Patent application number | Description | Published |
20090317834 | NOVEL CELLULAR GLYCAN COMPOSITIONS - The invention describes novel compositions of glycans, glycomes, from human embryonic stem cells, and especially novel subcompositions of the glycomes with specific monosaccharide compositions and glycan structures. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore, the invention is directed to stem cells carrying the modified glycomes on their surfaces. The glycomes are preferably analysed by profiling methods able to detect reproducibly and quantitatively numerous individual glycan structures at the same time. The most preferred type of the profile is a mass spectrometric profile. The invention specifically revealed novel target structures and is especially directed to the development of reagents recognizing the structures. | 12-24-2009 |
20100047827 | NOVEL SPECIFIC CELL BINDERS - The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies. | 02-25-2010 |
20100145032 | NOVEL CARBOHYDRATE PROFILE COMPOSITIONS FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF - The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies. | 06-10-2010 |
20100292095 | HUMAN MONOCLONAL ANTIBODIES DIRECTED TO SIALYL LEWIS C, SIALYL TN AND N GLYCOLYLNEURAMINIC ACID EPITOPES AND A METHOD OF ANALYSIS OF STEM CELLS COMPRISING SAID EPITOPES - This invention relates to antibody engineering technology. More particularly, the present invention relates to human IgM antibodies and derivatives thereof, which have novel binding specificity with regard to several oligosaccharide sequences and/or xenoantigenic sialic acid residue. The present invention also relates to processes for making and engineering such novel saccharide and/or NeuGc-binding monoclonal antibodies and to methods for using these antibodies and derivatives thereof in the field of immunodiagnostics, enabling qualitative and quantitative determination of xenoantigenic NeuGc in biological and raw material samples, as well as in immunotherapy, enabling blocking of xenoantigenic NeuGc in patients. | 11-18-2010 |
20110045497 | NOVEL ACIDIC GLYCAN MARKERS OF HUMAN CELLS - The invention is directed to the analysis of novel acidic glycan markers of several types of human cells. The analysis is performed by mass spectrometry or specific binder molecules. | 02-24-2011 |
20110143373 | METHOD OF EVALUATING THE INTEGRITY OF THE PLASMA MEMBRANE OF CELLS BY DETECTING GLYCANS FOUND ONLY INTRACELLULARLY - The invention describes novel reagents that can be applied for analysis of the quality of human cells. The method evaluates the integrity of the plasma membrane of the cells by detecting novel glyco structures found only intracellularly. The method can be applied, for example, to demonstrate exposure of therapeutic cell preparation to potentially harmful conditions. It can also be used as a quality control tool in methods in which intact cell membrane is essential and it can be applied in separation of damaged cells from non- damaged. | 06-16-2011 |
20120129712 | ANTIBODIES DIRECTED TO TRA ANTIGENS, AND METHODS OF PRODUCTION, SCREENING AND ANALYSIS OF SAID ANTIBODIES, AS WELL AS METHODS OF ANALYSIS OF STEM CELLS AND CANCER CELL - A complex of Tra-antibody bound to an isolated glycan comprising type I—N-acetyllactosamine comprising target structure, and methods and uses utilizing said complex. | 05-24-2012 |
20120202701 | AN ANTIBODY-GLYCAN COMPLEX TARGETING THE DISIALYL CORE II AND SIALYL LEWIS X STRUCTURES, AND USES THEREOF INVOLVING ANALYSIS OF STEM CELLS OR CANCER CELLS - Antibody-saccharide-complexes and methods and uses related to analysis of cells. Also disclosed is a method of selection of new antibody with CHO-specificity and to a use of antibodies produced for the analysis of stem cells or cancer cells or other cells or tissues known to bind to CHO-antibodies. | 08-09-2012 |
Patent application number | Description | Published |
20110160442 | METHOD FOR THE FRACTIONATION OF KNOTWOOD EXTRACT AND USE OF A LIQUID-LIQUID EXTRACTION FOR PURIFICATION OF KNOTWOOD EXTRACT - The invention relates to a method for the fractionation of knotwood extract, which has been obtained by extraction of knotwood with a hydrophilic solvent. The hydrophilic extract is extracted with a lipophilic solvent to remove lipophilic impurities. The invention also relates to the use of a liquid-liquid extraction for the purification of hydrophilic knotwood extract. The present process provides a purified knotwood extract, which contains more than 90% lignans, flavonoids and stilbenes and less than 10% impurities selected from resin acids, fatty acids, sterols, juvabiones, triglycerides and combinations thereof. | 06-30-2011 |
20110212217 | Method for modulating animal digestive tract microbiota and feed composition comprising bark extract - The present invention relates to a method for modulating animal digestive tract microbiota wherein the modulating comprises adding an extract of bark to animal feed. The invention further relates to a feed composition comprising a bark extract for enhancement of animal performance and gastrointestinal health. | 09-01-2011 |
20110212218 | Method for modulating animal digestive tract microbiota and feed composition comprising bark extract - The present invention relates to a method for modulating animal digestive tract microbiota wherein the modulating comprises adding an extract of birch bark to animal feed. The invention further relates to a feed composition comprising a birch bark extract for enhancement of animal performance and gastrointestinal health. | 09-01-2011 |
20140249271 | METHOD FOR INCREASING THE REACTIVITY OF LIGNIN - The present invention relates to a method for increasing the reactivity of lignin, wherein the method comprises the following steps: a) forming, under heating at a temperature of 30-70° C., an aqueous dispersion comprising alkali and lignin, wherein the alkali comprises a hydroxide of an alkali metal; and b) heating the dispersion formed in step a) at a temperature of 50-95° C. for producing alkalated lignin. | 09-04-2014 |
20150068112 | LIGNIN AND METHOD AND SYSTEM FOR PROCESSING LIGNIN - The invention relates to a method for processing lignin. The method includes feeding lignin material to the system, decreasing particle size of the lignin material in a grinding device in order to manufacture lignin powder having particle size distribution wherein at least 85 wt. % of the lignin agglomerates and particles are less than 300 microns, and increasing dry solids content of the lignin material at least 5 percentage units while decreasing the particle size in the grinding device. In addition, the invention relates to a system for processing lignin, a lignin powder, a method for manufacturing a product including lignin, a system for manufacturing a product including lignin and a product including lignin powder. | 03-12-2015 |
20150087781 | USE OF LOW MOLECULAR WEIGHT LIGNIN TOGETHER WITH LIGNIN FOR THE PRODUCTION OF A PHENOL-FORMALDEHYDE BINDER COMPOSITION - The present invention relates to a method for producing a binder composition, wherein the method comprises the following steps: (i) forming an aqueous composition comprising reactant components including lignin molecules of 11-60 lignin units, lignin molecules of 1-10 lignin units, polymerizable substance and crosslinking agent in the presence of a catalyst; and (ii) cooking the composition at a temperature of 60-95° C. for polymerizing the reactant components until a binder composition with a predetermined viscosity value is formed. | 03-26-2015 |
20150183813 | METHOD FOR FRACTIONATING LIGNIN - The present invention relates to a method for fractionating lignin, wherein the method comprises the following steps: (i) dissolving lignin into a mixture containing organic solvent and water; and (ii) ultrafiltrating the mixture formed in step (i) through one or more filtration membranes for producing a predetermined number of lignin fractions, wherein each fraction contains lignin with a molecular weight within a predetermined range. The present invention further relates to a lignin fraction and to the uses thereof. | 07-02-2015 |
20150232497 | METHOD FOR ESTERIFYING LIGNIN WITH AT LEAST ONE FATTY ACID - The present invention relates to a method for producing lignin esterified with at least one fatty acid, wherein the method includes the following steps: (i) reacting acetylated lignin with at least one fatty acid under the influence of heating and distilling at least part of the acetic acid formed during the reaction away from the reaction mixture, wherein per each mole of acetyl groups present in the lignin an excess molar amount of at least one fatty acid is used; and (ii) recovering lignin esterified with at least one fatty acid formed in step (i). | 08-20-2015 |