| Patent application number | Description | Published |
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| 20080200450 | Use of ivabradine for obtaining medicaments intended for the treatment of endothelial dysfunction - Use of ivabradine, or 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-methyl}-(methyl)-amino]-propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one, its addition salts with a pharmaceutically acceptable acid and their hydrates, for obtaining a medicament intended for the treatment of endothelial dysfunction. | 08-21-2008 |
| 20090186808 | Method and Compound for the Treatment of Valvular Disease - A method for treating valvular stenosis The method involves the administration of a therapeutically effective amount of a reverse lipid (in particular cholesterol) transport agonist to a mammal Most preferred is an Apolipoprotein A-1 mimetic peptide/phospholipid complex, the peptide of which is defined by the amino acid sequence of SEQ ID NO 1. | 07-23-2009 |
| 20100330683 | METHOD FOR QUANTIFYING OXIDATIVE STRESS CAUSED BY DIFFERENT BIOLOGICAL PATHWAYS - The present invention relates to methods for detecting a oxidative stress in a biological sample, methods of determining a cumulative record of oxidative injury, and methods of diagnosing diseases of aging, such as cardiovascular diseases, based on the presence or absence of a biomarker or a component thereof. The present invention also relates to a kit for detecting oxidative stress in a biological sample comprising a stabilizing reactant and an antibody. In some embodiments of the invention, the biomarker of oxidative stress is selected from an aldehyde-protein adduct and an aldehyde metabolite-protein adduct, and the proposed method further comprises measuring separately for the same protein biomarkers of oxydative stress formed with different amino acids of the protein. | 12-30-2010 |
| 20110092430 | METHOD AND COMPOUND FOR THE TREATMENT OF VALVULAR DISEASE - The present invention provides methods for preventing or treating a valvular stenosis or a valvular calcification in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a peptide/phospholipid complex, wherein the peptide of the complex is an Apolipoprotein A-1 mimetic peptide. In one embodiment the Apolipoprotein A-1 mimetic peptide has the sequence set forth in SEQ ID NO: 1. In another embodiment the phospholipid of the complex is egg sphingomyelin and 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine. | 04-21-2011 |
| 20110288072 | Use of ivabradine for obtaining medicaments intended for the treatment of endothelial dysfunction - Use of ivabradine, or 3-{3-[{[(7S)-3,4-dimethoxybicyclo [4.2.0]octa-1,3,5-trien-7-yl]-methyl }-(methyl)-amino]-propyl}-7,8-dimethoxy-1,3,4,5 -tetrahydro-2H-3-benzazepin-2-one, its addition salts with a pharmaceutically acceptable acid and their hydrates, for obtaining a medicament intended for the treatment of endothelial dysfunction. | 11-24-2011 |
| 20120021982 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION - The present invention features pharmaceutical compositions and methods of using the pharmaceutical compositions for treating left ventricular diastolic dysfunction. In particular, the pharmaceutical compositions include an apolipoprotein complex comprising a lipid fraction and a protein fraction. | 01-26-2012 |
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| 20100147900 | CAP FOR A CONDIMENT CONTAINER - The invention provides a cap for a container for storing condiments for human consumption. The cap comprises a member having a top portion with a peripheral wall that has means for retaining the cap onto the container extending downwardly for covering the mouth of the container, the top portion having dispensing openings for allowing passage of the condiments. The cap comprises a seal having a top portion comprising a central portion, a flange portion extending around the central portion for overlapping the dispensing openings of the member and a central peripheral wall extending downwardly from the top portion and having a lower end mountable to the member. In use, the seal is moveable between a closed position, wherein the flange portion covers the dispensing openings for preventing passage of the condiments outwards from the interior of the container, and an open position, wherein the flange portion and the flange portion frees the dispensing openings for allowing passage of the condiments outwards from the interior of the container. | 06-17-2010 |
| 20110036838 | CAP FOR A CONSUMABLE LIQUID CONTAINER - A cap for a consumable liquid container, comprising an inner member having a top portion with a peripheral wall extending downwardly for covering the mouth of the container and defining an opening, the peripheral wall of the inner member having means for retaining the cap onto the container, the inner member further comprising a first aperture for facing the interior of the container and a second aperture defined by a spout extending upwardly from the top portion, the first and second apertures being in liquid communication for allowing passage of the consumable liquid; an outer member having a top portion, an inner peripheral wall defining an inner aperture, and an external peripheral wall extending downwardly from the top portion of the outer member for covering at least partially the peripheral wall of the inner member; and a seal made of a flexible material and comprising a top section having a depressible portion and a flange portion at least partially surrounding the depressible portion for overlapping the spout and a peripheral wall extending downwardly from the top section and having a lower end mounted to the outer member in an area adjacent the inner aperture of the outer member; wherein the seal is in closed position where the depressible portion is above the flange portion and the flange portion has a portion covering the spout for hampering the outward flow of consumable liquid through the spout, and wherein, upon pressure of a user on the depressible portion, the depressible portion is moved downwardly such that the flange portion is above the depressible portion and frees the spout for allowing unimpeded passage of the consumable liquid outwards from the interior of the container. | 02-17-2011 |
| 20110186573 | CAP FOR A CONTAINER - A cap for a container for storing liquid comprising a base comprising at least one passage adapted to be in fluid communication with the interior of the container. The cap comprises a seal made of an elastomeric material and comprising a depressible portion, a flange portion at least partially surrounding the depressible portion, and a seal stem extending downwardly from the depressible portion. The seal is movable between a first position, wherein the depressible portion is above the flange portion and a second position, wherein the flange portion is above the depressible portion. The cap also comprises a valve connected to the seal stem and movable between a closed position, wherein the valve prevents the outward passage of the consumable liquid through the passage and an open position, wherein the valve allows passage of the consumable liquid through the passage. In use, upon pressure of a user on the depressible portion of the seal, the depressible portion is moved downwardly such that the valve is moved into the open position and the seal is moved into the second position, and wherein, upon pressure of the user on the flange portion of the seal, the depressible portion is moved upwardly such that the valve is moved into the closed position and the seal is moved into the first position. | 08-04-2011 |
