Patent application number | Description | Published |
20130190290 | Substituted phenylimidazopyrazoles and their use - The present application relates to novel 1-phenyl-1H-imidazo[1,2-b]pyrazole derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular angiogenic disorders and hyperproliferative disorders, where neovascularization plays a role, such as, for example, neoplastic disorders and tumour disorders. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures. | 07-25-2013 |
20130196964 | HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS - The present application relates to novel aryl compounds with heterocyclic substituents, processes for their preparation, their use for treatment and/or prevention of diseases and their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures. | 08-01-2013 |
20130210795 | SUBSTITUTED DICYANOPYRIDINES AND USE THEREOF - The present application relates to novel substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders. | 08-15-2013 |
20130267700 | ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF - The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders. | 10-10-2013 |
20130303559 | BENZIMIDAZOLE AND PYRAZOLOPYRIDINE DERIVATIVES FOR TREATING AND/OR PREVENTING CARDIOVASCULAR DISEASES - The present application relates to novel fused, heteroatom-bridged pyrazole and imidazole derivatives, to processes for their preparation, to their use, alone or in combination, for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders. | 11-14-2013 |
20140256718 | HYDROXYMETHYLARYL-SUBSTITUTED PYRROLOTRIAZINES AS ALK1 INHIBITORS - This invention relates to novel 5-[(hydroxymethyl)aryl]-substituted pyrrolo[2,1-f][1,2,4]triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders. | 09-11-2014 |
20140296295 | 2-ALKOXY-SUBSTITUTED DICYANOPYRIDINES AND THEIR USE - The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders. | 10-02-2014 |
20140296515 | ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF - The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders. | 10-02-2014 |
Patent application number | Description | Published |
20100127451 | SYSTEM FOR CONTROLLING FRICTION FORCES DEVELOPED ON AN ENVELOPE IN A MAILPIECE INSERTION MODULE - A system for controlling friction forces acting on a mailpiece in a mailpiece insertion module. The system includes at least one friction drive belt, a repositionable backstop assembly for arresting the motion of the envelope when disposed in a first position and permitting the conveyance along the feed path when disposed in a second position, an actuator operative to position the backstop assembly into the first and second positions and consuming energy to maintain the backstop assembly in the first position, a sensor for measuring the magnitude of energy consumed by the actuator; a means for developing a pressure differential across the envelope to urge the envelope into frictional engagement with the drive belts and for developing friction forces along a mating interface between the envelope and the friction drive surface, and a system controller, responsive to a sensed signal indicative of the energy consumed, for varying the magnitude of the pressure differential and the friction forces developed along the mating interface of the envelope. | 05-27-2010 |
20100236365 | METHOD AND APPARATUS FOR ENHANCED CUTTER THROUGHPUT USING AN EXIT MOTION PROFILE - A method and apparatus are for decelerating a sheet of paper in a paper-cutting system. The sheet of paper is cut using a cutter, and the sheet is then accepted into a take-away nip. The take-away nip is operated at an initial rate in order to move the sheet of paper away from the cutter at an initial speed. The take-away nip is then operated at a rate decreasing to a final rate, in order to decelerate the sheet of paper to a final speed by the time the sheet of paper exits the take-away nip. The take-away nip is subsequently operated at the initial rate again, prior to accepting another sheet of paper at the initial speed. | 09-23-2010 |
20130056927 | MAILPIECE INSERTER INCLUDING SYSTEM FOR CONTROLLING FRICTION FORCES DEVELOPED ON AN ENVELOPE - A system for controlling friction forces acting on a mailpiece in a mailpiece insertion module. The system includes a backstop assembly for arresting the motion of the envelope when disposed in a first position and permitting conveyance along the feed path when disposed in a second position, an actuator operative to position the backstop assembly into the first and second positions and consuming energy to maintain the backstop assembly in the first position, a sensor for acquiring data indicative of the magnitude of energy consumed by the actuator; a means for developing a pressure differential across the envelope to urge the envelope into frictional engagement with a plurality of drive belts and for developing friction forces along a mating interface, and a system controller, for varying the magnitude of the pressure differential and the friction forces developed along the mating interface of the envelope. | 03-07-2013 |