Patent application number | Description | Published |
20120276519 | CANNULA - Disclosed is a cannula including a first clamping portion, a second clamping portion and a force applying portion configured to apply at least two different clamping forces across the first clamping portion and the second clamping portion when the cannula is in a closed state. The first clamping portion includes a first gear, the second clamping portion includes a second gear, and the first gear and the second gear are in meshing engagement. | 11-01-2012 |
20120277681 | Living Donor Cannula - A cannula includes a first circumferential portion, a second circumferential portion, and a seal with a first clamping surface. The first circumferential portion and the second circumferential portion are configured to mutually cooperate to support a circumference of vasculature, and form a second clamping surface. The first clamping surface and the second clamping surface are configured to cooperate to secure an end of the vasculature. | 11-01-2012 |
20120277687 | LIVING DONOR CANNULA - Disclosed is a cannula including a first circumferential portion, a second circumferential portion, and a seal with a first clamping surface. The first circumferential portion and the second circumferential portion are configured to mutually cooperate to support a circumference of vasculature, and form a second clamping surface. The first clamping surface and the second clamping surface are configured to cooperate to secure an end of the vasculature. | 11-01-2012 |
Patent application number | Description | Published |
20080208117 | SYSTEM FOR DELIVERING SOLUTIONS AND REDUCING WASTE - An infusion system utilizes a solution reservoir divided into a first section and a second section which are fluidly isolated but volumetrically connected such that introduction of a pumping fluid into the first section of the reservoir causes displacement and flow of a solution out of the second section of the reservoir. The use of a separate reservoir, separation member, and delivery tubing allow for significantly decreased loss of feeding solution and the like due to dead volume. | 08-28-2008 |
20140017657 | ORGAN TRANSPORT APPARATUS WITH SAMPLE COMPARTMENTS - An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a coolant container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment. | 01-16-2014 |
20140017658 | PERFUSION APPARATUS WITH REDUCED PRESSURE FLUCTUATIONS, AND BUBBLE TRAP - An apparatus for separating gas bubbles that may be entrained in perfusate flow prevents such bubbles from continuing downstream and entering an organ or tissue. The apparatus may include a chamber having a top wall, a bottom wall and side walls. The chamber may include an inlet configured to allow at least one of gas and liquid to enter the chamber, an air opening configured to allow at least gas to exit the chamber and a first liquid opening configured to allow at least liquid to exit the chamber. The apparatus may function as an accumulator that reduces or eliminates pulsatility of the liquid flow and pressure. The apparatus may include a minimum volume of gas, initially or through the accumulation of gas, such that flow and pressure fluctuations in the liquid are dampened or eliminated. The apparatus may include a sampling port in a wall of the chamber. | 01-16-2014 |
20140017659 | ORGAN TRANSPORT APPARATUS WITH A DOCUMENT COMPARTMENT AND A TAMPER EVIDENT SEAL - A perfusion apparatus including a perfusion circuit that perfuses an organ or tissue has a compartment that supports an organ or tissue during perfusion, an internal cover, and an external cover that closes the apparatus. A wall portion may extend substantially perpendicularly between the internal cover and the external cover to define a document compartment between the internal cover, the external cover and the wall portion. A tamper evident seal will not permit the external cover to open without creating a record of whether the external cover has been opened after the tamper evident seal has been activated. | 01-16-2014 |
20140017660 | CANNULA WITH FLOATING CLAMP MEMBER - A cannula has a longitudinal base member having a first clamping end and a longitudinal arm member pivotally attached to the longitudinal base member and having a second clamping end, the cannula being in a closed position when the first and second clamping ends are brought together. A first clamp member is located at the first clamping end and has a first passage. A second clamp member is rotatably attached to the arm member at the second clamping end and has a second passage. The first and second passages form a combined passage when the clamp is in the closed position. The cannula may have a first locking member positioned on the arm member and a second locking member positioned on the base member. The first and second locking members interact with each other to lock the cannula in the closed position. | 01-16-2014 |
20140017661 | CANNULA - A cannula includes a first clamping surface on a closing portion of the cannula, a second clamping surface on a base of a cannula, a connecting structure that connects the closing portion and the base. The connecting structure may allow the closing portion to be rotated around the second clamping surface. The cannula may include a repeatably removable handle. | 01-16-2014 |
20140017662 | ORGAN PERFUSION APPARATUS WITH DOWNSTREAM FLOW CONTROL - An organ perfusion apparatus may include at least two tubes connected to an organ or tissue. A method of perfusing an organ or tissue may include connecting a first end of each of the at least two tubes to an organ or tissue, applying a fluid motive force to a perfusion fluid in the two tubes to force the fluid through the two tubes into the organ or tissue, and perfusing the organ or tissue through the at least two tubes such that the fluid motive force, provided by, e.g., a pump, and backpressure generated by the organ or tissue, establishes a flow balance between the at least two tubes. The flow balance may be altered without altering the fluid motive force that is applied. | 01-16-2014 |
20140017663 | ORGAN TRANSPORTER WITH TILT AND/OR SHOCK SENSING - An apparatus for perfusing an organ or tissue includes a perfusion circuit configured to perfuse the organ or tissue; at least one shock and/or tilt detector such as an accelerometer; and a controller. The controller may be configured to control perfusion based upon a signal received from the accelerometer, which may include stopping and/or starting the perfusion based upon the signal. The controller may also or alternatively sense and/or record shocks experienced by the apparatus. | 01-16-2014 |
20140017664 | TEMPERATURE SENSING IN ORGAN PRESERVATION APPARATUS - A temperature sensor for monitoring an organ or tissue is configured to measure a temperature inside of a container configured to contain the organ or tissue. The temperature sensor is disposed exterior to the organ container and the temperature sensor is a non-contact temperature sensor. The temperature sensor may be part of an apparatus for perfusing, transporting, and/or storing an organ or tissue. A coolant container may have an aperture through which the temperature sensor measures a temperature of at least one of the organ or tissue or a perfusate fluid surrounding the organ or tissue. The temperature sensor is preferably an infrared temperature sensor. Multiple temperature sensors may be provided that measure the temperature organ or tissue or perfusate fluid surrounding the organ or tissue, for example in case one of the temperature sensors fails. | 01-16-2014 |
20140017665 | ORGAN TRANSPORTER WITH OXYGEN GENERATION - An apparatus for perfusing an organ or tissue includes a perfusion circuit for perfusing the organ or tissue; an oxygenator for oxygenating perfusate that circulates through the perfusion circuit; and an oxygen supply device such as an oxygen concentrator or an oxygen generator configured to supply oxygen to the oxygenator. A method of perfusing an organ or tissue includes producing oxygen from a device such as an oxygen concentrator and an oxygen generator; supplying the produced oxygen, preferably as the oxygen is produced, to a perfusate to oxygenate the perfusate; and perfusing the organ or tissue with the oxygenated perfusate. The produced oxygen preferably has a concentration greater than the oxygen concentration in air. | 01-16-2014 |
20140017666 | FILTRATION IN ORGAN PERFUSION APPARATUS - A filter for filtering perfusate is integrated with an exterior portion of an organ container. The filter may be used in an apparatus for perfusing an organ. The perfusion apparatus may include an organ container configured to contain an organ, the filter integrated with an exterior portion of the organ container, and another filter. At least the filter integrated with an exterior portion of the organ container may be provided in a sterilized disposable kit. | 01-16-2014 |
20140017770 | ORGAN TRANSPORTER AND ORGAN TRANSPORTER COMPONENT KIT - A perfusion apparatus includes a coolant container having a basin-receiving recess that is at least partly surrounded by an inner chamber; a basin that is shaped to fit within the basin-receiving recess of the coolant container; and a cradle that is shaped to accept an organ and fit within the basin. The basin-receiving recess of the coolant container, the basin and the cradle each have positioning elements that are oriented such that the cradle is keyed to fit within the basin and the basin is keyed to fit within the coolant container, each in a single predetermined orientation. The plurality of positioning elements on the basin may include a plurality of protrusions on an outer surface of the basin. | 01-16-2014 |
20140329220 | CANNULA WITH FLOATING CLAMPING MEMBER - A cannula has a longitudinal base member having a first clamping end and a longitudinal arm member pivotally attached to the longitudinal base member and having a second clamping end, the cannula being in a closed position when the first and second clamping ends are brought together. A first clamp member is located at the first clamping end and has a first passage. A second clamp member is rotatably attached to the aim member at the second clamping end and has a second passage. The first and second passages form a combined passage when the clamp is in the closed position. The cannula may have a first locking member positioned on the arm member and a second locking member positioned on the base member. The first and second locking members interact with each other to lock the cannula in the closed position. | 11-06-2014 |
20150272111 | FILTRATION IN ORGAN PERFUSION APPARATUS - A filter for filtering perfusate is integrated with an exterior portion of an organ container. The filter may be used in an apparatus for perfusing an organ. The perfusion apparatus may include an organ container configured to contain an organ, the filter integrated with an exterior portion of the organ container, and another filter. At least the filter integrated with an exterior portion of the organ container may be provided in a sterilized disposable kit. | 10-01-2015 |
Patent application number | Description | Published |
20140013499 | Pool Access Apparatus - A pool access apparatus for moving a disabled person between a pool deck and a pool includes an arm supported for pivotal motion about a base axle and a seat supported for pivotal motion about a seat axle carried by the arm. A driver pivots the arm between a deployed position suspending the seat at least partially within the pool, and a stowed position suspending the seat in a position displaced laterally from the pool. The apparatus may include a chain-driven seat attitude maintenance linkage, an anchoring system comprising a sub-plate embedded in or disposed below the deck to which a base plate of the apparatus is removably connectable, and/or a wheeled portability kit that is removably connectable to the base plate. | 01-16-2014 |
20140289953 | Pool Crane Rotation Apparatus - An apparatus for rotating a crane for hoisting and moving a disabled person between a pool and an adjacent deck. The apparatus may include a post receptacle supported adjacent a pool and a post having a lower portion removably receivable in the post receptacle. The post may also have an upper portion that extends upward from the post receptacle when the lower portion of the post is received in the post receptacle. A turret sleeve may be supported on the post upper portion for rotation about a turret axis, and a turret arm may be carried by and extend radially outward from the turret sleeve. A seat may be carried by the arm. A turret driver may be operatively connected to the turret sleeve and configured to rotate the turret, arm, and seat about the turret axis. The apparatus may also include a remote controller configured to command the driver to rotate the turret, arm and seat about the turret axis. | 10-02-2014 |
20140331399 | Pool Lift Portability Method and Apparatus - An apparatus is provided for rendering a pool lift portable. The apparatus comprises a forewheel assembly comprising a forewheel attached to a base of a pool lift adjacent a forward edge of the base, and a jack comprising a jack wheels. The jack may be attached to the pool lift base in a position where the jack wheel is spaced from the forewheel, and the jack may be actuated to alternately lift and lower the apparatus by alternately moving the jack wheel between extended and retracted positions so as to rotate the pool lift base about the forewheel such that the pool lift base is in contact with a supporting surface when the jack wheel is in its retracted position, and such that the pool lift base is supported in a transport position spaced from the supporting surface by the forewheel and the jack wheel when the jack wheel is in its extended position. The apparatus may include a seat attitude maintenance linkage comprising a single-side two-link crank linkage having a long link spaced to prevent pinching. | 11-13-2014 |
Patent application number | Description | Published |
20130176110 | ARROW MOUNTED TRACKING APPARATUS - An animal tracking device for tracking an animal shot with an arrow. The animal tracking device may include an antenna, a controller, an accelerometer switch, a battery powering the controller and/or accelerometer switch, an animal attachment component, and a housing physically connecting components of the animal tracking device. The accelerometer switch may measure an amount of G force it experiences and send an interrupt signal to the controller when the amount of G force measured is at or greater than a threshold amount for a threshold amount of time, indicating that the arrow has been shot. The controller may send wireless signals to a receiver via the antenna in response to receiving the interrupt signal. The housing may be detachably attached to the arrow. The animal attachment component may attach to an animal shot by the arrow and force the housing away from the arrow. | 07-11-2013 |
20130176123 | ARROW MOUNTED TRACKING APPARATUS - An animal tracking device removably attachable to an arrow and including an antenna, a controller, a battery for powering the controller, a housing for housing the antenna, controller, and battery, and an animal attachment component fixed to the housing. The controller may transmit wireless signals to a receiver via the antenna. The housing may have a first and second portion pivotally attached at a first joint. The first and second portions may also meet, but not attach with each other, at a second joint in a closed position. The first and second portions may pivot between the closed position and an open position about the first joint, may be naturally biased in the open position, and may be detachably attached in the closed position to the arrow shaft. The animal attachment component may attach to an animal shot by the arrow, forcing the housing away from the arrow. | 07-11-2013 |
Patent application number | Description | Published |
20080202763 | Method to Optimize Production from a Gas-lifted Oil Well - A method for determining and reporting a general production state of a gas-lift system for an oil well, the oil well having associated tubing, casing, and gas-lift valves, and wherein sensor signals from the welt and its associated tubing and casing are input into mathematical models. The method comprises the steps of: a) extracting values from the mathematical models that indicate instantaneous states of production; b) supplying the sensor signals and the values to an associative memory agent; and c) using the associative memory agent to associate the sensor signals and the values to generate the general production state. | 08-28-2008 |
20080270328 | Building and Using Intelligent Software Agents For Optimizing Oil And Gas Wells - A system and method for monitoring processes in the production of oil and gas uses intelligent software agents employing associative memory techniques that receive data from sensors in the production environment and from other sources and perform pattern matching operations to identify normal and abnormal behavior of the well production. The agents report the behaviors to human operators or other software systems. The abnormal behavior may consist of any behavior of the production processes that is other than the desired behavior of the well. The intelligent software agents are trained to identify both specific behaviors and behaviors that have never before been observed and recognized in the well. | 10-30-2008 |
20090276094 | Apparatus And Method For An Autonomous Robotic System For Performing Activities In A Well - An autonomous robot performs maintenance and repair activities in oil and gas wells, and in pipelines. The robot uses the well and pipeline fluids to provide most of the energy required for its mobility, and to charge a turbine from which it may recharge batteries or power a motor for additional propulsion. A control system of associated systems controls the robot, enabling the robot to share plans and goals, situations, and solution processes with wells, pipelines, and external control systems. The control system includes decision aids in a series of knowledge bases that contain the expertise in appropriate fields to provide intelligent behavior to the control system. The intelligent behavior of the control system enables real time maintenance management of wells and pipelines, through actively collecting information, goal-driven system, reasoning at multiple levels, context sensitive communication, activity performing, and estimation of the operators' intent. | 11-05-2009 |
20100017134 | GRAVEL PACK ASSESSMENT TOOL AND METHODS OF USE - A gravel pack evaluation tool comprised of a low energy radiation source and multiple directionally-collimated radiation detectors to analyze small, azimuthal segments of a gravel pack. Methods of use are also provided. Collimators and radiation shielding used in conjunction with multiple detector arrays allow an azimuthal segmented view of a gravel pack, particularly at certain defined depths into a gravel pack. Radioactive tracers may be used in conjunction with these tools to produce enhanced images of gravel packs and formations. | 01-21-2010 |
20130043381 | METHOD FOR DETECTING FRACTURES AND PERFORATIONS IN A SUBTERRANEAN FORMATION - Fractures at a wellbore wall and in a region surrounding a wellbore wall can be detected by monitoring gamma rays scattered from the fractures. Gamma rays are strategically directed from a tool disposed within the wellbore and to the wall and/or the region. Some of the gamma rays scatter from the fractures and are detected with detectors set a designated axial distance from the gamma ray source. In addition to identifying the presence of the fractures, the location and size of the fractures is also estimated. Based on the location and disposition of the fractures, perforations are formed in the formation to provide communication between the fractures and the wellbore. | 02-21-2013 |
20140291500 | Method for Evaluating Voids in a Subterranean Formation - Voids adjacent a wellbore wall and in a region surrounding a wellbore wall can be detected by monitoring gamma rays scattered from the fractures. Gamma rays are strategically directed from a tool disposed within the wellbore and to the wall and/or the region. Some of the gamma rays scatter from the voids and are detected with detectors set a designated axial distance from the gamma ray source. In addition to identifying the presence of the voids, the location and size of the fractures/perforations is also estimated. Time lapsed imaging of the wellbore wall can yield changes in the voids that in turn can affect permeability of the well. Examples of the voids include fractures and/or perforations. | 10-02-2014 |
Patent application number | Description | Published |
20140013499 | Pool Access Apparatus - A pool access apparatus for moving a disabled person between a pool deck and a pool includes an arm supported for pivotal motion about a base axle and a seat supported for pivotal motion about a seat axle carried by the arm. A driver pivots the arm between a deployed position suspending the seat at least partially within the pool, and a stowed position suspending the seat in a position displaced laterally from the pool. The apparatus may include a chain-driven seat attitude maintenance linkage, an anchoring system comprising a sub-plate embedded in or disposed below the deck to which a base plate of the apparatus is removably connectable, and/or a wheeled portability kit that is removably connectable to the base plate. | 01-16-2014 |
20140289953 | Pool Crane Rotation Apparatus - An apparatus for rotating a crane for hoisting and moving a disabled person between a pool and an adjacent deck. The apparatus may include a post receptacle supported adjacent a pool and a post having a lower portion removably receivable in the post receptacle. The post may also have an upper portion that extends upward from the post receptacle when the lower portion of the post is received in the post receptacle. A turret sleeve may be supported on the post upper portion for rotation about a turret axis, and a turret arm may be carried by and extend radially outward from the turret sleeve. A seat may be carried by the arm. A turret driver may be operatively connected to the turret sleeve and configured to rotate the turret, arm, and seat about the turret axis. The apparatus may also include a remote controller configured to command the driver to rotate the turret, arm and seat about the turret axis. | 10-02-2014 |
20140331399 | Pool Lift Portability Method and Apparatus - An apparatus is provided for rendering a pool lift portable. The apparatus comprises a forewheel assembly comprising a forewheel attached to a base of a pool lift adjacent a forward edge of the base, and a jack comprising a jack wheels. The jack may be attached to the pool lift base in a position where the jack wheel is spaced from the forewheel, and the jack may be actuated to alternately lift and lower the apparatus by alternately moving the jack wheel between extended and retracted positions so as to rotate the pool lift base about the forewheel such that the pool lift base is in contact with a supporting surface when the jack wheel is in its retracted position, and such that the pool lift base is supported in a transport position spaced from the supporting surface by the forewheel and the jack wheel when the jack wheel is in its extended position. The apparatus may include a seat attitude maintenance linkage comprising a single-side two-link crank linkage having a long link spaced to prevent pinching. | 11-13-2014 |
Patent application number | Description | Published |
20140013499 | Pool Access Apparatus - A pool access apparatus for moving a disabled person between a pool deck and a pool includes an arm supported for pivotal motion about a base axle and a seat supported for pivotal motion about a seat axle carried by the arm. A driver pivots the arm between a deployed position suspending the seat at least partially within the pool, and a stowed position suspending the seat in a position displaced laterally from the pool. The apparatus may include a chain-driven seat attitude maintenance linkage, an anchoring system comprising a sub-plate embedded in or disposed below the deck to which a base plate of the apparatus is removably connectable, and/or a wheeled portability kit that is removably connectable to the base plate. | 01-16-2014 |
20140289953 | Pool Crane Rotation Apparatus - An apparatus for rotating a crane for hoisting and moving a disabled person between a pool and an adjacent deck. The apparatus may include a post receptacle supported adjacent a pool and a post having a lower portion removably receivable in the post receptacle. The post may also have an upper portion that extends upward from the post receptacle when the lower portion of the post is received in the post receptacle. A turret sleeve may be supported on the post upper portion for rotation about a turret axis, and a turret arm may be carried by and extend radially outward from the turret sleeve. A seat may be carried by the arm. A turret driver may be operatively connected to the turret sleeve and configured to rotate the turret, arm, and seat about the turret axis. The apparatus may also include a remote controller configured to command the driver to rotate the turret, arm and seat about the turret axis. | 10-02-2014 |
20140331399 | Pool Lift Portability Method and Apparatus - An apparatus is provided for rendering a pool lift portable. The apparatus comprises a forewheel assembly comprising a forewheel attached to a base of a pool lift adjacent a forward edge of the base, and a jack comprising a jack wheels. The jack may be attached to the pool lift base in a position where the jack wheel is spaced from the forewheel, and the jack may be actuated to alternately lift and lower the apparatus by alternately moving the jack wheel between extended and retracted positions so as to rotate the pool lift base about the forewheel such that the pool lift base is in contact with a supporting surface when the jack wheel is in its retracted position, and such that the pool lift base is supported in a transport position spaced from the supporting surface by the forewheel and the jack wheel when the jack wheel is in its extended position. The apparatus may include a seat attitude maintenance linkage comprising a single-side two-link crank linkage having a long link spaced to prevent pinching. | 11-13-2014 |
Patent application number | Description | Published |
20090142271 | DENDRITIC CELLS - The present invention provides systems for isolating, characterizing, and modulating brain dendritic cells. The invention may allow a better understanding of and opportunities to modulate neurodevelopmental processes (such as, for example, neurogenesis) and neurological diseases (such as, for example, Alzheimer's Disease). | 06-04-2009 |
20120135496 | Protein Belonging to the TNF Superfamily Involved in Signal Transduction, Nucleic Acids Encoding Same and Methods of Use Thereof - A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal. | 05-31-2012 |
20130064813 | Protein Belonging to the TNF Superfamily Involved in Signal Transduction, Nucleic Acids Encoding Same and Methods of Use Thereof - A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal. | 03-14-2013 |
Patent application number | Description | Published |
20090029469 | Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens - A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic cell precursors. The cultures of mature dendritic cells provide an effective means of producing novel T cell dependent antigens comprised of dendritic cell modified antigens or dendritic cells pulsed with antigen, including particulates, which antigen is processed and expressed on the antigen-activated dendritic cell. The novel antigens of the invention may be used as immunogens for vaccines or for the treatment of disease. These antigens may also be used to treat autoimmune diseases such as juvenile diabetes and multiple sclerosis. | 01-29-2009 |
20090098608 | Methods, systems and reagents for improved immunodetection - The instant invention provides methods, systems and reagents for immunodetection involving novel epitope tags and antibodies which recognize these new epitope tags as well as the antibodies which detect the FLAG epitope tag. Fusion proteins comprising the epitope tags, as well as methods of purifying these proteins and kits detecting these proteins are also provided. | 04-16-2009 |
20090117089 | GLYCOLIPIDS AND ANALOGUES THEREOF AS ANTIGENS FOR NK T CELLS - This invention relates to immunogenic compounds which may serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses. | 05-07-2009 |
20090175890 | USE OF IMMATURE DENDRITIC CELLS TO SILENCE ANTIGEN SPECIFIC CD8+ T CELL FUNCTION - This invention provides methods for silencing a pre-existing immune response in a mammal, as for example, in the setting of autoimmune diseases. The method comprises administering to a mammal immature dendritic cells which have been contacted in vitro with an antigen, or to target the antigen to immature dendritic cells in vivo, in order to silence and/or suppress a pre-existing CD8+ T cell immune response and induce IL-10 producing CD8+ T cells in said mammal. This invention further relates to methods for propagating immature dendritic cells, for maintaining immaturity by modification ex vivo, and uses thereof, including generation of regulatory T cells for passive immunotherapy. The present invention also relates to compositions and kits comprising immature dendritic cells and antigens. | 07-09-2009 |
20110183377 | METHODS, SYSTEMS AND REAGENTS FOR IMPROVED IMMUNODETECTION - The instant invention provides methods, systems and reagents for immunodetection involving novel epitope tags and antibodies which recognize these new epitope tags as well as the antibodies which detect the FLAG epitope tag. Fusion proteins comprising the epitope tags, as well as methods of purifying these proteins and kits detecting these proteins are also provided. | 07-28-2011 |
20120070845 | METHODS, SYSTEMS AND REAGENTS FOR IMPROVED IMMUNODETECTION - The instant invention provides methods, systems and reagents for immunodetection involving novel epitope tags and antibodies which recognize these new epitope tags as well as the antibodies which detect the FLAG epitope tag. Fusion proteins comprising the epitope tags, as well as methods of purifying these proteins and kits detecting these proteins are also provided. | 03-22-2012 |
Patent application number | Description | Published |
20090025693 | Filtration Device for Use with a Fuel Vapor Recovery System - A filtration device for filtering air for use with a fuel vapor recovery system. According to one aspect, the device includes a housing defining a chamber having a rotational axis an upper end and a lower end, a cap closes the housing and includes at least one generally helical passageway helically extending generally toward the lower end of the chamber and includes at least one air inlet. According to another aspect, the device includes a non-circular filter element disposed between an air inlet and an air outlet. | 01-29-2009 |
20120137884 | Multi-Stage Filtration Device - A filtration device for filtering air for use with a fuel vapor recovery system, the filtration device including a housing having a cover and a base. The cover defines an outlet and a plurality of inlets allowing air to enter the housing. The housing includes a plurality of internal walls defining a plurality of chambers. The plurality of internal walls define a plurality of inlets configured to direct air entering the device to flow along the inner circumference of a cylinder, thereby generating an air stream having a sufficient flow velocity such that centrifugal force forces contaminants to separate from the air. | 06-07-2012 |
20140020379 | Solenoid Valve - A solenoid valve includes a housing defining an interior cavity and at least a first and second port coupled to the housing and having associated passages configured to be in fluid communication with the interior cavity. The solenoid valve further includes a valve seat disposed about an opening between the first and second ports and interior cavity. The valve seat is integrally formed with the housing, such that the housing and valve seat are a single unitary structure. The solenoid valve further includes a bobbin supporting a coil and an armature and seal movably disposed within the bobbin and relative to the coil. The armature and seal are moveable between an open position and a closed position relative to the valve seat, wherein, in the closed position, the seal sealingly engages with the valve seat. | 01-23-2014 |
20150260134 | INLINE DUMP-ABLE FUEL SYSTEM DUST FILTER - A number of variations may include a product comprising a dump-able filter comprising: a filter body; a filter assembly, wherein the filter assembly is seated in the filter body; and a filter cap, wherein the filter cap attaches to the filter body and encloses at least a portion of the filter assembly. | 09-17-2015 |