Speake
Clive Christopher Speake, Birmingham GB
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20100238456 | Interferometer - An interferometer comprises a source of a light beam, and a beam splitter for splitting the light beam from the source into at least first and second beams. A first (reference) reflector is positioned in the path of the first light beam. A second reflector, comprising a convergent lens and a mirror, is positioned in the path of the second light beam following reflection from a target. At least one detector is provided for detecting fringes formed by interference of the first and second light beams following reflection from the first and second reflectors respectively. The mirror of the second reflector has a radius of curvature within 10% of the value determined using the formula (I): and the focal length f of the convergent lens is within 10% of the value determined using the formula (II): where i are the segments of optical path, each of length l | 09-23-2010 |
Georgina Speake, Macclesfield GB
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20110028471 | COMBINATION THERAPY 238 - There is provided a combination product comprising a VEGFR tyrosine kinase inhibitor and a m TOR-selective kinase inhibitor, and methods for the production of an anti-cancer effect in a patient, which is accordingly useful in the treatment of cancer in a patient. | 02-03-2011 |
Jason Speake, Winston-Salem, NC US
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20110257224 | PREPARATION AND THERAPEUTIC APPLICATIONS OF (2S,3R)-N-2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)-3,5-DIFLUO- ROBENZAMIDE - The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetyl-choline receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS). | 10-20-2011 |
20140163065 | PREPARATION AND THERAPEUTIC APPLICATIONS OF (2S, 3R)-N-2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)-3,5-DIFLUOROBE- NZAMIDE - The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS). | 06-12-2014 |
20140288169 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS - The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for their use, and their pharmaceutical compositions. | 09-25-2014 |
20140288185 | NICOTINIC RECEPTOR NON-COMPETITIVE MODULATORS - The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions. | 09-25-2014 |
20140315877 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS - The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions. | 10-23-2014 |
20150105421 | PREPARATION AND THERAPEUTIC APPLICATIONS OF (2S,3R)-N-2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)-3,5-DIFLUO- ROBENZAMIDE - The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS). | 04-16-2015 |
Jason D. Speake, Winston-Salem, NC US
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20130203860 | NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS - The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions. | 08-08-2013 |
Jason D. Speake, Cary, NC US
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20100105654 | SUBSTITUTED QUINAZOLINONE COMPOUNDS - A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structures VA, VB, VIIA and VIIB where the values of the variables are defined herein. | 04-29-2010 |
Jason Daniel Speake, Durham, NC US
Jason Daniel Speake, Research Triangle Park, NC US
Jason Daniel Speake, Winston-Salem, NC US
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20110263629 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF - The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS). | 10-27-2011 |
Jason Daniel Speake, Cary, NC US
Stuart Speake, Glasgow GB
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20150354857 | IMPROVEMENTS IN OR RELATING TO HEATING AND COOLING SYSTEMS - A manifold for a heating and/or cooling apparatus comprising a first conduit and a second conduit, wherein the second conduit is beatable within the first conduit and wherein the first conduit and/or the second conduit are at least partially resilient, and wherein the first conduit is sealed at one end thereof and the first and second conduits are configurable such that a fluid flow path exists between the first and second conduits, and wherein the first conduit includes one or more thermal transfer points. | 12-10-2015 |