Tew, US
Arthur H. Tew, Pinehurst, NC US
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20120143152 | DROP GENERATING DEVICE - A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use. | 06-07-2012 |
20140187969 | DROP GENERATING DEVICE - A method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use and a device for droplet ejection includes a fluid delivery system capable of delivering a defined volume of the fluid in the form of droplets having properties that afford adequate and repeatable high percentage deposition upon application. The method and device include a housing, a reservoir disposed within the housing for receiving a volume of fluid, an ejector mechanism configured to eject a stream of droplets having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on the eye of the subject during use. | 07-03-2014 |
Daniel Tew, Tipton, MI US
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20110275789 | Methods and Kits for Detection of Thromboxane A2 Metabolites - Methods, compositions and kits are provided for measuring aspirin's anti-thrombotic effectiveness on a subject. Included are a novel assay for quickly and specifically measuring TxA2 metabolite levels in urine and correlating the levels with aspirin dose in a subject. The methods, compositions and kits utilize a novel anti TxA2 metabolite antibody. | 11-10-2011 |
Daniel Tew, Ann Arbor, MI US
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20100227417 | Methods and Kits for Detection of Thromboxane A2 Metabolites - Methods, compositions and kits are provided for measuring aspirin's anti-thrombotic effectiveness on a subject. Included are a novel assay for quickly and specifically measuring TxA2 metabolite levels in urine and correlating the levels with aspirin dose in a subject. The methods, compositions and kits utilize a novel anti TxA2 metabolite antibody. | 09-09-2010 |
Daniel J. Tew, Tipton, MI US
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20110311990 | TETRANOR-PGEM/PGAM SPECIFIC IMMUNOGENS, ANTIBODIES, TRACERS, ASSAY KITS AND METHODS FOR MAKING SAME - Tetranor-PGEM/tetranor-PGAM-specific antibodies, immunogens used to generate them, the processes of their manufacture, and their uses for detecting and quantifying tetranor-PGEM in biological fluids for determining biosynthesis of PGE | 12-22-2011 |
20120021437 | TETRANOR-PGDM/PGJM SPECIFIC IMMUNOGENS, ANTIBODIES, TRACERS, ASSAY KITS AND METHODS FOR MAKING SAME - Tetranor-PGDM/tetranor-PGJM-specific antibodies, immunogens used to generate them, the processes of their manufacture, and their uses in assay kits for detecting and quantifying tetranor-PGDM and tetranor-PGJM in biological fluids for determining biosynthesis of PGD | 01-26-2012 |
David Tew, Fairfield, CT US
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20090266084 | Thermoelectric device based refrigerant subcooling - A subcooler ( | 10-29-2009 |
Gaik Wei Tew, South San Francisco, CA US
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20150307611 | METHODS FOR DIAGNOSING AND TREATING INFLAMMATORY BOWEL DISEASE - Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease. | 10-29-2015 |
Gregory Tew, South Deerfield, MA US
Patent application number | Description | Published |
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20100317870 | ANTIMICROBIAL POLYMERS - The invention generally relates to novel polymers (SMAMPs) and their syntheses and use. The polymers exhibit promising properties of AMPs. In particularly, for example, a ring-opening metathesis polymerization (ROMP) platform was developed that allows syntheses of SMAMPs that employ a minimum number of norbornene-based building blocks and/or enable easy and independent variation of hydrophobic and hydrophilic groups in the monomer units and/or along the polymeric backbone to finetune and select desirable properties of the polymers. | 12-16-2010 |
20120195849 | ANTIMICROBIAL POLYMERS - The invention generally relates to novel polymers (SMAMPs) and their syntheses and use. The polymers exhibit promising properties of AMPs. In particularly, for example, a ring-opening metathesis polymerization (ROMP) platform was developed that allows syntheses of SMAMPs that employ a minimum number of norbornene-based building blocks and/or enable easy and independent variation of hydrophobic and hydrophilic groups in the monomer units and/or along the polymeric backbone to finetune and select desirable properties of the polymers. | 08-02-2012 |
Gregory N. Tew, South Deerfield, MA US
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20130072650 | Water-Soluble and Water-Insoluble, Ring Opening Metathesis Polymerization Products, Monomers and Related Methods - The invention provides certain novel water-soluble and water-insoluble monomers for ring opening metathesis polymerization and novel polymers, compositions and products, and related methods thereof. | 03-21-2013 |
20140296425 | TELECHELIC BASED NETWORKS FROM NOVEL MACROMONOMERS, COMPOSITIONS, PREPARATION AND USES THEREOF - The invention provides highly resilient synthetic hydrogels, which can be prepared, for example, by using the efficient thiol-norbornene chemistry to cross-link hydrophilic poly(ethylene glycol) (PEG) and hydrophobic polydimethylsiloxane (PDMS) polymer chains. The simple hydrogel system with enhanced mechanical properties is useful in many applications, including in the biomedical field and in the design of protective and corrective wear. | 10-02-2014 |
Gregory N. Tew, Boston, MA US
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20150031738 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME - The present invention provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, mucositis, an ophthalmic infection, an otic infection, a cancer, or a | 01-29-2015 |
Gregory N. Tew, Amherst, MA US
Patent application number | Description | Published |
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20090082524 | Water-Soluble and Water-Insoluble, Ring Opening Metathesis Polymerization Products, Monomers and Related Methods - The invention provides certain novel water-soluble and water-insoluble monomers for ring opening metathesis polymerization and novel polymers, compositions and products, and related methods thereof. | 03-26-2009 |
20110064944 | Ferromagnetic block polymers and related methods - Ferromagnetic multi-block copolymers of the sort which can be used to provide high-density, highly ordered thin films, composites and related articles. | 03-17-2011 |
20110065195 | Terpyridine-substituted compounds and related selective detection methods - Terpyridine-substituted compounds, compositions and/or related methods, as can be used to selectively detect a wide range of analytes. | 03-17-2011 |
20120202887 | Facially Amphiphilic Polyaryl and Polyarylalkynyl Polymers and Oligomers and Uses Thereof - The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers. | 08-09-2012 |
20130023561 | Facially Amphiphilic Polymers and Oligomers and Uses Thereof - The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers. | 01-24-2013 |
20130280237 | PROTEIN TRANSDUCTION DOMAINS MIMICS - The invention generally relates to synthetic mimics of cell penetrating peptides. More particularly, the invention relates to certain novel monomers, oligomers and polymers (e.g., co-polymers) that are useful for the preparation of synthetic mimics of cell penetrating peptides, their compositions, preparations and use. | 10-24-2013 |
Jeffery Tew, Rochester, MI US
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20160034544 | SYSTEM AND METHOD FOR MULTI-DIMENSIONAL DATA REPRESENTATION OF OBJECTS - Systems and method for multi-dimensional data representation of an object is provided. The multi-dimensional data representation method includes evaluating a similarity measure for a query corresponding to an object. The similarity measure between the objects are used to compute the similarity values corresponding to the object and based on at least one metadata dimension associated with the object. The similarity value are sorted to create a multi-dimensional array of similarity values. The similarity values are represented in a scalar form and a visualization interface displays a multi visual representation of the similarity values and data associated with the object. | 02-04-2016 |
20160042104 | SYSTEM AND METHOD FOR MULTI-LEVEL DATA REPRESENTATION OF OBJECT LIFECYCLE - System and method for multi-level visualization of object lifecycle is provided. A visualization network displaying data associated with the object life cycle is provided. An object is selected from the visualization network to correlate the object across and within one or more object lifecycle stages from the visualization network by generating a relationship configuration. A multi-level visualization is generated for the selected object corresponding one or more object life cycle stage. The generated at least one multi-level visualization is modified based on a criterion of interest, the criterion of interest comprises one or more attribute associated with the selected object and relation derived from the relationship configuration. | 02-11-2016 |
Jeffrey Tew, Loveland, OH US
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20150371177 | TASK SCHEDULING ASSISTANCE - Methods and systems for providing assistance in scheduling a plurality of tasks pertaining to a project are described. The method may include obtaining information pertaining to each of the plurality of tasks associated with the project for scheduling execution of the plurality of tasks. Further, the method may include computing a certainty index and a controllability index for each of the plurality of tasks. The certainty index and the controllability index is computed based on corresponding certainty scores and controllability scores determined for each of the plurality of tasks. The method also includes distributing the plurality of tasks into quadrants based on a threshold value determined for the certainty index and the controllability index. In addition, the method may include generating a sequence of execution of the plurality of tasks of the project based on the division of the tasks. | 12-24-2015 |
Jeffrey D. Tew, Rochester, MI US
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20080306783 | Modeling a supply chain - A method, system, and computer program product for modeling a supply chain. The method includes modeling a storage element in the supply chain as a place node and modeling an activity in the supply chain as a transition node. The transition node includes at least one of an immediate transition node, a timed transition node, and a substitution transition node. An item moved through the supply chain is modeled as a token, where the token includes multiple attributes associated with the item. The place node is linked to the transition node with a directed arc, with the directed arc indicating the direction of token movement between the place node and the transition node. The linked place and transition nodes are organized as a supply chain model that represents the flow of items through the supply chain. In addition, performance metrics for the supply chain model are defined. | 12-11-2008 |
John G. Tew, Mechanicsville, VA US
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20090104221 | RAPID GENERATION OF T CELL-INDEPENDENT ANTIBODY RESPONSES TO T CELL-DEPENDENT ANTIGENS - The present invention comprises the use of follicular dendritic cells (FDCs) or FDC-like cells to generate FDC-dependent, but T cell-independent, B cell responses to T cell-dependent antigens, with antigen-specific and polyclonal antibody production in ˜48 h. In another embodiment, a germinal center (GC) lymphoid tissue equivalent (LTE) was used to generate antigen-specific IgM, followed by switching to IgG. The GC LTE model can be used in vaccine assessment. Dual forms of immunogen were used in the GC LTE and in vivo. Dual immunogens resulted in rapid, specific IgM responses and enhanced IgG responses. This vaccine design approach can be used, for example, to provide rapid IgM protection (˜24-48 h) and high-affinity IgG more quickly in people moving to areas with endemic disease, or in people with T cell insufficiencies, who can be immunized to rapidly generate protective IgM. | 04-23-2009 |
20100184148 | IN VITRO GERMINAL CENTERS - The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an AIS, in that it enables generation of an in vitro human humoral response by human B lymphocytes that is accurate and reproducible, without using human subjects. The invention also permits evaluation of, for example, vaccines, allergens, and immunogens, and activation of human B cells specific for a given antigen, which can then be used to generate human antibodies. In an embodiment of the present invention the function of the in vitro GC is enhanced by placing FDCs and other immune cells in a 3D ETC; FDCs appear more effective over a longer time (antibody production is sustained for up to about 14 days. | 07-22-2010 |
20100287630 | MODELS FOR VACCINE ASSESSMENT - The present invention is directed to methods for constructing and using in vivo and in vitro models of aspects of human immunity and, in particular, construction of a human immune system model for the testing of, for example, vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. The present invention comprises both in vivo and in vitro models of aspects of human immunity that are useful for assessing the interaction of substances with the immune system, and thus can be used to accelerate and improve the accuracy and predictability of, for example, vaccine, drug, biologic, immunotherapy, cosmetic and chemical development. The invention is also useful for the generation of human monoclonal and polyclonal antibodies. | 11-11-2010 |
20110250620 | METHODS OF EVALUATING AN IMMUNE RESPONSE TO AN ANTIGEN - The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an AIS, in that it enables generation of an in vitro human humoral response by human B lymphocytes that is accurate and reproducible, without using human subjects. The invention also permits evaluation of, for example, vaccines, allergens, and immunogens, and activation of human B cells specific for a given antigen, which can then be used to generate human antibodies. In an embodiment of the present invention the function of the in vitro GC is enhanced by placing FDCs and other immune cells in a 3D ETC; FDCs appear more effective over a longer time (antibody production is sustained for up to about 14 days. | 10-13-2011 |
20110269176 | METHODS FOR ASSAYING RESPONSES TO VACCINES - The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an AIS, in that it enables generation of an in vitro human humoral response by human B lymphocytes that is accurate and reproducible, without using human subjects. The invention also permits evaluation of, for example, vaccines, allergens, and immunogens, and activation of human B cells specific for a given antigen, which can then be used to generate human antibodies. In an embodiment of the present invention the function of the in vitro GC is enhanced by placing FDCs and other immune cells in a 3D ETC; FDCs appear more effective over a longer time (antibody production is sustained for up to about 14 days. | 11-03-2011 |
20140248640 | METHODS FOR TESTING AN IMMUNE RESPONSE USING CULTURES OF T CELLS, B CELLS, DENDRITIC CELLS AND FOLLICULAR DENDRITIC CELLS - The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. | 09-04-2014 |
Kevin Tew, Provo, UT US
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20150120252 | CAX MODEL SYNCHRONIZATION - A computer-implemented method for collaborative editing of an electronic model of a design object may include (1) identifying clients configured to submit design operations to be performed on a shared design model, (2) receiving, from a first client, a first design operation to be performed on the shared design model prior to receiving, from a second client, a second design operation to be performed on the shared design model, (3) performing the first design operation prior to attempting to perform the second design operation, (4) identifying a conflict between the two design operations, and (5) in response to identifying the conflict between the design operations, notifying the second client that the second design operation was not performed on the shared design model. Various other methods and systems are also disclosed herein. | 04-30-2015 |
20150213157 | MULTI-USER CAX EDITING OF A MODEL OF A DESIGN OBJECT - A computer-implemented method for multi-user CAx editing of a model of a design object may include (1) identifying one or more geometric elements referenced in response to creating a feature within the model of the design object, (2) receiving a feature operation that references the geometric elements referenced in response to creating the feature, (3) in response to receiving the feature operation, identifying a geometric element referenced by the feature operation, and (4) generating a unique persistent label for the geometric element. Various other methods and systems are also disclosed herein. | 07-30-2015 |
Kum W. Tew, Madison, AL US
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20150123598 | DETACHABLE CHARGING SYSTEM FOR A VEHICLE - A detachable charging system for a vehicle including an interface device that receives power from the vehicle and outputs the power to a detachable charging unit that detachably couples with and electrically connects to the interface device. The detachable charging unit includes a power storage device. The detachable charging unit outputs power stored in the power storage device to a mobile device when the charging unit is detached from the interface device. The detachable charging unit outputs power received from the interface device and/or stored in the power storage device to the mobile device when the charging unit is electrically connected to the interface device. | 05-07-2015 |
Kum Weng Tew, Madison, AL US
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20150123606 | Wireless Charging System with Data Tunneling - A media system for a vehicle. The media system comprises a vehicle interface, a wireless charger configured for wirelessly charging a personal electronic device, and a gateway. The gateway is coupled to the vehicle interface via a first communications bus conforming to a first protocol and to the wireless charger via a second communications bus conforming to a second protocol different from the first protocol. The gateway is configured for converting messages transmitted on the second communications bus in accordance with the second protocol to messages transmitted on the first communications bus in accordance with the first protocol. The wireless charger is configured to receive data from the personal electronic device regarding a level of charge of a battery of the personal electronic device and to transmit the data to the media hub for display on the vehicle interface. The wireless charger also detects interference by an object during charging. | 05-07-2015 |
Lucas A Tew, Raleigh, NC US
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20150066050 | INSTRUMENTS FOR MECHANIZED SURGICAL SYSTEM - A surgical instrument for use with a mechanized surgical system that includes a roll drive unit operable by a motor. The instrument includes an elongate shaft having a longitudinal axis, and an end effector and handle on the shaft. The handle includes an actuator manually operable by a user to mechanically actuate the end effector. The shaft includes a roll joint positioned between proximal and distal shaft portions, such that the distal shaft portion is longitudinally rotatable relative to the proximal shaft portion at the roll joint. The instrument further includes a drive segment on the distal shaft portion, the drive segment including first features rotationally engageable with second features of the roll drive unit such that operation of the motor causes the distal shaft portion to axially roll relative to the proximal shaft portion. | 03-05-2015 |
Matthew Timothy Tew, Gainesville, GA US
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20150127453 | WORD RECOGNITION AND IDEOGRAPH OR IN-APP ADVERTISING SYSTEM - A non-transitory processor readable medium storing processor executable instructions is described. The processor executable instructions, when executed by a processor, cause the processor to: receive application data indicative of text from a user device via a communications network; analyze the application data for one or more indicator being at least a portion of the text entered into the application and having one or more meaning; retrieve one or more selected ideograph from a database populated with ideographs received from and associated with one or more advertisers, the one or more selected ideograph being indicative of a graphical representation of the one or more meanings of the one or more indicator; transmit the one or more selected ideograph to the user device via the communications network; and charge a fee to at least one advertiser associated with the one or more selected ideograph. | 05-07-2015 |
20150127753 | Word Recognition and Ideograph or In-App Advertising System - A non-transitory processor readable medium is described having processor executable instructions that when executed by a processor cause the processor to monitor application data from a user device via a communications network, analyze the application data for one or more indicator, retrieved one or more ideograph indicative of a graphical representation of one or more meaning of the one or more indicator, and transmit the one or more ideograph to the user device via a communications network. The application data is indicative of text entered into an application by a user via the user device. The one or more indicator is at least a portion of the text entered into the application and has one or more meaning. | 05-07-2015 |
20150339706 | WORD RECOGNITION AND IDEOGRAPH OR IN-APP ADVERTISING SYSTEM - A non-transitory processor readable medium storing processor executable instructions is described. The processor executable instructions, when executed by a processor, cause the processor to: receive application data indicative of text from a user device via a communications network; analyze the application data for one or more indicator being at least a portion of the text entered into the application and having one or more meaning; retrieve one or more selected ideograph from a database populated with ideographs received from and associated with one or more advertisers, the one or more selected ideograph being indicative of a graphical representation of the one or more meanings of the one or more indicator; transmit the one or more selected ideograph to the user device via the communications network; and charge a fee to at least one advertiser associated with the one or more selected ideograph. | 11-26-2015 |
Michael Tew, South Jordan, UT US
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20130082490 | SYSTEMS AND METHODS FOR PROVIDING AN ERGONOMIC CAR SEAT AND HANDLE - An infant car seat configured to allow a substantial amount of the car seat's weight to rest on a user's arm is described herein. The car seat generally has an ergonomic handle and a seat shell. The handle includes a handgrip that has a first handle arm and a second handle arm that both extend from the handgrip. In some instances, a first end of the first handle arm and a second end of the second handle arm are rotatably connected to the seat shell. Additionally, while the first handle arm typically comprises a first bowed portion that opens in a first direction and a second bowed portion that opens in a second direction, the second handle arm comprises a third bowed portion that opens in the first direction. In some cases, the car seat also comprises a handhold disposed on a lateral side of the seat shell. | 04-04-2013 |
20150102640 | SYSTEMS AND METHODS FOR PROVIDING AN ERGONOMIC CAR SEAT AND HANDLE - An infant car seat configured to allow a substantial amount of the car seat's weight to rest on a user's arm is described herein. The car seat generally has an ergonomic handle and a seat shell. The handle includes a handgrip that has a first handle arm and a second handle arm that both extend from the handgrip. In some instances, a first end of the first handle arm and a second end of the second handle arm are rotatably connected to the seat shell. Additionally, while the first handle arm typically comprises a first bowed portion that opens in a first direction and a second bowed portion that opens in a second direction, the second handle arm comprises a third bowed portion that opens in the first direction. In some cases, the car seat also comprises a handhold disposed on a lateral side of the seat shell. | 04-16-2015 |
Neal Taylor Tew, Lehi, UT US
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20160042582 | ELECTRONIC LOCKING SYSTEM - A lock, such as a padlock or a door lock, having radio frequency identification (RFID) and/or Bluetooth capabilities is disclosed. The control system in the lock may obtain identifying information from a user device presented close to the lock, and operates an actuator to unlock the lock based on the identifying information. The lock may include both an RFID reader and a Bluetooth system in a single device, and may automatically lock and unlock the lock by detecting a presence or an absence of a user device near the lock. At least a portion of a front face of the lock may be made of non-metallic material. The lock may include an indicator for indicating a power-on state, a Bluetooth connection status, a locked or unlocked status, and/or a low-battery state. | 02-11-2016 |
Stephanie Michelle Tew, Salem, VA US
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20080216218 | Chemically protective articles with separable adsorptive liner - A chemically protective article comprising an outer shell and a separable adsorptive liner is provided. When the adsorption sites of the liner become saturated, the liner alone may be replaced without discarding the entire article. The liner also provides additional protection from harmful species should the outer shell be breached. Such chemically protective articles include garments, shelters, and coverings. | 09-11-2008 |
William B.m. Tew, Woodbridge, VA US
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20100224699 | PAINT SPRAYER - A paint sprayer includes a frame, a motor supported by the frame, a pump operably coupled to the motor to draw paint from a paint source and pressurize the paint, and a blower supported by the frame and operable to discharge pressurized air into the pressurized paint discharged by the pump. | 09-09-2010 |