Patent application number | Description | Published |
20100130641 | Polymers - The present invention relates to an amphiphilic branched copolymer obtainable by an addition polymerisation process, preferably a free-radical polymerisation process, which is the reaction product of: (a) an initiator, optionally but preferably a free-radical initiator, (b) optionally but preferably a compatible chain transfer agent (E and E′), (c) at least one ethylenically monounsaturated monomer (G and/or J), (d) at least one ethylenically polyunsaturated monomer (L), wherein at least one of E, E′, G, J and L is a hydrophilic residue; and at least one of E, E′, G, J and L is a hydrophobic residue, and the mole ratio of (d) to (c) is greater than 0.0005 to 1. The invention further relates to a branched copolymer particle comprising such an amphiphilic branched copolymer, methods for their preparation, compositions containing such copolymers and particles and their use as, for instance, encapsulating agents, nanoreactors, Pickering emulsifiers, controlled release agents and/or triggered release agents. | 05-27-2010 |
20100144958 | POLYMERS - The present invention relates to a branched polymer obtainable an addition polymerisation process, preferably a free-radical polymerisation process, which is the reaction product of: (a) an initiator, optionally but preferably a free-radical initiator, (b) optionally but preferably a compatible chain transfer agent (E and E′), (c) at least one ethylenically monounsaturated monomer (G and/or J), (d) at least one ethylenically polyunsaturated monomer (L), wherein at least one of (a)-(d) has a molecular weight of at least 1000 Daltons, and the mole ratio of (d) to (c) is greater than 0.0005 to 1. | 06-10-2010 |
20100145001 | BRANCHED ORGANIC-INORGANIC POLYMERS - A branched, hybrid polymer obtainable by an addition polymerisation process, preferably a free-radical polymerisation process, comprising organic chains and inorganic chains wherein: (a) said polymer comprises at least two organic chains which are covalently linked by a bridge other than at their ends, (b) at least one inorganic chain is present, either as a covalently-bonded pendant group on an organic chain or within the bridge, and (c) the polymer comprises a residue of optionally but preferably a chain transfer agent and a residue of an initiator, optionally but preferably a free-radical initiator. The invention further provides a method for the synthesis of these polymers. | 06-10-2010 |
20110172314 | AMPHIPHILIC BRANCHED POLYMERS AND THEIR USE AS EMULSIFIERS - The present invention relates to amphiphilic branched copolymers, methods for their preparation, emulsions comprising such copolymers and their use as emulsifiers. The polymers are responsive by nature, by forming non-covalent bonds between monomer residues upon applying external stimuli. In a preferred embodiment of the copolymer, the copolymer can be used to stabilise emulsions and the emulsion droplets can be reversibly aggregated and de-aggregated. | 07-14-2011 |
20130196852 | PROCESSES FOR PREPARING IMPROVED COMPOSITIONS - The invention provides a method for preparing an improved composition comprising at least one active agent and at least one solid carrier material, wherein the active agent is dispersed through the carrier material in nano-disperse form, which method comprises the steps of: (a) forming a liquid mixture comprising the active agent, the carrier material, a stabilizing agent, a first solvent for the active agent and the stabilizing agent and, a second solvent for the carrier material, and (b) drying the liquid mixture to remove the first and second solvents to obtain a substantially solvent-free nano-dispersion of the active agent with the stabilising agent in the carrier material, wherein the stabilizing agent is capable of stabilizing the active agent in the liquid mixture during drying and in a resultant liquid nano-dispersion of the improved composition. | 08-01-2013 |
Patent application number | Description | Published |
20080206349 | Spray Dried Compositions - The invention provides a method comprising the steps of: (i) providing an emulsion of: a) an aqueous solvent, such as water, b) a carrier material dispersible or soluble in (a), said carrier material being solid at ambient temperature, and preferably being a polymer and inorganic salt or a surfactant, c) a volatile second liquid phase (for example, chloroform) which is not miscible with (a), and d) a material which is dispersible or soluble in (c) but not in (a), and, (ii) Drying the emulsion at above ambient temperature (preferably by spray drying) to simultaneously remove (a) and (c) and thereby obtain the material (b) in solid form with (d) dispersed therein. | 08-28-2008 |
20080262100 | Method of Preparing Carrier Liquids - The invention provides a method for the preparation of a carrier liquid which comprises the steps of: (I) preparing an emulsion comprising: a) an aqueous phase, b) A second liquid phase which is volatile and which is immiscible with aqueous phase (a), c) A carrier material which is soluble in the continuous phase of the emulsion and which is liquid at ambient temperature, and d) A dopant which is soluble in the disperse phase of the emulsion, (II) cooling the emulsion produced in step (I) to a temperature at which at least both the continuous phase and the carrier material become solid, (III) removing water and the volatile second phase from the cooled emulsion in vapor form, and, (IV) returning the product of step (III) to ambient temperature to obtain a liquid product with the dopant dispersed therein. | 10-23-2008 |
20090175953 | Nanodispersions - The invention provides process for making contra-soluble nano-dispersions of at most sparingly-soluble materials in a soluble carrier material comprising the steps of: (i) providing a single phase mixture of: a) a solvent or a mixture of miscible solvents, b) at least one carrier material soluble in solvent (a), said carrier material being also contra-soluble to payload material (c) and solid at ambient temperature, c) at least one a payload material which is soluble in solvent (a), and, (ii) drying the mixture to remove solvent (a) and thereby obtain the carrier material (b) in solid form with payload (c) dispersed therein as nanoparticles. | 07-09-2009 |
20090239749 | Biocidal compositions - The invention provides a solvent-free biocidal composition of improved efficacy comprising at least one water insoluble biocide (preferably a herbicide) and a water-soluble carrier material, wherein the water-insoluble biocide is dispersed through the carrier material in nano-disperse form having a peak diameter of the nano-disperse form below 1000 nm. The invention also provides a process which comprises spray drying a solution of the biocide and a solution of a water-soluble carrier to obtain a solvent free dispersion of the biocide in the carrier, which, when dissolved in water, produces a nano-disperse biocide. The invention also provides an aqueous dispersion of a water insoluble biocide and a water-soluble carrier obtained by the dispersion of the composition of the solvent free composition in water. | 09-24-2009 |
20090304806 | Pharmaceutical Compositions - A process for the production of a composition comprising a water-insoluble sartan which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble sartan, ii) a water soluble carrier, iii) a solvent for each of the sartan and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the sartan in the carrier. | 12-10-2009 |
20100015229 | Pharmaceutical compositions - A process for the production of a composition comprising a water-insoluble statin which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble statin ii) a water soluble carrier, iii) a solvent for each of the statin and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the statin in the carrier. | 01-21-2010 |
20100015233 | anti-parasitic compositions - The present invention relates to nanodisperse antiparasitics and provides a composition comprising at least one water insoluble anti-parasitic drug and a water-soluble carrier material, wherein the water-insoluble anti-parasitic drug (preferably an Artemisinin-type drug or a quinine type drug) is dispersed through the carrier material in nano-disperse form having a peak diameter of the nano-disperse form below 1000 nm. The invention further provides an aqueous dispersion of a water insoluble anti-parasitic drug and a water-soluble carrier material, wherein the anti-parasitic drug is in nano-disperse form having a peak diameter of the nano-disperse form below 1000 nm, the invention further subsists in a process for preparing an anti-parasitic composition comprising a water insoluble anti-parasitic agent and a water-soluble carrier, which comprises the steps of either: a) providing an emulsion comprising a solution of the anti-parasitic agent in a water-immiscible solvent for the same, and an aqueous solution of the carrier, or providing a mixture comprising at least one non-aqueous solvent optional water a water-soluble carrier material soluble in the mixture and a water-insoluble anti-parasitic agent soluble in the mixture, and, b) drying the emulsion (preferably by spray drying) to remove water and the water-immiscible solvent to obtain a substantially solvent-free nano-dispersion of the anti-parasitic agent in the carrier. | 01-21-2010 |
20120134940 | NANODISPERSIONS - The invention provides process for making water-soluble nano-dispersions of water-insoluble materials in a water-soluble carrier material comprising the steps of:
| 05-31-2012 |
20120135058 | NANODISPERSIONS - The invention provides process for making contra-soluble nano-dispersions of at most sparingly-soluble materials in a soluble carrier material comprising the steps of:
| 05-31-2012 |
Patent application number | Description | Published |
20110217340 | NANODISPERSE COMPOSITIONS - A process for the production of a soluble composition comprising a water-insoluble active which comprises either the steps of: a) providing a liquid mixture comprising: i) a dissolved water-insoluble active, ii) a dissolved water-soluble carrier, iii) a solvent for each of the active and the carrier, and b) spray-granulating the mixture to remove the, or each, solvent and obtain a substantially solvent-free nano-dispersion of the water-insoluble active in the carrier said water-insoluble active being in nano-particles having a size range of 999-20 nm; or, the steps of: a) providing a substantially solvent-free powder comprising a water-insoluble active dispersed in a water soluble carrier, said water-insoluble active being in nano-particles having a size range of 999-20 nm, and, b) spray-granulating the powder to obtain larger and denser particles. The invention also relates to solvent-free, granular products with a particle size in the range 20 microns to 10 mm and a bulk-density of greater than 0.4 g/cm3 comprising a water-soluble carrier material, the carrier material having dispersed therein a water-insoluble active, wherein on addition of water the carrier dissolves to form an aqueous dispersion of the active with a peak (z-average) particle size of below 800 nm, preferably below 500 nm and more preferably below 200 nm. The invention also relates to an analogous “reverse” process in which the active is water soluble and the carrier is oil soluble. | 09-08-2011 |
20110217381 | PHARMACEUTICAL COMPOSITIONS - The present invention provides a substantially solvent-free nano-dispersion of an active in a carrier, wherein the carrier comprises an enteric carrier soluble at intestinal pH, but insoluble at stomach pH, and wherein the enteric carrier comprises at least 50% by weight of the nano-dispersion; and processes for the preparation of a substantially solvent-free nano-dispersion of an active in a carrier. | 09-08-2011 |
20110313054 | BRANCHED COPOLYMERS, COMPOSITION AND USES - The present invention relates to a branched copolymer obtainable by an addition polymerisation process and uses and compositions thereof comprising a hydrophilic component, said polymer comprising:
| 12-22-2011 |
20120059069 | AMPHIPHILIC BRANCHED COPOLYMER, METHODS OF PREPARATION, EMULSIONS, AND USES - The present invention relates to an amphiphilic branched copolymer obtainable by an addition polymerisation process, the method of production of same and uses thereof as emulsions wherein said polymer comprises:
| 03-08-2012 |
20120095111 | BRANCHED POLYMER DISPERSANTS - The present invention relates to the use of a branched addition copolymer as a dispersant in a gaseous, liquid or solid formulation in a range of applications and branched addition copolymers suitable for same wherein the copolymer is obtainable by an addition polymerisation process, wherein said copolymer comprises: at least two chains which are covalently linked by a bridge other than at their ends; and wherein the at least two chains comprise at least one ethyleneically monounsaturated monomer, and wherein the bridge comprises at least one ethyleneically polyunsaturated monomer; and wherein the polymer comprises a residue of a chain transfer agent and wherein the mole ratio of polyunsaturated monomer(s) to monounsaturated monomer(s) is in a range of from 1:100 to 1:4; and wherein the branched copolymer dispersant contains anchoring, solubilising or stabilising moieties and wherein the resulting copolymer comprises at least 10% styrenic monomer, brancher or chain transfer agent. | 04-19-2012 |
20120095112 | BRANCHED POLYMER DISPERSANTS - The present invention relates to the use of a branched addition copolymer as a dispersant in a gaseous, liquid or solid formulation in a range of applications and to the copolymers per se wherein the copolymer is obtainable by an addition polymerisation process, wherein said copolymer comprises: at least two chains which are covalently linked by a bridge other than at their ends; and wherein the at least two chains comprise at least one ethyleneically monounsaturated monomer, and wherein the bridge comprises at least one ethyleneically polyunsaturated monomer; and wherein the polymer comprises a residue of a chain transfer agent and wherein the mole ratio of polyunsaturated monomer(s) to monounsaturated monomer(s) is in a range of from 1:100 to 1:4; and wherein the branched copolymer dispersant contains anchoring, solubilising or stabilising moieties and wherein the resulting copolymer has a weight average molecular weight of greater than 100,000 Da. | 04-19-2012 |
20120108678 | BRANCHED COPOLYMERS, COMPOSITIONS AND USES - The present invention relates to a branched copolymer obtainable by an addition polymerisation process and uses and compositions thereof comprising:
| 05-03-2012 |
20120108679 | BRANCHED COPOLYMERS, COMPOSITION AND USES - The present invention relates to a branched copolymer comprising a hydrophilic component obtainable by an addition polymerisation process and compositions and uses thereof said copolymer comprising:
| 05-03-2012 |
20120157318 | Use of Branched Copolymers in Polymer Blends - The present invention relates to the use of a branched addition copolymer in combination with a polymer in a solution or melt formulation to reduce the viscosity of the solution formulation and/or melt formulation compared to the viscosity of a solution and/or melt comprising the polymer alone wherein the branched addition copolymer is obtainable by an addition polymerisation process, methods for the preparation of the formulations, and novel branched addition copolymers for use as same. | 06-21-2012 |
20120157551 | Use of Polymers - The present invention relates to the use of branched addition copolymers possessing melt or solution viscosities lower than the linear polymer analogues of equivalent or greater weight average molecular weight, compositions comprising said copolymers, methods for their preparation, and he use of novel polymers per se in for example but not limited to solution formulations or melt formulations. | 06-21-2012 |
20120178835 | USE OF BRANCHED ADDITION COPLYMERS IN FILMS AND MEMBRANES - The present invention relates to branched addition copolymers which can be cured post synthesis to form films or membranes, methods for their preparation, compositions comprising such copolymers and their use in film or membrane preparation. | 07-12-2012 |
20130345358 | USE OF BRANCHED ADDITION COPOLYMERS IN CURING SYSTEMS - The present invention relates to the use of branched addition copolymers in systems which can be cured post synthesis to form for example polymer coatings, sealants, inks, adhesives or composites and also relates to methods of preparing the cured systems, compositions comprising such copolymers and the use of the compositions in for example but not limited to coatings, inks, sealants, adhesives or composites. | 12-26-2013 |
20140212466 | METHOD OF PREPARING CARRIER LIQUIDS - The invention provides a method for the preparation of a carrier liquid which comprises the steps of: (I) preparing a single phase solution comprising: (a) a solvent or a mixture of miscible solvents, (b) a liquid carrier material, which is soluble in solvent (a), and (c) a dopant material which is also soluble in solvent (a); (II) cooling (preferably freezing) the single phase solution produced in step (I) to a temperature at which at least both the solvent (a) and carrier material (b) become solid; and (III) removing solid solvent (a) from the cooled (frozen) single phase solution in vapour form, such that the remaining cooled (frozen) carrier material (b) and dopant material (c) are returned to ambient temperature thus providing a product of liquid carrier material (b) having dopant material (c) dispersed therein. | 07-31-2014 |
20140212501 | COMPOSITIONS OF LOPINAVIR - The present invention relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug lopinavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof. The present invention also relates to processes for preparing both the solid composition and the aqueous dispersion, as well as to their use in therapy for the treatment and/or prevention of retroviral infections such as human immunodeficiency virus (HIV). | 07-31-2014 |
20140220140 | COMPOSITIONS OF EFAVIRENZ - The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug efavirenz. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof. The present invention also relates to processes for preparing both the solid composition and the aqueous dispersion, as well as to their use in therapy for the treatment and/or prevention of retroviral infections such as human immunodeficiency virus (HIV). | 08-07-2014 |
20140220141 | COMPOSITIONS OF LOPINAVIR AND RITONAVIR - The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drugs lopinavir and ritonavir. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant. The surfactant is selected from vitamin-E-polyethylene glycol-succinate (Vit-E-PEG-succinate), a polyoxyethylene sorbitan fatty acid ester, N-alkyldimethylbenzylammonium chloride, sodium deoxycholate, dioctyl sodium sulfosuccinate, polyethyleneglycol-12-hydroxystearate, polyvinyl alcohol (PVA), and a block copolymer of polyoxyethylene and polyoxypropylene, or a combination thereof. The hydrophilic polymer is suitably selected from polyvinyl alcohol (PVA), a polyvinyl alcohol-polyethylene glycol graft copolymer, a block copolymer of polyoxyethylene and polyoxypropylene, polyethylene glycol, hydroxypropyl methyl cellulose (HPMC), and polyvinylpyrrolidone, or a combination thereof. The present invention also relates to processes for preparing both the solid composition and the aqueous dispersion, as well as to their use in therapy for the treatment and/or prevention of retroviral infections such as human immunodeficiency virus (HIV). | 08-07-2014 |