Somers, US
Daniel Somers, Riverside, IL US
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20090281876 | SYSTEM AND METHOD FOR ELECTRICAL POWER DERIVATIVES - A method, system and program product for facilitating trading derivatives of energy constraints, the method comprising in one embodiment: obtaining electronically historical constraint price data on transmission elements or groups of transmission elements over a number of respective time increments; performing electronically an algorithm calculation on the constraint prices for one of the transmission elements or one of the groups of transmission elements over a number of time increments within a given period of time, to obtain constraint price data for the one transmission element or group of transmission elements for the given period of time; performing this algorithm calculation step for a plurality of the periods of time to obtain constraint price data for each of the plurality of transmission elements or groups of transmission elements for the plurality of periods of time; and making accessible the constraint price data. The invention further includes market making embodiments, binding hours derivative embodiments, and load derivative embodiments. In a further embodiment, a method, system and program product for operating an electronic trading exchange for power derivatives is disclosed. | 11-12-2009 |
Dan L. Somers, Port Matilda, PA US
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20090123289 | Quiet Airfoils For Small and Large Wind Turbines - Thick airfoil families with desirable aerodynamic performance with minimal airfoil induced noise. The airfoil families are suitable for a variety of wind turbine designs and are particularly well-suited for use with horizontal axis wind turbines (HAWTs) with constant or variable speed using pitch and/or stall control. In exemplary embodiments, a first family of three thick airfoils is provided for use with small wind turbines and second family of three thick airfoils is provided for use with very large machines, e.g., an airfoil defined for each of three blade radial stations or blade portions defined along the length of a blade. Each of the families is designed to provide a high maximum lift coefficient or high lift, to exhibit docile stalls, to be relatively insensitive to roughness, and to achieve a low profile drag. | 05-14-2009 |
David Somers, Madison, WI US
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20090138985 | METHODS FOR PLANT TRANSFORMATION USING SPECTINOMYCIN SELECTION - The present invention relates to methods and compositions for transforming soybean, corn, cotton, or canola explants using spectinomycin as a selective agent for transformation of the explants. The method may further comprise treatment of the explants with cytokinin during the transformation and regeneration process. | 05-28-2009 |
20120073015 | METHODS FOR PLANT TRANSFORMATION USING SPECTINOMYCIN SELECTION - The present invention relates to methods and compositions for transforming soybean, corn, cotton, or canola explants using spectinomycin as a selective agent for transformation of the explants. The method may further comprise treatment of the explants with cytokinin during the transformation and regeneration process. | 03-22-2012 |
20120077264 | METHODS FOR PLANT TRANSFORMATION USING SPECTINOMYCIN SELECTION - The present invention relates to methods and compositions for transforming soybean, corn, cotton, or canola explants using spectinomycin as a selective agent for transformation of the explants. The method may further comprise treatment of the explants with cytokinin during the transformation and regeneration process. | 03-29-2012 |
David A. Somers, Madison, WI US
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20140007299 | METHODS FOR PLANT TRANSFORMATION USING SPECTINOMYCIN SELECTION | 01-02-2014 |
20150113683 | METHODS FOR PLANT TRANSFORMATION USING SPECTINOMYCIN SELECTION - The present invention relates to methods and compositions for transforming soybean, corn, cotton, or canola explants using spectinomycin as a selective agent for transformation of the explants. The method may further comprise treatment of the explants with cytokinin during the transformation and regeneration process. | 04-23-2015 |
David Alan Somers, St. Louis, MO US
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20110015084 | Methods for Identifying Genetic Linkage - The present invention provides a high-throughput system for determining linkage of distinct polynucleotides and determining the sequence of polynucleotides that are linked to the distinct polynucleotides. The methods are particularly useful for analyzing transgenes in a transformed host organism. The disclosed methods provide for the detection of linkage between distinct transgenic polynucleotides in transformed hosts and sequencing of DNA regions linked to the distinct transgenic polynucleotides. Methods for identifying a transgenic plant containing a transgene insertion in an undesirable genomic location are also disclosed. | 01-20-2011 |
Diane Somers, Holmdel, NJ US
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20090003534 | Telephone Software Testing System and Method - The present invention provides a system and method for a computer controlled test system in which the computer can change and monitor the compound observable state of an electronic device or telephone during testing procedure. In the preferred embodiment of the invention, the compound observable state of the electronic device includes a display bit map file or the status of lights or buttons. The compound observable state can be evaluated by the computer in real-time to alert nearby operators of a failure (i.e. a telephone that needs to be rebooted) or malfunction (not rising to the level of a failure). Also, the data related to the compound observable state can be stored in the computer for later review to assist in debugging the telephone's software. | 01-01-2009 |
Elizabeth B. Somers, West Grove, PA US
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20160003829 | METHODS FOR DETERMINING PROGNOSIS OF COLORECTAL CANCER - Provided herein are methods for determining the risk that a subject diagnosed with colorectal cancer will develop a recurrence of colorectal cancer and methods of predicting clinical outcome for a subject diagnosed with colorectal cancer by a) determining the level of expression for each marker of a panel of markers in a panel of tumor compartments in a tumor tissue sample from the subject, wherein the panel of markers comprises at least two of TEM1, HIF2α, CAIX, PDGFRβ, fibronectin, collagen I, collagen IV, and CD31 and wherein the panel of tumor compartments comprises at least three tumor compartments of pure stroma, tumor, stromal vessel, and tumor vessel; b) determining the TAPPS score for said subject; and c) comparing the TAPPS score of the subject to the TAPPS score of a population of subjects diagnosed with colorectal cancer. Also provided are related computer-implemented methods and systems, kits, and tumor microarrays. | 01-07-2016 |
Elizabeth Brooke Somers, Unionville, PA US
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20120207771 | FOLATE RECEPTOR ALPHA AS A DIAGNOSTIC AND PROGNOSTIC MARKER FOR FOLATE RECEPTOR ALPHA-EXPRESSING CANCERS - The present invention provides methods and kits for assessing whether a subject is afflicted with an FRα-expressing cancer, methods and kits for predicting the progression of ovarian cancer in a subject afflicted with an FRα-expressing cancer, methods and kits for assessing the level of risk that a subject will develop an FRα-expressing cancer, and methods of stratifying a subject with an FRα-expressing cancer into cancer therapy groups. The methods involve determining the level of folate receptor alpha (FRα) which is not bound to a cell in a sample derived from the subject and comparing this level with the level of FRα in a control sample. | 08-16-2012 |
James Somers, North Logan, UT US
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20120275891 | WHEELCHAIR LIFT DEVICE - An easy to use and compact wheelchair lift device that can be quickly and easily installed to load a wheelchair into the trunk of a vehicle. A representative lift is designed such that the wheelchair may be loaded properly and completely without the lift or the wheelchair striking the vehicle. The representative lift is also designed to reduce back strain on an operator by precluding the need to lift the wheelchair. In one embodiment, the wheelchair lift comprises a base frame that may be installed in the trunk of an automobile, a wheelchair platform configured to hold a wheelchair, a sliding frame configured to slide the wheelchair platform to or from the trunk of a vehicle, and a pivoting lift mechanism configured to raise or lower the wheelchair platform to or from the ground. | 11-01-2012 |
James Scott Somers, Addison, TX US
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20090038534 | FLAGPOLE ASSEMBLIES - A flagpole assembly comprising a flagpole body having an aperture disposed in the side thereof, one or two internal fastening plates, disposed within the flagpole body, an external fastening plate and door assembly and a set of threaded fasteners securing the flagpole assembly together. A cleat or winch mount may be secured to the internal fastening plate, having a winch secured thereto for securement of a flag halyard inside the flagpole body. | 02-12-2009 |
Jeffrey Somers, Northboro, MA US
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20090037765 | SYSTEMS AND METHODS FOR MAINTAINING LOCK STEP OPERATION - A system is provided for rapidly synchronizing two or more processing elements in a fault-tolerant computing system. Embodiments of this system allow for the rapid synchronization of two processing elements through partial copies of the contents of memory associate with each processing element. | 02-05-2009 |
Jonathan Somers, Jacksonville, FL US
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20130185795 | METHODS AND SYSTEMS FOR PROVIDING NETWORK PROTECTION BY PROGRESSIVE DEGRADATION OF SERVICE - Systems and methods are provided for protecting a defense with a self defending intrusion system. Data packets may be monitored to detect a pattern of activity indicating a potential attack. Upon detection of a threat, a countermeasure or progressive degradation of network services may be initiated on a selected basis so controllable reduce performance of data communication of the device. | 07-18-2013 |
20130212680 | METHODS AND SYSTEMS FOR PROTECTING NETWORK DEVICES FROM INTRUSION - Methods and systems for protecting a computing device to ensure network security are provided. In particular, one or more blacklists may be maintained by an Intrusion Protection System (IPS) for a computing device. Such blacklists may include information such as network addresses of suspected or confirmed rogue entities that pose threat to the security of the computing device. In an embodiment, the blacklists are dynamically updated (e.g., purged) when a network-related change is detected indicating, for example, that the computing device is moving from one network location to another. In some embodiments, one or more blacklists may each correspond to a communication channel, application, process or the like. In some embodiments, only selected blacklists are updated, such as those that are rendered stale or inapplicable by the detected network changes. | 08-15-2013 |
20140211614 | METHODS AND SYSTEMS FOR PROVIDING REDUNDANCY IN DATA NETWORK COMMUNICATIONS - Methods and systems are provided for providing redundancy in data network communications. Data traffic on a first network channel used for the data communication between the two or more host systems can be monitored to obtain one or more attributes associated with the data traffic. Based on the data attributes, it may be determined whether one or more anomalies associated with the attributes exist. If so, the anomalies may be used to determine whether they are indicative of an imminent or current network event or condition. In response to a determination that the one or more anomalies are indicative of the event or condition, a second network channel may be selected for the data communication between the two or more host systems. | 07-31-2014 |
Jonathan Somers, Ponte Vedra, FL US
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20140068720 | SYSTEM AND METHOD FOR PROTECTING DEVICES ON DYNAMICALLY CONFIGURED NETWORK - Provided herein are systems and methods for implementing a more secure network client device in connection with the dynamic host configuration protocol (DHCP). Incoming DHCP Offer packets containing configuration information are temporarily collected. Once all incoming Offers are judged to have been received, offers are scored and a winning offer is selected. The winning offer is used to configure the device's network stack. | 03-06-2014 |
Jonathan Somers, Tucker, GA US
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20100216603 | EXERCISE MONITORING SYSTEM - An exercise monitoring system for use with an exercise device including a selectorized weight stack includes a static-stack light transmitter for transmitting a reference light to a static-stack reflector and a static-stack receiver positioned to receive reflected reference light from the static-stack reflector. The exercise monitoring system further includes a weight-determination module that outputs a weight indicator based on an amount of reflected static-stack reference light. | 08-26-2010 |
20120268391 | APPARATUS AND ASSOCIATED METHODS - An apparatus comprising at least one processor and at least one memory including computer program code, the at least one memory and the computer program code configured to, with the at least one processor, cause the apparatus at least to: | 10-25-2012 |
Joy Somers, King, NC US
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20090310774 | CUSTOMER SERVICE METHODS, APPARATUS AND REPORT/ALERT GENERATION BASED ON CUSTOMER SERVICE CALL INFORMATION - Methods and apparatus that provide customer service representatives with information for supporting a customer service call are described. Also described are method and apparatus for collecting customer service call information and generating reports and/or alerts there from. Through the use of customer service call data from multiple divisions, problems and/or underperformance at a division can be identified and rectified in a timely manner. Information from one division can also be used to predict possible problems at other divisions allowing problems to be addressed, in some cases, prior to customer complaints at a division to be addressed in some cases before an increase in the number of customer service calls at the individual division triggers an alert. | 12-17-2009 |
J. Scott Somers, Addison, TX US
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20110192340 | FLAGPOLE ARRANGEMENT WITH INTEGRAL COUNTERWEIGHT - A flag arrangement with an integral counterweight for an internal halyard flagpole having a longitudinal axis, the counterweight having a flexible segment and opposed ends with first and second attachment means and a surrounding sheath where the first attachment means is in connection to a halyard having an external end. In some aspects, the first attachment means engages a secondary linkage having a rotatable swivel attached to the halyard external end, wherein the first and second attachment means are in cooperating relationship with a flag attachment means. In another aspect, the first attachment means engages a secondary linkage having a rotatable swivel attached to the halyard external end. | 08-11-2011 |
Lauren A. Somers, Bloomington, MN US
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20150331761 | HOST SWAP HYPERVISOR THAT PROVIDES HIGH AVAILABILITY FOR A HOST OF VIRTUAL MACHINES - A host swap hypervisor provides a high availability hypervisor for virtual machines on a physical host computer during a failure of a primary hypervisor on the physical host computer. The host swap hypervisor resides on the physical host computer that runs the primary hypervisor, and monitors failure indicators of the primary hypervisor. When the failure indicators exceed a threshold, the host swap hypervisor is then autonomically swapped to become the primary hypervisor on the physical host computer. The original primary hypervisor may then be re-initialized as the new host swap hypervisor. | 11-19-2015 |
20150331763 | HOST SWAP HYPERVISOR THAT PROVIDES HIGH AVAILABILITY FOR A HOST OF VIRTUAL MACHINES - A host swap hypervisor provides a high availability hypervisor for virtual machines on a physical host computer during a failure of a primary hypervisor on the physical host computer. The host swap hypervisor resides on the physical host computer that runs the primary hypervisor, and monitors failure indicators of the primary hypervisor. When the failure indicators exceed a threshold, the host swap hypervisor is then autonomically swapped to become the primary hypervisor on the physical host computer. The original primary hypervisor may then be re-initialized as the new host swap hypervisor. | 11-19-2015 |
Marc Stacey Somers, Longview, TX US
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20150225490 | AMORPHOUS PROPYLENE-ETHYLENE COPOLYMERS - Amorphous propylene-ethylene copolymers are described herein that can include high amounts of ethylene and exhibit desirable softening points and needle penetrations. The desirable combinations of softening points and needle penetrations in these propylene-ethylene copolymers allow them to have a broad operating window. Due their broad operating window, the propylene-ethylene copolymers can be utilized in a wide array of applications and products, including hot melt adhesives. | 08-13-2015 |
20150225619 | AMORPHOUS PROPYLENE-ETHYLENE COPOLYMERS - Amorphous propylene-ethylene copolymers are described herein that can include high amounts of ethylene and exhibit desirable softening points and needle penetrations. The desirable combinations of softening points and needle penetrations in these propylene-ethylene copolymers allow them to have a broad operating window. Due their broad operating window, the propylene-ethylene copolymers can be utilized in a wide array of applications and products, including hot melt adhesives. | 08-13-2015 |
20150225620 | AMORPHOUS PROPYLENE-ETHYLENE COPOLYMERS - Amorphous propylene-ethylene copolymers are described herein that can include high amounts of ethylene and exhibit desirable softening points and needle penetrations. The desirable combinations of softening points and needle penetrations in these propylene-ethylene copolymers allow them to have a broad operating window. Due their broad operating window, the propylene-ethylene copolymers can be utilized in a wide array of applications and products, including hot melt adhesives. | 08-13-2015 |
20150225621 | AMORPHOUS PROPYLENE-ETHYLENE COPOLYMERS - Amorphous propylene-ethylene copolymers are described herein that can include high amounts of ethylene and exhibit desirable softening points and needle penetrations. The desirable combinations of softening points and needle penetrations in these propylene-ethylene copolymers allow them to have a broad operating window. Due their broad operating window, the propylene-ethylene copolymers can be utilized in a wide array of applications and products, including hot melt adhesives. | 08-13-2015 |
20150225622 | AMORPHOUS PROPYLENE-ETHYLENE COPOLYMERS - Amorphous propylene-ethylene copolymers are described herein that can include high amounts of ethylene and exhibit desirable softening points and needle penetrations. The desirable combinations of softening points and needle penetrations in these propylene-ethylene copolymers allow them to have a broad operating window. Due their broad operating window, the propylene-ethylene copolymers can be utilized in a wide array of applications and products, including hot melt adhesives. | 08-13-2015 |
Mark Somers, Brighton, MA US
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20140270599 | MICROSTRUCTURE CONNECTING MECHANISM AND PLASTIC STORAGE BAG WITH MICROSTRUCTURE CLOSURE MECHANISM - A connection mechanism including a plurality of microstructure features. The connection mechanism includes a first strip, with a plurality of protrusions extending from the first strip, and a second strip, with a plurality of protrusions extending from the second strip. The protrusions define grooves between adjacent protrusions. A pressure sensitive adhesive is provided in at least some of the grooves. When the first and second strips are brought together, the protrusions from one strip are received in the grooves of the other, and some of the protrusions contact the pressure sensitive adhesive, thereby connecting the first and second strips. The connection mechanism can be used as a closure mechanism for a plastic storage bag. | 09-18-2014 |
Micah Somers, Minneapolis, MN US
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20150378230 | Method of Pre-Attaching Assemblies to an Electrochromic Glazing for Accurate Fit or Registration After Installation - A device and method of pre-attaching assemblies to glazing can provide for accurate fit or registration after installation. A solar panel provides power to an insulated glass unit. Mounting brackets are secured to the insulated glass unit. A plate adjustably attaches to the mounting brackets. After positioning the plate on the mounting brackets a solar panel is attached to the plate and the insulated glass unit is installed in a frame. The plate is adapted to be moved toward the frame such that the solar panel is flush to the frame after moving the plate. Trim pieces can then be installed over the portions of the plate not covered by the solar panel. | 12-31-2015 |
Patricia K. Somers, Atlanta, GA US
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20080214660 | Compounds and Methods for the Inhibition of the Expression of VCAM-1 - This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases. | 09-04-2008 |
Rebecca C. Somers, Cambridge, MA US
Patent application number | Description | Published |
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20090221088 | Fluorescent Sensor and Methods - Binding an analyte can cause a change in fluorescence emission of a sensor. The change in fluorescence can be related to the amount of analyte present. The sensor can include a semiconductor nanocrystal linked to a fluorescent moiety. Upon excitation, the fluorescent moiety can transfer energy to the semiconductor nanocrystal, or vice versa. | 09-03-2009 |
20120094390 | Fluorescent Sensor and Methods - Binding an analyte can cause a change in fluorescence emission of a sensor. The change in fluorescence can be related to the amount of analyte present. The sensor can include a semiconductor nanocrystal linked to a fluorescent moiety. Upon excitation, the fluorescent moiety can transfer energy to the semiconductor nanocrystal, or vice versa. | 04-19-2012 |
20130102088 | Fluorescent Sensor and Methods - Binding an analyte can cause a change in fluorescence emission of a sensor. The change in fluorescence can be related to the amount of analyte present. The sensor can include a semiconductor nanocrystal linked to a fluorescent moiety. Upon excitation, the fluorescent moiety can transfer energy to the semiconductor nanocrystal, or vice versa. | 04-25-2013 |
Richard Somers, San Antonio, TX US
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20090015674 | OPTICAL IMAGING SYSTEM FOR UNMANNED AERIAL VEHICLE - An optical imaging system and associated methods for capturing images from an aircraft, such as a UAV. A camera unit on-board the aircraft is remotely controlled from an image control station. The image control station receives image data from the camera unit, and also delivers control signals for determining a viewing mode of the image. | 01-15-2009 |
Robert Edward Somers, San Luis Obispo, CA US
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20140303807 | SYSTEM AND METHOD FOR REAL-TIME SYNTHESIS AND PERFORMANCE ENHANCEMENT OF AUDIO/VIDEO DATA, NOISE CANCELLATION, AND GESTURE BASED USER INTERFACES IN A VEHICULAR ENVIRONMENT - A method includes establishing communication channels between an on-board unit (OBU) of a vehicle and a plurality of nodes, tagging each of a plurality of data from the plurality of nodes with a priority level, storing the plurality of data in a priority queue according to respective priority levels, selecting a medium to present a first data of the plurality of data to a user, and presenting the first data to the user via the medium. In the method, the plurality of nodes includes a remote node and an in-vehicle device. Another method includes receiving a data from a remote node, generating a plurality of data streams from the data and transmitting the plurality of data streams across a plurality of wireless interfaces. Another method includes enhancing audio signals from a plurality of microphones and speakers. Yet another method includes various gesture based user interfaces coupled to the OBU. | 10-09-2014 |
20150264554 | SYSTEM AND METHOD FOR ROUTING, MOBILITY, APPLICATION SERVICES, DISCOVERY, AND SENSING IN A VEHICULAR NETWORK ENVIRONMENT - A method includes selecting a path for routing a data packet from a source node to a destination node in a vehicular ad hoc network, storing the data packet if the selected path is identified as a dead end, and establishing a communication link with a first node. The method also includes forwarding the data packet to the first node if a first distance between the first node and the destination node is less than a second distance between the source node and the destination node. More specific embodiments include sending a query for location information of the destination node, receiving the location information including two or more available paths from the source node to the destination node, and determining the path for routing the data packet is an optimal path of the two or more available paths. | 09-17-2015 |
Roger Somers, Hudson, NH US
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20120174501 | Flood vent - A structurally adaptive flood vent device disposed to allow the passage of both air and flood fluid through and existent structure, in order to relieve buildup of excess water around a structure, while concurrently affording protection from intrusion of foreign matter. The instant design features constant aeration properties, in conjunction with automatic operation toward relief upon the onset of external structural flooding. Use of a door assembly which is entirely removed in an automated process upon flooding is featured. | 07-12-2012 |
Steve Somers, Chino Hills, CA US
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20080273089 | METHOD AND APPARATUS FOR DYNAMICALLY TESTING VIDEO EQUIPMENT - A method and apparatus are presented for dynamically testing video equipment. One or more test patterns utilize different regions of video signal characteristics. Adjustment is made to the video characteristics of a region until a perceived parameter of the region matches a second region. A performance parameter of said video equipment is determined from said adjustment. | 11-06-2008 |
20080314614 | MIRRORED ARC CONDUCTING PAIR - A mirrored arc geometrical arrangement of two conductors configured to perform similar functions as a traditional twisted pair of wires is presented. The mirrored arc conductor pair occupies the same physical space required by prior art twisted pair cable designs. Each conductor pair includes two inward-facing arc shaped conductors placed within a dielectric material. Each arc shaped conductor may be constructed from thin foil strips of a conducting metal or from a group of separate bare metal conductors which are placed side by side in intimate contact so as to effectively create the same mirrored arc geometry. The conductor pairs may subsequently be bundled to create a data network cable bundle. | 12-25-2008 |
20110122256 | METHOD AND APPARATUS FOR DYNAMICALLY TESTING VIDEO EQUIPMENT - A method and apparatus are presented for dynamically testing video equipment. One or more test patterns utilize different regions of video signal characteristics. Adjustment is made to the video characteristics of a region until a perceived parameter of the region matches a second region. A performance parameter of said video equipment is determined from said adjustment. | 05-26-2011 |
Virend K. Somers, Rochester, MN US
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20080214943 | Detection of Blood Flow Using Emitted Light Absorption - Perfused tissue is illuminated and light passing through the tissue or reflected from it is detected to produce an electrical signal. Amplitude pulses corresponding to the subject's heart beat are detected in the electrical signal and the areas of these pulses are calculated to produce blood flow values indicative of the blood volume pumped by the heart. The blood flow values may be used alone or in combination with other measured cardiac parameters to evaluate cardiac function. | 09-04-2008 |
20100323379 | SLEEP APNEA - This document relates to methods and materials involved in diagnosing sleep apnea and assessing the effectiveness of a treatment for sleep apnea. For example, methods and materials for using markers to determine whether or not a mammal (e.g., a human) has sleep apnea are provided. In addition, methods and materials that can be used to determine whether or not a mammal (e.g., a human) responds to a sleep apnea treatment are provided. | 12-23-2010 |
20130144190 | SLEEP APNEA DETECTION SYSTEM - This document provides methods and materials (e.g., systems) related to assessing sleep conditions (e.g., sleep apnea). | 06-06-2013 |
20130184599 | NON-INVASIVE MONITORING OF PHYSIOLOGICAL CONDITIONS - This document provides methods and materials related to the non-invasive measurement of analytes in blood. | 07-18-2013 |
20150105640 | NON-INVASIVE MONITORING OF PHYSIOLOGICAL CONDITIONS - This document provides methods and materials related to the non-invasive measurement of analytes in blood. | 04-16-2015 |
William Somers, Lexington, MA US
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20150376271 | DUAL PDGF/VEGF ANTAGONISTS - The invention provides a dual VEGF/PDGF antagonist comprising a VEGF antagonist linked to a PDGF antagonist. The VEGF antagonist is an antibody to a VEGF or VEGFR or is a VEGFR extracellular trap segment (i.e., a segment from the extracellular region of one or more VEGFR receptors that inhibits binding of at least one VEGFR to at least one VEGF). The PDGF antagonist is an antibody to a PDGF or PDGFR or is a PDGFR extracellular trap segment (i.e., segment from the extracellular region of one or more PDGFRs, which inhibits binding of at least one PDGFR and at least one PDGF). The dual antagonist is preferably conjugated to a half-life extending moiety, such as a HEMA-PC polymer. The dual antagonist is particularly useful for treating wet aged related macular degeneration. | 12-31-2015 |
William S. Somers, Cambridge, MA US
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20080227960 | Crystal structure of estrogen receptor-beta complex and uses thereof - This invention is directed to the crystal structure of Estrogen Receptor-β (ER-β) complexed with genistein, and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of ER-β, which may be useful as novel chemotherapeutic agents. | 09-18-2008 |