of making and using such substances. | 06-27-2013 |
20130165346 | SYSTEM AND METHOD FOR SCREENING A LIBRARY OF SAMPLES - A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system. | 06-27-2013 |
20130188196 | LATERAL DISTORTION CORRECTED OPTICAL COHERENCE TOMOGRAPHY SYSTEM - A lateral-distortion corrected optical coherence tomography system. The system can include an optical coherence tomography sensor, a light source, a fiber-optic system arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to communicate with the optical detection system and receive the detection signals. The data processing system can be configured to assemble an image corresponding to a scanning path by constructing a plurality of A-scans from the detection signals, determining displacement information from the plurality of A-scans, and arranging the plurality of A-scans according to the displacement information. | 07-25-2013 |
20130197370 | Automated Pneumothorax Detection - A method of determining the presence of a pneumothorax includes obtaining a series of frames of image data relating to a region of interest including a pleural interface of a lung. The image data includes at least a first frame and a second frame. The method further includes identifying, via processing circuitry, the pleural interface in at least the first frame and the second frame, determining, based on computing optical flow between the first and second frames, a pleural sliding classification of the image data at the pleural interface, and determining whether a pneumothorax is present in the pleural interface based on the pleural sliding classification. | 08-01-2013 |
20130197540 | DEVICES, SYSTEMS AND METHODS FOR MINIMALLY INVASIVE SURGERY OF THE THROAT AND OTHER PORTIONS OF MAMMALIAN BODY - Featured are systems, devices and apparatuses for use in minimally invasive surgical, diagnostic or therapeutic methods and/or techniques, in particular methods and/or techniques for a mammalian throat. In particular embodiments, a dexterity apparatus including one or more dexterity devices is featured, where each of the dexterity devices comprises surgical tools and each is configured and arranged with end-tip dexterity for enhanced manipulation. A portion of the dexterity devices is snake like, which is re-configurable (i.e., can be bent) so as to in effect maneuver the surgical tool and put the tool in a desired position with respect to the surgical site. Another portion of the dexterity device includes the surgical tool thereby providing the capability of performing surgical actions such as sewing, gripping, soft tissue manipulation, cutting and suction of saliva, blood and other materials from the surgical site. | 08-01-2013 |
20130197671 | Multiple Grasp Prosthetic Terminal Device - A prosthetic terminal device includes a wrist interface portion, a passive element and an active element. The passive element includes at least two finger-like projections extending from a base in a direction substantially away from the wrist interface portion. The passive element is fixed in relation to the wrist interface portion. The active element is configured to be positioned relative to the passive element and the wrist interface portion to achieve a plurality of grasp positions of the prosthetic terminal device based on one dimension of closure control of the active element in combination with a plurality of different fixable orientation positions of the active element. Each of the different fixable orientation positions is associated with at least one grasp position and at least one of the fixable orientation positions is associated with at least two grasp positions. | 08-01-2013 |
20130204331 | METHOD AND DEVICE FOR NON-INVASIVE ANATOMICAL AND SYSTEMIC COOLING AND NEUROPROTECTION - The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and/or energy removal. The present invention provides for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of mucus to the dry fluid yields evaporation of body fluid, removal of energy, cooling of the anatomical feature, and systemic cooling. Therefore, therapeutic hypothermia may be achieved for neuroprotection of various organs after ischemic insult, like the brain after cardiac arrest. Similarly, excess fluid removal is achievable for treatment of cardiogenic shock or other conditions that cause significant fluid build-up, especially in cases of compromised renal function. Additionally, the invention may be used to reduce fever, and other conditions where removal of heat, energy and/or water are beneficial. | 08-08-2013 |
20140060178 | Chip-Scale Optomechanical Gravimeter - An method and apparatus for measuring gravitational force are described where at least one first radiation can be provided to at least one optomechanical oscillator, the at least one optomechanical oscillator being structured to deform under the gravitational force to cause a shift in resonance associated with the at least one optomechanical oscillator. In addition, at least one second radiation is received from the at least one optomechanical oscillator, wherein the at least one second radiation is associated with the shift in the resonance, and the shift in the resonance can be determined based on the first and second radiations. | 03-06-2014 |