Smith, Oxford
A. David Smith, Oxford GB
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20110182820 | METHODS FOR THE PREDICTION OF SHORT-TERM AND LONG-TERM COGNITIVE DECLINE IN ALZHEIMER'S DISEASE PATIENTS USING CSF BIOMARKERS - The present invention provides a method for predicting the short-term and long-term cognitive decline in Alzheimer's disease patients and uses thereof in predicting efficacy of an AD therapeutic. The method uses baseline levels of CSF biomarkers to predict decreases over time in CAMCOG and MMSE scores. | 07-28-2011 |
Adrian Smith, Oxford GB
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20100279317 | Method - The present invention provides a method for identifying a single or group of T cell receptors (TCR) protective and/or effective against a disease, having the following steps: i) obtaining T cells from a donor non-human animal; ii) adoptive transfer of the T cells into a plurality of T cell-deficient recipient non-human animals in a number such that at least one recipient animal is protected against the disease but at least one animal remains unprotected; and iii) determination of the TCR(s) present only in the protected animals. These TCR can be used to identify the determinants or antigens for inclusion in a vaccine or other treatment. | 11-04-2010 |
20130216569 | VACCINE - The present invention provides a polypeptide comprising the amino acid sequence as shown as SEQ ID No. 1 or a homologue or fragment thereof, a nucleic acid capable of encoding such a polypeptide and a vaccine comprising such a polypeptide/nucleic acid. The vaccine may be used for the treatment and/or prevention of a disease associated with an apicomplexan parasite. | 08-22-2013 |
Anthony David Smith, Oxford GB
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20130142769 | TREATMENT OF COGNITIVE DISORDERS - The invention relates to treatments of cognitive disorders e.g. Mild Cognitive Disorder comprising the use of agents which are capable of lowering homocysteine levels in a subject, preferably a human subject. Aspects of the invention relate to a method of treating such disorders comprising administering one or more B vitamins e.g. folic acid, Vitamin B | 06-06-2013 |
Ben Smith, Oxford GB
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20130117268 | Identifying and suggesting classifications for financial data according to a taxonomy - A method includes identifying a table within a first document. The method includes analyzing at least one of: a column heading in the table, a row heading in the table, and data in a cell in the table. The method includes determining, based on the analysis, that the table contains financial data classifiable according to a taxonomy. The method includes analyzing, by a classification component comprising at least one classification engine, at least one of a column heading in the table and a row heading in the table. The method includes generating, by the classification component, a classification suggestion for at least one element in the table, based on the analysis of the classification component. | 05-09-2013 |
Brian John Smith, Oxford GB
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20110276296 | CALIBRATION OF PARTICLE DETECTORS - A method of calibrating an optical detector arrangement ( | 11-10-2011 |
Edward R. Smith, Oxford GB
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20080300535 | Particle cassette, method and kit therefor - A kit of parts for use in the manufacture of a self-contained particle cassette for a needleless syringe device. In an exemplary embodiment, the kit includes a first cassette part having a first rupturable membrane sealed thereto, and a second cassette part having a second rupturable membrane sealed thereto. In this exemplary embodiment, the first and second cassette parts are arranged to be attached together by a method other than heat sealing so as to form the self-contained particle cassette and so as to create a chamber for the confinement of particles between the first and second membranes. | 12-04-2008 |
Geoffrey L. Smith, Oxford GB
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20090191237 | Methods and reagents for vaccination which generate A CD8 T cell immune response - New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition. | 07-30-2009 |
20090324632 | Methods and reagents for vaccination which generate a CD8 T cell immune response - New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition. | 12-31-2009 |
20100119551 | Methods and reagents for vaccination which generate a CD8 T cell immune response - New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition. | 05-13-2010 |
20110159034 | METHODS AND REAGENTS FOR VACCINATION WHICH GENERATE A CD8 T CELL IMMUNE RESPONSE - New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition. | 06-30-2011 |
George David William Smith, Oxford GB
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20100003536 | METAL MATRIX COMPOSITE MATERIAL - According to the present invention there is provided a metal matrix composite material and a method for the manufacture thereof, the material comprising an aluminium-based alloy matrix, the matrix comprising a microstructure composed of at least a first aluminium alloy phase and having a second phase of nanostructured quasicrystalline particles embedded therein and further including in said matrix fibrils of at least one other dissimilar material. | 01-07-2010 |
Jason Michael Smith, Oxford GB
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20150098478 | MINIATURE TUNABLE DYE LASER - A miniature tunable dye laser comprises a pair of mirrors opposed along an optical axis and shaped to provide an optical cavity with stable resonance in at least one mode and having a cavity length of at most 50 μm. A laser dye is inside the optical cavity. A laser pump illuminates the dye with pump EM radiation having a band of wavelengths that is wider than the mode of said cavity An actuator system moves move the mirrors relative to each other along the length of the optical cavity for tuning the wavelength of the mode of said cavity. | 04-09-2015 |
20150103343 | TUNABLE OPTICAL FILTER - An apparatus for performing spectroscopy incorporates, between an EM source and a detector, an optical filter comprising a pair of mirrors opposed along the optical axis and shaped to provide an optical cavity with stable resonance and having a cavity length of at most 50 μm and a mode at a wavelength within said band of wavelengths for bandpass filtering EM radiation passing therethrough. The actuator system is arranged to move the mirrors relative to each other along the length of the optical cavity for tuning the wavelength of said mode. | 04-16-2015 |
Julian Philip Smith, Oxford GB
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20120096441 | SYSTEM AND METHOD FOR DEBUGGING OF COMPUTER PROGRAMS - We describe techniques which relate to bi-directional, in particular backwards, debugging of computer programs. Thus we describe identifying processes with shared memory access, such as threads or multicore processes, by arranging process (thread) memory ownership to deliberate provoke memory page faults to identify and handle concurrent memory access by multiple threads in such a manner as to enable deterministic replay, and hence backwards debugging. | 04-19-2012 |
Nathan James Smith, Oxford GB
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20090213147 | SINGLE VIEW DISPLAY - A single view display of reduced power consumption is provided. The display comprises a display device for displaying the single view and an optical system for concentrating light modulated by the single view into a reduced angular range. A viewer direction determining system determines the direction of a viewer relative to the display and controls the display device and the optical system so that the angular range includes the direction of the viewer. | 08-27-2009 |
20100066960 | LIQUID CRYSTAL DEVICE AND DISPLAY APPARATUS - A liquid crystal device comprises a first alignment surface which induces a high pretilt greater than 45° but less than 90°; a typical value is 85°. The pretilt has a component parallel to the surface pointing in a predetermined direction. A second alignment surface induces a low pretilt which is less than 45° but greater than 0°; a typical pretilt is 5°. The low pretilt has a component parallel to the second surface which also points in the predetermined direction. A layer of crystal material is disposed in between the first and second surfaces. A novel liquid crystal mode is thus provided and is referred to as the “splay-twist mode”. Such a device may be used in a switchable public/private display. | 03-18-2010 |
20100220043 | LIQUID CRYSTAL DEVICE - A liquid crystal device comprises an active matrix substrate ( | 09-02-2010 |
20100302481 | ABSORBING WIRE GRID POLARIZER - A polarizer consisting of a wire grid that includes a plurality of wires aligned in parallel. From at least one side of the wire grid, the wire grid intrinsically mainly absorbs electromagnetic energy having a polarization direction parallel to the wires and mainly transmits electromagnetic energy having a polarization direction perpendicular to the wires. | 12-02-2010 |
20100309204 | DISPLAY - A display comprises a parallax optic ( | 12-09-2010 |
20110018860 | DISPLAY - A display is provided having private and public viewing modes. The display comprises a display device and a parallax optic ( | 01-27-2011 |
20110122329 | DISPLAY - A display for providing several viewing modes of different angular viewing characteristics comprises a display device and a passive optical device ( | 05-26-2011 |
20110175936 | ANGULAR DEPENDENT PIXELS FOR TRICK VIEW - A display device having a display panel for displaying an image by spatial light modulation includes a plurality of pixel groups, each pixel group including a first pixel having a first type of luminance against viewing angle response, and a second pixel having a second type of luminance against viewing angle response, wherein the first and second luminance against viewing angle responses are different from one another. The display device further includes a controller operatively coupled to each of the plurality of pixel groups, wherein the controller is configured to drive each of the plurality of pixel groups such that on average the plurality of pixel groups simultaneously provide a predetermined on-axis luminance and an predetermined off-axis luminance for a region of the image corresponding to each pixel group. | 07-21-2011 |
20110234605 | DISPLAY HAVING SPLIT SUB-PIXELS FOR MULTIPLE IMAGE DISPLAY FUNCTIONS - A display which includes a plurality of sub-pixels each split into a plurality of sub-regions. Each sub-pixel includes a single gate line and a single signal line, and each sub-region within a given sub-pixel includes a corresponding storage capacitor line. An optical element cooperatively combines with the plurality of sub-pixels to create distinct angularly dependent brightness functions in association with corresponding sub-regions within the sub-pixels. Control electronics are configured to provide image data levels in the form of signal data voltages to each sub-region included within each sub-pixel via the gate line and signal line included within the sub-pixel; and to independently modify the signal data voltages provided to each sub-region within the sub-pixels via the corresponding storage capacitor lines whereby the display operates in accordance with at least two different image functions. | 09-29-2011 |
20120176378 | MULTIPLE VIEW DISPLAY - A multiple view display comprises a display device and a plurality of converging lenses, such as a lenticular screen. Each lens cooperates with a respective region of the display device comprising one or more pixels (L) for displaying part of a first image for viewing in a first viewing region (Region | 07-12-2012 |
20130335649 | OPTICAL COMPONENT AND DISPLAY - An optical component ( | 12-19-2013 |
20130342512 | MULTIPLE FUNCTION DISPLAY SYSTEM - A display system which includes a first image display; a second image display; a reflective polariser disposed between the first image display and the second image display, with the second image display disposed on a viewing side of the display system; and a controller for addressing image data to the first image display and the second image display, wherein the controller, the first image display and second image display are configured to selectively operate in accordance with: a first display function in which the first image display is visible to a viewer through the second image display and the second image display appears substantially transparent to the first image display; a second display function in which the display system appears as a plane mirror to the viewer; and a third display function in which the display system appears as a patterned mirror to the viewer. | 12-26-2013 |
20130342664 | SWITCHABLE IMAGING DEVICE, SWITCHABLE OPTICAL DEVICE, AND DISPLAY - A switchable imaging device ( | 12-26-2013 |
20140160177 | DISPLAY - A display comprises independently addressable pixels, a pixel comprising first and second electrodes ( | 06-12-2014 |
20150042704 | DISPLAY SYSTEM WITH DIFFUSE AND SPECULAR REFLECTIVE MODES - A display system which includes a first image display; a second image display; a reflective polariser disposed between the first image display and the second image display, with the second image display disposed on a viewing side of the display system; and a controller for addressing image data to the first image display and the second image display, wherein the controller, the first image display and second image display are configured to selectively operate in accordance with: a first display function in which the first image display is visible to a viewer through the second image display and the second image display appears substantially transparent to the first image display; a second display function in which the display system is in a reflective mode that conveys information to a user; and a third display function in which images are addressed to both the first image display and the second image display. The second display function may be generated by utilizing a diffusively reflective element such that the display system appears as a patterned diffuse reflection to the view. | 02-12-2015 |
Nicholas Smith, Oxford GB
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20150301015 | QUADRUPLEX METHOD - The invention relates to a new method of determining in a sample the presence, absence or concentration of one or more target analytes, such as micro-ribonucleic acids (microRNAs or miRNAs). The invention may therefore relate to a multiplex assay for determining the presence or absence of each target analyte in a group of multiple analytess. The invention uses one or more probes comprising a quadruplex and transmembrane pores. | 10-22-2015 |
Nicolas Smith, Oxford GB
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20140222354 | COMPUTATION METHOD OF RELATIVE CARDIOVASCULAR PRESSURE - The present invention provides a method for the determination of relative pressure fields from flow-sensitive data, the method comprising: applying a finite element discretisation to the Pressure Poisson Equation (PPE): | 08-07-2014 |
Nicolas Peter Smith, Oxford GB
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20100106475 | BIOPHYSICAL VIRTUAL MODEL DATABASE AND APPLICATIONS - A biophysical virtual model of a body or body section of a human subject contains measured parameter values, scan data and images from surface or full body imaging systems, and also descriptive and subject identification data. Data in the model are applied to customize external objects ergonomically to fit a subject, by adjustment or by selection when the objects are configured for one or a group of subjects. The database can be centralized and/or mobile devices carried by users can supply model data to external apparatus. Where a parameter value needed for a subject is unknown, the statistical distribution of the database and the correlation of parameters can supply a probable value and level of certainty. In connection with values that are known for an individual, complexities inherent in the combination of plural parameters can be collected in the model and used in later security screens to confirm the identity of a subject. | 04-29-2010 |
Thomas C.b. Smith, Oxford GB
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20130302182 | PUMPING APPARATUS AND METHODS - This invention relates to apparatus and methods for pumping liquids, in particular using hydraulic ram pump techniques. The techniques we describe can advantageously be used, for example, for drawing water from a deep well in a developing country. We describe a hydraulic ram liquid pump, the pump comprising: a liquid conduit having first and second arms and a connecting portion to connect said arms; first and second one-way inlet valves to said liquid conduit; first and second internal shockwave generating devices within said liquid conduit between said first and second inlets; at least one one-way exit valve from said liquid conduit; wherein, in use, when said second shockwave generating device is sealed a column of liquid in said first arm is in fluid communication with a said exit valve and when said first shockwave generating device is sealed a column of liquid in said second arm. | 11-14-2013 |