Terlau, DE
Heinrich Terlau, Eckernfoerde DE
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20080274976 | USES OF NOVEL POTASSIUM CHANNEL BLOCKERS - The present invention is directed to kappaM (κM) conopeptide RIIIK and its use for blocking the flow of potassium ions through voltage-gated potassium channels. The κM conopeptides include unglycosylated and O-glycosylated peptides. | 11-06-2008 |
20100093620 | TYROSINE-RICH CONOPEPTIDES - The invention relates to relatively short peptides (termed Conopeptide-Y family peptides or CPY family peptides or CPY peptides herein), about 30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which are rich in the amino acid tyrosine. | 04-15-2010 |
20130244933 | USE OF CONKUNITZIN-S1 FOR THE MODULATION OF GLUCOSE-INDUCED INSULIN SECRETION - The present invention relates to a (poly)peptide or a peptidomimetic thereof having the biological activity of Conkunitzin-S1, wherein said (poly)peptide is selected from (a) a polypeptide comprising or having the amino acid sequence of SEQ ID NO: 1; (b) a polypeptide having at least 85% sequence identity to SEQ ID NO:1; or (c) a fragment of a) or b); wherein said (poly)peptide or peptidomimetic specifically modulates the activity of a channel having the activity of a Kv1.7 containing channel, for the treatment or prevention of metabolic diseases or conditions, or secondary diseases or conditions related to said metabolic diseases or conditions. | 09-19-2013 |
Heinrich Terlau, Eckernforde DE
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20110224135 | USE OF CONKUNITZIN-S1 FOR THE MODULATION OF GLUCOSE-INDUCED INSULIN SECRETION - The present invention relates to a (poly)peptide or a peptidomimetic thereof having the biological activity of Conkunitzin-S1, wherein said (poly)peptide is selected from (a) a polypeptide comprising or having the amino acid sequence of SEQ ID NO: 1; (b) a polypeptide having at least 85% sequence identity to SEQ ID NO:1; or (c) a fragment of a) or b); wherein said (poly)peptide or peptidomimetic specifically modulates the activity of a channel having the activity of a Kv1.7 containing channel, for the treatment or prevention of metabolic diseases or conditions, or secondary diseases or conditions related to said metabolic diseases or conditions. The present invention furthermore relates to a method of screening for (poly)peptides derived from Conkunitzin-S1 suitable for specifically modulating the activity of a channel having the activity of a Kv1.7 containing channel, comprising: (a) altering the amino acid sequence of Conkunitzin-S1 represented by SEQ ID NO: 1 by deleting and/or inserting and/or replacing at least one amino acid; and (b) determining the modulatory effect of the (poly)peptide obtained in step (a) (i) on a channel having the activity of a Kv1.7 containing channel and (ii) on channels, preferably potassium channels, not having the activity of a Kv1.7 containing channel, which are optionally expressed on the same cell as the channel having the activity of a Kv1.7 containing channel. | 09-15-2011 |
Heinz Terlau, Eckernfoerde DE
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20110064668 | J-SUPERFAMILY CONOTOXIN PEPTIDES - The invention relates to relatively short peptides (termed J-Superfamily conotoxin peptides, J-conotoxins or J-conotoxin peptides herein), about 25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The J-conotoxins are useful for treating disorders involving voltage gated ion channels and/or receptors. | 03-17-2011 |
Martin Terlau, Murrhardt DE
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20100075821 | METHOD AND MACHINE FOR FOLDING SHEETS - A folding machine and a method of folding sheets of paper, board and the like with underlapping, include at least a first folding station with folding units and an imbricated feeder for feeding sheets to the first folding station, over an aligning table, in a first transporting direction. The imbricated feeder has a device for separating the sheets and a suction configuration which can be adjusted in and counter to the first transporting direction and is intended for the underlapping transfer of sheets from a sheet stack of the imbricated feeder to the aligning table. | 03-25-2010 |
20100075822 | METHOD AND FOLDING MACHINE FOR FOLDING SHEETS - A folding machine and a folding method perform overlapped folding of sheets of paper, paperboard and the like. The folding machine has at least one first and one second folding station each having driven folding rolls, a transport device disposed between the first and second folding stations, a drive and a common control unit connected to the drives. The products are transported between the first and the second folding stations in an overlapping manner. | 03-25-2010 |
Norbert Terlau, Kurten DE
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20080277923 | Connector Device for Media Conduits - The invention relates to a connector device for plugingly connecting at least one media conduit. The conduit device ( | 11-13-2008 |
20080296815 | Pressure Medium Connector Unit for a Vehicle Gas Spring - In at least one embodiment of the present invention a connector unit for a pressure medium connection between an outer connection part and a spring head of a vehicle gas spring is provided. The connector unit comprises a line configured to be connected to an inner connection part and the outer connection part and is elastically deformable in at least regions during relative rotation movement of the spring head. The line has a deformation section between an end-side line section and an outer line section. The deformable section is disposed in a region of the spring head which is offset to the spring axis and is of helical configuration. | 12-04-2008 |
20090102184 | PLUG CONNECTOR FOR PLASTIC PIPE CONDUITS - A plug connector for inserting a tubular plug-in part in a fluid-tight manner, useful for plastic pipe conduits is provided, consisting of a housing part with a plug-in receptacle, a retaining element and a fluid seal arranged in the plug receptacle; the housing part having a two-piece base part consisting of a receiving part for the retaining element and a connection part for connection of the housing part, to e.g., a threaded bore. | 04-23-2009 |
20090167017 | PLUG CONNECTOR FOR PIPING - A plug connector for pipelines, in particular pipelines made of plastic, having a housing part comprising, in two-part form, a receiving part for a retaining element and fluid seal; and a coupling part for coupling the housing part to an assembly, and can be sealed with respect to the assembly, characterized in that the housing part is divided in such a way that the receiving part can be sealed directly with respect to the assembly. | 07-02-2009 |
Norbert Terlau, Kuerten DE
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20080278365 | Method of Verifiably Detecting the Speed of a Vehicle - A method of measuring the speed of a vehicle wherein the speed and the distance of the vehicle from a radar system and/or the measuring angle of the vehicle relative to the radar axis is determined by means of a radar measurement so as to characterize or determine the vehicle lane of the vehicle by means of the distance and/or the measuring angle. Knowledge of the vehicle lane makes it possible to unequivocally identify the detected vehicle in a group of vehicles unequivocally. | 11-13-2008 |
20090102699 | Method for Detecting and Documenting Traffic Violations at a Traffic Light - A method for detecting and documenting red-light violations and/or speeding violations in which a radar beam is directed across all lanes of a roadway of interest and in which the speed and the position of a vehicle which passes through the radar beam are determined from the radar signals so as to be able to predict the probability of a red-light violation from the speed and the determined distance of the measured vehicle from a stop line and to trigger the recording of images of the violating vehicle at predetermined distances from the stop line. | 04-23-2009 |