Somberg, US
Benjamin L. Somberg, Shoreview, MN US
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20100102950 | SYSTEM AND METHOD FOR PROVIDING A SYNERGISTIC ALERT CONDITION PROCESSING IN AN AUTOMATED PATIENT MANAGEMENT SYSTEM - A system and method for providing synergistic alert condition processing in an automated patient management system is presented. An alert condition is classified along a continuum that includes adverse outcome potential versus medical intervention impact potential. The alert condition is managed by assigning a disposition based on relative placement of the alert condition along the continuum. An alert notification is communicated over a selectable mode of communications and is conditioned upon the assigned disposition being actionable. | 04-29-2010 |
20110004277 | System and Method for Managing Locally-Initiated Medical Device Interrogation - A system and method for managing locally-initiated medical device interrogation is presented. An interface is provided over which to retrieve patient data recorded and transiently staged by a medical device monitoring physiological measures of a patient. The patient data is periodically retrieved by interfacing to and interrogating the medical device per a pre-defined schedule through the interface. Further retrieval of the patient data is permitted independent of the pre-defined schedule. The system stores remotely-specifiable criteria specified by a caregiver and controls patient-initiated patient data retrieval in accordance with the criteria. | 01-06-2011 |
20110106555 | SYSTEM AND METHOD FOR PROVIDING SYNERGISTIC ALERT CONDITION PROCESSING IN AN AUTOMATED PATIENT MANAGEMENT SYSTEM - A system and method for providing synergistic alert condition processing in an automated patient management system is presented. An alert condition is classified along a continuum that includes adverse outcome potential versus medical intervention impact potential. The alert condition is managed by assigning a disposition based on relative placement of the alert condition along the continuum. An alert notification is communicated over a selectable mode of communications and is conditioned upon the assigned disposition being actionable. | 05-05-2011 |
Craig Somberg, Lafayette, CA US
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20100284605 | Methodology to Optimize and Provide Streaming Object Rotation Using Composite Images - Optimizing and presenting various sequences of images and/or photographs for viewing with a Web browser, is accomplished without the necessity of loading the entire image set, for example in connection with the 3D display of a product of interest. To represent an object that is rotating, a set of images must be taken. These images are taken at various angles, typically using either using a fixed camera or a turntable. The illusion of an object being rotated is created when the captured images based on the angle being viewed are displayed. To ensure a seamless rotation of an object, a technique is taught that significantly concentrates on reducing the loading time of the captured images by prioritizing which images should be transferred first according to their size, and their number of object views or view angles. A seamless rotation is thus achieved while less than the total number of images is loaded. In fact, an embodiment of the invention teaches that, by selectively loading certain images with specific angular values, it is possible to achieve an object rotation, i.e. using horizontal and vertical adjacent images positioning. | 11-11-2010 |
John Somberg, Lake Forest, IL US
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20100029577 | Chiral separation, characterization and biological action of optically active isomers of digoxin - Disclosed herein is the method for separation of enantiomers or isomers of digoxin. These isomers are to be used-in the treatment of heart failure without adverse or unneeded cardiac actions in humans. Additionally what is claimed is an isolate with less or no cardiac contractile effect but with AV node slowing such that the composition would be an effective therapy for the control of the ventricular response in atrial fibrillation. Also disclosed are methods for assaying these isomeric compounds present in biological fluids to enable the separation of pharmacologic actions. | 02-04-2010 |
20130184296 | PARENTERAL SOLUTIONS CONTAINING METOLAZONE - Disclosed herein are parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamide in N,N-dimethylacetamide, polyethylene glycol and D | 07-18-2013 |
20130190621 | THROMBOSIS WARNING SYSTEM - The present invention relates to a device for detecting the potential formation of a thrombus in a patient on a ventricular assist device. The device uses an energy source and sensor to detect changes in rheology of the patient. | 07-25-2013 |
John C. Somberg US
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20090325918 | Synthesis and separation of optically active isomers and cyclopropyl derivatives of spironolactone and their biological action - Methods for separation and synthesis of the optically active 7-thioester isomers and mono or bis-cyclopropyl derivatives of spironolactone are provided. Preferred stereoisomerically purified 7-thioester isomers and mono or bis-cyclopropyl derivatives of spironolactone have fewer effects mediated by gonadal steroid receptors relative to effect mediated by minteralocorticoid progesterone receptors, compared to the stereoisomerically unpurified form of the compound. These optically active compounds can be useful for obtaining reduction in moderate essential hypertension and it the treatment of congestive heart failure in humans with minimized undesirable side effects such as gynecomastia, tender breast enlargement and menstrual irregularities in women, and loss of libido in men. | 12-31-2009 |
John C. Somberg, Lake Forest, IL US
Patent application number | Description | Published |
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20090233951 | Parenteral solutions containing metolazone - Disclosed herein are parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamide in N,N-dimethylactamide, polyethylene glycol and D | 09-17-2009 |
20120004256 | PARENTERAL FORMULATION OF CLOPIDOGREL - Described herein are ways to solubilize clopidogrel for parenteral administration containing clopidogrel and a diluent NNDMA (N,N-dimethylacetamide); useful in the prevention of platelet aggregation in acute coronary syndrome, acute myocardial infarction or to prevent platelet facilitated thrombosis following coronary angioplasty and/or coronary stenting. | 01-05-2012 |
20120077829 | PARENTERAL SOLUTIONS CONTAINING METOLAZONE - Disclosed herein are parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamide in N,N-dimethylactamide, polyethylene glycol and D | 03-29-2012 |
20130137716 | PARENTERAL DEXTROSE FORMULATION OF CLOPIDOGREL - Described herein are ways to solubilize clopidogrel for parenteral administration containing clopidogrel and D | 05-30-2013 |
John C. Somberg, Lake Bluff, IL US
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20130217779 | METHADONE CHIRAL ISOLATE AS AN IMPROVED PHARMACEUTICAL - The present invention relates to a method for treating drug addiction or neuropathic pain in a patient known to be vulnerable to life threatening cardiac arrhythmias (e.g., abnormally prolonged QT intervals, potassium chanelopathies, hypokalemia, or a combination thereof) by administering the R isolate of methadone to the patient. | 08-22-2013 |
John Charin Somberg, Lake Forest, IL US
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20080255229 | Parenteral solution containing amiodarone in NNDMA (N,N,-Dimethylacetamide) - Disclosed herein are parenteral solutions containing 3-diethylaminoethoxy benzoyl-benzofurans, such as amiodarone, in a diluent NNDMA (N,N-Dimethylacetamide) useful in the treatment of cardiac arrhythmias both supraventricular, ventricular as well as, the condition of cardiac arrest. | 10-16-2008 |
20090060894 | Treatment to aid in the metabolism of alcohol - Alcohol intoxication is a serious problem. Many individuals are more sensitive to alcohol intoxication and placed at a decided disadvantage in social drinking situations. What is proposed is a way to facilitate alcohol metabolism in individuals who have consumed alcohol by the administration of enzymes to speed the alcohols metabolism. | 03-05-2009 |
20100010096 | Methadone chiral isolate as an improved pharmaceutical - Methadone is a frequently employed agent for the treatment of drug addiction and the treatment of pain. Methadone prolongs the cardiac action potential, which on the surface electrocardiogram is represented by QT prolongation. This QT prolongation is known to increase the risk for the development of cardiac arrhythmias, especially the form of ventricular tachycardia known as Torsade de Pointes. For this reason, the FDA has inserted a “black box” warning for potential life threatening arrhythmias. The invention described in this application is the surprising finding that the R-isomer of methadone causes less inhibition of the potassium channel, IKr and thus would have less of a chance of causing life threatening arrhythmias. What is claimed is a method of chirally separating methadone with one isomer having less QT prolongation and more analgesic action that would make a superior pharmacologic agent than the racemate R,S methadone. | 01-14-2010 |
20100173875 | Formulation of aspirin that is stable and showing minimal hydrolysis for parenteral adminstration for the treatment of cardiovascular and other disease states - Disclosed herein are ways to solubilize aspirin for parenteral administration containing aspirin and a diluent NNDMA (N,N-Dimethylacetamide) useful in the treatment of acute coronary syndromes as well as other disease states. The solution so constituted is stable at room temperature for prolonged periods without decomposition and avoids significant hydrolysis of the aspirin and thus the loss of the anti-platelet action when stored. | 07-08-2010 |
Louise Caroline Somberg, East Greenwich, RI US
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20080303230 | Shopping cart handle protector - A wrap or cover is shown for a handle to protect against germs or bacteria on the handle. The wrap or cover includes a pair of layers of a soft washable material having a length greater than the width and joined at their periphery by a stitching of the respective materials that comprise the layers so as to form a unitary wrap layer. A set of fasteners is attached respectively to opposite sides of the wrap layer. Each fastener includes a strip of fastener material having a length greater than its width. Each fastener comprises a Velcro material that includes a Velcro loop and a Velcro hook material. | 12-11-2008 |
Reuven Somberg, Las Vegas, NV US
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20140323210 | VIRTUALIZED MAGNETIC PLAYER CARD - A method of implementing a player tracking system in a gaming network includes receiving a virtual player tracking card identifier and a virtual player tracking card password, authenticating the identifier and the password; receiving a virtual player tracking card PIN, identifying a gaming machine that transmitted the virtual player tracking card PIN, and crediting an account associated with the virtual player tracking card PIN based on game play on the gaming machine. | 10-30-2014 |
Richard Somberg, Madison, WI US
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20100021949 | Method for Detecting Transferase Enzymatic Activity - Methods and kits for detecting transferase activity in a sample by measuring ATP using a composition comprising an ATP-dependent bioluminescence-generating enzyme, a luminogenic molecule and one or more transferase quenching agents. | 01-28-2010 |
20100240080 | KINASE AND PHOSPHATASE ASSAYS - Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described. | 09-23-2010 |
20110081670 | LUCIFERASE-BASED ASSAYS - A method and kit are provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the luciferase with a tolerance enhancement agent in an amount sufficient to substantially protect luciferase enzyme activity from interference of the compound and minimize interference by at least about 10% relative to an assay not having tolerance enhancement agent. | 04-07-2011 |
20120083427 | KINASE AND PHOSPHATASE ASSAYS - Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described. | 04-05-2012 |
20130217051 | LUCIFERASE-BASED ASSAYS - A method and kit are provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the luciferase with a tolerance enhancement agent in an amount sufficient to substantially protect luciferase enzyme activity from interference of the compound and minimize interference by at least about 10% relative to an assay not having tolerance enhancement agent. | 08-22-2013 |
20130217052 | LUCIFERASE-BASED ASSAYS - A method and kit are provided for enhancing the tolerance of an assay reagent to compounds in an assay sample, the assay reagent including a luciferase enzyme. The method includes contacting the luciferase with a tolerance enhancement agent in an amount sufficient to substantially protect luciferase enzyme activity from interference of the compound and minize interference by at least about 10% relative to an assay not having tolerance enhancement agent. | 08-22-2013 |