Patent application number | Description | Published |
20090318668 | Water-Soluble CC-1065 Analogs and Their Conjugates - This invention relates to novel analogs of the DNA-binding alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and their conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor. | 12-24-2009 |
20110065767 | Substituted CC-1065 Analogs and Their Conjugates - This invention relates to novel agents that are analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and their conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor. | 03-17-2011 |
20110207767 | Novel cc-1065 Analogs and Their Conjugates - This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor. | 08-25-2011 |
20130224227 | NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS - This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor. | 08-29-2013 |
Patent application number | Description | Published |
20090239457 | Method and Apparatus For Mechanically Processing an Organ or Organs Taken Out From Slaughtered Poultry - Method and apparatus are provided for mechanically processing an organ or organs taken out from slaughtered poultry in a processing device or processing line, which organ or organs form part of an organ package and wherein said organ or organs are separated from the organ package. The organ package is spatially oriented by the processing device without notably breaking tissue connections in the package, and in a preselected order so as to cause harvesting of organs from the package to occur in a preselected sequence that depends on the location of the organ package in the processing device or processing line. | 09-24-2009 |
20100279593 | Gizzard Peeler and Method of Peeling a Gizzard - A gizzard peeler is provided that includes a series of rollersets. Each rollerset includes, in an exemplary embodiment, a first roller and a second roller that in use rotate in opposite directions. The rollersets collectively form a cylindrical wall of a rotatable drum or form part of such a wall, whereby the drum is provided at its outer circumference with guide and pressure means for guiding and pressing a gizzard along at least a part of the drum's outer circumference. | 11-04-2010 |
20110061996 | Apparatus and Method for Conveying Organ Packages to a Processing Station - An apparatus and method for conveying organ packages to a processing station or stations is provided. The apparatus can include a tray-conveyor having a series of trays movable in the conveying direction. Each such tray is arranged to receive an organ package. The tray-conveyor has at least one discharge-station for the organ packages that are to be moved to the processing station or stations. | 03-17-2011 |
20110237171 | Method and Apparatus For Mechanically Processing an Organ or Organs Taken Out From Slaughtered Poultry - Method and apparatus are provided for mechanically processing an organ or organs taken out from slaughtered poultry in a processing device or processing line, which organ or organs form part of an organ package and wherein said organ or organs are separated from the organ package. The organ package is spatially oriented by the processing device without notably breaking tissue connections in the package, and in a preselected order so as to cause the harvesting of organs from the package to occur in a preselected sequence that depends on the location of the organ package in the processing device or processing line. | 09-29-2011 |
20110244773 | Method and Apparatus For Mechanically Processing an Organ or Organs Taken Out From Slaughtered Poultry - Method and apparatus are provided for mechanically processing an organ or organs taken out from slaughtered poultry in a processing device or processing line, which organ or organs form part of an organ package and wherein said organ or organs are separated from the organ package. The organ package is spatially oriented by the processing device without notably breaking tissue connections in the package, and in a preselected order so as to cause the harvesting of organs from the package to occur in a preselected sequence that depends on the location of the organ package in the processing device or processing line. | 10-06-2011 |