Song, MD
Alex Woo Song, West Friendship, MD US
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20160071208 | Systems and Method for Improving Computation Efficiency in the Detection of Fraud Indicators for Loans with Multiple Applicants - Certain embodiments of the disclosed technology include systems and methods for increasing efficiency in the detection of identity-based fraud indicators associated with a loan application. A method is provided that includes receiving applicant data associated with a loan application having a plurality of applicants. The application data includes at least a name, a social security number, and a street address for each of the plurality of applicants. The method includes querying one or more databases with the applicant data; receiving a plurality of independent information in response to the querying; determining a validity indication of the applicant data; creating disambiguated applicant records; determining relationships among the disambiguated applicant records; scoring at least one parameter of the applicant data; determining one or more indicators of fraud based on the scoring; and outputting, for display, one or more indicators of fraud. | 03-10-2016 |
Haifeng Song, Ellicott City, MD US
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20100287630 | MODELS FOR VACCINE ASSESSMENT - The present invention is directed to methods for constructing and using in vivo and in vitro models of aspects of human immunity and, in particular, construction of a human immune system model for the testing of, for example, vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. The present invention comprises both in vivo and in vitro models of aspects of human immunity that are useful for assessing the interaction of substances with the immune system, and thus can be used to accelerate and improve the accuracy and predictability of, for example, vaccine, drug, biologic, immunotherapy, cosmetic and chemical development. The invention is also useful for the generation of human monoclonal and polyclonal antibodies. | 11-11-2010 |
Hong Song, Towson, MD US
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20100061607 | SYSTEM AND METHOD FOR DETERMINING AMOUNT OF RADIOACTIVE MATERIAL TO ADMINISTER TO A PATIENT - In one embodiment, a computerized system and method are provided for determining an optimum amount of radioactivity to administer to a patient, comprising: assuming an activity retention limit; utilizing the activity retention limit to determine a dose rate for a phantom category; utilizing the dose rate for the phantom category to determine the dose rate for a second phantom category; and utilizing the dose rate for a second phantom category to find information regarding the second phantom category. In other embodiments, a computerized system and method are provided for determining an optimum amount of radioactivity to administer to a patient, comprising: obtaining at least one image relating to anatomy of a particular patient; obtaining multiple images regarding radioactivity distribution over time in the particular patient; combining the radioactivity images with the anatomy images; running a Monte Carlo simulation to obtain dose image information; and using the dose image information to obtain BED and/or EUD information. | 03-11-2010 |
Hong Song, Reiserstown, MD US
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20110165223 | Antitumor Immunization by Liposomal Delivery of Vaccine to the Spleen - The present invention relates to methods for preventing, reducing or treating a variety of conditions, including cancer, and vaccines, compositions and liposomes used to elicit or amplify an immune response specific to the condition by delivering to the spleen of an individual a pegylated liposome construct having a diameter of greater than about 300 nm and including a therapeutic agent and an adjuvant for eliciting or amplifying the immune response. | 07-07-2011 |
Hongjun Song, Clarksville, MD US
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20110136145 | METHODS FOR PROMOTING FUSION AND REPROGRAMMING OF SOMATIC CELLS - The invention features methods for reprogramming somatic cells by treating the cells with one or more agents to induce de-differentiation, in particular by targeting demethylase and methyltransferase genes. The invention also features methods of monitoring somatic cell fusion and reprogramming and methods of identifying agents that alter somatic cell fusion and reprogramming. The invention also features reprogrammed cells and kits. | 06-09-2011 |
20120088812 | COMPOSITIONS FOR PROMOTING EPIGENETIC DNA DEMETHYLATION AND METHODS OF USE THEREFORE - The invention features compositions and methods for modulating the expression of Gadd45 and the use of such compositions and methods as neuroprotectants, to enhance neurogenesis, and for the treatment of mood disorders. | 04-12-2012 |
Hongjun Song, Baltimore, MD US
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20110002944 | Compositions and Methods to Promote Neural Cell Growth - The instant invention provides methods and compositions for promoting neural cell growth by inhibiting myelin associated glycoprotein (MAG)-induced inhibition of axonal regeneration. The invention relates to methods for identifying agents that inhibit MAG-induced inhibition of neural cell growth. Methods for inhibiting myelin associated glycoprotein (MAG)-induced inhibition of neural cell growth in a patient, methods for treating or preventing a MAG-induced disease or disorder of the CNS or PNS, comprising the step of administering at least one of the compositions according to this invention are provided. The invention includes kits comprising one or more agents identified according to the invention. | 01-06-2011 |
Jee-Hoon Song, Baltimore, MD US
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20140031246 | CIRCULATING MICRORNAS ARE BIOMARKERS OF VARIOUS DISEASES - The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of biomarkers to diagnose and monitor various diseases such as cancer. | 01-30-2014 |
20140031258 | SERUM-BASED MIRNA MICROARRAY AND ITS USE IN DIAGNOSIS AND TREATMENT OF BARRETT'S ESOPHAGUS (BE) AND ESOPHAGEAL ADENOCARCINOMA (EAC) - Robust and reliable molecular diagnostic screening tools for early detection of esophageal and gastrointestinal tract cancers and pre-cancerous lesions, such as Barrett's Esophagus, and esophageal adenocarcinoma are provided. Included in the invention is an array of miRNA probes specific for identifying, diagnosing and prognosticating esophageal and gastrointestinal tract cancers and pre-cancerous lesions in subjects from blood or serum samples. A biochip comprising the array as well as methods for its use are also provided. | 01-30-2014 |
Jian Song, Germantown, MD US
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20090168916 | METHOD AND SYSTEM FOR PROVIDING MULTI-INPUT-MULTI-OUTPUT (MIMO) DOWNLINK TRANSMISSION - An approach is provided for supporting transmission in a multi-input-multi-output (MIMO) communication system including a plurality of terminals. A preamble portion of a frame is transmitted by a multiple transmit antennas of a hub using Orthogonal Frequency Division Multiplexing (OFDM) to the terminals over a channel, wherein each of the terminals determines a characteristic of the channel with respect to the transmit antennas as feedback information. The hub receives the feedback information from the terminals. The hub selects, according to the feedback information, a subset of the antennas for transmission of a remaining portion of the frame to the terminal. | 07-02-2009 |
20120294266 | METHOD AND SYSTEM FOR PROVIDING MULTI-INPUT-MULTI-OUTPUT (MIMO) DOWNLINK TRANSMISSION - An approach is provided for supporting transmission in a multi-input-multi-output (MIMO) communication system including a plurality of terminals. A preamble portion of a frame is transmitted by a multiple transmit antennas of a hub using Orthogonal Frequency Division Multiplexing (OFDM) to the terminals over a channel, wherein each of the terminals determines a characteristic of the channel with respect to the transmit antennas as feedback information. The hub receives the feedback information from the terminals. The hub selects, according to the feedback information, a subset of the antennas for transmission of a remaining portion of the frame to the terminal. | 11-22-2012 |
Jin Song, Baltimore, MD US
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20100068724 | Biomaker for ovarian and endometrial cancer: hepcidin - The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status as well as endometrical cancer status in a patient. In particular, it has been found that hepcidin is a biomarker for both ovarian cancer and endometrial cancer and that a panel of biomarkers, including hepcidin, transthyretin and optionally other markers are useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry. | 03-18-2010 |
20140005059 | BIOMARKERS FOR CANCER | 01-02-2014 |
Jin Song, Clarksville, MD US
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20120004289 | ANNEXIN A11 AND ASSOCIATED GENES AS BIOMARKERS FOR CANCER - The instant invention provides methods and compositions for the diagnosis and treatment of cancer. The invention also provides method and compositions for determining if a subject is, or is at risk of becoming, chemoresistant. | 01-05-2012 |
Ting Song, Clarksburg, MD US
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20110075902 | SYSTEM AND METHOD FOR MULTI-SEGMENT CENTER POINT TRAJECTORY MAPPING - A computer implemented method of mapping of multiple regional center point trajectory movements of cavity walls is provided in which images are acquired and a region-of-interest is identified in each of the images. The region-of-interest is divided into a plurality of distinct regions and a regional center point for each of the regions is located in the images. For each regional center point, a center point trajectory is determined based on variances in position of the center points from each other in the images. The center point trajectory of each regional center point is decomposed into radial and circumferential components so as to isolate radial component of the center point trajectory for each regional center point in each of the images and radial motion versus time curves are displayed for each regional center point based on the determined radial component for each regional center point in each of the images. | 03-31-2011 |
20120008833 | SYSTEM AND METHOD FOR CENTER CURVE DISPLACEMENT MAPPING - A system and method for center point trajectory mapping includes a computer readable storage medium having stored thereon a computer program comprises instructions, which when executed by a computer, cause the computer to obtain a first plurality of images, each image comprising an unmasked portion and a masked portion, and to calculate a center curve in the unmasked portion in each of the first plurality of images. The instructions further cause the computer to calculate a displacement of the center curve in each of the first plurality of images from a reference center curve, plot a map based on the calculated displacements, and display the map on a display. | 01-12-2012 |
20130090946 | SYSTEMS AND METHODS FOR IMAGING WORKFLOW - An imaging workflow system includes a workstation for acquiring patient information and requesting a patient scan. The request for a patient scan includes scan information for performing the scan. A registration module receives the scan information and the patient information. The registration module automatically schedules the patient scan based on the scan information and the patient information. The registration module determines an imaging protocol based on the patient information and the scan information. An imaging module within an imaging system receives the imaging protocol. The imaging module automatically sets scan parameters based on the imaging protocol. The imaging system scans the patient based on the scan parameters to acquire image data. A user interface controls the patient scan. The user interface includes a display to display images generated from the acquired image data. | 04-11-2013 |
Ting Song, Rockville, MD US
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20100245360 | SYSTEM AND METHOD FOR CENTER POINT TRAJECTORY MAPPING - A system and method for center point trajectory mapping includes a computer readable storage medium having stored thereon a computer program comprises instructions, which when executed by a computer, cause the computer to acquire a first plurality of images, each image comprising a masked portion. The instructions also cause the computer to locate a center point of the masked portion in each of the plurality of images and to plot a map based on variances in position of the center points from each other. The instructions further cause the computer to display the map on a display. | 09-30-2010 |
20110228998 | SYSTEM AND METHOD FOR AUTOMATIC COMPUTATION OF MR IMAGING SCAN PARAMETERS - A system and method for automatic computation of MR imaging scan parameters include a computer programmed to acquire a first set of MR data from an imaging subject, the first set of MR data comprising a plurality of slices acquired at a first field-of-view. The computer is also programmed to reconstruct the plurality of slices into a plurality of localizer images and identify a 3D object based on the plurality of localizer images. The computer is further programmed to prescribe a scan, execute the prescribed scan to acquire a second set of MR data, and reconstruct the second set of MR data into an image. The prescribed scan includes one of a reduced field-of-view based on a boundary of the 3D object and a shim region based on the boundary of the 3D object. | 09-22-2011 |
Xiaolei Song, Baltimore, MD US
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20160075667 | COMPOSITIONS AND METHODS FOR CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) MAGNETIC RESONANCE IMAGING (MRI) - The invention features novel heterocyclic compounds that are useful as MRI contrast agents. Specifically, the invention relates to a novel class of MRI contrast agents that produce significantly improved contrast in MR images that is detectable through chemical exchange saturation transfer (CEST) or frequency labeled exchange (FLEX) imaging. The MRI contrast agents of the invention include those delineated in the formulae provided herein. The invention also relates to various methods in which the MRI contrast agents are employed. Kits and pharmaceutical compositions thereof are also provided. | 03-17-2016 |
20160082132 | COMPOSITIONS AND METHODS FOR CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) BASED MAGNETIC RESONANCE IMAGING (MRI) - Compositions and methods for chemical exchange saturation transfer (CEST) based magnetic resonance imaging (MRI) or frequency labeled exchange (FLEX) imaging are disclosed. Beta-hydroxycarboxylate and beta-aminocarboxylate derivatives including salicylic acid, salicylates, salicylic acid prodrugs, N-alkyl/aryl/acyl/sulfonyl-anthranilic acid analogs, and any aromatic compound with OH/NH group ortho to the carboxylic acid group are disclosed. Such compounds can be used as general MRI organic contrast agents and produce significantly improved contrast in MR images detectable through CEST or FLEX. | 03-24-2016 |
Xiaolei Song, Lutherville-Timonium, MD US
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20120271159 | CEST Phase and Magnitude Imaging Using a Multi-Parametric Varied Saturation Scheme - An embodiment in accordance with the present invention provides a method for obtaining a magnetic resonance image (MRI) or spectrum. The method includes a step of performing a chemical exchange saturation transfer (CEST) or magnetization transfer (MT) magnetic labeling experiment of a subject using an MRI machine. When performing the CEST or MT magnetic labeling experiment aspects of a saturation pulse or a serial saturation pulse sequence, such as length (t | 10-25-2012 |
Xiaolei Song, Lutherville, MD US
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20160106871 | NOVEL PEPTIDE HYDROGELS GENERATING CHEMICAL EXCHANGE SATURATION TRANSFER MRI CONTRAST AND USES THEREOF - The present invention provides novel hydrogels through peptides, which are designed to self-assemble and produce magnetic resonance (MR) contrast through chemical exchange saturation transfer (CEST). The location and integrity of these gels could consequently be tracked using MR imaging. The self-assembly of the peptides into hydrogels can be brought about by a change in pH, ionic strength, temperature, and concentration of ions. | 04-21-2016 |
Yun-Jeong Song, Rockville, MD US
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20120263718 | BLOCKADE OF TL1A-DR3 INTERACTIONS TO AMELIORATE T CELL MEDIATED DISEASE PATHOLOGY AND ANTIBODIES THEREOF - Provided are methods and compositions for treating inflammatory autoimmune diseases in a subject comprising blocking the interaction between DR3 and TL1A. The interaction between DR3 and TL1A can be blocked by reducing expression of TL1A. The interaction between DR3 and TL1A can be blocked by administration of anti-DR3 antibodies. The interaction between DR3 and TL1A can be blocked by administration of anti-TL1A antibodies. In the methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be an autoimmune disease with a T cell component. In the methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be asthma, multiple sclerosis, rheumatoid arthritis, type 1 diabetes, graft versus host disease or inflammatory bowel disease (IBD). | 10-18-2012 |
20160053007 | ANTIBODIES THAT BIND TO TL1A AND METHODS OF TREATING INFLAMMATORY OR AUTOIMMUNE DISEASE COMPRISING ADMINISTERING SUCH ANTIBODIES - Methods and compositions for treating inflammatory or autoimmune diseases in a subject comprising blocking the interaction between DR3 and TL1A. In the methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be an autoimmune disease with a T cell component, including asthma, multiple sclerosis, rheumatoid arthritis, type 1 diabetes, graft versus host disease or inflammatory bowel disease. | 02-25-2016 |
Yunke Song, Baltimore, MD US
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20150031573 | MIRNA ANALYSIS METHODS - The present invention provides a PCR-free, multiplexed ligation assay for miRNA expression analysis that produces highly quantitative, 10-100 plex miRNA profiling in a single reaction. The inventive methods use a 2-step ligation assay to generate an array of miRNA specific ligation products that can be decoded and quantified by a size discrimination method such as gel electrophoresis or single molecule separation. One embodiment is a low-cost assay that can be performed using standard tools available in nearly all molecular biology laboratories. This assay requires nothing more than a gel apparatus and reader for detection. Other embodiments include use of magnetic beads and other size exclusion apparatus which give increasingly higher sensitivity, lower sample consumption, and reduced processing steps. | 01-29-2015 |
Zhexuan Song, Silver Spring, MD US
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20090172781 | TRUSTED VIRTUAL MACHINE AS A CLIENT - The embodiments provide generating a dedicated virtual machine image (DVMI) including functionality for a target service provider and launching the DVMI in the host device as a dedicated virtual machine (DVM). A measurement of the DVMI and/or the launched DVM, as a Trusted Dedicated Virtual Machine (TDVM), is transmitted to the target service provider server. The target service provider determines a trust level for the TDVM, based upon the measurement and provides a level of service by the target service provider server to the TDVM, according to the trust level of the TDVM. | 07-02-2009 |
20090235068 | Method and Apparatus for Identity Verification - A method for identity verification includes receiving a request for proof of identity from a service provider and receiving biometric information associated with a user of a communication device. The method also includes determining that the received biometric information matches a biometric profile that contains biometric information associated with a registered user of the communication device. The method also includes unlocking a private key associated with the registered user in response to determining that the received biometric information matches a biometric profile and sending a request for a digital certificate that is signed with the private key associated with the registered user. The method further includes receiving the digital certificate that includes a public key associated with the registered user and satisfies the request for proof of identity. The method also includes with forwarding the digital certificate to the service provider. | 09-17-2009 |
20100088745 | METHOD FOR CHECKING THE INTEGRITY OF LARGE DATA ITEMS RAPIDLY - The embodiments read, by a computer, target data and divide the target data into chunks. Initial digest values for each chunk of the target data are maintained. Digest values for a subset of the chunks, based upon the target data, is obtained. And a computer compares the obtained subset of digest values of the target data with corresponding subset of maintained initial digest values and verifies integrity of the target data according to the comparison. | 04-08-2010 |
20110072502 | Method and Apparatus for Identity Verification - A method for identity verification includes receiving a request for proof of identity from a service provider and receiving biometric information associated with a user of a communication device. The method also includes determining that the received biometric information matches a biometric profile that contains biometric information associated with a registered user of the communication device. The method also includes unlocking a private key associated with the registered user in response to determining that the received biometric information matches a biometric profile and sending a request for a digital certificate that is signed with the private key associated with the registered user. The method further includes receiving the digital certificate that includes a public key associated with the registered user and satisfies the request for proof of identity. The method also includes with forwarding the digital certificate to the service provider. | 03-24-2011 |
20110126008 | Method and Apparatus for Sharing Documents - A method for securely sharing electronic documents on a document storage system. The method includes receiving an electronic document from a creating user, generating an encryption key unique to the electronic document, encrypting the electronic document using the encryption key to create an encrypted electronic document, and communicating the encrypted electronic document to a document repository for storage/ The method also includes identifying a resource locator for uniquely identifying the storage location of the encrypted electronic document and communicating the encryption key and the resource locator to the creating user. The method also includes receiving the encryption key and the resource locator from a requesting user, retrieving the encrypted electronic document from the document repository using the resource locator, decrypting the encrypted electronic document using the encryption key, and communicating the decrypted electronic document to the requesting user. | 05-26-2011 |
Zhexuan Song, College Park, MD US
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20100023755 | METHOD AND APPARATUS FOR SECURE INFORMATION TRANSFER TO SUPPORT MIGRATION - A system and method are disclosed for providing and maintaining a high level of security during migration of data from one platform to another. The disclosed system combines user and equipment authentication with equipment environment authorization guaranteed by a security module such as supported by a trusted platform module (TPM) in parallel, for secure information transfer to support migration between platforms. | 01-28-2010 |