Patent application number | Description | Published |
20090216267 | CLOSURE DEVICE WITH RAPIDLY DISSOLVING ANCHOR - Closure devices with a rapidly dissolving anchor, systems delivering closure devices, and methods for making and using the same. An example closure device for closing an opening in a body lumen may include a plug, a rapidly dissolving anchor, and a suture coupling the plug to the anchor. The rapidly dissolving anchor may be configured to dissolve within the body lumen within about 30 days or less. At least a portion of the plug may be disposed adjacent an exterior surface of the body lumen. At least a portion of the rapidly dissolving anchor may be disposed within the body lumen. | 08-27-2009 |
20110263921 | Patterned Denervation Therapy for Innervated Renal Vasculature - A renal denervation apparatus includes a treatment element dimensioned for deployment on or within a renal artery of a patient. The treatment element comprises a predefined pattern arranged to complete at least one revolution of the treatment element. The apparatus includes a treatment source. The treatment source and treatment element are configured to cooperatively facilitate communication of an agent from the treatment source to the pattern arrangement of the treatment element. The treatment element is configured to deliver denervation therapy using the agent via the pattern arrangement to one or more regions of the renal artery adjacent the pattern arrangement, such that at least one complete revolution of the renal artery is subjected to the denervation therapy. | 10-27-2011 |
20110264116 | Compressive Denervation Apparatus for Innervated Renal Vasculature - Devices, systems, and methods facilitate modification of renal sympathetic nerve activity using a force generating arrangement. A device for mechanically modifying renal sympathetic nerve activity includes a contact arrangement having a shape that generally conforms to a portion of a renal artery wall and is configured for placement at the renal artery wall portion. A compression arrangement is configured to cooperate with the contact arrangement to place the wall portion of the renal artery in compression sufficient to achieve a desired reduction in renal sympathetic nerve activity. The compression arrangement and the contact arrangement are preferably configured to cooperatively place the wall portion of the renal artery in compression sufficient to irreversibly terminate renal sympathetic nerve activity. | 10-27-2011 |
20110270238 | Compliant Cryoballoon Apparatus for Denervating Ostia of the Renal Arteries - A cryotherapy balloon catheter includes a compliant cryotherapy balloon comprising a distal balloon section dimensioned for placement within a renal artery and a proximal balloon section dimensioned to abut against an ostium of the renal artery and extend into at least a portion of the abdominal aorta. The compliant balloon has a diameter that varies non-uniformly along a length of the compliant balloon, such that a diameter at the proximal balloon section is larger than a diameter of the distal balloon section. The cryotherapy balloon catheter may be configured to deliver cryogenic therapy to at least the ostium of the renal artery sufficient to irreversibly terminate renal sympathetic nerve activity, such as by causing neurotmesis of renal nerve fibers and ganglia at the ostium of the renal artery. | 11-03-2011 |
20120059286 | Self-Powered Ablation Catheter for Renal Denervation - An ablation catheter includes a flexible shaft having length sufficient to access a patient's renal artery. An electrode arrangement is provided at the distal end of the shaft. A handle unit includes a housing configured for hand-held manipulation and is coupled to the catheter. A battery and one or both of a high frequency AC generator and ultrasound generator are provided in the housing. The battery serves as the sole source of power for the generator. The generator is configured to generate energy sufficient to ablate perivascular renal nerve tissue using energy stored in the battery. The catheter may be disposable and the housing re-usable. Both the catheter and the housing may be disposable. | 03-08-2012 |
Patent application number | Description | Published |
20100269838 | MAGNETIC PARTICLES FOR DELIVERING THERAPEUTIC AGENT TO A TARGET LOCATION - A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel. | 10-28-2010 |
20100331760 | BIODEGRADABLE IMPLANT FOR TREATING OR PREVENTING REPERFUSION INJURY - A biodegradable implant for iontophoretic therapeutic agent delivery is provided. The implant comprises a biodegradable battery and at least one biodegradable iontophoresis electrode assembly. The biodegradable battery comprises first and second biodegradable electrodes and a biodegradable polymer electrolyte layer between the first and second biodegradable electrodes. The biodegradable iontophoresis electrode assembly comprises a biodegradable iontophoresis electrode and a charged therapeutic agent. When the biodegradable battery is electrically connected to generate an electric current through the biodegradable iontophoresis electrode assembly, the charged therapeutic agent is delivered by iontophoresis to a target location. The charged therapeutic agent may be a scavenger for reactive oxygen species. The electrical connection of the biodegradable battery may be controlled remotely. | 12-30-2010 |
20100331775 | IMPLANTABLE SELF-POWERED BIODEGRADABLE MEDICAL DEVICE TO TREAT OR PREVENT REPERFUSION INJURY - In one embodiment, the present disclosure provides a biodegradable, self-powered medical device for preventing or reducing reperfusion injury, comprising a galvanic cell, the galvanic cell comprising: a first biodegradable electrode member; and a second biodegradable electrode member comprising a biodegradable conductive polymer and an electrode-releasable therapeutic agent, wherein the galvanic cell generates an electric force sufficient to cause the electrode-releasable therapeutic agent to be released from the biodegradable conductive polymer and elute to a target location. The device may further include a reservoir material containing a burst-release therapeutic agent. | 12-30-2010 |
20120123303 | Minimally Invasive Access for Renal Nerve Ablation - An elongated flexible medical device is inserted into a patient's body via a natural orifice, and advanced through the natural orifice to a location proximate innervated tissue that influences renal sympathetic nerve activity. The medical device can be advanced into a body organ and to a location within the organ proximate the innervated tissue. The organ may comprise an organ of the gastrointestinal tract or urinary tract. The medical device may be advanced through and beyond an access hole in a wall of the organ, and situated at a location proximate the innervated tissue. One or both of imaging and ablation energy is delivered from a distal end of the medical device to the innervated tissue. Innervated renal tissue can be ablated using various forms of energy, including RF energy, ultrasound energy, optical energy, and thermal energy. | 05-17-2012 |
20120172870 | RENAL ABLATION ELECTRODE WITH FORCE-ACTIVATABLE CONDUCTION APPARATUS - An electrode is provided at a distal end of a catheter and dimensioned for deployment within a renal artery. A deformable cover of the electrode incorporates a force-activatable conduction apparatus. The cover is configured to conduct electrical energy only through a region or regions of the cover subject to deformation due to contact with a wall of the target vessel. The electrical energy is sufficient to ablate perivascular renal nerves proximate the deformed region or regions of the electrode cover. The cover is configured to prevent conduction of electrical energy through the cover in the absence of a deformation force applied to the cover. | 07-05-2012 |
Patent application number | Description | Published |
20080306580 | BLOOD ACESS APPARATUS AND METHOD - A blood access for dialysis includes a radially distensible support structure having an open lattice structure defining a support wall having interstitial open areas and defining exterior and luminal wall surfaces; a first porous polymeric portion having a plurality of pores, the first porous polymeric portion being securably disposed over at least a portion of the exterior wall portion of the support structure; a second porous polymeric portion having a plurality of pores, the second porous polymeric portion being securably disposed over at least a portion of the luminal portion of the support structure; and a biodegradable and/or bioabsorbable material disposed within the pores of the first polymeric portion and/or pores of the second polymeric portion. | 12-11-2008 |
20090041978 | Synthetic composite structures - A composite biomaterial having a continuous metal sheet with arcuate members that define a first fenestration pattern, and a polymer layer over at least one surface of the continuous metal sheet. The arcuate members elastically stretch to allow the continuous metal sheet to bend in more than one axis without buckling or wrinkling. | 02-12-2009 |
20090117334 | SYNTHETIC COMPOSITE STRUCTURES - A composite biomaterial having a continuous metal sheet with arcuate members that define a first fenestration pattern, and a polymer layer over at least one surface of the continuous metal sheet. The arcuate members elastically stretch to allow the continuous metal sheet to bend in more than one axis without buckling or wrinkling. | 05-07-2009 |
20100131004 | METHODS AND APPARATUS FOR EMBOLI REMOVAL - Improved methods and apparatus for capturing emboli and subsequently removing or immobilizing the captured emboli are described. Emboli can be captured within a blood vessel and can be withdrawn to a position exterior to the blood vessel. Some filters can remain within a blood vessel yet direct emboli to a position exterior to the blood vessel. | 05-27-2010 |
20100331955 | ROLLING MEMBRANE STENT DELIVERY SYSTEM - A medical device delivery system, having a rolling retractable sheath covering a medical device mounting region on the system is disclosed. The rolling retractable sheath comprises an inner wall and an outer wall and may be formed of one or more materials, optionally porous. Optionally, a lubricant maybe applied selectively to the interior and exterior walls of the stent. | 12-30-2010 |
20110004297 | TRANSLUMENAL APPARATUS, SYSTEM, AND METHOD - Methods, apparatus, and systems for altering the configuration of a heart valve. Methods, apparatus, and systems include the use of a cord delivered into the heart by a delivery catheter that can be manipulated by a receiving catheter so as to improve the heart valve function. | 01-06-2011 |
20120022585 | VASCULAR CLOSURE DEVICE WITH BIODEGRADABLE ANCHOR - This disclosure pertains to controllably bioabsorbable devices, particularly anchors for vascular closure plugs and to methods of use thereof. | 01-26-2012 |
20120101525 | FIBROUS CONTAINMENT FOR HEMOSTASIS PLUG - A device for sealing an opening in a vessel includes an anchor attached to a suture. The anchor is inserted through the opening into the vessel, and the suture pulls the anchor against the vessel wall, forming a seal. A plug is inserted over the suture and is axially compressed toward the anchor, locking the elements in place. The suture is braided or woven outside of the anchor so that it may be stored and handled easily, and is unbraided, unwoven and/or untangled at its distal end inside the anchor, so that individual filaments within the suture may extend laterally within the anchor. The laterally extending filaments subtend a larger footprint within the anchor than a comparable footprint if the suture were to remain braided or tied into a knot within the anchor, which may more effectively distribute the retaining forces within the anchor. | 04-26-2012 |
20120143238 | INTRAVASCULAR FILTER WITH BIODEGRADABLE FORCE-REDUCING ELEMENT - An intravascular filter for a vessel includes a non-biodegradable apical hub and non-biodegradable struts extending generally distally from the hub. The struts extend radially outward from a longitudinal axis of the hub. The distal ends of the struts exert an expansile force against an interior of the vessel. One or more struts includes one or more time-degrading connectors along its length, which can be formed from a biodegradable element made from a fixation material. Prior to degradation, the fixation material rigidly connects a proximal section to a distal section of the respective strut. After degradation, the fixation material is dissolved or softened, and reveals a link that has a strong resistance to longitudinal movement of the distal section with respect to the proximal section and may have a weak resistance to rotational movement of the distal section with respect to the proximal section, such as a pair of interlocked loops. | 06-07-2012 |
20120209378 | Venous Valve With Sinus - A venous valve-with a structural member and valve leaflets that provide a sinus. | 08-16-2012 |
20130204075 | Pelvic Implant System and Method - Systems and methods are provided and adapted to engage and pull (e.g., pull up) or reposition urethral support tissue, such as the portion of the perineal membrane above or below the urethra. The perineal membrane intersects the urethra and vagina at the midurethra or distal location and can thus be stabilized or controlled in a manner that helps restore continence. | 08-08-2013 |