| Patent application number | Description | Published |
|---|
| 20090088429 | Isoquinoline Derivatives - The invention relates to 6-piperidinyl-substituted isoquinoline derivatives of the formula (I) | 04-02-2009 |
| 20090203694 | INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE - The present invention relates to compounds that are selective and/or potent inhibitors of UPPS. In addition to compounds which inhibit UPPS, the invention also provides pharmaceutical compositions comprising these compounds and methods of using these compounds for treating bacterial disease, such as bacterial infection. | 08-13-2009 |
| 20090306149 | USE OF BIARYLCARBOXAMIES IN THE TREATMENT OF HEDGEHOG PATHWAY-RELATED DISORDERS - The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway. In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, Hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of the invention (e.g., a compound of Formula I). | 12-10-2009 |
| 20090325948 | INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE - The present invention relates to compounds that are selective and/or potent inhibitors of UPPS. In addition to compounds which inhibit UPPS, the invention also provides pharmaceutical compositions comprising these compounds and methods of using these compounds for treating bacterial disease, such as bacterial infection. | 12-31-2009 |
| 20100081671 | Cycloalkylamine substituted isoquinoline derivatives - The invention relates to 6-substituted isoquinoline derivatives of the formula (I) | 04-01-2010 |
| 20110021462 | SUBSTITUTED TETRAHYDRO-2H-ISOQUINOLIN-1-ONE DERIVATIVES, AND METHODS FOR THE PRODUCTION AND USE THEREOF - This invention relates to compounds according to the general formula (I), where the definitions of the substituents R1, R2, Ar and X are as specified in the description, and to their physiologically tolerated salts, methods for the preparation of these compounds and their use as medicaments. | 01-27-2011 |
| 20110039850 | Leukemia Treatment - A combination of a BCR-ABL inhibitor and a hedgehog pathway inhibitor for the treatment of leukemia. | 02-17-2011 |
| Patent application number | Description | Published |
|---|
| 20100041663 | Organic Compounds as Smo Inhibitors - The present invention relates generally to novel compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders. The present invention includes novel compounds, novel compositions, methods of their use and methods of their manufacture, where such compounds are generally pharmacologically useful as agents in therapies whose mechanism of action involve methods of inhibiting tumorigenesis, tumor growth and tumor survival using agents that inhibit the Hedgehog and Smo signaling pathway. | 02-18-2010 |
| 20100069368 | Organic Compounds and Their Uses - The present disclosure relates to compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders; specifically relating to compounds of formula I: | 03-18-2010 |
