Tate, GB
Christopher Godon Tate, Cambridge GB
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20120165507 | MUTANT PROTEINS AND METHODS FOR PRODUCING THEM - A method for producing a mutant G-protein coupled receptor (GPCR) with increased stability relative to a parent GPCR, the method comprising making one or more mutations in the amino acid sequence that defines a parent GPCR, wherein (i) the one or more mutations are located within a window of / plus or minus 5 residues, where / is the position of amino acid residue 2.46 in the parent GPCR when the parent GPCR is a Class 1 GPCR, or where / is the position of an equivalent amino acid residue in the parent GPCR when the parent GPCR is a Class 2 or 3 GPCR, and/or (ii) the one or more mutations are located within an amino acid sequence of transmembrane helix 7 in the parent GPCR which amino acid sequence interacts with the window of / plus or minus 5 residues, to provide one or more mutants of the parent GPCR with increased stability. | 06-28-2012 |
Christopher Gordon Tate, Cambridge GB
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20100190188 | MUTANT G-PROTEIN COUPLED RECEPTORS AND METHODS FOR SELECTING THEM - A method for selecting a G-protein coupled receptor (GPCR) with increased stability, the method comprising (a) providing one or more mutants of a parent GPCR, (b) selecting a ligand, the ligand being one which hinds to the parent GPCR when the GPCR is residing in a particular conformation, (c) determining whether the or each mutant GPCR has increased stability with respect to binding the selected ligand compared to the stability of the parent GPCR with respect to binding that ligand, and (d) selecting those mutants that have an increased stability compared to the parent GPCR with respect to binding the selected ligand. Mutants of β-adrenergic receptor, adenosine receptor and neurotensin receptor are also disclosed. | 07-29-2010 |
20110046351 | MUTANT PROTEINS AND METHODS FOR SELECTING THEM - A method for selecting a membrane protein with increased stability, the method comprising: a) providing one or more mutants of a parent membrane protein in a membrane-containing composition, wherein the one or more mutants are exposed to an amount of a membrane destabilising agent which is effective to destabilise the parent membrane protein in-situ, b) determining whether the or each mutant membrane protein has increased stability with respect to its structure and/or a biological activity compared to the stability of the parent membrane protein with respect to its structure and/or the same biological activity, and c) selecting the one or more mutants which have increased stability compared to the stability of the parent membrane protein. | 02-24-2011 |
20110112037 | CRYSTAL STRUCTURE - The invention provides a method of predicting a three dimensional structural representation of a target protein of unknown structure, or part thereof, comprising: providing the coordinates of the turkey β1-AR structure listed in Table A, Table B, Table C or Table D, optionally varied by a root mean square deviation of residue backbone atoms of not more than 1.235 A, or selected coordinates thereof; and predicting the three-dimensional structural representation of the target protein, or part thereof, by modelling the structural representation on all or the selected coordinates of the turkey β1-AR. The invention also provides the use of the turkey β1-AR coordinates to select or design one or more binding partners of β1-AR. | 05-12-2011 |
20120270230 | MUTANT G-PROTEIN COUPLED RECEPTORS AND METHODS FOR SELECTING THEM - The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein coupled receptors are provided. In some aspects, host cells comprising the polynucleotides are provided. In some aspects, the invention relates to crystallized forms of the mutant G-protein coupled receptors, and methods of preparing the same. | 10-25-2012 |
Christopher Neville Tate, Hertfordshire GB
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20120086551 | Headset Ear Detection - A device capable of providing information to a user through a plurality of different alerting signals, includes a sensing system capable of sensing indications that the device is in a first particular physical relationship to the user's body; an alerting system capable of conveying information to the user through a plurality of different alerting signals, the alerting signals including: a first set of alerting signals and a second set of alerting signals that are such as to be less noticeable to the user if the device is in the first particular physical relationship to the user's body than the first set of alerting signals, the device further including comprising a controller responsive to the sensing system and configured to estimate from the indications whether the device is in the first particular physical relationship to the user's body, and while it is to control the alerting system so as to suppress the provision of information to the user through the second set of alerting signals. | 04-12-2012 |
Clare Tate, Durham GB
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20130160304 | VEGETATION CUTTING DEVICE - A vegetation cutting device comprises, a housing, and a motor located within the housing. The motor comprises a rotating output shaft for driving a pair of reciprocating blades. The vegetation cutting device also comprises a rotatable front handle being rotatably mounted on the housing and is adapted to rotate with respect to the housing. The rotatable front handle comprises, a first trigger wherein the motor is operable on actuation of the first trigger. A release button is mechanical cooperation with the rotatable front handle for actuating rotation of the front handle. The vegetation cutting device also comprises an interlock mechanism mechanically coupling the release button and the first trigger wherein actuation of the release button prevents actuation of the first trigger and actuation of the first trigger prevents actuation of the release button. | 06-27-2013 |
20140310911 | BLOWER VACUUM DEVICE AND ATTACHMENT THEREOF - An attachment for a blower vacuum device comprising a collection bag; a coupler for removeably coupling the attachment to an air outlet of the blower vacuum device and for directing air from the air outlet into the collection bag; and a rotatable cuff fixed to the collection bag and rotatably mounted to the coupler such that the collection bag is rotatable with respect to the air outlet. | 10-23-2014 |
Clare Tate, Co. Durham GB
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20100281697 | Hedgetrimmer with Rotatable Rear Handle - A hedgetrimmer having a housing, a motor located within the housing for driving a reciprocating blade for cutting vegetation. A front handle located at a front end of the housing and a rear handle located at a rear end of the housing. The rear handle having a trigger to actuate the motor, the rear handle being rotatable around a longitudinal axis of the housing. The rear handle is lockable at one of several positions so that a user can grip the two handles in the most comfortable position for the desired cutting operation. | 11-11-2010 |
Clare Tate, Newton Aycliffe GB
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20090000055 | Means for collecting garden waste - The present invention provides a blower-vacuum device having means for collecting garden waste, the garden waste collecting means comprising: an attachment part ( | 01-01-2009 |
Daniel Tate, Yorks GB
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20130328828 | GLOVE TOUCH DETECTION FOR TOUCH DEVICES - Apparatuses and methods of glove touch detection are described. One method performs a first scan to detect an object proximate to a sense array. The first scan comprises a first sensitivity parameter. The method compares touch data from the first scan against a plurality of thresholds. The method performs a second scan to detect a touch event when the first scan's touch data exceeds a glove saturation threshold of the plurality of thresholds. The second scan comprising a second sensitivity parameter that is different than the first sensitivity parameter. The method reports a glove touch event when the first scan's touch data does not exceed the glove saturation threshold and exceeds a glove-reporting threshold of the plurality of thresholds. | 12-12-2013 |
Derek Tate, Wiltshire GB
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20090145325 | PLATFORM SCREEN DOORS - An apparatus and method for controlling the operation of a screen door system. The apparatus includes a first transceiver adapted to be mounted on a train, a second transceiver adapted to be mounted on either a train platform or a portion of the platform screen door system. The first and second transceivers are configured to communicate with each other such that when a train is stopped at the train platform within a predetermined distance of and adjacent to a door of the platform screen door system, a signal is transmitted from the first transceiver to the second transceiver to open the door. When passenger embarkation and debarkation is complete, a signal is transmitted from the first transceiver to the second transceiver to close the door, and when the door is closed and locked, a signal is transmitted to the train to depart. | 06-11-2009 |
20100063632 | PLATFORM SCREEN DOOR - A control system for a platform screen door system. The platform screen door system includes a door configured to be opened and closed. The control system includes a door drive means and a microprocessor door drive control means configured to control an opening and closing of the door according to a predetermined profile. Also included is at least one probe configured to monitor one or both of the door drive means and a motion of the door. Further included is a controller configured to control the door drive means such that when the controller is in use the controller brakes the door drive means when a signal from the probe is outside a predetermined door operating envelope. | 03-11-2010 |
Edward William Tate, London GB
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20110245460 | SOLVENT RESISTANT DIAFILTRATION OF PEPTIDES, PNA OR OLIGONUCLEOTIDES - According to the present invention, there is provided a process for the preparation of a first compound selected from peptides, oligonucleotides and peptide nucleic acids. The process comprises synthesising the first compound and then separating the first compound formed in step (i) from a second compound, which is a reaction by-product of the synthesis of the first compound and/or an excess of a reagent used for the synthesis of a first compound by a process of diafiltration. The membrane used for the diafiltration process is stable in organic solvents and provides a rejection for the first compound which is greater than the rejection for the second compound. | 10-06-2011 |
Matthew Tate, Wakefield GB
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20120035079 | GENOTOXICITY TESTING - The present invention relates to methods for detecting for the presence of an agent that putatively causes or potentiates DNA damage comprising subjecting a cell (containing a DNA sequence encoding | 02-09-2012 |
20140302512 | GENOTOXICITY TESTING - The present invention relates to methods for detecting for the presence of an agent that putatively causes or potentiates DNA damage comprising subjecting a cell (containing a DNA sequence encoding | 10-09-2014 |
Michael Tate, Norfolk GB
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20100064672 | EXCHANGE GAS HEAT EXCHANGER - A heat-exchanger ( | 03-18-2010 |
Richard P. Tate, Hampshire GB
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20090049171 | SYSTEM AND COMPUTER-READABLE MEDIUM FOR CONTROLLING ACCESS IN A DISTRIBUTED DATA PROCESSING SYSTEM - Controlling access to information in a distributed data processing system. The distributed data processing system has a server, which stores the information and also further comprises a logging tool for creating a log file. The distributed data processing system also has a client computer comprising an application program for controlling a software agent. When the software agent requests information from the server, a process to identify the software agent is invoked. In response to the identification, all the requests from the identified software agent are stored in the log file and this data in the log file is analyzed. The data is also utilized in the process of monitoring the behavior of the identified software agent. In response to the monitoring process, at least one of a plurality of pre-defined rules is invoked, in order to control the behavior of the identified software agent. | 02-19-2009 |