Steitz
Benedikt Steitz, Vevey CH
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20110045081 | MAGNETIC, PARAMAGNETIC AND/OR SUPERPARAMAGNETIC NANOPARTICLES - The present invention relates to nanoparticles having a mean diameter of <500 nm and comprising, at their surface, a selected material. The nanoparticles are taken up by cells under physiological conditions and can be used to isolate interaction partners of the selected material within the cells. The present invention provides important advantages in that it opens up new ways of identifying cellular components and of delivering a substance of interest specifically to a selected cell compartment. The nanoparticles are also useful as a tool of diagnosis and for the constitution of chemical libraries. | 02-24-2011 |
Benedikt Steitz, Ludwigshafen DE
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20100098763 | PHARMACEUTICAL FORMULATION 514 - The present invention relates to a pharmaceutical formulation comprising the drug 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one in a solid dispersion with a matrix polymer that exhibits low hygroscopicity and high softening temperature, such as copovidone. The invention also relates to a daily pharmaceutical dose of the drug provided by such a formulation. In addition, the invention relates to the use of a matrix polymer that exhibits low hygroscopicity and high softening temperature in solid dispersion with 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one for increasing the bioavailability of the drug. | 04-22-2010 |
20140066447 | IMMEDIATE RELEASE PHARMACEUTICAL FORMULATION OF 4-[3-(4-CYCLOPROPANECARBONYL-PIPERAZINE-1-CARBONYL)-4-FLUORO-BENZYL]-2H-P- HTHALAZIN-1-ONE - The present invention relates to a pharmaceutical formulation comprising the drug 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one in a solid dispersion with a matrix polymer that exhibits low hygroscopicity and high softening temperature, such as copovidone. The invention also relates to a daily pharmaceutical dose of the drug provided by such a formulation. In addition, the invention relates to the use of a matrix polymer that exhibits low hygroscopicity and high softening temperature in solid dispersion with 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one for increasing the bioavailability of the drug. | 03-06-2014 |
Benedikt Steitz, Speyer DE
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20120252851 | DELIVERY SYSTEM FOR SUSTAINED RELEASE OF A CALCIUM-CHANNEL BLOCKING AGENT - A delivery system for sustained release of a calcium-channel blocking agent is adapted for introduction in the cerebrospinal fluid of a subject. The delivery system comprises a solid dispersion product of a calcium-channel blocking agent in a mixture of a (i) first poly(lactide-co-glycolide) having a molecular weight distribution centered around a first number average molecular weight Mn | 10-04-2012 |
Eric S. Steitz, Woburn, MA US
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20140207450 | Real-Time Customizable Media Content Filter - According to one embodiment of the present disclosure, an approach is provided in which a processor receives a media stream that includes media content. The processor selects a media stream segment included in the media stream, and generates annotated data based upon a portion of the media content included in the selected media stream segment. The processor, in turn, compares the annotated data with obfuscation preferences that correspond to prohibited content, and modifies the media stream segment in response to the comparison. | 07-24-2014 |
Jack E. Steitz, Los Gatos, CA US
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20120226858 | METHOD FOR MANAGING HIERARCHICAL STORAGE DURING DETECTION OF SENSITIVE INFORMATION, COMPUTER READABLE STORAGE MEDIA AND SYSTEM UTILIZING SAME - Examples of methods, systems, and computer-readable media for detection of sensitive information on hierarchical storage management mainframes are described using multiple techniques. The techniques may include determining if data has been migrated from a first storage medium to a second storage medium, recalling the migrated data from a second storage medium to the first storage medium, reading the migrated data, then remigrating the data to the second storage medium. | 09-06-2012 |
Karl-Heinz Steitz, Mainz DE
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20110284170 | Device and method for changing the rotational angle position of a pneumatic tire on a wheel rim - Disclosed is a device for changing the rotational angle position of a pneumatic tire relative to a rim, on which the pneumatic tire is fitted to the rim, comprising a manipulating device ( | 11-24-2011 |
20120042724 | Method and device for checking the tire seat on vehicle wheels - In order to check the seat of a tubeless tire ( | 02-23-2012 |
Philip W. Steitz, Scottsdale, AZ US
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20100121882 | Method and System for Implementing and Managing an Enterprise Identity Management for Distributed Security in a Computer System - A method and system for facilitating the management of user identities includes an ownership component, a registration component, and a servicing component. When a user first desires to access a system using the present invention, the registration component verifies the user's ownership of the underlying account by asking a variety of questions. Thereafter, when a user desires to service his account, the user may be re-queried to determine if he is attempting to access the correct information. An authentication and access component provides the functionality to access a system of the present invention. An audit component can be configured to periodically monitor the various accounts to ensure a continued linking between users and accounts. | 05-13-2010 |
20110289569 | METHOD AND SYSTEM FOR IMPLEMENTING AND MANAGING AN ENTERPRISE IDENTITY MANAGEMENT FOR DISTRIBUTED SECURITY - An Enterprise Identity Management system includes a registration component, an ownership component, and an audit component. The registration component is configured to associate a user ID with specific accounts that are accessible via a computer system. The ownership component is configured to verify the ownership of the accounts. The audit component is configured to perform periodic checks to ensure the validity of the association between the user ID and the ownership of the accounts. | 11-24-2011 |
Thomas Steitz, Branford, CT US
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20100204253 | Ribosome Structure and Protein Synthesis Inhibitors - The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism. | 08-12-2010 |
Thomas A. Steitz, Branford, CT US
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20100131258 | Method for identifying protein synthesis inhibitors by ribosome structure - The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism. | 05-27-2010 |
20140066623 | Ribosome Structure and Protein Synthesis Inhibitors - The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism. | 03-06-2014 |