Patent application number | Description | Published |
20140330542 | Method and System to Unify and Display Simulation and Real-time Plant Data for Problem-Solving - A computer-based method and system brings together data from two business domains: real-time actual plant status operation data and predictive process simulation data based upon a design specification. This method and system correlates the plant data and the simulation data, and displays the results side-by-side for the user. The results assist the user, to determine whether the plant is operating properly, and to make further improvements to both the plant assets and to the simulation models. The invention assists with monitoring, maintaining, trouble shooting, and problem solving of plant operation. The invention facilitates a progressive visual collaborative environment between plant operation and process engineering teams, where engineers from respective domains may socialize and trouble shoot problems. The Progressive Visual Collaboration helps professionals with searching, sharing, mapping, analyzing, framing problems, removing ambiguity and uncertainty by considering facts and figures, and providing a progressive workflow that solves plant problems. | 11-06-2014 |
20140330783 | Method and System for Stateful Recovery and Self-Healing - The ability to perform non-destructive editing of files and models requires the generation and persistence of input deltas that capture changes that are made to a base starting point. Reconstitution of saved state may be achieved through the application of deltas. This capability is useful for failover remediation in client/server environments since the client has access to the deltas, such that in the event that a stateful service becomes unresponsive (and therefore, no longer available), the service may be taken offline and a new resource may be assigned as a replacement. In such an event, the service is directed to load the baseline data and any changes may be reapplied, restoring the service state. | 11-06-2014 |
Patent application number | Description | Published |
20110179214 | VIRTUAL TARGET ADDRESSING DURING DIRECT DATA ACCESS VIA VF OF IO STORAGE ADAPTER - A method of virtual machine (VM) access to physical storage through a direct path to a virtual function (VF) of a storage adapter, the method for use in a system that includes a host computing machine configured to implement a virtualization intermediary and the virtual machine (VM) and that includes the storage adapter the method, comprising: sending virtual SCSI IO request from the VM to the physical storage that identifies a virtual disk address; mapping within the VF the identified virtual address to at least one physical region of the physical storage; creating within the VF a physical SCSI IO request that identifies a physical address for the mapped-to physical region; sending the physical SCSI IO request from the VF to the physical storage. | 07-21-2011 |
20110179413 | Guest/Hypervisor Interrupt Coalescing for Storage Adapter Virtual Function in Guest Passthrough Mode - A system and method are provided that involve a host computing machine and an SR IOV storage adapter in which the host machine hosts a virtual machine having a guest operating system (guest) coupled for direct passthrough IOV data path and also hosts a virtualization intermediary; a guest operating system (guest) and a virtualization intermediary exchange information concerning IO completions through a shared memory space; the guest writes information to a shared memory space that is indicative of whether an IO completion queue has reached a fill level since the most recently dispatched interrupt at which it is unsafe to coalesce an interrupt; the virtualization intermediary writes information to the shared memory space that is indicative of the interrupt most recently delivered to the guest; the virtualization intermediary reads the information written by the guest to the shared memory space that is indicative of whether an IO completion queue has reached a fill level since the most recently dispatched interrupt at which it is unsafe to coalesce an interrupt; the guest reads the information written to the shared memory space that is indicative of the interrupt most recently delivered to the guest; virtual interrupt coalescing determinations are made based upon the information shred through the shared memory space. | 07-21-2011 |
20110179414 | CONFIGURING VM AND IO STORAGE ADAPTER VF FOR VIRTUAL TARGET ADDRESSING DURING DIRECT DATA ACCESS - A method is provided for use in a system that includes a host computing machine configured to implement a virtualization intermediary and that includes a physical storage adapter, the configures a virtual machine (VM) and a virtual function (VF) to support IO operations to physical storage through a direct IOV path to the VF of the physical storage adapter, the method comprises: creating by the virtualization intermediary mapping information that includes a first mapping between virtual disks and physical regions of physical storage and that includes a second mapping between virtual disks and virtual disk addresses; transmitting the mapping information from the virtualization intermediary over the physical storage adapter from a physical function (PF) of the physical storage adapter to the VF; associating a virtual port with the mapping information within the virtualization intermediary; binding the virtual port to the VF; communicating virtual disk addresses indicated within the second mapping within the transmitted mapping information for the allocated virtual disks to the VM. | 07-21-2011 |
20110179416 | Virtual Machine Access to Storage Via a Multi-Queue IO Storage Adapter With Optimized Cache Affinity and PCPU Load Balancing - A method is provided for use in a system that includes a host machine that includes multiple physical CPUs (PCPUs) and at least two cache nodes that are shared by different sets of the PCPUs, comprising: creating in a memory device multiple sets of lanes each lane set associated with a respective PCPU set; tracking levels of processing activity of the PCPUs of each PCPU set; using an MSIX vector value to associate lanes with PCPUs; receiving a IO request from any given PCPU from among the multiple PCPUs; and assigning the IO request to a respective lane based at least in part upon the PCPU set associated with the lane and PCPU processing activity levels. | 07-21-2011 |
20110239213 | VIRTUALIZATION INTERMEDIARY/VIRTUAL MACHINE GUEST OPERATING SYSTEM COLLABORATIVE SCSI PATH MANAGEMENT - A method of direct access by a virtual machine (VM) running on a host machine to physical storage via a virtual function (VF) running on an input/output (IO) adapter comprising: providing by a virtualization intermediary running on the host machine an indication of an active path associated with a virtual storage device; obtaining by a guest driver running within a guest operating system of the VM the stored indication of the active path from the shared memory region; dispatching an IO request by the guest driver to the VF that includes an indication of the active path; and sending by the VF an IO request that includes the indicated active path. | 09-29-2011 |
20120042034 | LIVE MIGRATION OF VIRTUAL MACHINE DURING DIRECT ACCESS TO STORAGE OVER SR IOV ADAPTER - A method is provided to migrate a virtual machine from a source computing machine to a destination computing machine comprising: suspending transmission of requests from a request queue disposed in source computing machine memory associated with the VM from the request queue to a VF; while suspending the transmission of requests, determining when no more outstanding responses to prior requests remain to be received; in response to a determination that no more outstanding responses to prior requests remain to be received, transferring state information that is indicative of locations of requests inserted to the request queue from the VF to a PF and from the PF to a memory region associated with a virtualization intermediary of the source computing machine. After transferring the state information to source computing machine memory associated with a virtualization intermediary, resuming transmission of requests from locations of the request queue indicated by the state information to the PF; and transmitting the requests from the PF to the physical storage. | 02-16-2012 |
20120239832 | GUEST/HYPERVISOR INTERRUPT COALESCING FOR STORAGE ADAPTER VIRTUAL FUNCTION IN GUEST PASSTHROUGH MODE - A method is described for coalescing input/output (IO) interrupts to a virtual machine (VM) running on a host computer. At a virtualization layer of the host computer that supports execution of the VM receives an IO interrupt in response to a completion of an IO request of the VM, wherein a transmission of the IO request by the VM to an IO device bypasses the virtualization layer. The virtualization layer then determines whether the VM has responded to a most recently delivered IO interrupt to the VM by the virtualization layer, and drops the IO interrupt if the VM has not responded to the most recently delivered IO interrupt, thereby failing to deliver the IO interrupt to the VM. | 09-20-2012 |
20130305246 | LIVE MIGRATION OF VIRTUAL MACHINE DURING DIRECT ACCESS TO STORAGE OVER SR IOV ADAPTER - A method is provided to migrate a virtual machine from a source computing machine to a destination computing machine comprising: suspending transmission of requests from a request queue disposed in source computing machine memory associated with the VM from the request queue to a VF; while suspending the transmission of requests, determining when no more outstanding responses to prior requests remain to be received; in response to a determination that no more outstanding responses to prior requests remain to be received, transferring state information that is indicative of locations of requests inserted to the request queue from the VF to a PF and from the PF to a memory region associated with a virtualization intermediary of the source computing machine. After transferring the state information to source computing machine memory associated with a virtualization intermediary, resuming transmission of requests from locations of the request queue indicated by the state information to the PF; and transmitting the requests from the PF to the physical storage. | 11-14-2013 |
20140019969 | CONFIGURING VM AND IO STORAGE ADAPTER VF FOR VIRTUAL TARGET ADDRESSING DURING DIRECT DATA ACCESS - A method is provided for use in a system that includes a host computing machine configured to implement a virtualization intermediary and that includes a physical storage adapter, the configures a virtual machine (VM) and a virtual function (VF) to support IO operations to physical storage through a direct IOV path to the VF of the physical storage adapter, the method comprises: creating by the virtualization intermediary mapping information that includes a first mapping between virtual disks and physical regions of physical storage and that includes a second mapping between virtual disks and virtual disk addresses; transmitting the mapping information from the virtualization intermediary over the physical storage adapter from a physical function (PF) of the physical storage adapter to the VF; associating a virtual port with the mapping information within the virtualization intermediary; binding the virtual port to the VF; communicating virtual disk addresses indicated within the second mapping within the transmitted mapping information for the allocated virtual disks to the VM. | 01-16-2014 |
20140032644 | Server Aggregated Application Streaming - A software-implemented method which allows the streaming of applications from a server or cluster of server to one or more clients, typically mobile devices. The invention also enables the sharing, through a social network cloud service, of applications located on connected computers or on the cloud. When applications are streamed to mobile devices, the user interface of the application may be modified to fit the native user interface of the device. | 01-30-2014 |
Patent application number | Description | Published |
20130280274 | METHODS TO MODULATE LYSINE VARIANT DISTRIBUTION - The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations. | 10-24-2013 |
20130344084 | CELL CULTURE METHODS TO REDUCE ACIDIC SPECIES - The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations. | 12-26-2013 |
20140024116 | Non-Static Suspension Culture of Cell Aggregates - The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, endodermal, and mesodermal embryonic germ layers, e.g., stem cells. | 01-23-2014 |
20140161815 | CELL CULTURE METHODS TO REDUCE ACIDIC SPECIES - The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations. | 06-12-2014 |
20150110775 | MODULATED LYSINE VARIANT SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME - The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. | 04-23-2015 |
20150110799 | LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME - The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. | 04-23-2015 |
20150132801 | LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME - The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. | 05-14-2015 |
20150140006 | LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME - The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. | 05-21-2015 |
20150259410 | LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME - The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. | 09-17-2015 |
20160039925 | CELL CULTURE METHODS TO REDUCE ACIDIC SPECIES - The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations. | 02-11-2016 |
20160046708 | METHODS TO MODULATE LYSINE VARIANT DISTRIBUTION - The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the distribution or amount of lysine variants expressed by host cells, as well as to compositions and processes for controlling the amount of lysine variants present in purified preparations. | 02-18-2016 |
Patent application number | Description | Published |
20090093198 | Techniques for cylindrical grinding - Methods for cylindrical grinding a workpiece are disclosed. The method includes cylindrical grinding, with a bonded abrasive wheel having a permeable structure that includes interconnected porosity, a workpiece at a specific cutting energy of less than about 12 Hp/in | 04-09-2009 |
20100006082 | WIRE SLICING SYSTEM - A wire slicing system and method for using it include one or more of the following features: arrangements and/or operations that relate to handling the wire; apparatus and methods that relate to wire tensioning; equipment and techniques for manipulating the workpiece; arrangements and/or operations designed for cooling and swarf (debris) removal; controls and/or automation that can be used in conjunction with these features. | 01-14-2010 |
20110045292 | ABRASIVE ARTICLES INCLUDING ABRASIVE PARTICLES BONDED TO AN ELONGATED BODY, AND METHODS OF FORMING THEREOF - An abrasive article includes an elongated body, a bonding layer including a metal overlying a surface of the elongated body, and a coating layer including a polymer material overlying the boding layer. The abrasive article further includes abrasive grains contained within the bonding layer and coating layer, and wherein the bonding layer comprises an average thickness (t | 02-24-2011 |
20120034847 | ABRASIVE TOOL AND A METHOD FOR FINISHING COMPLEX SHAPES IN WORKPIECES - An abrasive tool includes a bonded abrasive body having abrasive grains contained within a bonding material, wherein the bonded abrasive body comprises a complex shape having a form depth (FD) of at least about 0.3. The form depth is described by the equation [(Rl−Rs)/Rl], wherein Rs is a smallest radius (Rs) at a point along the longitudinal axis of the bonded abrasive body and Rl is a largest radius (Rl) at a point along the longitudinal axis of the bonded abrasive body. The abrasive tool can be used to finish complex shapes in workpieces. | 02-09-2012 |
20120055097 | Abrasive Articles and Methods of Forming - A method of forming an abrasive article includes directing a beam of electromagnetic radiation at a starting location on an abrasive preform comprising a bonding layer and abrasive grains within the bonding layer, and increasing the power of the beam of electromagnetic radiation to a scanning power while directed at the starting location. The method further includes changing the position of the beam relative to the abrasive preform from the starting location to a second location on the abrasive preform. | 03-08-2012 |
20120167482 | ABRASIVE ARTICLE AND METHOD OF FORMING - An abrasive article having a substrate, a tacking film overlying the substrate, abrasive particles comprising a coating layer bonded to the tacking film such that a bond between the coating layer and the tacking film defines a metallic bonding region, and a bonding layer overlying the abrasive particles and the tacking film, | 07-05-2012 |
20130061535 | ABRASIVE ARTICLE AND METHOD OF FORMING - An abrasive article having a substrate, a tacking film overlying the substrate, abrasive particles comprising a coating layer bonded to the tacking film such that a bond between the coating layer and the tacking film defines a metallic bonding region, and a bonding layer overlying the abrasive particles and the tacking film, | 03-14-2013 |
20130199105 | SHAPED ABRASIVE PARTICLE AND METHOD OF FORMING SAME - A method of forming a mixture including a ceramic material into a sheet, sectioning at least a portion of the sheet using a mechanical object and forming at least one shaped abrasive particle from the sheet, such that the at least one shaped abrasive particle can have a two-dimensional shape as viewed in a plane defined by a length and a width of the shaped abrasive particle selected from the group consisting of polygons, ellipsoids, numerals, Greek alphabet characters, Latin alphabet characters, Russian alphabet characters, complex shapes having a combination of polygonal shapes, and a combination thereof. | 08-08-2013 |
20140325917 | SHAPED ABRASIVE PARTICLE AND METHOD OF FORMING SAME - A method of forming a mixture including a ceramic material into a sheet, sectioning at least a portion of the sheet using a mechanical object and forming at least one shaped abrasive particle from the sheet, such that the at least one shaped abrasive particle can have a two-dimensional shape as viewed in a plane defined by a length and a width of the shaped abrasive particle selected from the group consisting of polygons, ellipsoids, numerals, Greek alphabet characters, Latin alphabet characters, Russian alphabet characters, complex shapes having a combination of polygonal shapes, and a combination thereof. | 11-06-2014 |
20150079883 | Abrasive Tool and a Method for Finishing Complex Shapes in Workpieces - An abrasive tool includes a bonded abrasive body having abrasive grains contained within a bonding material, wherein the bonded abrasive body comprises a complex shape having a form depth (FD) of at least about 0.3. The form depth is described by the equation [(R1−Rs)/R1], wherein Rs is a smallest radius (Rs) at a point along the longitudinal axis of the bonded abrasive body and R1 is a largest radius (R1) at a point along the longitudinal axis of the bonded abrasive body. The abrasive tool can be used to finish complex shapes in workpieces. | 03-19-2015 |
Patent application number | Description | Published |
20100209467 | TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS - The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders. | 08-19-2010 |
20130231294 | TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS - The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders. | 09-05-2013 |
20150126451 | TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS - The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders. | 05-07-2015 |
Patent application number | Description | Published |
20150099791 | COMPOSITIONS AND METHODS FOR MODULATING UTRN EXPRESSION - Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of UTRN. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of UTRN. Methods for modulating expression of UTRN using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of UTRN. | 04-09-2015 |
20150133362 | COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION - Aspects of the invention provide methods for selecting a candidate oligonucleotide for activating expression of a target gene. Further aspects of the invention provide methods of selecting a set of oligonucleotides that is enriched in oligonucleotides that activate expression of a target gene. Further aspects provide single stranded oligonucleotides that modulate gene expression and compositions and kits comprising the same. Methods for modulating gene expression using the single stranded oligonucleotides are also provided. | 05-14-2015 |
20150133528 | COMPOSITIONS AND METHODS FOR MODULATING HEMOGLOBIN GENE FAMILY EXPRESSION - Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of hemoglobin genes (HBB, HBD, HBE1, HBG1 or HBG2). Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of hemoglobin genes. Methods for modulating expression of hemoglobin genes using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of hemoglobin genes. | 05-14-2015 |
20150133529 | COMPOSITIONS AND METHODS FOR MODULATING BDNF EXPRESSION - Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of BDNF. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of BDNF. Methods for modulating expression of BDNF using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of BDNF. | 05-14-2015 |
20150141320 | COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION - Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of a target gene. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of a target gene. Methods for modulating expression of a target gene using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of a target gene. | 05-21-2015 |
20150152410 | COMPOSITIONS AND METHODS FOR MODULATING MECP2 EXPRESSION - Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of MECP2. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of MECP2. Methods for modulating expression of MECP2 using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of MECP2. | 06-04-2015 |
20150159160 | COMPOSITIONS AND METHODS FOR MODULATING ATP2A2 EXPRESSION - Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of ATP2A2. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of ATP2A2. Methods for modulating expression of ATP2A2 using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of ATP2A2. | 06-11-2015 |
20150159161 | COMPOSITIONS AND METHODS FOR MODULATING PTEN EXPRESSION - Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of PTEN. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of PTEN. Methods for modulating expression of PTEN using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of PTEN. | 06-11-2015 |
20150191722 | COMPOSITIONS AND METHODS FOR MODULATING APOA1 AND ABCA1 EXPRESSION - Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of APOA1 or ABCA1. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of APOA1 or ABCA1. Methods for modulating expression of APOA1 or ABCA1 using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of APOA1 or ABCA1. | 07-09-2015 |
20150218560 | COMPOSITIONS FOR MODULATING GENE EXPRESSION - Aspects of the invention provide methods for selecting a candidate oligonucleotide for activating expression of a target gene. Further aspects of the invention provide methods of selecting a set of oligonucleotides that is enriched in oligonucleotides that activate expression of a target gene. Further aspects provide single stranded oligonucleotides that modulate gene expression and compositions and kits comprising the same. Methods for modulating gene expression using the single stranded oligonucleotides are also provided. | 08-06-2015 |
20150232836 | COMPOSITIONS AND METHODS FOR MODULATING GENE EXPRESSION - Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of a target gene. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of a target gene. Methods for modulating expression of a target gene using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of a target gene. | 08-20-2015 |
20150247141 | MULTIMERIC OLIGONUCLEOTIDE COMPOUNDS - The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided | 09-03-2015 |
20150252364 | COMPOSITIONS AND METHODS FOR MODULATING SMN GENE FAMILY EXPRESSION - Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of SMN1 or SMN2. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of SMN1 or SMN2 that comprises exon 7. Methods for modulating expression of SMN1 or SMN2 using the single stranded oligonucleotides are also provided. Further aspects of the invention provide methods for selecting a candidate oligonucleotide for activating or enhancing expression of SMN1 or SMN2. | 09-10-2015 |
20150299695 | MULTIMERIC OLIGONUCLEOTIDES COMPOUNDS - The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided. | 10-22-2015 |
20150315585 | MULTIMERIC OLIGONUCLEOTIDE COMPOUNDS HAVING NON-NUCLEOTIDE BASED CLEAVABLE LINKERS - The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided | 11-05-2015 |
20150315586 | METHODS OF DELIVERING MULTIPLE TARGETING OLIGONUCLEOTIDES TO A CELL USING NON-NUCLEOTIDE BASED CLEAVABLE LINKERS - The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided | 11-05-2015 |
20150315587 | MULTIMERIC OLIGONUCLEOTIDES COMPOUNDS HAVING CLEAVABLE LINKERS - The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided | 11-05-2015 |
20150315588 | METHODS OF DELIVERING MULTIPLE TARGETING OLIGONUCLEOTIDES TO A CELL USING CLEAVABLE LINKERS - The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided | 11-05-2015 |
Patent application number | Description | Published |
20130302348 | AGENTS FOR INFLUENZA NEUTRALIZATION - The present invention provides antibodies (e.g., monoclonal antibodies, human antibodies, humanized antibodies, etc.), which bind to multiple influenza strains. Such antibodies are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of influenza. | 11-14-2013 |
20130302349 | NOVEL HA BINDING AGENTS - This disclosure relates to novel peptide agents, e.g., antibodies and antigen-binding fragments thereof, that bind hemagglutinin protein of influenza viruses, and methods of their use. | 11-14-2013 |
20140148581 | NOVEL HA BINDING AGENTS - This disclosure relates to novel peptide agents, e.g., antibodies and antigen-binding fragments thereof, that bind hemagglutinin protein of influenza viruses, and methods of their use. | 05-29-2014 |
20140206603 | ENGINEERED POLYPEPTIDE AGENTS FOR TARGETED BROAD SPECTRUM INFLUENZA NEUTRALIZATION - The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The present invention provides a system for analyzing interactions between infolds and the interaction partners that bind to them. | 07-24-2014 |
20150037352 | NOVEL HA BINDING AGENTS - This disclosure relates to novel peptide agents, e.g., antibodies and antigen-binding fragments thereof, that bind hemagglutinin protein of influenza viruses, and methods of their use. | 02-05-2015 |