Patent application number | Description | Published |
20080209989 | AFM FOR SIMULTANEOUS RECOGNITION OF MULTIPLE FACTORS - An atomic force microscope and a method for detecting interactions between a probe and two or more sensed agents on a scanned surface and determining the relative location of two or more sensed agents is provided. The microscope has a scanning probe with a tip that is sensitive to two or more sensed agents on said scanned surface; two or more sensing agents tethered to the tip of the probe; and a device for recording the displacement of said probe tip as a function of time, topographic images, and the spatial location of interactions between said probe and the two or more sensed agents on said surface. | 09-04-2008 |
20080223121 | APTAMER PROBE FOR LOCATING MOLECULES AND METHOD OF USE - An atomic force microscope and a method for detecting interactions between a probe and at least one sensed agent on a scanned surface is provided. The microscope has a scanning probe with a tip that is sensitive to a property of said scanned surface; a nucleic acid aptamer tethered to the tip of the probe; and a device for simultaneously recording the displacement of said probe tip as a function of time, topographic images, and the spatial location of interactions between said probe and the at least one sensed agent on said surface. | 09-18-2008 |
20090018028 | Self-Assembled Nucleic Acid Nanoarrays and Uses Therefor - The present invention provides self-assembling, finite nucleic acid tiling arrays, and methods for their synthesis and use, which overcome a major hurdle in self-assembled DNA nanostructures, and therefore have numerous potential applications for nanofabrication of complex structures and useful devices, as further disclosed herein. | 01-15-2009 |
20100084276 | Devices and Methods for Target Molecule Characterization - The present invention provides a device having at least one constriction that is sized to permit translocation of only a single copy of the molecule. The device has a pair of spaced apart sensing electrodes that border the constriction, which may be a nanopore. The first electrode is connected to a first affinity element and the second electrode is connected to a second affinity element. The first and second affinity elements are configured to temporarily form hydrogen bonds with first and second portions of the target molecule as the latter passes through the constriction. | 04-08-2010 |
20100216658 | Modified Nucleic Acid Nanoarrays and Uses Therefor - The present invention provides finite, addressable, and self-assembling nucleic acid tiling arrays, and methods for their use. | 08-26-2010 |
20110120868 | Nanopore and Carbon Nanotube Based DNA Sequencer and a Serial Recognition Sequencer - The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer. | 05-26-2011 |
20110168562 | Nanopore and Carbon Nanotube Based DNA Sequencer - The present invention provides a device for analyzing the composition of a heteropolymer comprising a carbon nanotube through which the heteropolymer is driven by electrophoresis. The carbon nanotube also serves as one electrode in a reading circuit. One end of the carbon nanotube is held in close proximity to a second electrode, and each end of the carbon nanotube is functionalized with flexibly-tethered chemical-recognition moieties, such that one will bind one site on the emerging polymer, and the second will bind another site in close proximity, generating an electrical signal between the two electrodes when the circuit is completed by the process of chemical recognition. | 07-14-2011 |
20120288948 | CONTROLLED TUNNEL GAP DEVICE FOR SEQUENCING POLYMERS - The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo- or hetero-polymer such as DNA, RNA, a polysaccharide, or a peptide. The device includes electrodes that form a tunnel gap through which the polymer can pass. The electrodes are functionalized with a reagent attached thereto, and the reagent is capable of forming a transient bond to a polymer unit. When the transient bond forms between the reagent and the unit, a detectable signal is generated and used to analyze the polymer. | 11-15-2012 |
20130186757 | Nanopore and Carbon Nanotube Based Dna Sequencer and A Serial Recognition Elements - The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer. | 07-25-2013 |
20130302901 | Electrodes for Sensing Chemical Composition - Some embodiments of the present disclosure provide methods, devices, and systems for sequencing nucleic acid polymers that utilize palladium (Pd), for example, at least in part, as an electrode material that is (i) functionalized with one or more adaptor molecules and (ii) capable for use to sense one or more chemical compositions. | 11-14-2013 |
20140113386 | SYSTEMS AND DEVICES FOR MOLEUCLE SENSING AND METHOD OF MANUFACTURING THEREOF - Embodiments of the disclosure are directed to a device for molecule sensing. In some embodiments, the device includes a first electrode separated from a second electrode by a dielectric layer. The first electrode comprises a large area electrode and the second electrode comprises a small area electrode. At least one opening (e.g., trench) cut or otherwise created into the dielectric layer exposes a tunnel junction therebetween whereby target molecules in solution can bind across the tunnel junction. | 04-24-2014 |
20140162247 | MOLECULAR TRANSISTOR - Fluidic nanotube devices and methods for their use are provided wherein the flow of charged molecules through a channel is controlled by the voltage potential of a gate electrode. In at least some embodiments, a molecular transistor is provided that includes a channel having a diameter such that only one target molecule at a time may traverse the channel. The channel may be a carbon nanotube that is electrically isolated from, and in communication with, a gate electrode. Methods are provided for controlling the flow of an individual molecule through the channel and for detecting a single chemical reaction. | 06-12-2014 |
20140357527 | METHOD AND APPARATUS FOR MEASURING PHOSPHORYLATION KINETICS ON LARGE ARRAYS - The disclosure provides for methods and apparatuses relating to technology for monitoring chemical and/or biological reactions. Some methods provided herein relate to utilization of NAPPA technology to create large protein arrays suitable for use in combination with various ISFET arrays to enable massive parallel assays of kinase activity and inhibition. Some devices provided herein relate to CMOS chips which utilize the NAPPA array technology to build protein inventories of interest upon an ISFET architecture. Further devices provided herein are capable, inter alia, of processing the arrays created by the combination of NAPPA technology and ISFET architecture. | 12-04-2014 |