Patent application number | Description | Published |
20080310052 | Apparatus and method for a ferroelectric disk and ferroelectric disk drive - A ferroelectric disk is disclosed including disk surfaces and an electrode coupling formed on at least one of the disk surfaces and electrically coupled to an electrode sheet covered by a probe surface. A slider is disclosed including a resistive probe and an electrical coupling. A head gimbal assembly, head stack assembly and ferroelectric disk drive are disclosed including the slider. The ferroelectric disk drive is disclosed including at least one of the ferroelectric disks. Access operations for a track on the disk surface of a ferroelectric disk are disclosed. | 12-18-2008 |
20090059414 | Hard disk drive with power saving feature - A hard disk drive with a head, and a disk that is rotated by a spindle motor. The drive includes a controller that operates in a low-speed idle mode where the spindle motor speed is reduced and the head is moved to a contact start-stop zone of the disk. Reducing the speed of the spindle motor, instead of spinning down the disk allows the disk drive to rapidly resume normal operation. Parking the head at a certain area of the disk, instead of a position off disk, allows the drive to more readily re-establish a mode where data can be retrieved or stored. | 03-05-2009 |
20090174962 | Apparatus and method for slider-disk contact indication by monitoring the spindle control signal in a hard disk drive - A hard disk drive including an electrical property meter sensing a spindle control signal to create an electrical property reading. Spindle control signal stimulates spindle motor to rotate at least one disk, creating rotating disk surface accessed by slider. Control circuit receives electrical property reading to create contact indication of slider contacting rotating disk surface, which may further include determining contact indication as spike in electrical property history of the readings. The electrical property meter may include ammeter and/or voltmeter. The control circuit, printed circuit board assembly, and/or motor control interface may include the electrical property meter. The control circuit may also include processor receiving electrical property reading to create contact indication. The hard disk drive may update contact log when contact indicated and may further update access parameter list for the slider accessing the rotating disk surface based upon the contact log. | 07-09-2009 |
20090195923 | Heat assisted spindle motor of a hard disk drive - A hard disk drive with a spindle motor that rotates a disk. When the disk drive is exposed to low temperatures a current can be provided to the spindle motor to heat the motor. For example, a DC current can be provided to the spindle motor. The current flowing through the spindle motor coil generates heat. The current can be provided for a predetermined time interval to sufficiently heat the spindle motor so that the fluid bearings of the motor can operate. The current is terminated and then an AC current is provided to the spindle motor to cause motor rotation. | 08-06-2009 |
Patent application number | Description | Published |
20090110509 | Self-tapping insert and method of utilizing the same to replace damaged bores and threads - A self-tapping insert is installed in a pre-existing bore hole in a workpiece by rotating the insert, causing cutting threads on the exterior of the self-tapping insert to cut new threads. Engagement threads on the exterior of the self-tapping insert engage the new threads to retain the self-tapping insert within the workpiece. The self-tapping insert may comprise internal threads which are used to replaced damaged threads in the workpiece. The exterior threads of the self-tapping insert may be configured as left-handed threads, while the internal threads are right-handed threads. The top of the self-tapping insert may comprise a plurality of castellations, and a drive head having matching castellations may be employed to install the self-tapping insert, eliminating the need for installing the insert with a drive bolt. The exterior of the self-tapping insert may further comprise a leading edge for cutting the new threads, where the leading edge has greater radial extension than the trailing edge. This feature provides greater chip relief, thereby reducing the torque required to install the self-tapping insert. | 04-30-2009 |
20100329803 | SELF-ALIGNING THREAD TAP AND METHOD OF UTILIZING THE SAME TO TAP EXISTING BORE HOLES - A self-aligning tap is used to produce correctly aligned new threads in an existing smooth bore hole. The design of the tap's shank, flutes, and cutting surfaces is that of commonly used existing taps. The flat end of the tap—the end that enters the existing bore hole—contains a threaded bore. A removable pilot that aligns the tap to the axis of the existing bore consists of a cylindrical body with a diameter slightly smaller than the existing bore hole, and a length no greater than the diameter of the major diameter of the tap. The upper end of the cylindrical pilot—the end that shoulders against the tap—comprises a threaded stem whose thread pitch matches that of the tap end's bore, and whose length is slightly less than the tap end bore's depth. Once the cylindrical pilot's stem is threaded into the tap end's bore and the resulting assembly is placed into the existing bore hole, it serves to align the tap so that its cutting teeth produce pilot threads which are accurately aligned to the existing bore hole's axis. Once the pilot threads have been produced by rotation of the tap, the tap may be removed from the existing bore hole, the pilot detached by unscrewing it, and the tap reinserted into the newly formed pilot threads. Further rotation of the tap completes the tapping operation of the existing bore hole to the desired depth. | 12-30-2010 |
20100329813 | Self-Tapping and Self-Aligning Insert to Replace Damaged Threads - A self-tapping insert is installed in a pre-existing bore hole in a workpiece by rotating the insert, causing cutting threads on the exterior of the self-tapping insert to cut new threads. Engagement threads on the exterior of the self-tapping insert engage the new threads to retain the self-tapping insert within the workpiece. The self-tapping insert may comprise internal threads which are used to replace damaged threads in the workpiece. The means of installing the self-tapping insert may include a drive bolt having threads which make up into those of the self-tapping insert's internal threads. The self-tapping insert is aligned within the bore hole by means of a detachable pilot, which is connected to the insert with attachment means. The attachment means include the pilot being attached to the drive bolt. The pilot may be attached to the drive bolt means of left-handed threads in an axially-centered aperture of the pilot and matching left-handed threads on the end of the drive bolt. | 12-30-2010 |
20100329814 | Self-Tapping Insert and Method of Utilizing the Same to Replace Damaged Bores and Threads - A self-tapping insert is installed in a pre-existing bore hole in a workpiece by rotating the insert, causing cutting threads on the exterior of the self-tapping insert to cut new threads. Engagement threads on the exterior of the self-tapping insert engage the new threads to retain the self-tapping insert within the workpiece. The self-tapping insert may comprise internal threads which are used to replace damaged threads in the workpiece. The exterior threads of the self-tapping insert may be configured as left-handed threads, while the internal threads are right-handed threads. The top of the self-tapping insert may comprise a recessed hexagon configuration, and a drive device having substantially the same configuration may be employed to install the self-tapping insert, eliminating the need for a drive-bolt or special tooling, and allowing the counter-clockwise installation of the self-tapping insert. The exterior of the self-tapping insert may further comprise an integral pilot for aligning the insert straight with the axis of the bore, as well as a leading edge for cutting the new threads, which edge has a radial extension equal to or greater than the trailing edge. | 12-30-2010 |
20100329816 | Self-Tapping Insert and Method of Utilizing the Same to Replace Damaged Threads for Hydraulic and Pneumatic Applications - A self-tapping insert is installed in a pre-existing bore hole in a workpiece by rotating the insert, causing cutting threads on the exterior of the self-tapping insert to cut new threads. Engagement threads on the exterior of the self-tapping insert engage the new threads to retain the self-tapping insert within the workpiece. The self-tapping insert may comprise internal threads which are used to replaced damaged threads in the workpiece. The exterior threads of the self-tapping insert may be configured as left-handed threads, while the internal threads are right-handed threads. The top of the self-tapping insert may comprise an integral hexagonal shape, and a drive socket of corresponding size and shape may be employed to install the self-tapping insert, eliminating the need for installing the insert with a drive bolt, and permitting the left-handed rotation of the self-tapping inserts external threads. | 12-30-2010 |
Patent application number | Description | Published |
20090035757 | SUBSTRACTIVE SINGLE LABEL COMPARATIVE HYBRIDIZATION - Provided are methods of determining differences between nucleic acids in a test sample and a reference sample. In certain embodiments the methods are used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. In particular, provided are advanced methods of performing array-based comparative hybridization that allow reproducibility between samples and enhanced sensitivity by using the same detectable label for both test sample and reference sample nucleic acids. Invention methods are useful for the detection or diagnosis of particular disease conditions such as cancer, and detecting predisposition to cancer based on detection of chromosomal or genetic abnormalities and gene expression level. Invention methods are also useful for the detection or diagnosis of hereditary genetic disorders or predisposition thereto, especially in prenatal samples. Moreover, invention methods are also useful for the detection or diagnosis of de novo genetic aberrations associated with post-natal developmental abnormalities. | 02-05-2009 |
20090088335 | NUCLEIC ACID SEQUENCING BY SINGLE-BASE PRIMER EXTENSION - The present invention pertains to a method for determining a sequence of contiguous bases within a polynucleotide, the method relying on single-base primer extension using labeled dideoxynucleotide terminators. The primers are immobilized to solid supports (e.g. microspheres or two-dimensional arrays), allowing for the identification of the labeled terminator incorporated into each primer. | 04-02-2009 |
20090117541 | METHODS OF DETECTING TPMT MUTATIONS - Methods and compositions are described for use in the rapid and simultaneous screening of one or more samples for one or more mutations in the TPMT gene. The methods and compositions of the present invention can be used to rapidly determine if a mutation of the TPMT gene is present in the genome of a subject. Identifying which mutations are present in an individual allows the clinician to design an appropriate therapy using drugs metabolized by TPMT for that individual. | 05-07-2009 |
20090155809 | SUBTRACTIVE SINGLE LABEL COMPARATIVE HYBRIDIZATION - Provided are methods of determining differences between nucleic acids in a test sample and a reference sample. In certain embodiments the methods are used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. In particular, provided are advanced methods of performing array-based comparative hybridization that allow reproducibility between samples and enhanced sensitivity by using the same detectable label for both test sample and reference sample nucleic acids. Invention methods are useful for the detection or diagnosis of particular disease conditions such as cancer, and detecting predisposition to cancer based on detection of chromosomal or genetic abnormalities and gene expression level. Invention methods are also useful for the detection or diagnosis of hereditary genetic disorders or predisposition thereto, especially in prenatal samples. Moreover, invention methods are also useful for the detection or diagnosis of de novo genetic aberrations associated with post-natal developmental abnormalities. | 06-18-2009 |
20100167284 | NUCLEIC ACID SIZE DETECTION METHOD - The present invention provides methods of determining the size of a particular nucleic acid segment of interest in a sample of nucleic acids through fragmentation of DNA, size fractionation, an optional second fragmentation, and identification using a marker sequence. In particular aspects, an expansion or reduction of tandem repeat sequences can be detected. In further aspects, carriers and individuals afflicted with fragile X syndrome or other diseases associated with tandem repeats can be distinguished from normal individuals. | 07-01-2010 |
20110143957 | SUBTRACTIVE SINGLE LABEL COMPARATIVE HYBRIDIZATION - Provided are methods of determining differences between nucleic acids in a test sample and a reference sample. In certain embodiments the methods are used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. In particular, provided are advanced methods of performing array-based comparative hybridization that allow reproducibility between samples and enhanced sensitivity by using the same detectable label for both test sample and reference sample nucleic acids. Invention methods are useful for the detection or diagnosis of particular disease conditions such as cancer, and detecting predisposition to cancer based on detection of chromosomal or genetic abnormalities and gene expression level. Invention methods are also useful for the detection or diagnosis of hereditary genetic disorders or predisposition thereto, especially in prenatal samples. | 06-16-2011 |
20130115595 | METHOD TO DETECT REPEAT SEQUENCE MOTIFS IN NUCLEIC ACID - Methods for determining the presence or absence of expansion of CGG repeat sequence in the FMR1 gene presence or absence of expansion of CCG repeat sequence in the FMR2 gene are provided. The methods are useful in identifying an individual with normal/intermediate, versus premutation or full mutation allele of FMR1 gene and FMR2 gene due to the expansion of CGG repeats and CCG repeats in the 5′-untranslated region respectively. The methods are also useful for screening newborns for fragile X syndrome or for screening women to determine heterozygosity status with full premutation of the CCG repeat tract. The methods are also useful in estimating the premutation and full mutation carrier frequency and estimating the prevalence of FXTAS AND FXPOI in a population. The methods are simple, rapid and require small amount of sample. | 05-09-2013 |
20140377751 | NUCLEIC ACID ANALYSIS USING EMULSION PCR - The present invention provides methods for analyzing large nucleic acids including chromosomes and chromosomal fragments. In one aspect, the present invention provides a method of nucleic acid analysis comprising the steps of (a) obtaining a sample of nucleic acid comprising at least one chromosome or fragment greater than about 1 000 base pairs in length and containing a target region; (b) creating an emulsion in which each drop of the emulsion contains an average of between about 0-2, 0-1.75, 0-1.5, 0-1.0, 0-0.75, 0-0.5, or fewer chromosomes or fragments of step (a), (c) performing emulsion PCR, (d) quantifying the number of emulsion droplets containing amplified nucleic acid from the target region; (e) calculating the ratio of droplets containing amplified nucleic acid from the target region to total droplets; and (f) comparing the ratio of step (e) to a reference ratio representing a known genotype. | 12-25-2014 |
20150086996 | APTAMERS AND DIAGNOSTIC METHODS FOR DETECTING THE EGF RECEPTOR - The present invention provides aptamers that specifically bind to the EGF receptor in a sample, and diagnostic and analytical methods using those aptamers. In some embodiments, the aptamers include a 3′ cap. In some embodiments, the 3′ cap is an inverted deoxythymidine. In some embodiments the aptamers include a spacer and at least one moiety selected from the group consisting of binding pair member and a detectable label, wherein the spacer is attached to the 5′-end of the aptamer and the moiety is attached the 5′ end of the spacer. In some embodiments the spacer is hexaethylene glycol. In some embodiments, the binding pair member biotin. In some embodiments the detectable label is a fluorophore. | 03-26-2015 |
Patent application number | Description | Published |
20080242186 | TOY AIRCRAFT WITH MODULAR POWER SYSTEMS AND WHEELS - Toy aircraft may include an airframe, a modular power system, first and second wheel supports, and first and second wheels. The modular power system may be configured for selective use with and selective removal from the airframe. The power system may include a propulsion unit operable to propel the toy aircraft and a power unit, which may include an energy source configured to supply energy to the propulsion unit. The airframe may include a fuselage, a propulsion unit mount, which may be disposed on the airframe and configured to removably retain the propulsion unit, and a power unit mount, which may be disposed on the fuselage and configured to removably retain the power unit. The first and second wheel supports may extend from the power unit mount toward respective first and second wheel mounts to which the first and second wheels may be rotatably mounted. | 10-02-2008 |
20110130066 | TOY AIRCRAFT WITH MODULAR POWER SYSTEMS AND WHEELS - Toy aircraft may include an airframe, a modular power system, first and second wheel supports, and first and second wheels. The modular power system may be configured for selective use with and selective removal from the airframe. The power system may include a propulsion unit operable to propel the toy aircraft and a power unit, which may include an energy source configured to supply energy to the propulsion unit. The airframe may include a fuselage, a propulsion unit mount, which may be disposed on the airframe and configured to removably retain the propulsion unit, and a power unit mount, which may be disposed on the fuselage and configured to removably retain the power unit. The first and second wheel supports may extend from the power unit mount toward respective first and second wheel mounts to which the first and second wheels may be rotatably mounted. | 06-02-2011 |