Smith, Essex
Andrew James Smith, Essex GB
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20100054757 | BIAS CONTROLLER FOR AN OPTICAL MODULATOR - A bias controller for an optical modulator. The modulator includes a bias electrode that is operable when appropriately biased by an applied bias voltage to configure the modulator to operate at quadrature, and the bias controller includes: a generating arrangement for generating power signals indicative of the optical output power of the modulator; and a processor operably connected to the generating arrangement and said bias electrode and arranged to receive said power signals from said generating arrangement and to control the bias voltage applied to said bias electrode. The processor is configured to vary the bias voltage applied to said bias electrode and to determine from power signals received from said generating arrangement a peak optical output power for said modulator, and to determine in dependence upon said peak optical power a target optical power for quadrature with reference to a store of predetermined values for peak output power and respective corresponding values of target optical power for quadrature. Other embodiments relate to a multi-channel bias controller, and to a method for controlling voltage bias in a modulator. | 03-04-2010 |
20100245968 | BIAS CONTROLLER - The present invention relates to a bias controller for a dual output electro-optic modulator and a method for controlling the bias of a dual output electro-optic modulator. The invention further comprises an optical commutator switch with a plurality of dual-output electro-optic modulators interconnected in a tiered arrangement, and control means for deriving measurements of optical power from each of the modulators. The optical commutator is further used for determining respective bias control signals to achieve and maintain operation of the modulators substantially at their quadrature bias points, and further for generating said respective bias control signals for applying them to the respective modulators. | 09-30-2010 |
Damon Smith, Essex GB
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20100313530 | DOCUMENT INSERTING APPARATUS - An apparatus for inserting a document into an envelope, the apparatus comprising: means for holding an envelope at an insert station; pivotally mounted fingers for opening the envelope; and means for moving the document to be inserted along a platform over the fingers and into the envelope; wherein the platform is pivoted at an upstream end and upwardly spring biased so that the platform is depressed against the spring bias, by an amount dependent on the weight of the insert document moving over, so that a light insert document follows a path which subtends a steeper angle to the horizontal compared to a heavy insert document. | 12-16-2010 |
20110031682 | TRANSPORT SYSTEM - A method for controlling a variable speed transport system for moving a plurality of documentary items at a predetermined speed, acceleration and deceleration the method comprising: determining a mass of each pack of documents; using the determined mass to determine a maximum speed, acceleration and deceleration; and adjusting the predetermined speed acceleration and deceleration in dependence upon the determined maximum speed, acceleration and deceleration. | 02-10-2011 |
Geoffrey Paul Smith, Essex GB
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20090118128 | Preparation of templates for nucleic acid sequencing - The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: | 05-07-2009 |
20090181370 | Method for Sequencing a Polynucleotide Template - The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which permit the sequential determination of nucleotide sequences in two distinct and separate regions on complementary strands of the double-stranded polynucleotide template. The two regions for sequence determination may or may not be complementary to each other. | 07-16-2009 |
20110009276 | Method for Sequencing a Polynucleotide Template - The invention provides methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. | 01-13-2011 |
20120172259 | USING POPULATIONS OF BEADS FOR THE FABRICATION OF ARRAYS ON SURFACES - The present invention provides a method of creating an array of features. The method can include steps of (a) providing a plurality of beads, wherein each bead in the plurality of beads includes probe content; (b) contacting the plurality of beads with a surface to produce a layer of beads on the surface; and (c) transferring the probe content from the beads to the surface to create an array of spatially discrete features on the surface, wherein each spatially discrete feature includes probe content from a bead in the plurality of beads. | 07-05-2012 |
20130079232 | METHODS AND COMPOSITIONS FOR NUCLEIC ACID SEQUENCING - The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected. | 03-28-2013 |
20130244302 | Modified polymerases for improved incorporation of nucleotide analogues - The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3′ position of the sugar moiety that are larger in size than the naturally occurring 3′ hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing. | 09-19-2013 |
20140194324 | SAMPLE PREPARATION ON A SOLID SUPPORT - Presented are methods and compositions for using immobilized transposase and a transposon end for generating an immobilized library of 5′-tagged double-stranded target DNA on a surface. The methods are useful for generating 5′- and 3′-tagged DNA fragments for use in a variety of processes, including massively parallel DNA sequencing. | 07-10-2014 |
20140287415 | Polymerases - Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The modified polymerases may be used in a number of DNA sequencing applications, especially in the context of clustered arrays. | 09-25-2014 |
Ian Charles Smith, Essex GB
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20100139179 | Transportable Medical Facility - A transportable medical facility ( | 06-10-2010 |
Kenneth Bird Smith, Essex GB
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20090318539 | Process for Preparing a Particle Comprising a Biological Molecule and a Carrier Polymer - A process for preparing a particle comprising a biological molecule typically a DNA plasmid, and a carrier polymer, typically poly-lactic acid (PLA), in which an organic solvent solution of the biological molecule and the carrier polymer in an organic solvent medium, nearly saturated with the biological molecule, is prepared, then this solution is contacted with an antisolvent substance, typically supercritical carbon dioxide to separate a particle comprising the biological molecule and the carrier polymer. High loadings of the biological molecule in the particle can be achieved. | 12-24-2009 |
Mark Edward Brennan Smith, Essex GB
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20110059865 | Modified Molecular Arrays - The invention relates to the preparation of a hydrogel surface useful in the formation and manipulation of arrays of molecules, particularly polynucleotides and to the chemical modification of these and other arrays. In particular, the invention relates to a method of preparing a hydrogel immobilised to a solid support comprising polymerising on the support a mixture of a first comonomer which is acrylamide, methacrylamide, hydroxyethyl methacrylate or N-vinyl pyrrolidinone and a second comonomer which is a functionalised acrylamide or acrylate. | 03-10-2011 |
Melanie Anne Smith, Essex GB
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20100167954 | METHOD OF LIBRARY PREPARATION AVOIDING THE FORMATION OF ADAPTOR DIMERS - The invention relates to a method of preparing a library of template polynucleotides which reduces and/or prevents the formation of adaptor-dimers. The invention also relates to the use of a library of templates prepared using the method of the invention for solid-phase nucleic acid amplification. In particular, the invention relates to a method of preparing a library of template polynucleotides which have common sequences at their 5′ ends and at their 3′ ends which is substantially free of adaptor-dimers. | 07-01-2010 |
Paul William Smith, Essex GB
Patent application number | Description | Published |
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20080255195 | Compounds Which Have Activity at M1 Receptor and Their Uses in Medicine - Compounds of formula (I) and salts are provided: | 10-16-2008 |
20080261945 | Compounds Having Activity at Nk3 Receptor and Uses Thereof in Medicine - The present invention relates to compounds of formula (I), a pharmaceutically acceptable salt, solvate or prodrug thereof: | 10-23-2008 |
20080293770 | Compounds Which Have Activity at M1 Receptor and Their Uses In Medicine - Compounds of formula (I) and salts are provided: | 11-27-2008 |
20080306112 | Benzimidazolones Which Have Activity at M1 Receptor - Compounds of formula (I) and salts are provided: | 12-11-2008 |
Richard Jonathan Smith, Essex GB
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20150159760 | MECHANICAL SEALS - A mechanical seal face component having a base material with a high ductility or tensile strength and being substantially covered with a coating for providing a sealing surface. The base material preferably includes carbon or stainless steel. The coating preferably includes hard metal alloy, for example, a tungsten-based alloy, and preferably has a thickness no greater than 1.5 mm, which may be applied by vapor deposition. | 06-11-2015 |
Rodney Edward Smith, Essex GB
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20100025091 | Printed Circuit Boards - A printed circuit board to which a localised solder connection is to be made, the surface of said printed circuit board having a continuous or non-continuous coating of a composition comprising a halo-hydrocarbon polymer at a thickness of from 1 nm to 10 μm. | 02-04-2010 |
20110186334 | Apparatus with a Wire Bond and Method of Forming the Same - In some embodiments, a printed circuit board (PCB) comprises a substrate comprising an insulating material. The PCB further comprises a plurality of conductive tracks attached to at least one surface of the substrate. The PCB further comprises a multi-layer coating deposited on the at least one surface of the substrate. The multi-layer coating (i) covers at least a portion of the plurality of conductive tracks and (ii) comprises at least one layer formed of a halo-hydrocarbon polymer. The PCB further comprises at least one electrical component connected by a solder joint to at least one conductive track, wherein the solder joint is soldered through the multi-layer coating such that the solder joint abuts the multi-layer coating. | 08-04-2011 |
20110253429 | Apparatus with a Multi-Layer Coating and Method of Forming the Same - In some embodiments, a printed circuit board (PCB) comprises a substrate comprising an insulating material. The PCB further comprises a plurality of conductive tracks attached to at least one surface of the substrate. The PCB further comprises a multi-layer coating deposited on the at least one surface of the substrate. The multi-layer coating (i) covers at least a portion of the plurality of conductive tracks and (ii) comprises at least one layer formed of a halo-hydrocarbon polymer. The PCB further comprises at least one electrical component connected by a solder joint to at least one conductive track, wherein the solder joint is soldered through the multi-layer coating such that the solder joint abuts the multi-layer coating. | 10-20-2011 |
20130334292 | Printed Circuit Boards - A printed circuit board to which a localised solder connection is to be made, the surface of said printed circuit board having a continuous or non-continuous coating of a composition comprising a halo-hydrocarbon polymer at a thickness of from 1 nm to 10 μm. | 12-19-2013 |
Vincent Smith, Essex GB
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20120196758 | METHOD FOR NUCLEOTIDE DETECTION - A method of inhibiting light-induced degradation of nucleic acids includes irradiating a portion of the nucleic acids in the presence of a detection solution comprising a polyphenolic compound. A method of detecting a nucleic acid having a fluorescent tag includes irradiating at least a portion of the nucleic acid with light of a suitable wavelength to induce a fluorescence emission and detecting the fluorescence emission. Optionally, the polyphenolic compound is gallic acid, a lower alkyl ester thereof, or mixtures thereof. A kit includes one or more nucleotides, an enzyme capable of catalyzing incorporation of the nucleotides into a nucleic acid strand and a polyphenolic compound suitable for preparing a detection solution. | 08-02-2012 |
Vincent Peter Smith, Essex GB
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20110009276 | Method for Sequencing a Polynucleotide Template - The invention provides methods for pairwise sequencing of a double-stranded polynucleotide template, which methods result in the sequential determination of nucleotide sequences in two distinct and separate regions of the polynucleotide template. | 01-13-2011 |
20140080721 | METHODS FOR REDUCING NUCLEIC ACID DAMAGE - Provided herein is a method of inhibiting degradation of nucleic acids during a nucleic acid processing step selected from fragmentation and detection comprising contacting the nucleic acids with a solution comprising gallic acid, analogues, derivatives thereof or mixtures thereof, during the processing step, wherein the contacting inhibits degradation of the nucleic acids. Also provided herein is a method of inhibiting light-induced degradation of nucleic acids. Additionally, provided herein is a method of reducing or inhibiting nucleic acid damage during preparation of a nucleic acid sample comprising fragmenting the nucleic acid sequences in the sample in a solution comprising one of more compounds, the compounds inhibiting degradation of the nucleic acid sequences in the sample. | 03-20-2014 |