Patent application number | Description | Published |
20110024450 | Composite container and method for manufacturing same ("Multi-Layer Preform") - A composite container, comprising a form-retaining outer container and a flexible inner container is presented. The inner container comprises a dispensing opening and can be mounted in a neck of the outer container, and the inner container is further connected to the outer container by an adhesive or weld connection over a portion of its periphery. The adhesive or weld connection can take the form of a ring adhesion or weld extending transversely to a central longitudinal axis of the container, or can cover the entire surface area of a defined portion of the respective inner container and outer container walls, such as, for example, the upper one-half of the container. The adhesion or weld can be substantially permanent, or alternatively, the adhesive or weld connection can be adapted to detach in controlled manner under the influence of pressures occurring in the container. Additionally, a method for manufacturing such a composite container is also presented, including forming a form-retaining outer container pre-form comprising a neck, forming a flexible inner container pre-form comprising a dispensing opening, inserting the inner container pre-form into the outer container pre-form and fixing said inner container pre-form to the neck of the outer-container pre-form. If the two containers are to be connected by adhesive, then prior to inserting the inner container pre-form into the outer container pre-form, a glue or adhesive can be applied either to the outer surface of the inner container pre-form or to the inner surface of the outer container pre-form, defining a portion of the surface area of the inner and outer containers where they will be connected. Once the two pre-forms are assembled, the composite container can be blown to full size under significant pressures, and the inner container becomes connected to the outer container over the defined portion of their periphery (e.g., their upper halves) by the adhesive spreading under such pressure, or by welding, into an air-tight seal. In exemplary embodiments of the present invention, the remaining portion of the inner container pre-form can be coated with an anti-stick coating prior to insertion into the outer container pre-form, so as to facilitate motion of the remaining portion of the flexible inner container relative to the outer container. In exemplary embodiments of the present invention, in operation, under pressure supplied by a displacing medium, the non-adhering portion of the inner container moves upwards within the outer container in a piston-like motion so as to dispense a product provided inside it, until it has completely folded on itself so that it its inner wall fully contacts the inner wall of the adhering portion of the inner container. | 02-03-2011 |
20140299565 | COMPOSITE CONTAINER AND METHOD FOR MANUFACTURING SAME ("MULTI-LAYER PREFORM") - A composite container, comprising a form-retaining outer container and a flexible inner container is presented. The inner container comprises a dispensing opening and can be mounted in a neck of the outer container, and the inner container is further connected to the outer container by an adhesive or weld connection over a portion of its periphery. The adhesive or weld connection can take the form of a ring adhesion or weld extending transversely to a central longitudinal axis of the container, or can cover the entire surface area of a defined portion of the respective inner container and outer container walls, such as, for example, the upper one-half of the container. The adhesion or weld can be substantially permanent, or alternatively, the adhesive or weld connection can be adapted to detach in controlled manner under the influence of pressures occurring in the container. Additionally, a method for manufacturing such a composite container is also presented, including forming a form-retaining outer container pre-form comprising a neck, forming a flexible inner container pre-form comprising a dispensing opening, inserting the inner container pre-form into the outer container pre-form and fixing said inner container pre-form to the neck of the outer-container pre-form. If the two containers are to be connected by adhesive, then prior to inserting the inner container pre-form into the outer container pre-form, a glue or adhesive can be applied either to the outer surface of the inner container pre-form or to the inner surface of the outer container pre-form, defining a portion of the surface area of the inner and outer containers where they will be connected. Once the two pre-forms are assembled, the composite container can be blown to full size under significant pressures, and the inner container becomes connected to the outer container over the defined portion of their periphery (e.g., their upper halves) by the adhesive spreading under such pressure, or by welding, into an air-tight seal. In exemplary embodiments of the present invention, the remaining portion of the inner container pre-form can be coated with an anti-stick coating prior to insertion into the outer container pre-form, so as to facilitate motion of the remaining portion of the flexible inner container relative to the outer container. In exemplary embodiments of the present invention, in operation, under pressure supplied by a displacing medium, the non-adhering portion of the inner container moves upwards within the outer container in a piston-like motion so as to dispense a product provided inside it, until it has completely folded on itself so that it its inner wall fully contacts the inner wall of the adhering portion of the inner container. | 10-09-2014 |
20150108077 | COMPOSITE CONTAINER AND METHOD FOR MANUFACTURING SAME ("MULTI-LAYER PREFORM") - A composite container, comprising a form-retaining outer container and a flexible inner container is presented. The inner container comprises a dispensing opening and can be mounted in a neck of the outer container, and the inner container is further connected to the outer container by an adhesive or weld connection over a portion of its periphery. The adhesive or weld connection can take the form of a ring adhesion or weld extending transversely to a central longitudinal axis of the container, or can cover the entire surface area of a defined portion of the respective inner container and outer container walls, such as, for example, the upper one-half of the container. The adhesion or weld can be substantially permanent, or alternatively, the adhesive or weld connection can be adapted to detach in controlled manner under the influence of pressures occurring in the container. Additionally, a method for manufacturing such a composite container is also presented, including forming a form-retaining outer container pre-form comprising a neck, forming a flexible inner container pre-form comprising a dispensing opening, inserting the inner container pre-form into the outer container pre-form and fixing said inner container pre-form to the neck of the outer-container pre-form. If the two containers are to be connected by adhesive, then prior to inserting the inner container pre-form into the outer container pre-form, a glue or adhesive can be applied either to the outer surface of the inner container pre-form or to the inner surface of the outer container pre-form, defining a portion of the surface area of the inner and outer containers where they will be connected. Once the two pre-forms are assembled, the composite container can be blown to full size under significant pressures, and the inner container becomes connected to the outer container over the defined portion of their periphery (e.g., their upper halves) by the adhesive spreading under such pressure, or by welding, into an air-tight seal In exemplary embodiments of the present invention, the remaining portion of the inner container pre-form can be coated with an anti-stick coating prior to insertion into the outer container pre-form, so as to facilitate motion of the remaining portion of the flexible inner container relative to the outer container. In exemplary embodiments of the present invention, in operation, under pressure supplied by a displacing medium, the non-adhering portion of the inner container moves upwards within the outer container in a piston-like motion so as to dispense a product provided inside it, until it has completely folded on itself so that it its inner wall fully contacts the inner wall of the adhering portion of the inner container. | 04-23-2015 |
Patent application number | Description | Published |
20100304362 | NEW DETECTION METHOD FOR CERVICAL HPVS - The invention describes a consensus PCR based method (i.e. HRE7-PCR) for the simultaneous detection of 14 Human Papilloma Virus types (i.e. HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68) that are classified as (probably) high-risk, relating to the causation of cervical cancer) and a candidate hrHPV type (i.e. HPV 67) using sets of 6 overlapping forward primers and 9 overlapping backward primers that together amplify a fragment of about (215) to (245) base pairs of the E7 open reading frame of these hrHPV types. For the detection of reaction products an EIA format can be used with the aid of a cocktail of type-specific oligoprobes as exemplified herein. Furthermore, we have developed a method for an efficient typing of these (15) HPVs that is compatible with the method for detection. This RLB typing system involves hybridisation of PCR products with immobilised type-specific oligoprobes. | 12-02-2010 |
20110104660 | MAL, A MOLECULAR DIAGNOSTIC MARKER FOR HPV-INDUCED INVASIVE CANCERS AND THEIR HIGH-GRADE PRECURSOR LESIONS - The inventors now have developed a (molecular) diagnostic marker based on MAL alterations, in particular reduced MAL mRNA and protein expression as well as MAL promoter hypermethylation, to identify human papillomavirus (HPV)-induced high-grade precancerous lesions such as premalignant cervical lesions of invasive cervical cancer, and high-risk human papillomavirus (HPV)-induced precursor lesions of non-cervical invasive cancers within, cell material obtained via scraping, lavage or by other means and/or tissue. In particular, the present invention relates to the use of the MAL gene (including its promoter) and the gene products thereof as marker for HPV-induced high-grade premalignant lesions, allowing early detection and better treatment option for the individual patient. | 05-05-2011 |
20110171628 | CERVICAL SCREENING ALGORITHMS - This invention describes new protocols for screening for cervical carcinomas or high-grade premalignant cervical lesions based on combinations of testing for the presence of high-risk HPV, HPV genotyping, marker analysis, and/or cytology. With these protocols the number of women that have to undergo follow-updiagnostic testing and/or clinical examinations will decrease. Further, the number of false positives and false negatives will decrease. | 07-14-2011 |
20150225796 | METHYLATION ANALYSIS ON SELF-SAMPLES AS TRIAGE TOOL FOR HPV-POSITIVE WOMEN - The inventors now have developed a (molecular) diagnostic assay based on detection of alterations in markers MAL and hsa-mi R124, in particular promoter hypermethylation, to identify human papillomavirus (HPV)-induced high-grade precancerous lesions such as premalignant cervical lesions of invasive cervical cancer, within cell material obtained via self-sampling. In particular, the present invention relates to the use of the MAL gene (including its promoter) and the hsa-mi R124 gene as marker for HPV-induced high-grade premalignant lesions, allowing early detection and a better treatment option for the individual patient. | 08-13-2015 |