Patent application number | Description | Published |
20090131636 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 05-21-2009 |
20100003195 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 01-07-2010 |
20100158814 | Fibrin-Binding Peptides and Conjugates Thereof - Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging., etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof. | 06-24-2010 |
20100202967 | FIBRIN BINDING PEPETIDE CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel peptides able to bind fibrin, to a process for their preparation and to compositions thereof for use in therapy and diagnostics. The compounds of the invention bind, in particular, to fibrin present in the extracellular matrix (EC) of tumor or connective tissue of stroma thus acting as targeting moieties able to bring and successfully bound an active moiety linked thereto to fibrin depositions inside solid tumors. | 08-12-2010 |
20100233090 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 09-16-2010 |
20110070165 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 03-24-2011 |
20110097275 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 04-28-2011 |
20110286929 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 11-24-2011 |
20110286936 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 11-24-2011 |
20120328512 | Fibrin-Binding Peptides and Conjugates Thereof - Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging, etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof. | 12-27-2012 |
20130266519 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 10-10-2013 |
20140031520 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 01-30-2014 |
20140107041 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 04-17-2014 |
20140161732 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 06-12-2014 |
20140205545 | MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS - The invention provides compositions and methods for therapeutic and diagnostic applications. | 07-24-2014 |
20140206837 | TARGETING VECTOR-PHOSPHOLIPID CONJUGATES - Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA. | 07-24-2014 |
20140286864 | KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY - The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K | 09-25-2014 |
Patent application number | Description | Published |
20100040066 | NETWORK ADDRESS LOOKUP BASED ON BLOOM FILTERS - In one embodiment, IP lookup into a routing table having prefixes of different prefix lengths is performed using a Bloom filter that was programmed with the prefixes corresponding to all of the different prefix lengths without having to expand any of the prefixes programmed into the Bloom filter. Membership probes are performed into the Bloom filter using candidate prefix values of a given network address. The Bloom filter can be implemented in a distributed manner using Bloom sub-filters, where each Bloom sub-filter is hashed based on a set of hash functions, where each different hash function in the set corresponds to a different prefix length in the routing table. Each Bloom sub-filter can in turn be implemented using a plurality of practically realizable multi-port memory devices controlled by a port scheduler. False-positive matches can be detected and next-hop information for true-positive matches retrieved using an off-chip, hash-based prefix table. | 02-18-2010 |
20100040067 | HASH FUNCTIONS FOR APPLICATIONS SUCH AS NETWORK ADDRESS LOOKUP - In one embodiment, IP lookup into a routing table having prefixes of different prefix lengths is performed by hashing a candidate prefix value to generate a plurality of hash values, where m seed hash values are generated by applying m seed hash functions and one or more additional hash values are generated by combining two or more of the seed hash values in different ways, e.g., using a bit-wise XOR function. The hash values are used to perform membership probes into a Bloom filter programmed with the prefixes corresponding to all of the different prefix lengths in the routing table without having to expand any of the prefixes programmed into the Bloom filter. | 02-18-2010 |
20100266215 | VARIABLE-STRIDE STREAM SEGMENTATION AND MULTI-PATTERN MATCHING - A variable-stride multi-pattern matching apparatus segments patterns and input streams into variable-size blocks according to a modified winnowing algorithm. The variable-stride pattern segments are used to determine the block-symbol alphabet for a variable-stride discrete finite automaton (VS-DFA) that is used for detecting the patterns in the input streams. Applications include network-intrusion detection and protection systems, genome matching, and forensics. The modification of the winnowing algorithm includes using special hash values to determine the position of delimiters of the patterns and input streams. The delimiters mark the beginnings and ends of the segments. In various embodiments, the patterns are segmented into head, core, and tail blocks. The approach provides for memory, memory-bandwidth, and processor-cycle efficient, deterministic, high-speed, line-rate pattern matching. | 10-21-2010 |
20100269024 | METHOD AND APPARATUS FOR MULTISET MEMBERSHIP TESTING USING COMBINATORIAL BLOOM FILTERS - A method and apparatus providing improved set membership determination and group membership identification of candidate data elements using a single Bloom filter programmed to provide a plurality of non-zero f-bit binary vectors, where each of the f-bit binary vectors is associated with a respective group. The Bloom filter is programmed using one or more (but not all) of a plurality of hash filter sets. | 10-21-2010 |
20100316051 | PACKET PROCESSING USING BRAIDED TRIES - Packets are processed (e.g., routed or classified) in accordance with a braided trie, which represents the combination of two or more different original tries (e.g., representing different forwarding/classification tables). The different tries are combined by twisting the mappings for specific trie nodes to make the shapes of the different tries more similar. Each node in the braided trie contains a braiding bit for at least one original trie indicating the mapping for that trie's node. Trie braiding can significantly reduce the number of nodes used to represent the different original tries, thereby reducing memory usage and improving scalability. Braided tries can be used for such applications as virtual routers and packet classification in which different forwarding/classification tables are represented by a single braided trie stored in shared memory. | 12-16-2010 |
20100322255 | PROVIDING CLOUD-BASED SERVICES USING DYNAMIC NETWORK VIRTUALIZATION - The invention is directed to providing cloud-based services using dynamic network virtualization. Embodiments of the invention provide a cloud-based service over a system that has a dynamic network virtualization architecture. The architecture includes a set of distributed forwarding elements with centralized control, and at least one virtual machine that is bound to one of the forwarding elements. These features enable the virtual machine to be migrated across a wide area network while maintaining its original IP address and service continuity. | 12-23-2010 |
20110090911 | METHOD AND APPARATUS FOR TRANSPARENT CLOUD COMPUTING WITH A VIRTUALIZED NETWORK INFRASTRUCTURE - A capability is provided for providing transparent cloud computing with a virtualized network infrastructure. A method for enabling use of a resource of a data center as an extension of a customer network includes receiving, at a forwarding element (FE), a packet intended for a virtual machine hosted at an edge domain of the data center, determining a VLAN ID of the VLAN for the customer network in the edge domain, updating the packet to include the VLAN ID of the VLAN for the customer network in the edge domain, and propagating the updated packet from the FE toward virtual machine. The edge domain supports a plurality of VLANs for a respective plurality of customer networks. The packet includes an identifier of the customer network and a MAC address of the virtual machine. The VLAN ID of the VLAN for the customer network in the edge domain is determined using the identifier of the customer network and the MAC address of the virtual machine. The FE may be associated with the edge domain at which the virtual machine is hosted, an edge domain of the data center that is different than the edge domain at which the virtual machine is hosted, or the customer network. Depending on the location of the FE at which the packet is received, additional processing may be provided as needed. | 04-21-2011 |
20110137930 | METHOD AND APPARATUS FOR GENERATING A SHAPE GRAPH FROM A BINARY TRIE - A capability is provided for representing a set of data values using data structures, including converting a binary trie data structure representing the set of data values to a shape graph data structure representing the set of data values. The shape graph data structure is generated from the binary trie data structure based on the shapes of the sub-trees rooted at the nodes of the binary trie data structure. The shape graph includes vertices representing shapes of the sub-trees of the binary trie data structure. A shape graph data structure permits operations similar to the operations that may be performed on the binary trie data structure for performing lookups for data values from the set of data values, while at the same time reducing the structural redundancy of the binary trie data structure such that the shape graph data structure provides significant improvements in memory usage over the binary trie data structure. | 06-09-2011 |
20120136846 | METHODS OF HASHING FOR NETWORKS AND SYSTEMS THEREOF - Example embodiments are directed to methods of hashing for networks and systems thereof. At least one example embodiment provides a method of processing elements in a system. The method includes receiving a first element, generating a first plurality of hash values based on the first element and a first plurality of hash functions, determining a first plurality of buckets in a table based on the first plurality of hash values, each of the first plurality of buckets associated with a different one of the hash values, selecting one of the first plurality of buckets, storing a first associated value in the selected bucket, the first associated value being associated with the first element, and encoding an identifier (ID) of the hash function generating the hash value associated with the selected bucket into a filter based on the hash value. | 05-31-2012 |
20130011136 | Apparatus And Method For Protection In A Data Center - A manner of providing redundancy protection for a data center network that is both reliable and low-cost. In a data center network where the data traffic between numerous access nodes and a network core layer via primary aggregation nodes, an optical network device such as and OLT (optical line terminal) is provided as a backup aggregation node for one or more of the primary aggregation nodes. When a communication path through a primary aggregation node fails, traffic is routed through the optical network device. In a preferred embodiment, a communication link is formed from a plurality of access nodes to a single port of the OLT or other optical network device via an optical splitter that combines upstream transmissions and distributes downstream transmissions. The upstream transmissions from the plurality of access nodes may occur according to an allocation schedule generated when the backup aggregation node is needed. | 01-10-2013 |
20130166943 | Method And Apparatus For Energy Efficient Distributed And Elastic Load Balancing - Various embodiments provide a method and apparatus of providing a load balancing configuration that adapts to the overall load and scales the power consumption with the load to improve energy efficiency and scalability. The energy efficient distributed and elastic load balancing architecture includes a collection of multi-tiered servers organized as a tree structure. The handling of incoming service requests is distributed amongst a number of the servers. Each server in the virtual load distribution tree accepts handles incoming service requests based on its own load. Once a predetermined loading on the receiving server has been reached, the receiving server passes the incoming requests to one or more of its children servers. | 06-27-2013 |
Patent application number | Description | Published |
20080255250 | Compounds and Compositions for Delivering Active Agents - Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well. | 10-16-2008 |
20090092580 | DIALKYL ETHER DELIVERY AGENTS - The present invention provides dialkyl ether compounds and pharmaceutically acceptable salts thereof, compositions containing the same and one or more active agents, and methods of administering active agents with the same. | 04-09-2009 |
20100062970 | SYNTHESIS OF PROPYL PHENOXY ETHERS AND USE AS DELIVERY AGENTS - The present invention provides propyl phenoxy ether compounds and pharmaceutically acceptable salts thereof, compositions containing the same and one or more active agents, and methods of administering active agents with the same. The delivery agents of the present invention are well suited for forming non-covalent mixtures with active agents for oral, intracolonic, pulmonary, and other routes of administration to animals. | 03-11-2010 |
20100105604 | ALLYLOXY AND ALKYLOXY BENZOIC ACID DELIVERY AGENTS - The present invention relates to pharmaceutical compounds for delivering active agents, such as biologically or chemically active agents, to a target. The invention also relates to pharmaceutical compositions comprising at least one delivery agent compound of the present invention and at least one active agent, and unit dosage forms comprising such compositions. Methods for the preparation and administration of the pharmaceutical compositions are also disclosed. | 04-29-2010 |
Patent application number | Description | Published |
20090192864 | System for optimizing bulk product allocation, transportation and blending - A computer application loaded on a computer readable medium, a computer apparatus comprising the same, and process employing the same, is described herein. The computer application, when executed, causes a computer to optimize, for maximum net profit margin, the product allocation, transportation routing, transportation vehicle/route scheduling and, optionally, blending, of bulk products that are produced by and loaded from supply locations and delivered to and consumed by demand locations, using a heterogeneous fleet of transportation vehicles over a pre-defined period of time. | 07-30-2009 |
20100088142 | Bulk Material Ship Routing and Inventory Management Schedule Optimization - The present invention is a computational system to generate feasible marine transportation schedules given a proposed bulk material supply chain. The decision support tool will fulfill the objectives and scope defined above. The technology employed will require (a) the use of mathematical programming modeling techniques (mixed integer linear programming) to mathematically formulate the business problem, and (b) advanced proprietary solution methods to produce solutions satisfying all constraints of the mathematical model while optimizing an objective function. The decision support tool has the following capabilities: Read input data, Generate feasible bulk material ship Schedule, Evaluate bulk material ship Schedule with User-defined Objective Function, Allow Case comparison, Graphical user interface (GUI) for specifying input data and displaying results. | 04-08-2010 |
20100287073 | METHOD FOR OPTIMIZING A TRANSPORTATION SCHEME - A method and apparatus for optimal transporting of cargo is provided. The method includes optimizing a plurality of transportation decisions and mechanically transporting cargo through movement of a plurality of vehicles in accordance with a set of optimized transportation decisions. The decisions include transportation routes and schedules for the transportation vehicles, allocation of cargo to be transported to one or more demand locations by the transportation vehicles, nomination of cargo pickup by the transportation vehicles from the one or more supply locations, the use of specialized transportation locations, and vehicle assignments for each of the transportation vehicles. The set of decisions is optimized by collecting data relating to the various transportation decisions, using the data collected as part of a mixed integer linear programming model, and obtaining a solution to the model to arrive at a set of optimized transportation decisions. | 11-11-2010 |
20100332273 | TOOLS FOR ASSISTING IN PETROLEUM PRODUCT TRANSPORTATION LOGISTICS - A tool to assist decision-making in the logistics of bulk product transportation. For example, the tool may be used to solve a problem involving the transportation and the inventory management of crude oil, in which the transportation of crude oil between supply ports and discharge ports are performed by a fleet of ships. The tool is capable of handling a typical petroleum product transportation problem, which can be quite complex. The tool uses advanced modeling and optimization technology to find a solution (either optimal or near optimal) for the allocation of bulk products, vehicle routing, vehicle scheduling, and/or bulk product blending operations. | 12-30-2010 |
Patent application number | Description | Published |
20090162400 | Compositions of influenza viral proteins and methods of use thereof - Compositions, fusion proteins and polypeptides comprise at least one pathogen-associated molecular pattern and at least a portion of at least one integral membrane protein of an influenza viral antigen. The compositions, fusion proteins and polypeptides are used to stimulate an immune response in a subject. | 06-25-2009 |
20090270508 | GluR2 receptor modulators - The present invention provides for compositions and methods for modulating the GluR2 receptor. It is based, at least in part, on the discovery, by X-ray crystallography, that a known GluR2 agonist binds to the receptor in two different orientations, thereby diminishing its potency. The present invention provides for structural alternatives in which alternative binding possibilities are substantially eliminated. | 10-29-2009 |
20110135680 | DELETION MUTANTS OF FLAGELLIN AND METHODS OF USE - Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one viral antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to viral infection. | 06-09-2011 |
20140205624 | TETRAVALENT AND MIXED HEAD BIVALENT DENGUE VACCINE - The present invention relates to immunogenic compositions and vaccines of flavivirus. In particular, the present invention relates to improved Dengue vaccines and the design and making of such vaccines that enhance immunogenicity of the vaccine. The vaccines and immunogenic compositions of the present invention relate to mixed head bivalent flagellin-dengue antigen fusion proteins which can be combined with other bivalent dengue antigen fusion proteins or monovalent dengue antigen fusion proteins to produce multivalent vaccine including tetravalent vaccines. | 07-24-2014 |
Patent application number | Description | Published |
20130136763 | Methods Of Treatment With Compositions That Include Hemagglutinin - Methods that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the protein portion includes at least a portion of a globular head and at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and wherein the protein portion lacks a transmembrane domain, a cytoplasmic domain and an HA2 subunit. Compositions administered to the subject can further include a carrier and can be administered in single or multiple doses. | 05-30-2013 |
20130224798 | Methods of Making Hemagglutinin Proteins - Methods of making a protein that stimulates a protective immune response in a subject include separating a portion of a protein from a naturally occurring influenza viral hemagglutinin to form a protein portion. The protein portion includes at least a portion of a globular head, and at least a portion of at least one secondary structure having at least one β-sheet at a bottom of the globular head that causes the globular head to essentially retain its tertiary structure. The protein portion made by the methods of the invention lacks a transmembrane domain, a cytoplasmic domain and an HA2 subunit. A nucleic acid sequence encoding the protein portion is transformed into a prokaryotic host cell. | 08-29-2013 |
20130330367 | COMPOSITIONS WITH ENHANCED IMMUNOGENICITY AND/OR REDUCED REACTOGENICITY - The present invention relates to improved vaccines and the design and making of such vaccines that enhance immunogenicity of the vaccine and/or reduce reactogenicity to the vaccine when administered. In particular the vaccines and immunogenic compositions of the present invention relate to flagellin-antigen fusion proteins in which the spatial orientation of the flagellin to antigen and the charge distribution of the antigen is optimized to enhance immunogenicity and/or reduce reactogenicity. The present invention also relates to methods of evaluating the vaccines by measuring the relative expression of certain gene markers. Altered expression of the genes relative to flagellin control sample may indicate that the vaccine is suitable to stimulate an adaptive immune response to the antigen component in the subject with minimal side effects. | 12-12-2013 |
20140037683 | Methods of Stimulating Protective Immunity Employing Dengue Viral Antigens - Compositions that include at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one member selected from the group consisting of a Den1 viral envelope protein, a Den2 viral envelope protein, a Den3 viral envelope protein and a Den4 viral envelope protein are employed in methods to stimulate a protective immune response in a subject. | 02-06-2014 |
20140065177 | FUSION PROTEINS AND METHODS OF USE - Compositions that include a fusion protein comprising flagellin and at least one antigen that has an isoelectric point greater than about 7.0 and that is fused to at least one domain 3 of the flagellin activate Toll-like Receptor 5. Methods of stimulating an immune response, in particular, a protective immune response include administering a composition that includes an antigen fused to a loop of domain 3 of flagellin. | 03-06-2014 |
20140235836 | Immunologic Constructs and Methods - The present invention relates to improved vaccines and the design and making of such vaccines that enhance immunogenicity of the vaccine and/or reduce reactogenicity to the vaccine when administered. In particular the vaccines and immunogenic compositions of the present invention relate to flagellin-antigen fusion proteins in which the spatial orientation of the flagellin to antigen and the charge distribution of the antigen is optimized to enhance immunogenicity and/or reduce reactogenicity and/or improve folding of the protein. | 08-21-2014 |
20140255438 | FUSION PROTEINS AND METHODS OF USE - Compositions that include a fusion protein comprising flagellin and at least one antigen that has an isoelectric point greater than about 7.0 and that is fused to at least one domain 3 of the flagellin activate Toll-like Receptor 5. Methods of stimulating an immune response, in particular, a protective immune response include administering a composition that includes an antigen fused to a loop of domain 3 of flagellin. | 09-11-2014 |
20150031858 | Methods of Stimulating Protective Immunity Employing Dengue Viral Antigens - Compositions that include at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one member selected from the group consisting of a Den1 viral envelope protein, a Den2 viral envelope protein, a Den3 viral envelope protein and a Den4 viral envelope protein are employed in methods to stimulate a protective immune response in a subject. | 01-29-2015 |
Patent application number | Description | Published |
20100150888 | CELLS FOR JOINT FLUID - Disclosed are methods of enhancing recovery from joint surgery, comprising administering to the joint during surgery a composition comprising stem or progenitor cells in an amount effective to enhance recovery, and a pharmaceutically acceptable carrier. | 06-17-2010 |
20100166822 | Adhesive cartilage implant - A method of producing a cartilage implant which may include coating a substrate with a thermo-sensitive polymer, seeding the polymer with a cell suspension comprising cells that may differentiate into chrondocyte-like cells, wherein the seeding may be conducted at a first temperature, culturing the cell suspension at an increased temperature, whereby cells in the suspension may adhere to the polymer and differentiate into chrondrocyte-like cells, which may form a cartilagenous implant, and decreasing the temperature of the polymer which may allow detachment of the implant from the polymer. The present invention may also include an implant based on this method. The invention may further include a cartilage implant for use in a patient in need thereof, which may include a random three-dimensional configuration of differentiated cells, which may have a natural adhesion surface on at least a portion of the outer surface of the three-dimensional configuration. | 07-01-2010 |
20120230967 | DEVICE AND METHOD TO ACTIVATE PLATELETS - The present invention includes a method for activating platelets in a platelet solution, the method may include passing the platelet solution through an activator at least once to activate at least one of the platelets in the platelet solution to produce an activated platelet solution. The activator may further include a flow disruption element. The method may further induce administering the activated platelet solution to the repair site of a patient. The present invention may also be a system for treating a medical condition at a repair site within a patient in need thereof, which may include a platelet solution container for housing a platelet solution; an activator to activate at least one platelet; and an introducer to direct the at least one activated platelet to the repair site. | 09-13-2012 |
20120258086 | PLATELET SOLUTION FOR USE IN JOINT SURGERY - The invention is directed to a method of accelerating healing in a joint comprising administering a platelet composition to the joint. | 10-11-2012 |
20120328578 | PRIMED STEM CELLS AND USES THEREOF TO TREAT INFLAMMATORY CONDITIONS IN JOINTS - Disclosed are methods of treating inflammation within a synovial joint, comprising administering to the joint a composition comprising primed stem or progenitor cells in an amount effective to enhance recovery, and a pharmaceutically acceptable carrier. | 12-27-2012 |
Patent application number | Description | Published |
20090165992 | GEOTHERMAL HEAT EXCHANGE SYSTEM AND METHOD - Provided is a geothermal heat exchange system and method including a plurality of heat depots, each including a sealed container filled with a heat exchange fluid and further including an input heat transfer line and an output heat transfer line for carrying the heat transfer fluid. The input line proceeds through a top surface of the container at least a minimal distance into the container, and the output heat transfer line originates immediately at the upper surface of the container. Multiple heat depots connected to one another in a continuous unbroken chain are also provided. | 07-02-2009 |
20110067437 | Air Source Heat Exchange System and Method Utilizing Temperature Gradient and Water - An air source heat exchange system and method in which usable heat is exchanged between a prescribed volume of a fluid heat exchange medium, preferably water, within a heat exchange chamber and ambient air outside the chamber. At least one and preferably a plurality of air source heat exchange chambers are provided, each having a volume for containing the prescribed volume of water dwelled within the chamber. The chamber has a chamber wall constructed of a material enabling effective heat transfer between the water dwelled within the chamber and adjacent ambient air outside the chamber. A circulation system circulates the water along a path of flow passing into and out of the volume of the chamber at a rate of flow so related to the prescribed volume of water that usable heat is transferred through the chamber wall, between the ambient air and the prescribed volume of water dwelled within the chamber. | 03-24-2011 |
20110169266 | Method and Apparatus for Harnessing Hydro-kinetic Energy - Apparatus and method is disclosed for generating usable power derived from oscillatory hydro-kinetic energy available in the movement of waves having a given height and being spaced apart by a predetermined distance at the surface of a body of water. Apparatus and method is disclosed for generating usable power derived from hydro-kinetic energy available in a body of water moving in at least one direction of movement, the at least one direction being substantially horizontal or substantially vertical. Apparatus and method is disclosed for generating usable power derived from hydro-gravitational forces available at a site having a source of water at a first elevation higher than a second elevation at a selected location where the usable power is to be derived. | 07-14-2011 |
20130328312 | Method and Apparatus for Harnessing Hydro-Kinetic Energy - Apparatus and method is disclosed for generating usable power derived from oscillatory hydro-kinetic energy available in the movement of waves having a given height and being spaced apart by a predetermined distance at the surface of a body of water. Apparatus and method is disclosed for generating usable power derived from hydro-kinetic energy available in a body of water moving in at least one direction of movement, the at least one direction being substantially horizontal or substantially vertical. Apparatus and method is disclosed for generating usable power derived from hydro-gravitational forces available at a site having a source of water at a first elevation higher than a second elevation at a selected location where the usable power is to be derived. | 12-12-2013 |
20140159370 | Method and Apparatus for Harnessing Hydro-Kinetic Energy - Apparatus and method is disclosed for generating usable power derived from oscillatory hydro-kinetic energy available in the movement of waves having a given height and being spaced apart by a predetermined distance at the surface of a body of water. Apparatus and method is disclosed for generating usable power derived from hydro-kinetic energy available in a body of water moving in at least one direction of movement, the at least one direction being substantially horizontal or substantially vertical. Apparatus and method is disclosed for generating usable power derived from hydro-gravitational forces available at a site having a source of water at a first elevation higher than a second elevation at a selected location where the usable power is to be derived. | 06-12-2014 |
Patent application number | Description | Published |
20130068498 | Thiobis Phenolic Antioxidant/Polyethylene Glycol Blends - Thiobis phenolic antioxidants are efficiently dry or melt blended with a tree-resistant, crosslinkable polyethylene by first forming a blend, preferably a dry blend, of the antioxidant with a polyalkylene glycol (PAG), and then mixing the blend with the polyethylene. The incorporation of thiobis phenolic antioxidant and PAG blend into polyethylene provides the PE with high oxidative induction time (OIT) which is a measure of the oxidative stability of the PE. | 03-21-2013 |
20140134436 | Thiobis Phenolic Antioxidant/Polyethylene Glycol Blends - Thiobis phenolic antioxidants are efficiently dry or melt blended with a tree-resistant, crosslinkable polyethylene by first forming a blend, preferably a dry blend, of the antioxidant with a polyalkylene glycol (PAG), and then mixing the blend with the polyethylene. The incorporation of thiobis phenolic antioxidant and PAG blend into polyethylene provides the PE with high oxidative induction time (OIT) which is a measure of the oxidative stability of the PE. | 05-15-2014 |
20140182882 | Thiobis Phenolic Antioxidant/Polyethylene Glycol Blends - Thiobis phenolic antioxidants are efficiently dry or melt blended with a tree-resistant, crosslinkable polyethylene by first forming a blend, preferably a dry blend, of the antioxidant with a polyalkylene glycol (PAG), and then mixing the blend with the polyethylene. The incorporation of thiobis phenolic antioxidant and PAG blend into polyethylene provides the PE with high oxidative induction time (OIT) which is a measure of the oxidative stability of the PE. | 07-03-2014 |
20140343213 | Ethylene-Propylene-Diene Interpolymer Composition - The present disclosure is directed to a composition and articles containing the composition. The composition includes an ethylene-propylene-diene interpolymer (EPDM) having a rheology ratio greater than 33. The EPDM also has a molecular weight distribution greater than 3.0. The composition has a dissipation factor less than or equal to 0.01 radians as measured in accordance with ASTM D 150 (130° C., 60 Hz). | 11-20-2014 |
Patent application number | Description | Published |
20090162375 | RESISTIN ANTAGONISTS AND THEIR USE - Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis. | 06-25-2009 |
20110071277 | RESISTIN ANTAGONISTS AND THEIR USE - Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis. | 03-24-2011 |
20140099311 | Anti-IL-6 Antibodies, Compositions, Methods and Uses - An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. | 04-10-2014 |
Patent application number | Description | Published |
20120246612 | SYSTEM AND METHOD FOR VERIFICATION AND VALIDATION OF REDUNDANCY SOFTWARE IN PLC SYSTEMS - Formal methods are instituted to verify and validate the finite state machine (FSM) of PLC redundancy software. The method and system is implemented through each phase in the lifecycle of the redundancy software; that is, the requirement phase, design phase, implementation phase and, finally, integration phase (including system integration). At each step along the way, the verification and validation process uses tools such as a checklist-based review and inspection, a requirement traceability analysis, formal verification (model checking) and the like to ensure that the created redundancy software is error-free and will perform as intended when implemented in the redundant PLC system. | 09-27-2012 |
20120256492 | Passive RF Energy Harvesting Scheme For Wireless Sensor - A radio frequency energy harvester harvests RF energy from the environment. The energy harvester may include a local power source. The energy harvester may have an associated crystal radio antenna that harvests AM radio waves ubiquitously. The radio frequency energy harvested may be stored via a super capacitor. The stored energy may power a self-contained processing unit directly when the level of the energy harvested remains above a threshold level. However, if the energy harvested drops below the threshold level, the processing unit, which may include a radio, may switch to the local power source and/or a low power mode of operation. The low power mode of operation may reduce the amount of processing and/or transmitting by the radio. The processing unit may be part of a network of radios. The energy harvester may supply energy for a variety of applications, including building automation, industrial automation, power generation, and healthcare. | 10-11-2012 |
20130035799 | METHOD AND SYSTEM FOR ENERGY EFFICIENT COLLABORATIVE HIGH PERFORMANCE BUILDING CONTROL - A method and system for enabling facility managers and occupants of commercial buildings to collaboratively define energy policy for building energy control is disclosed. | 02-07-2013 |
20130110295 | ADVANCED HUMAN-MACHINE INTERFACE FOR COLLABORATIVE BUILDING CONTROL | 05-02-2013 |
20130231792 | System and Method of Energy Management Control - A method of controlling energy consumption in a building includes receiving occupancy data including at least one of occupant request data and occupant schedule data, receiving weather data including at least one of current weather measurement data and weather forecast data, generating an output control signal based on the occupancy data and the weather data, and transmitting the output control signal to a building automation system (BAS) of the building. The occupant request data includes a current request, and the occupant schedule data includes a predicted occupant schedule. The output control signal adjusts a building control device in a zone in the building. | 09-05-2013 |
20130274940 | CLOUD ENABLED BUILDING AUTOMATION SYSTEM - A method of controlling energy consumption in a building. The method includes receiving occupant request data comprising a plurality of requests, wherein each of the plurality of requests corresponds to one of a plurality of zones in the building wherein the occupant request data is received via a cloud computing resource. The method also includes receiving weather data comprising at least one of current weather measurement data and weather forecast data wherein the weather data is received via a cloud computing resource. In addition, a facility management rule is received via a cloud computing resource. Further, the method includes generating a plurality of output control signals via cloud computing resource, wherein each of the plurality of output control signals is based on one of a plurality of requests and predicted occupant schedules, energy price data and the facility management rule. The control signals are generated by using simulation-based model predictive control method to determine a set of optimized control signals based on optimized energy use or optimized energy cost. The optimized control signals are transmitted to controllers. | 10-17-2013 |
20130304235 | SYSTEM AND METHOD FOR FAULT PROGNOSTICS ENHANCED MPC FRAMEWORK - A model predictive control (MPC) framework is enhanced to provide prognostic information and fault tolerant control strategies. A system fault is calculated based on predicted values and is used to generate an internal reference trajectory to which the system is controlled using MPC. If the system fault exceeds a threshold maximum, then the MPC control model is either tuned or reconfigured depending on whether the fault is external or internal. | 11-14-2013 |
Patent application number | Description | Published |
20090264473 | Novel Crystalline Forms of Antidiabetic Compounds - A novel crystalline anhydrate of the free acid and a crystalline anhydrous besylate salt of a selective PPAR gamma partial agonist which has a fused bicyclic aromatic group attached to an oxypropanoic acid moiety are stable and non-hygroscopic. The compounds are suitable for preparing pharmaceutical formulations for the treatment of type 2 diabetes, hyperglycemia, obesity, and dyslipidemia. | 10-22-2009 |
20100087419 | HIV INTEGRASE INHIBITORS - Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: | 04-08-2010 |
20110319627 | METHODS OF SYNTHESIZING FACTOR Xa INHIBITORS - Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof. | 12-29-2011 |
20120232247 | PROCESSES FOR PREPARING PROTEASE INHIBITORS OF HEPATITIS C VIRUS - The present invention relates to synthetic processes useful in the preparation of macrocyclic compounds of Formula (I) that are useful as inhibitors of the hepatitis C virus NS3 protease and have application in the treatment of conditions caused by the hepatitis C virus. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. | 09-13-2012 |
20130211094 | METHODS OF SYNTHESIZING FACTOR Xa INHIBITORS - Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof. | 08-15-2013 |
20130338141 | HIV INTEGRASE INHIBITORS - Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: | 12-19-2013 |
20140200343 | PROCESS AND INTERMEDIATES FOR PREPARING MACROLACTAMS - The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams from the intermediates. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications. | 07-17-2014 |