Patent application number | Description | Published |
20130035283 | ENGINEERED OPSONIN FOR PATHOGEN DETECTION AND TREATMENT - The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis. | 02-07-2013 |
20130157283 | RAPID PATHOGEN DIAGNOSTIC DEVICE AND METHOD - A microfluidic device of a diagnostic and detection system includes an inlet port connected by one or more microchannels to an outlet port and includes a capture and visualization chamber (CVC) connected to at least one microchannel. A fluid to be analyzed can be mixed with magnetic microbeads that have an affinity to become bound to target components, such as pathogens in the fluid. The fluid including the magnetically bound target components can be injected through the microfluidic device. Magnetic field gradient, such as provided by permanent or electro-magnets, can be applied to the fluid and the magnetically bound target components flowing through the microfluidic device to cause the magnetically bound target components to migrate into the (CVC) and become separated from the fluid. The magnetically bound target components can be analyzed and tested using various techniques to detect the presence of specific organic and inorganic materials, such as pathogens in bio-fluids and contamination in liquid food sources (e.g. water). The device and method provide a system for rapidly detecting pathogens and contamination in relatively small fluid samples. | 06-20-2013 |
20130334120 | FLUID CLEANSING DEVICES AND METHODS OF USE - A system and method for removing a target species from a fluid source is provided. The system includes a reciprocating fluid cleansing device, including a processing chamber with a port at a first end for fluid passage and a movable plunger at a second end, wherein the plunger in contact with a fluid includes a motorized mixing element for mixing the fluid with species-targeting magnetic particles. Motion of the plunger in a first direction transfers a first volume of the fluid from the fluid source into the processing chamber. Motion of the plunger in a second direction transfers the first volume of the fluid from the processing chamber to a fluid destination. At least one magnetic element provides a magnetic field gradient within the processing chamber. A connector connects the port of the first processing chamber to the fluid source and the fluid destination. | 12-19-2013 |
20140187666 | SLIPPERY LIQUID-INFUSED POROUS SURFACES AND BIOLOGICAL APPLICATIONS THEREOF - A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria. | 07-03-2014 |
20140220617 | DIALYSIS LIKE THERAPEUTIC (DLT) DEVICE - A dialysis like therapeutic (DLT) device is provided. The DLT device includes at least one source channel connected at least one collection channels by one or more transfer channels. Fluid contacting surface of the channels can be an anti-fouling surface such as slippery liquid-infused porous surface (SLIPS). Fluids can be flown at high flow rates through the channels. The target components of the source fluid can be magnetic or bound to magnetic particles using an affinity molecule. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis. The source channel and the collection channels of the microfluidic device are analogous to the splenic arterioles and venules, respectively; the transfer channels mimic the vascular sinusoids of the spleen where opsonized particles are retained. Thus, the device acts as a dialysis like therapeutic device by combining fluidics and magnetics. | 08-07-2014 |
20140288288 | ANTI-CD19 ANTIBODIES WITH REDUCED IMMUNOGENICITY - Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response. | 09-25-2014 |
20140342954 | MODIFICATION OF SURFACES FOR FLUID AND SOLID REPELLENCY - Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has a head group that is covalently linked to, or adsorbed onto, the surface and a functional group. The functional group of the treated surface has an affinity for a lubricating layer, which is applied to the treated surface. The anchoring layer and replenishable lubricating layer are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within. | 11-20-2014 |
20150064703 | RAPID ANTIBIOTIC SUSCEPTIBILITY TESTING - Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein. | 03-05-2015 |
Patent application number | Description | Published |
20090280032 | IMPROVED MULTI-WELL ASSAY PLATE - The invention relates to the field of analytical chemistry, in particular to multi-well assay plates having a unique flatness for use in high throughput (bio)chemical and biological assays which rely on luminescence detection. Provided is a multi-well assay plate a top layer including walls defining a plurality of adjacent sample wells for receiving assay samples, and a bottom layer defining the bottom of the wells, having a bottom surface facing away from the wells and wherein said bottom surface is provided with a grid structure forming a plurality of mock wells at the plate bottom, characterized in that the total volume of the mock wells is less than the total volume of the sample wells. | 11-12-2009 |
20100297370 | MOLDED BODY HAVING A WALL COMPRISING A TRANSPARENT POLYMERIC MATERIAL AND GLASS PARTICLES - A molded body ( | 11-25-2010 |
20110223551 | MIXING DEVICE FOR A GAS BURNER - A mixing device ( | 09-15-2011 |
20140080075 | BURNER CONTROL SYSTEM - A burner control system for improving burner performance and efficiency. The system may determine fuel and air channel or manifold parameters. Determination of parameters may be performed with a sensor connected across the air and fuel channels. A signal from the sensor may control the parameters which in turn affect the amounts of fuel and air to the burner via a controller. Parameter control of the fuel and air in their respective channels may result in more accurate fuel and air ratio control. One or more flow restrictors in fuel and/or air bypass channels may further improve accuracy of the fuel and air ratio. The channels may be interconnected with a pressure or flow divider. Byproducts of combustion in the exhaust, temperatures of gas and air, flame quality and/or other items may be monitored and adjusted with control of the fuel and air ratio for optimum combustion in the burner. | 03-20-2014 |
20150114479 | REGULATING DEVICE - A regulating device may include a housing that defines an inlet chamber and an outlet chamber, with a flow restriction seat between the inlet chamber and the outlet chamber. A flow restriction valve is movable relative to the flow restriction seat to adjust the flow between the inlet chamber and the outlet chamber of the regulating device. A servo valve having a servo chamber may be used to adjust the position of the flow restriction valve. The servo chamber may be fluidly coupled to the inlet chamber though a fixed flow restriction and to the outlet chamber though an adjustable flow restriction. A stepper motor may be used to adjust the servo valve to adjust the adjustable flow restriction between the servo chamber and the outlet chamber. This causes a change of the servo pressure, which moves the flow restriction valve and adjusts the flow of the regulating device. | 04-30-2015 |