Stefano
Francisco Stefano, Buenos Aires AR
Patent application number | Description | Published |
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20100087768 | TRANSDERMAL DRUG DELIVERY SYSTEM FOR LIQUID ACTIVE INGREDIENT - A monolithic device for transdermal administration of an active pharmaceutical ingredient which is selected from propargylamines and rivastigmine and is liquid at 25° C., has an adhesive matrix layer which includes the active ingredient in an acrylic polymer pressure sensitive adhesive without cross-linker agent containing a metal atom, the adhesive having a shear value of between 1.5 and 15 hours, and further includes a non-volatile coadjuvant selected from squalene and triethylcitrate present in the layer in an amount of 1 to 15 wt %. The combination provides good release of the drug in use, reduces loss of the drug during a drying step in manufacture, reduces chemical interaction of the layer with the drug and achieves low level of skin irritation. | 04-08-2010 |
Francisco Jose Evaristo Stefano, Ciudad Autonoma De Buenos Aires AR
Patent application number | Description | Published |
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20140221942 | A Device for the Transdermal Delivery of Alkaline Compounds that are Susceptible to Degradation in Their Free Base Form - The present invention pertains generally to the field of transdermal drug delivery. More specifically, the invention relates to a device for the transdermal delivery of an alkaline pharmaceutically active compound that is susceptible to degradation in its free base form (e.g., rivastigmine) that comprises an adhesive matrix layer, a backing layer and a release or protective layer, wherein the adhesive matrix layer comprises said pharmaceutically active compound, triethylcitrate and hydrochloric acid. The invention also relates to methods of preparing such devices. | 08-07-2014 |
Marc Pierre Stefano, Livry-Gargan FR
Patent application number | Description | Published |
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20100234972 | METHOD OF THREE-DIMENSIONAL GRAPHICAL MODELLING - The invention relates to the field of methods of three-dimensional graphical modelling. This is a method of three-dimensional graphical modelling of an interface between several elements, comprising at least: for at least two elements, a step of determining one or more parameters of the element that relate to the interface; a step of displaying, at the level of a software resource, a three-dimensional graphical modelling of the interface with the aid of the parameters determined, at least one of the elements being a phase of a manufacturing method, at least one determined parameter of which used for the displaying step corresponds to a constraint imposed by the manufacturing method phase. | 09-16-2010 |
Re Fiorentin Stefano, Orbassano (torino) IT
Patent application number | Description | Published |
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20110198070 | MOTOR-VEHICLE WITH AN AUXILIARY COOLING SYSTEM INCLUDING ONE OR MORE RADIATORS CONSTITUTED BY VEHICLE BODY COMPONENTS - A motor-vehicle is provided with an auxiliary cooling system, having a low temperature cooling liquid, entirely independent from the cooling circuit of the engine and including a radiator located at the front part of the motor-vehicle facing the radiator of the cooling circuit of the engine. The auxiliary cooling circuit comprises one or more auxiliary radiators which are connected parallel to the radiator of the auxiliary circuit and which are constituted by motor-vehicle body components. | 08-18-2011 |