Patent application number | Description | Published |
20120157524 | 3-METHANESULFONYLPROPIONITRILE FOR TREATING INFLAMMATION AND PAIN - The present invention relates to purified 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, and a method for preparing such compound. The compound has at least 90% (w/w) purity. The present invention is also directed to a pharmaceutical composition comprises the purified compound and a pharmaceutically acceptable carrier. The present invention is further directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof. | 06-21-2012 |
20130172410 | 3-METHANESULFONYLPROPIONITRILE FOR TREATING INFLAMMATION AND PAIN - The present invention relates to purified 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, and a method for preparing such compound. The compound has at least 90% (w/w) purity. The present invention is also directed to a pharmaceutical composition comprises the purified compound and a pharmaceutically acceptable carrier. The present invention is further directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof. | 07-04-2013 |
20130324601 | PHARMACEUTICAL COMPOSITION FOR TREATING INFLAMMATION AND PAIN - The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a ω-(arylsulfonyl)alkylnitrile compound, or a pharmaceutically acceptable salt thereof. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering an ω-(arylsulfonyl)alkylnitrile compound or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof. | 12-05-2013 |
20130324603 | PHARMACEUTICAL COMPOSITION FOR TREATING INFLAMMATION AND PAIN - The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a methanesulfonylalkylnitrile compound, or a pharmaceutically acceptable salt or solvate thereof. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering a methanesulfonylalkylnitrile compound or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof. | 12-05-2013 |
20150087701 | PHARMACEUTICAL COMPOSITION COMPRISING OMEGA-(ARYLSULFONYL)ALKYLNITRILE - The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a ω-(arylsulfonyl)alkylnitrile compound, or a pharmaceutically acceptable salt thereof. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering an ω-(arylsulfonyl)alkylnitrile compound or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof. | 03-26-2015 |
20150231106 | 3-METHANESULFONYLPROPIONITRILE FOR TREATING INFLAMMATION AND PAIN - The present invention relates to purified 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt thereof, and a method for preparing such compound. The compound has at least 90% (w/w) purity. The present invention is also directed to a pharmaceutical composition comprises the purified compound and a pharmaceutically acceptable carrier. The present invention is further directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof. | 08-20-2015 |
Patent application number | Description | Published |
20100151533 | Synthesis of (6S)-5methyl-5,6,7,8-tetrahydrofolic acid - A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methylTHFA; and (4) isolating (6S)-5-methylTHFA. | 06-17-2010 |
20100240756 | COMPOUNDS FOR TREATING INFLAMMATION AND PAIN - The present invention is directed to a compound of 2-N halo-4-methylsulfonyl-butyric acid, such as 2-N chloro-4-methylsulfonyl-butyric acid, or a pharmaceutically acceptable salt or solvate thereof. The present invention is also directed to a pharmaceutical composition comprises the compound and a pharmaceutically acceptable carrier. The present invention is further directed to a method for treating inflammation or inflammatory-related disorders, bacterial infection, pain, or skin conditions, by administering 2-N halo-4-methylsulfonyl-butyric acid to a subject in need thereof. | 09-23-2010 |
20110136188 | SYNTHESIS OF FATTY ALCOHOL ESTERS OF ALPHA-HYDROXY CARBOXYLIC ACIDS AND THEIR USE AS PERCUTANEOUS ABSORPTION ENHANCERS - The present invention provides a novel approach for the preparation of fatty alcohol esters of α-hydroxy carboxylic acids. In one form of the invention, the target fatty alcohol ester of α-hydroxy carboxylic acid is produced by converting a lower alkyl ester of α-hydroxy carboxylic acid into a fatty alcohol ester of α-hydroxy carboxylic acid via alcoholysis (i.e., transesterification). The transesterification process is an equilibrium reaction, catalyzed chemically (i.e., with acids or bases) or enzymatically, that is shifted in the desired direction to produce the desired product. One preferred way of shifting the reaction in the direction of the desired product is by reducing the concentration of one of the products (e.g., distillation of a lower-boiling alcohol as soon as it is formed). Another preferred way of shifting the reaction in the direction of the desired product is by increasing the concentration of one of the reactants (e.g., adding more of the starting ester). | 06-09-2011 |
20120289725 | SYNTHESIS OF FATTY ALCOHOL ESTERS OF ALPHA-HYDROXY CARBOXYLIC ACIDS AND THEIR USE AS PERCUTANEOUS ABSORPTION ENHANCERS - The present invention provides a novel approach for the preparation of fatty alcohol esters of α-hydroxy carboxylic acids. In one form of the invention, the target fatty alcohol ester of α-hydroxy carboxylic acid is produced by converting a lower alkyl ester of α-hydroxy carboxylic acid into a fatty alcohol ester of α-hydroxy carboxylic acid via alcoholysis (i.e., transesterification). The transesterification process is an equilibrium reaction, catalyzed chemically (i.e., with acids or bases) or enzymatically, that is shifted in the desired direction to produce the desired product. One way of shifting the reaction in the direction of the desired product is by reducing the concentration of one of the products (e.g., distillation of a lower-boiling alcohol as it is formed). Another preferred way of shifting the reaction in the direction of the desired product is by increasing the concentration of one of the reactants. | 11-15-2012 |
20120315679 | SYNTHESIS OF (6S)-5,6,7,8-TETRAHYDROFOLIC ACID - A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methlTHFA; and (4) isolating (6S)-5-methylTHFA, | 12-13-2012 |
20130089577 | NOVEL ESTER CONTAINING COMPOSITIONS AND METHODS - Described herein are compositions (e.g., a pharmaceutical composition) and methods for controlling the delivery of a therapeutic agent, and their use in the treatment and/or prevention of diseases and disorders. | 04-11-2013 |
20130096192 | NOVEL COMPOSITONS AND METHODS - Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, and their use in the treatment and/or prevention of diseases and disorders. | 04-18-2013 |
20130178646 | NOVEL COMPOSITIONS AND METHODS - Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, methods of making compounds of formula (I) and their use in the treatment and/or prevention of diseases and disorders. | 07-11-2013 |
20130225865 | PROCESS FOR PREPARING 3-METHYLSULFONYLPROPIONITRILE - The present invention relates to processes for preparing 3-methylsulfonylpropionitrile. The processes provide a good yield and a good purity of the final product and provide a controllable reaction. The present invention also relates to a crystalline form of 3-methylsulfonylpropionitrile having X-ray diffraction peaks at 13.9±0.1, 19.2±0.1, 20.0±0.1, 22.5±0.1, 23.2±0.1, 25.7±0.1, 28.1±0.1, 29.9±0.1, and 30.6±0.1 degrees 2θ, and wherein the most intense peak is the peak at 13.9±0.1 degrees 2θ. | 08-29-2013 |
20140330037 | CRYSTALLINE FORM OF 3-METHYLSULFONYLPROPIONITRILE - The present invention relates to processes for preparing 3-methylsulfonylpropionitrile. The processes provide a good yield and a good purity of the final product and provide a controllable reaction. The present invention also relates to a crystalline form of 3-methylsulfonylpropionitrile having X-ray diffraction peaks at 13.9±0.1, 19.2±0.1, 20.0±0.1, 22.5±0.1, 23.2±0.1, 25.7±0.1, 28.1±0.1, 29.9±0.1, and 30.6±0.1 degrees 2θ, and wherein the most intense peak is the peak at 13.9±0.1 degrees 2θ. | 11-06-2014 |
20140357600 | NOVEL ESTER CONTAINING COMPOSITIONS AND METHODS - Described herein are compositions (e.g., a pharmaceutical composition) and methods for controlling the delivery of a therapeutic agent, and their use in the treatment and/or prevention of diseases and disorders. | 12-04-2014 |
20150057252 | PHARMACEUTICAL COMPOSITION AND USE OF DIETHYL (2-CYANOETHYL)PHOSPHONATE - The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and diethyl(2-cyanoethyl)phosphonate, or a pharmaceutically acceptable salt thereof. The present invention is directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering diethyl(2-cyanoethyl)phosphonate, or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof. | 02-26-2015 |
20150080476 | METHOD FOR TREATING SKIN INFLAMMATORY DISEASES - The present invention is directed to a method for treating skin inflammatory diseases such as dermatitis, psoriasis, and acne, and rosacea, by administering 3-methanesulfonylpropionitrile or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof. The method alleviates the symptoms of the disease treated. The active compound can be administered by a systemic route or topical route. Topical administration is a preferred route of administration. | 03-19-2015 |
20150094366 | COMPOUNDS FOR TREATING INFLAMMATION AND PAIN - The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and 3-(methylthio)propionitrile, or a pharmaceutically acceptable salt thereof. The present invention is directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering ω-(methylthio)alkylnitriles such as 3-(methylthio)propionitrile, or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof. | 04-02-2015 |
20150094373 | COMPOUNDS FOR TREATING INFLAMMATION AND PAIN - The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and ω-(methylsulfonyl)alkylamine or ω-(methylsulfonyl)alkylamide. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering ω-(methylsulfonyl)alkylamine or ω-(methylsulfonyl)alkylamide, or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof. | 04-02-2015 |
20150182488 | METHODS FOR TREATING INFLAMMATION AND PAIN - The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an ω-(methanesulfonyl)alkenylnitrile compound, or a pharmaceutically acceptable salt thereof. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering an ω-(methanesulfonyl)alkenylnitrile compound or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof. Oral and topical administration are preferred. | 07-02-2015 |
20150210695 | COMPOSITIONS COMPRISING FOLIC ACID DERIVATIVES, THEIR PREPARATIONS AND METHODS OF USE - Described herein are methods for making folic acid derivatives, intermediates, pharmaceutical compositions and uses thereof. | 07-30-2015 |
20150232421 | PROCESS FOR PREPARING 3-METHYLSULFONYLPROPIONITRILE - The present invention relates to processes for preparing 3-methylsulfonylpropionitrile. The processes provide a good yield and a good purity of the final product and provide a controllable reaction. The present invention also relates to a crystalline form of 3-methylsulfonylpropionitrile having X-ray diffraction peaks at 13.9±0.1, 19.2±0.1, 20.0±0.1, 22.5±0.1, 23.2±0.1, 25.7±0.1, 28.1±0.1, 29.9±0.1, and 30.6±0.1 degrees 20, and wherein the most intense peak is the peak at 13.9±0.1 degrees 20. | 08-20-2015 |
20160060206 | FATTY ALCOHOL ESTERS OF HYDROXYCARBOXYLIC ACIDS - Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, methods of making compounds of formula (I) and their use in the treatment and/or prevention of diseases and disorders. | 03-03-2016 |
Patent application number | Description | Published |
20110208864 | SYSTEM FOR THE TRANSMISSION AND PROCESSING CONTROL OF NETWORK RESOURCE DATA BASED ON COMPARING RESPECTIVE NETWORK TERMINAL AND NETWORK RESOURCE LOCATION INFORMATION - A method and corresponding system for providing access to network resources, the system comprising: a resource registry including resource records associated with each of the network resources, at least one of the resource records identifies a physical location of the associated network resource; and an administration server for responding to a query containing criteria wherein at least one of the criteria is geographical coordinates, the administration server is configured to access the resource registry to obtain a list of one or more nearest network resources to the geographical coordinates based on the respective physical location of the network resources, and to transmit the list of nearest network resources in response to the query. | 08-25-2011 |
20110209211 | MULTI-STAGE POLLING MECHANISM AND SYSTEM FOR THE TRANSMISSION AND PROCESSING CONTROL OF NETWORK RESOURCE DATA - A method and corresponding system for coordinating submission of network resource data across a first network to a network resource located on a second network, the second network being coupled to the first network by a firewall such that the second network has a higher level of trust than that of the first network, the method comprising the steps of: receiving and storing in a storage the network resource data submitted by a network terminal coupled to the first network, the network resource data containing a network resource identifier for associating the network resource data with the network resource; receiving and storing in the storage control data associated with the network resource data, the control data for coordinating one or more actions on the network resource data; receiving a first poll message initiated through the firewall by a polling server located on the second network, the first poll message requesting stored network resource data containing the network resource identifier and forwarding the network resource data matching the network resource identifier to the polling server; and receiving a second poll message initiated through the firewall by the polling server, the second poll message requesting stored data matching the control data associated with the network resource data and forwarding the matched control data to the polling server. | 08-25-2011 |
20120069385 | SYSTEM AND METHOD FOR MANAGING PRINTER RESOURCES ON AN INTERNAL NETWORK - A system and method are provided for routing print requests and managing internal printer resource data on an internal network with global printer resource data stored on an external network. Print requests are received for printer resources and it is determined whether the request may be served with printer resource data stored on the internal network. If the printer resource data is invalid or stale, then printer resource data is requested from the global server and the internal printer resource data is updated. The print request is then routed to the appropriate printer resource based on location information in the printer resource data associated with the requested printer resource. Network client devices may also be configured to connect to a print traffic server when connected to an internal network, and to the global server otherwise. | 03-22-2012 |
20120069386 | SYSTEM AND METHOD FOR RELEASING PRINT JOBS BASED ON LOCATION INFORMATION - A system and method that provides a user interface on a mobile network terminal for operation with a printer resource access system wherein the user interface is modified for releasing a print job from a nearby printer resource. Since printer resources may include any number of print job release mechanism each requiring different authentication information, the user interface must be modified appropriately. The mobile network terminal obtains location information from a location service, such as GPS or an internet based location service, and provides the location information to a printer directory service in a printer resource access system. The printer directory service then consults the database of printer resource information and provides connection and configuration information for printer resource located nearby the mobile network terminal. The mobile network terminal modifies its user interface to accept the appropriate type of authentication and configuration information specified by the printer directory service. The authentication information may then be provided over a secure network connection to the printer resource to release the print job. | 03-22-2012 |
20120072595 | SYSTEM AND METHOD FOR UPDATING PRINTER LOCATION INFORMATION FIELD - A system and method are provided for updating location information associated with a printer resource stored in a printer resource registry in a network resource access system. Updating the location information for the printer resource may involve obtaining a unique identifier for the printer resource, determining the location of the printer using GPS or other location based services, authenticating access to the printer resource registry, and submitting the location information to the printer resource registry. Systems for updating location information in the resource registry may operate on the printer resource by itself or in conjunction with a mobile device. System may operate autonomously or provide a user interface for a system administrator to update location information. | 03-22-2012 |
20140168685 | SYSTEM AND METHOD FOR RELEASING PRINT JOBS BASED ON LOCATION INFORMATION - A system and method that provides a user interface on a mobile network terminal for operation with a printer resource access system wherein the user interface is modified for releasing a print job from a nearby printer resource. Since printer resources may include any number of print job release mechanism each requiring different authentication information, the user interface must be modified appropriately. The mobile network terminal obtains location information from a location service, such as GPS or an internet based location service, and provides the location information to a punter directory service in a printer resource access system. The printer directory service then consults the database of printer resource information and provides connection and configuration information for printer resource located nearby the mobile network terminal. The mobile network terminal modifies its user interface to accept the appropriate type of authentication and configuration information specified by the printer directory service. The authentication information may then be provided over a secure network connection to the printer resource to release the print job. | 06-19-2014 |
20150222563 | STREAMLINED SYSTEM FOR THE TRANSMISSION OF NETWORK RESOURCE DATA - A client system of a network resource service, the network resource service administering a plurality of distributed network resources, the client system comprising: a computer processor for executing stored instructions to: receive over a proximity based wireless communication a network resource identifier of a network resource of the plurality of network resources and a service identifier of the network resource service, the service identifier defining a network address of the network resource service on a communications network configured for non-proximity based communication; and transmit application data to the network resource addressed to the network address on the communications network for subsequent processing by the network resource. | 08-06-2015 |
20150254248 | SYSTEM FOR SUGGESTING NETWORK RESOURCE FOR USE BY A NETWORK TERMINAL BASED ON NETWORK RESOURCE RANKING - A network resource access system for providing access by a user to network resources over a communications network, the system comprising: a resource registry including stored resource records associated with each of the network resources and a stored user profile containing a list of network resources such that the network resources have a ranking relative to each other based at least in part on user behaviour with respect to usage of each of the network resources, the user profile associated with the user such that the list of network resources contains the network resources previously accessed by the user; and a resource service for receiving an access query from a network terminal identifying the user and associated with submission of application data for processing by a selected network resource from the list, the resource service further configured for accessing the user profile to identify a suggested network resource from the list in view of the relative ranking and for sending identification of the suggested network resource to the network terminal in response to the access query. | 09-10-2015 |