Smit, NL
Adrianus Theodorus Smit, Petten NL
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20160024712 | PROCESS FOR THE TREATMENT OF LIGNOCELLULOSIC BIOMASS - Lignocellulosic biomass can be fractionated for the purpose of increasing cellulose purity in the pulp, increasing native lignin content of the isolated lignin, and improving cellulose hydrolysis, by performing the steps of: (a) extracting the biomass with an extracting liquid comprising at least 20 wt % of a first organic solvent at a temperature below 100° C.; (b) treating the extracted biomass with a treatment liquid comprising a second organic solvent selected from lower alcohols, ethers and ketones, optionally water and optionally an acid, at a temperature between 120° C. and 280° C., and, optionally: (c) subjecting a cellulose-enriched product stream resulting from step (b) to enzymatic hydrolysis. The first and second organic solvent may be different or the same; in particular they comprise ethanol or acetone. | 01-28-2016 |
Adrianus Theodorus Smit, Breezand NL
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20150329889 | PROCESS FOR ENZYMATIC HYDROLYSIS OF CELLULOSE - Cellulose from lignocellulosic biomass which also contains protein, such as grasses and straws, can be enzymatically converted to valuable products such as glucose at lower enzyme consumption by: (a) extracting the biomass with water at 15-75° C. to produce an extracted biomass and a protein-containing aqueous extract; (b) mechanically, chemically and/or thermally pretreating cellulose-containing-biomass, in particular by organosolv treatment; and (c) contacting biomass pretreated in step (b) with: (i) an enzyme capable of hydrolysing cellulose; and (ii) the protein-containing aqueous extract obtained in step (a). | 11-19-2015 |
Andries Jan Smit, Groningen NL
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20130217984 | METHOD AND APPARATUS FOR DETERMINING AN AUTOFLUORESCENCE VALUE OF SKIN TISSUE - A method for determining an autofluorescence value of skin tissue of a subject, comprising the steps of: | 08-22-2013 |
Arendt Jan Smit, En Muntendam NL
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20100291501 | BURNER SYSTEM HAVING PREMIXED BURNERS AND FLAME TRANSFER MEANS - The invention relates to a burner system having a number of premixed burners ( | 11-18-2010 |
Arendt Jan Smit, Muntendam NL
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20120031594 | Heat Exchanger and Fin Suitable for Use in a Heat Exchanger - A heat exchanger for a heating appliance, comprising a channel for conveying a heated gas in a longitudinal direction of said channel and a multitude of fins for conveying a liquid, said fins being provided with an inlet and an outlet, which open in a common plane, wherein the fins are provided on a wall of the channel, extending into said channel, wherein the inlets and outlets of the fins open in the plane of the wall and wherein the heat exchanger further comprises connecting elements for connecting at least one outlet to at least one inlet of separate fins. | 02-09-2012 |
August B. Smit, Armsterdam NL
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20140329757 | TUBULIN-INTERACTING PROTEIN, CALTUBIN, PROMOTES AXONAL GROWTH - A novel isolated protein, referred to herein as “caltubin”, is provided. Caltubin promotes axonal regeneration, and prevents or at least reduces axonal retraction in neurons. | 11-06-2014 |
August Benjamin Smit, Amsterdam NL
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20100273865 | Polypeptides involved in neuronal regeneration-associated gene expression - The present invention relates to methods for promoting regeneration response of peripheral and central nervous systems in mammals in need of such biological effects. The methods comprise altering the activity or steady state level of specific transcription factors that control regeneration of injured or degenerated neuronal cells. Preferably the activity or steady state level of specific transcription factors is altered by introducing nucleic acids to increase or decrease expressing of these transcription factors. These are useful in or suffering from neurodegenerative disorders. | 10-28-2010 |
20110046006 | MEANS AND METHODS FOR TYPING A CELL ISOLATE OF AN INDIVIDUAL SUFFERING FROM A PSYCHIATRIC DISORDER OR AT RISK OF SUFFERING THERE FROM - The present invention relates to a method for typing a cell isolate of an individual suffering from a pychiatric disorder, or at risk for suffering there from, the method comprising providing an RNA sample from a cell isolate from said individual; determining RNA levels for a set of genes in said RNA sample, wherein said set of genes comprises at least two of the genes listed in Table 9; and typing said isolate on the basis of the levels of RNA determined for said set of genes. | 02-24-2011 |
Barthelomeus Johannes Theodorus Smit, Ph Hoogkarspel NL
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20110041400 | METHOD AND DEVICE FOR TREATING PLANT SEEDS - In intensive agriculture it is important to provide high-quality seeds with a good, rapid and uniform germination. The invention relates to a method for treating plant seeds. The invention also relates to a device for treating plant seeds by applying such a method. | 02-24-2011 |
Berend Smit, Bloemendaal NL
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20100121122 | HYDROCARBON CONVERSION USING MOLECULAR SIEVE SSZ-75 - The present invention relates to new crystalline molecular sieve SSZ-75 prepared using a tetramethylene-1,4-bis-(N-methylpyrrolidinium) dication as a structure-directing agent, and its use in catalysts for hydrocarbon conversion reactions. | 05-13-2010 |
20100121124 | HYDROCARBON CONVERSION USING MOLECULAR SIEVE SSZ-75 - The present invention relates to new crystalline molecular sieve SSZ-75 prepared using a tetramethylene-1,4-bis-(N-methylpyrrolidinium) dication as a structure-directing agent, and its use in catalysts for hydrocarbon conversion reactions. | 05-13-2010 |
Casper Maria Smit, Eindhoven NL
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20130200270 | DRIFT CONTROL IN A CHARGED PARTICLE BEAM SYSTEM - A method and apparatus for reducing drift in a charged particle beam system. The method includes providing a charged particle beam column including a charged particle beam, a lens system, and a sample chamber; disposing a temperature-controlled device between the lens system and the sample chamber to control heat transfer between the lens system and the sample chamber; and controlling the temperature of the temperature-controlled device to reduce or eliminate the thermal drift of the position of a sample within the sample chamber relative to the position of the charged particle beam. | 08-08-2013 |
Cornelis Jacobus Smit, Amsterdamnl NL
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20100031572 | Coal to Liquid Processes - A method of increasing the hydrogen/carbon monoxide (H | 02-11-2010 |
Edwin Hendrikus Cornelis Smit, Hoofddorp NL
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20110126923 | Valve Assembly - A valve assembly for a liquid storage tank, the storage tank having a wall, the assembly comprising: a pressure relief conduit; a gas inlet valve device having a gas inlet aperture through which gas may pass into the tank; and a gas outlet valve device having a gas outlet aperture through which gas may pass out from the tank, the inlet valve device and outlet valve device being arranged to control a flow of gas into and out from the storage tank, respectively, whereby a pressure of gas in the tank may be maintained between an upper pressure value being a value in excess of a reference pressure value by a prescribed amount and a lower pressure value being a value below the reference pressure value by a prescribed amount, the gas inlet and outlet apertures being provided in gaseous communication with the pressure relief conduit, the pressure relief of conduit being arranged such that gas flowing into or out from the storage tank by means of an operation of the value assembly is caused to pass through the conduit, the tank further having a liquid inlet, the liquid inlet being switchable between a sealed condition in which liquid may not be fed into the tank through the liquid inlet and an open condition in which liquid may be fed into the tank through the liquid inlet, wherein the inlet valve device comprises a valve member arranged whereby movement of the inlet valve device between closed and open conditions, respectively, the assembly being arranged to be coupled to the tank so as to assume a first orientation in normal use with the tank in the sealed condition, in the first orientation movement of the valve member of the inlet valve device between the open and closed conditions being arranged to involve movement of the valve member in a substantially non-vertical plane. | 06-02-2011 |
Egbert Smit, Sittard NL
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20100172938 | MODIFIED BACTERIAL SURFACE LAYER PROTEINS - Modified bacterial surface layer (S-layer) proteins are disclosed where the modification is the insertion, at an internal location, of a heterologous polypeptide, or polypeptide of interest. The polypeptide is a binding or target protein, such as an antigen or antibody, or part thereof, in particular a bacterial antigen (e.g. from | 07-08-2010 |
Erik Smit, Andijk NL
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20080320630 | Impatiens plant named 'Fify Lave07' | 12-25-2008 |
Evert Smit, Zwolle NL
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20100190918 | Pressure Sensitive Adhesive Composition as well as a Method of Applying It and a Method for the Preparation Thereof - The present invention relates to a pressure sensitive adhesive composition comprising a copolymer having cross-linkable epoxy groups as well as a solvent. The copolymer is made up of one or more first, second and third monomers, wherein the first monomer possesses an epoxy group and third monomer has a bulky side chain. Surprisingly, the third monomer provides for stability without affecting the ability of the copolymer to form cross-links. The invention also relates to a method of preparing the pressure sensitive adhesive composition and to a method of its use. | 07-29-2010 |
Franciscus Petrus Smit, Nijmegen NL
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20120108453 | MOLECULAR MARKERS IN PROSTATE CANCER - The present invention relates to methods for diagnosing prostate cancer and especially diagnosing LG, i.e., individuals with good prognosis; HG, i.e., individuals with poor prognosis of primary tumour; PrCa Met, i.e., individuals with poor prognosis and metastasis; and CRPC, i.e., individuals with poor prognosis suffering from aggressive localized disease. Specifically, the present invention relates to method for establishing the presence, or absence, of prostate cancer in a human individual comprising: a) determining the expression of one or more genes chosen from the group consisting of RRM2, HOXC6, TGM4, RORB, HOXDlO, SFRP2, and SNAI2 in a sample originating from said human individual; b) establishing up, or down, regulation of expression of said one or more genes as compared to expression of said respective one or more genes in a sample originating from said human individual not comprising prostate tumour cells or prostate tumour tissue, or from an individual not suffering from prostate cancer; and c) establishing the presence, or absence, of prostate cancer based on the established up- or down regulation of said one or more genes. | 05-03-2012 |
20120142553 | Molecular Markers in Kidney Cancer - The present invention relates to methods for establishing the presence, or absence, of a kidney, or renal, tumour in a human individual suspected of suffering from kidney, or renal, cancer. Specifically, the present invention relates to methods for establishing the presence, or absence, of a kidney tumour in a human individual suspected of suffering from kidney cancer comprising: a) determining the expression of one or more genes chosen from the group consisting of NDUFA4l2, ANGPTL4, EGLN3, PTHLH, and ATP6V1B1 in a sample originating from said human individual; b) establishing up, or down, regulation of expression of said one or more genes as compared to expression of said respective one or more genes in a sample originating from said human individual not comprising kidney tumour cells or tissue, or from an individual, or group of individuals, not suffering from kidney cancer; and c) establishing the presence, or absence, of a kidney tumour based on the established up- or down regulation of said one or more genes. | 06-07-2012 |
20140073535 | MOLECULAR MARKERS IN PROSTATE CANCER - The present invention relates to methods for diagnosing prostate cancer and especially diagnosing LG, HG, PrCa Met and CRPC. Specifically, the present invention relates to methods for in vitro diagnosing prostate cancer in a human individual comprising: 1) determining the expression of one or more genes chosen from the group consisting of ACSM1, ALDH3B2, CGREF1, COMP, C19orf48, DLX1, GLYATL1, MS4A8B, NKAIN1, PPFIA2, PTPRT, TDRD1 and/or UGT2B15; | 03-13-2014 |
20140106363 | MOLECULAR MARKERS IN PROSTATE CANCER - The present invention relates to methods for diagnosing prostate cancer and especially diagnosing LG, i.e., individuals with good prognosis; HG, i.e., individuals with poor prognosis of primary tumour; PrCa Met, i.e., individuals with poor prognosis and metastasis; and CRPC, i.e., individuals with poor prognosis suffering from aggressive localized disease. Specifically, the present invention relates to method for establishing the presence, or absence, of prostate cancer in a human individual comprising: a) determining the expression of HOXC4 in a sample originating from said human individual; b) establishing up, or down, regulation of expression of HOXC4 as compared to expression of HOXC4 in a sample originating from said human individual not comprising prostate tumour cells or prostate tumour tissue, or from an individual not suffering from prostate cancer; and c) establishing the presence, or absence, of prostate cancer based on the established up- or down regulation of HOXC4. | 04-17-2014 |
20150017640 | Combinations of Molecular Markers in Prostate Cancer providing a Diagnostic Tool with Improved Sensitivity/Specificity - The present invention relates to methods for in vitro establishing, or diagnosing, high grade or low grade prostate cancer in a sample, preferably from a readily obtainable sample such as an urine, a prostatic fluid or ejaculate sample or a processed, or derived sample thereof, originating from human individual suspected of suffering from prostate cancer using expression level analysis of a combination of two, or three molecular markers for prostate cancer selected from DLX1, HOXC6 and HOXD10. The present invention further relates to the use in expression level analysis of these combined markers for in vitro establishing high grade or low grade prostate cancer and to a kit of parts providing expression analysis of combinations of the present molecular markers for establishing high grade or low grade prostate cancer. | 01-15-2015 |
Frank Smit, Nijmegen NL
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20090233285 | SPECIFIC METHOD OF PROSTATE CANCER DETECTION BASED ON PCA3 GENE, AND KITS THEREFOR - The present invention relates, in general, to prostate cancer. More specifically, the present invention relates to a method to diagnose prostate cancer in a patient by detecting a PCA3 sequence, and more particularly a PCA3 RNA, the PCA3 sequence detected in a sample from the patient being specifically associated with prostate cancer. In a particular embodiment the method and kit enables an amplification of a PCA3 RNA through an exon-exon junction of a spliced PCA3 mRNA. The invention also relates to methods and kits to detect such an amplified PCA3 RNA, using a probe which spans the amplified exon-exon junction. In particular the methods and kits are designed to detect a PCA3 RNA which lacks one intron or more, and in particular case is intron-less. The invention further relates to a method of detecting PCA3 RNA expressed in non-prostate tissue or cells of the urinary tract, that comprises PCA3 intron 3. | 09-17-2009 |
20120309006 | SPECIFIC METHOD OF PROSTATE CANCER DETECTION BASED ON PCA3 GENE, AND KITS THEREFOR - The invention relates to a method to diagnose prostate cancer by detecting a PCA3 sequence. In one embodiment the method and kit enables amplification of PCA3 RNA through an exon-exon junction of a spliced PCA3 mRNA, and methods and kits to detect an amplified PCA3 RNA, using a probe which spans the amplified exon-exon junction. The methods and kits can detect a PCA3 RNA lacking one intron or more. Also provided are methods of detecting PCA3 RNA expressed in non-prostate tissue or cells of the urinary tract, which comprises PCA3 intron 3. In addition, methods are provided to determine whether a sample from a subject contains or lacks prostate cells, by performing a hybridization and/or amplification reaction on RNA from the sample to detect the presence or level of PCA3 RNA that lacks at least one intron and distinguishing a prostate cell from a non-prostate cell. | 12-06-2012 |
Gerard Clement Smit, Amerongen NL
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20110048241 | BREW THROUGH LID, ASSEMBLY OF A THERMAL CARAFE AND A BREW THROUGH LID AS WELL AS A COFFEE MAKER INCLUDING SUCH AN ASSEMBLY - A brew through lid for a thermal carafe that has a pouring provision and an internal liquid reservoir. The brew through lid has a cap member with a cone shaped cap top wall, a brew inlet in a centre of the cap top wall at a lowest part of the cone shaped cap top wall, a substantially cylindrical connection wall having a top edge that is connected to the cap top wall and a lid connector that is an integral part of the connection wall. The brew through lid further has a pouring skirt wall that extends around an upper portion of the connection wall and defines a liquid space between the connection wall and the pouring skirt wall. A plurality of pouring passages is circumferentially spaced in the pouring skirt wall and that allow passage of brew liquid out of the liquid space. A plurality of connection wall passages that are circumferentially spaced in the cylindrical connection wall and is configured to allow passage of brew liquid from the internal liquid reservoir of the carafe to the liquid space. | 03-03-2011 |
20130247776 | COFFEE FILTER HOLDER AND COFFEE MAKER - Coffee filter holder including, a funnel wall, a substantially flat bottom wall having an outer edge and a coffee brew outlet, a drip-stop valve assembly that can be brought in an opened and a closed condition, the drip-stop valve assembly including a valve member mounted on a valve member carrier consisting of a blade spring that is connected to the bottom wall, the drip-stop valve assembly further including an actuator lever slideably connected to the bottom wall, the actuator lever including an integral piece of sheet material with a first end that extends beyond the outer edge of the bottom wall so as to be engageable by hand and having a second end that is positioned under the substantially flat bottom wall to engage the valve member carrier to bring valve member from the opened position to the closed position and vice versa. | 09-26-2013 |
Gerardus Hubertus Smit, Enschede NL
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20080317978 | Artificial Grass Turf and Infill for Sports Fields - The present invention relates to an artificial turf suitable for sports fields including a substrate to which first artificial grass fibers are attached and a granular infill, which is provided between the first artificial grass fibers and which is made of a recyclable synthetic material. The invention also relates to an improved granular infill for use in an artificial turf suitable for sports fields. | 12-25-2008 |
Gerrit Smit, Wierden NL
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20160120198 | CHEESE AND METHOD FOR ITS MANUFACTURING - The invention relates to a method for making cheese wherein cheese is salted with a salting agent comprising milk minerals and NaCl or a mixture thereof. The invention also relates to ripened cheese having a ratio of K/Na of 0.39 to 4.0 and a K content of more than 0.08%. | 05-05-2016 |
Gerrit Hendrik Smit, Rosmalen NL
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20140278732 | DYNAMIC RISK STRUCTURE CREATION SYSTEMS AND/OR METHODS OF MAKING THE SAME - A governance, risk management, and compliance (GRC) computer system is provided that includes at least one processor, a user input device, and a storage system that stores meta-model. The meta-model includes at least one process element, a plurality of dynamic risk elements, and a plurality of dynamic control elements. The risk meta-model is loaded from the storage system. Input is accepted from the user input device for creating a new dynamic risk model based on the loaded extended risk meta-model. At least one process element is added to the new dynamic risk model based on user provided input and the extended risk meta-model. A first dynamic risk element is added from the plurality of dynamic risk elements based on user provided input. A risk type of the first dynamic risk element is determined based on user provided input. | 09-18-2014 |
Guus Smit, Amsterdam NL
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20100048678 | Nucleic acids and polypeptides that are useful in controlling neuronal regeneration - The present invention relates to methods for promoting regeneration response of peripheral and central nervous systems in mammals in need of such biological effects. The methods comprise altering the activity or steady state level of specific polypeptides that control regeneration of injured or degenerated neuronal cells. Preferably the activity or steady state level of specific polypeptides is altered by introducing nucleic acids to increase or decrease expressing of the polypeptides. These are useful in or suffering from neurodegenerative disorders. | 02-25-2010 |
Henk H.w. Smit, Groesbeek NL
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20090097489 | METHOD FOR TRACKING TRANSMISSION STATUS OF DATA TO ENTITIES SUCH AS PEERS IN A NETWORK - A method for tracking a transmission status of one or more data elements to one or more devices. In one example, the method includes providing a list including one or more devices and one or more data elements; processing the list to determine a data element of the one or more data elements to transmit to a device of one of the one or more devices; and upon successfully transmitting the data element to the device, adjusting the list so that the list indicates that the device has received the transmitted data element. In this manner, the status of whether a particular data element has been sent to a particular device can be easily derived from the list. | 04-16-2009 |
20110196985 | METHOD FOR TRACKING TRANSMISSION STATUS OF DATA TO ENTITIES SUCH AS PEERS IN A NETWORK - A method for tracking a transmission status of one or more data elements to one or more devices. In one example, the method includes providing a list including one or more devices and one or more data elements; processing the list to determine a data element of the one or more data elements to transmit to a device of one of the one or more devices; and upon successfully transmitting the data element to the device, adjusting the list so that the list indicates that the device has received the transmitted data element. In this manner, the status of whether a particular data element has been sent to a particular device can be easily derived from the list. | 08-11-2011 |
Jasper Roelf Smit, Amsterdam NL
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20090057608 | ALKOXYLATE COMPOSITION AND A PROCESS FOR PREPARING THE SAME - A process for the preparation of an alkoxylate composition, said process comprising the steps of: (a) introducing into a reactor system one or more compounds with one or more active hydrogen atoms, selected from the group comprising alkanoic acids, alkanoic amides, alkanoic ethanolamides, alcohols and alkylmercaptans, and a double metal cyanide catalyst; (b) contacting the one or more compounds with one or more active hydrogen atoms and the double metal cyanide catalyst with propylene oxide and/or butylene oxide to form a first product mixture comprising double metal cyanide catalyst and compounds formed by the addition of one of more propylene oxide and/or butylene oxide units to the one or more compounds with one or more active hydrogen atoms; and (c) contacting the first product mixture with ethylene oxide to form a second product mixture comprising compounds formed by the addition of one of more ethylene oxide units to the compounds formed in step (b). | 03-05-2009 |
20090203557 | METHOD AND COMPOSITION FOR ENHANCED HYDROCARBONS RECOVERY - The present invention provides a method of treating a hydrocarbon containing formation comprising (a) providing a hydrocarbon recovery composition to at least a portion of the hydrocarbon containing formation, wherein the composition comprises one or more internal olefin sulfonates having 17 or more carbon atoms, (b) adding water and/or brine from the hydrocarbon formation to the composition, (c) adding a solubilizer which comprises an ethoxylated alcohol wherein the alcohol before ethoxylation had an average molecular weight of at least about 220 and (d) allowing the composition to interact with hydrocarbons in the hydrocarbon containing formation. The solubilizer may comprise less than about 0.1 wt %, preferably from about 0.02 to about 0.05 wt %, of the total composition and it may have from about 5 to about 9 moles of ethylene oxide per mole of alcohol. | 08-13-2009 |
20100010251 | PREPARATION OF ALKOXYSULFATES - A process for the preparation of alkoxysulfates from organic compounds containing one or more nucleophilic groups by reacting said organic compound, in a water-miscible solvent selected from the group consisting of sulfur-containing solvents such as dimethylsulfoxide (DMSO) or sulfolane, or polar solvents such as tetrahydrofuran (THF), dimethylformamide (DMF), dimethylacetamide (DMA) and hexamethylphosphoric triamide (HMPT), with an alkylene sulfate, in a non-water-miscible solvent selected from the group consisting of chlorinated solvents such as methylene chloride, chloroform, carbon tetrachloride, trichloroethane or chlorinated aromatics, such as chlorobenzene or dichlorobenzene, and non-chlorinated aromatics, such as toluene or xylenes, in the presence of a base selected from the group consisting of hydroxides, carbonates and hydrogen carbonates of alkali metals or alkaline earth metals. | 01-14-2010 |
20120181025 | METHOD AND COMPOSITION FOR ENHANCED HYDROCARBONS RECOVERY FROM A VERY HIGH SALINITY, HIGH TEMPERATURE FORMATION - A method of treating a very high salinity high temperature hydrocarbon containing formation is described. The method includes (a) providing a hydrocarbon recovery composition to at least a portion of a hydrocarbon containing formation having a brine salinity of above about 13 wt % and a temperature of above about 7° C., wherein the composition comprises a C | 07-19-2012 |
20130190543 | METHOD AND COMPOSITION FOR ENHANCED OIL RECOVERY - A method is provided for treating a hydrocarbon containing formation. The method comprises providing a hydrocarbon recovery composition comprising a mixture of branched internal olefin sulfonate molecules, and contacting hydrocarbons in the hydrocarbon containing formation with the hydrocarbon recovery composition. The mixture of branched internal olefin sulfonate molecules has an average number of carbon atoms of between 19 and 23, and an average number of branches of at least 0.6 per molecule. A hydrocarbon composition produced from a hydrocarbon containing formation, and a hydrocarbon recovery composition comprising a mixture of branched internal olefin sulfonate molecules are also provided. | 07-25-2013 |
Johan Paul Smit, Amsterdan NL
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20140135551 | Catalyst Systems for the Catalytic Oligomerization of Olefinic Monomers - The present invention relates to a ligand and its use in a catalyst for the oligomerization of olefinic monomers, the ligand having the general formula (VI); | 05-15-2014 |
John Smit, Amsterdam NL
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20140107304 | CATALYST SYSTEMS FOR THE CATALYTIC OLIGOMERIZATION OF OLEFINIC MONOMERS - The present invention relates to a ligand and its use in a catalyst for the oligomerization of olefinic monomers, the ligand having the general formula (IV); | 04-17-2014 |
Josephus P.a. Smit, Arnhem NL
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20090270729 | Implantable Device and Method for Monitoring Venous Diameter - An implantable medical device system and associated method receive a signal from an implantable sensor operatively positioned relative to a vein, the signal being responsive to changes in a diameter of the vein. A diameter of the vein is determined in response to the sensor signal and used in estimating central venous pressure (CVP). | 10-29-2009 |
20090270748 | System and Method to Monitor Ejection Time and QT Interval to Alert Patients Before Syncopal Events - An implantable medical device and associated method predict syncope based on detecting a change in ejection time. A physiological signal is sensed that is responsive to mechanical changes associated with the cardiac ejection phase. A time interval corresponding to cardiac ejection time is detected from the physiological signal. A sudden change in the time interval is used as a predictor of syncope and causes a patient alert to be generated in response to the detected change. | 10-29-2009 |
Jozefus A.c. Smit, Boxmeer NL
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20120109095 | METHOD AND EQUIPMENT FOR FASTENING A THREAD TO A TAMPON - A method for fastening a thread ( | 05-03-2012 |
20120111094 | TUBE WELD STEAM TEST DEVICE AND METHOD - A tube weld seam test method and device for testing a tube weld seam ( | 05-10-2012 |
20120289935 | TOOL FOR MANIPULATING AN OBJECT IN A BODY CAVITY - A tool for manipulating a solid object ( | 11-15-2012 |
Klaas Gerrit Smit, Anna Paulowna NL
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20140193326 | PROCESS FOR THE GASIFICATION OF WET BIOMASS - A process for the gasification of wet biomass comprises feeding the wet biomass at a temperature of at most 370 C. and a pressure of at least 22.1 MPa (absolute) to a reactor. The reactor comprises a bed of solid particles suspended in a fluid. The temperature of the feed is increased in the presence of the bed of suspended solid particles to a temperature of at least 375° C., forming supercritical water and converting in the presence of the supercritical water at least a portion of the organic materials present in the wet biomass into fluid gasification product. | 07-10-2014 |
20140202080 | PROCESS AND A REACTION APPARATUS FOR THE GASIFICATION OF WET BIOMASS - A process for the gasification of wet biomass. The process comprises heating wet biomass at a pressure in the range of from 22.1 MPa to 35 MPa. The wet biomass is heated from a temperature of at most T | 07-24-2014 |
20140202845 | REACTION APPARATUS AND A PROCESS FOR THE GASIFICATION OF WET BIOMASS - A reaction apparatus for the gasification of wet biomass comprises a feeding system for feeding wet biomass at a pressure of at least 22.1 MPa (absolute), a reactor comprising a reaction tube and a heating device, and a recovery system. The reaction tube is configured to comprise a bed of solid particles suspended in a fluid, and to receive wet biomass from the feeding system at a temperature below the critical temperature of water. The bed of solid particles suspended in a fluid is a bubbling fluidised bed having a length of at least 0.5 m and a cross sectional area of at most 20 dm | 07-24-2014 |
Leo Smit, Oirsbeek NL
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20080287990 | Elongated Surgical Repair Product Based on Uhmwpe Filaments - The invention relates to an elongated surgical repair product comprising an elongated member of core-sheath structure, wherein the core contains a plurality of high-strength ultra-high molar mass polyethylene (UHMWPE) filaments, and wherein the elongated member has a UHMWPE sheath that is substantially non-porous. This product combines high tensile strength, good flexibility and favourable knotting characteristics. The invention also relates to a process of making said elongated surgical repair product, comprising a step wherein an elongated precursor member containing a plurality of UHMWPE filaments is subjected to a heat treatment while keeping the filaments under tension. | 11-20-2008 |
20090143864 | Process for manufacturing a prosthetic joint - The application relates to a process for manufacturing a prosthetic joint with at least one loaded surface which consists at least partially of polyethylene, comprising compressing one or more layers of a woven fabric of drawn gel-spun polyethylene fibres into the desired shape in a hollow mould part using a plug at a pressure of at least 0.05 MPa and at a temperature of between 120 and 165° C. and below the crystalline melting point of the polyethylene at the prevailing temperature and pressure, without a matrix material being present, and at least the woven fabric in a layer situated on a loaded surface comprising at least 90 wt % of fibres with a titre of at most 1000 denier, and to a prosthetic joint with a crease-free surface. | 06-04-2009 |
Leo Smit, Ae Orisbeek NL
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20120046750 | SPINAL FUSION CAGE - The invention is directed to a spinal fusion cage for implantation between two adjacent vertebrae, wherein the total cage has, under a load, a maximum compression that is higher than 0.05% of the original height of the spinal fusion cage and the maximum compression does not change the structural integrity of the cage. | 02-23-2012 |
Mark H. Smit, Maarssen NL
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20090006543 | SYSTEM AND METHOD FOR ASYNCHRONOUS RETRIEVAL OF INFORMATION BASED ON INCREMENTAL USER INPUT - A system and method for asynchronously retrieving information over a network based on incremental input. The system comprises a client part, a communication protocol, and a server part. The server part receives incremental text-based input from one or more objects in the client part, and asynchronously returns matching information to the client part depending on server-defined content channels that each query one or more underlying or connected content sources, such as databases or search engines, to return matches for the latest input and for the latest values and state of other content channels. | 01-01-2009 |
20120284329 | SYSTEM AND METHOD FOR ASYNCHRONOUS CLIENT SERVER SESSION COMMUNICATION - The invention provides a session-based bi-directional multi-tier client-server asynchronous information database search and retrieval system for sending a character-by-character string of data to an intelligent server that can be configured to immediately analyze the lengthening string character-by-character and return to the client increasingly appropriate database information as the client sends the string. | 11-08-2012 |
Mark Hans Smit, Maarssen NL
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20110106966 | SYSTEM AND METHOD FOR UTILIZING ASYNCHRONOUS CLIENT SERVER COMMUNICATION OBJECTS - A session-based client-server asynchronous information search and retrieval system for sending character-by-character or multi-character strings of data to an intelligent server, that can be configured to immediately analyze the lengthening string and return to the client increasingly appropriate search information. Embodiments include integration within an Internet, web or other online environment, including applications for use in interactive database searching, data entry, online searching, online purchasing, music purchasing, people-searching, and other applications. In some implementations the system may be used to provide dynamically focused suggestions, auto-completed text, or other input-related assistance, to the user. | 05-05-2011 |
20140095539 | SYSTEM AND METHOD FOR ASYNCHRONOUS CLIENT SERVER SESSION COMMUNICATION - The invention provides a session-based bi-directional multi-tier client-server asynchronous information database search and retrieval system for sending a character-by-character string of data to an intelligent server that can be configured to immediately analyze the lengthening string character-by-character and return to the client increasingly appropriate database information as the client sends the string. | 04-03-2014 |
Martin Smit, Bloemendaal NL
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20100311567 | REGENERATION OF ZEOLITE CARBONYLATION CATALYSTS - A process for the in-situ regeneration of a zeolite catalyst in a carbonylation process for the production of at least one of methyl acetate and acetic acid by contacting methanol, dimethyl ethyl or dimethyl carbonate with carbon monoxide in the presence of a zeolite catalyst, ceasing contact of the catalyst with the reactant, regenerating the catalyst with a regenerating gas selected from hydrogen or a mixture of hydrogen and carbon monoxide at a temperature in the range 250 to 600° C., terminating the hydrogen regenerating step and resuming contact of the catalyst with the reactant and carbon monoxide. | 12-09-2010 |
20100317888 | CARBONYLATION PROCESS WITH IN SITU REGENERATION OF MORDENITE CATALYST - A process for the carbonylation of dimethyl ether, dimethyl carbonate and/or methanol with carbon monoxide and hydrogen in the presence of a mordenite catalyst to produce at least one of acetic acid and methyl acetate in which process the mordenite catalyst is regenerated in-situ by contacting the catalyst with a regenerating gas comprising a molecular oxygen-containing gas and an inert diluent at a total pressure in the range 1 to 100 bar and wherein the partial pressure of the molecular oxygen-containing gas is such that the temperature of the catalyst is maintained within the range 225 to 325° C. | 12-16-2010 |
20110108132 | REACTION ASSEMBLY AND FLOW SPLITTER - The invention pertains to reaction systems in which at least one capillary unit is applied. The capillary unit comprises: —a unit inlet for receiving a fluid flow, —a unit outlet for releasing said fluid flow, —a capillary, which capillary is arranged between the unit inlet and the unit outlet such that said fluid flow passes through the capillary, —a heater and/or a cooler for adjusting the temperature of the capillary and therewith influencing the flow rate of the fluid flow passing through said capillary, —a housing for accommodating at least the capillary and heater and/or cooler of said capillary unit, which housing provides thermal insulation of the capillary, —a flow sensor for measuring the flow rate of the fluid flow through the capillary unit, which flow sensor can be arranged either inside or outside the housing, A capillary unit is combined with or further has a flow adjustment unit for adjusting the flow rates of the secondary fluid flows, which flow adjustment unit comprises a temperature control device for individually controlling the heater and/or cooler of each capillary unit in response to the flow rate that is measured by the flow sensor of that capillary unit. | 05-12-2011 |
Martine Smit, Amsterdam NL
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20110206660 | AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRS AND COMPOUNDS COMPRISING THE SAME - The present invention relates to amino acid sequences that are directed against (as defined herein) G-protein coupled receptors (GPCRs) and in particular to CXCR4 and CXCR7, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences (also referred to herein as “amino acid sequences of the invention”, “compounds of the invention”, and “polypeptides of the invention”, respectively). Furthermore, the invention provides a new method of making amino acid sequences that are directed against transmembrane protein, and in particular for multiple spanning transmembrane proteins for which the native conformation cannot be reproduced in other “in vitro” system (e.g. GPCRs in general). | 08-25-2011 |
20110262438 | BIOLOGICAL MATERIALS RELATED TO CXCR7 - The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. | 10-27-2011 |
20110318347 | AMINO ACID SEQUENCES TARGETING HUMAN CD4, CXCR4, CCR5, TLR4, ALPHAV INTEGRIN, BETA3-INTEGRIN, BETA1-INTEGRIN, HUMAN ALPHA2-INTEGRIN, CD81, SR-BI, CLAUDIN-1, CLAUDIN-6 AND CLAUDIN-9, RESPECTIVELY, AND NEUTRALIZING VIRAL ENTRY - The present invention relates to amino acid sequences that are directed against (as defined herein) human cellular receptors for viruses and/or bacteria such as e.g. Nanobodies specifically recognizing hCD4, hCXCR4, hCCR5. hTLR4, human alphaV integrin, human beta3 integrin, human beta1 integrin, human alpha2 integrin, hCD81, hSR-B1, hClaudin-1, hClaudin-6 and hClaudin-9, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. Said amino acid sequences may be used to prevent human cell entry of HIV, HCV, adenoviruses, hantavirus, herpesvirus, echo-virus 1 and others. | 12-29-2011 |
20130130379 | AMINO ACID SEQUENCES DIRECTED AGAINST GPCRS AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF GPCR-RELATED DISEASES AND DISORDERS - The present invention relates to amino acid sequences that are directed against G-protein coupled receptors (GPCRs), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes. | 05-23-2013 |
20140178390 | BIOLOGICAL MATERIALS RELATED TO CXCR7 - The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumour growth. | 06-26-2014 |
20150110796 | BIOLOGICAL MATERIALS RELATED TO CXCR7 - The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. | 04-23-2015 |
20150158948 | BISPECIFIC ANTI-CXCR7 IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS - The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumour growth. | 06-11-2015 |
20150299327 | AMINO ACID SEQUENCES DIRECTED AGAINST CELLULAR RECEPTORS FOR VIRUSES AND BACTERIA - The present invention relates to amino acid sequences that are directed against (as defined herein) human cellular receptors for viruses and/or bacteria such as e.g. Nanobodies specifically recognizing hCD4, hCXCR4, hCCR5, hTLR4, human alphaV integrin, human beta3 integrin, human beta1 integrin, human alpha2 integrin, hCD81, hSR-BI, hClaudin-1, hClaudin-6 and hClaudin-9, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. Said amino acid sequences may be used to prevent human cell entry of HIV, HCV, adenoviruses, hantavirus, herpesvirus, echo-virus 1 and others. | 10-22-2015 |
Marvin Smit, Almere NL
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20120197718 | SYSTEMS, METHODS, AND MEDIA FOR WEB CONTENT MANAGEMENT - Systems, methods, and media for managing web content. Exemplary methods may include the steps of providing a web content management application via a web site, generating a web marketing campaign from at least a portion of a global marketing framework via a web server, gathering via the web server marketing data from at least one of the web server associated with the web marketing campaign and consumer devices accessing the web marketing campaign, the marketing data including information indicative of interests of consumers, storing the marketing data in a database, associating consumers together according to at least one common interest to create one or more consumer groups, and providing the one or more consumer groups to at least one marketing content author. | 08-02-2012 |
Meertinus Jan Smit, Oss NL
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20120039843 | CONJUGATES OF A POLYPEPTIDE AND AN OLIGOSACCHARIDE - The present invention relates to conjugates of a polypeptide and an oligosaccharide, wherein the polypeptide is conjugated to at least one oligosaccharide-spacer residue, the oligosaccharide being a synthetic sulfated oligosaccharide comprising 4-18 monosaccharide units and per se having affinity to antithrombin III and the spacer being a bond or an essentially pharmacologically inactive flexible linking residue, or a pharmaceutically acceptable salt thereof. | 02-16-2012 |
Meint Koert Smit, Best NL
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20110216789 | SEMICONDUCTOR LASER DEVICE - The present invention is directed to a semiconductor laser device comprising a first resonator section for resonating an optical resonator signal for providing an optical output signal at an output of said laser device, wherein said first resonator section is arranged for selectively resonating at a plurality of discrete output wavelengths, and wherein said laser device further comprises a second resonator section operatively connected to said first resonator section, said second resonator section being arranged for providing an optical feedback signal at a feedback wavelength to said first resonator section for locking said first resonator section into resonating at a selected output wavelength of said discrete output wavelengths, which selected output wavelength corresponds to said feedback wavelength for providing said optical output signal. | 09-08-2011 |
Nico Smit, Amsterdam NL
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20110262553 | Compositions Suitable For Treating Cutaneous Signs Of Aging - Compositions comprising vitamin E, vitamin C, and white tea extract for treating cutaneous signs of aging are disclosed. The compositions reduce signs of wrinkles and improve other skin conditions, such as increased skin elasticity and skin softness. Moreover, the prevention or treatment of unhealthy skin, such as aged skin or skin overexposed to sunlight, may advantageously be accomplished by the administration of the compositions of the present invention. The compositions includes the combination of a number of different components, which interact to provide the desired improvements to the skin. Further advantageous ingredients of the compositions may comprise, naturally occurring antioxidants extracted from e.g. grape seeds and tomato, an extract comprising glycosaminoglycans, a transition metal component in an amount effective to bind collagen and elastic fibers and thicken skin, and a catechin-based component present in an amount sufficient to inhibit the presence of anti-collagen enzyme in the skin. | 10-27-2011 |
Obed Smit, Sappemeer NL
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20120084895 | Ficinia plant named 'Frosty' - A new and distinct | 04-05-2012 |
20130227753 | Peperomia plant named 'Eden Rosso' - A new and distinct | 08-29-2013 |
Raymond Maurice Smit, Geldrop NL
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20130035049 | MOBILE COMMUNICATION DEVICE AND METHOD FOR SELECTIVELY TURNING ON AN ADDITIONAL WIRELESS TRANSCEIVER - A mobile communication device includes a main wireless transceiver unit for sending and receiving wireless signals, an additional wireless transceiver unit for sending and receiving wireless signals, a motion detection unit, connected to a processing unit and arranged to send a motion signal to a processing unit, and the processing unit, arranged to receive the motion signal and to determine therefrom a parameter representative of a velocity of the mobile communication device, wherein the processing unit is arranged and constructed to turn on the additional wireless transceiver unit when the parameter exceeds a first threshold value. Furthermore, the processing unit is arranged and constructed to turn off the additional wireless transceiver unit when the parameter representative of a velocity remains below a second threshold value for a predetermined period of time. | 02-07-2013 |
Ruud Smit, Haarlem NL
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20090042914 | Delayed release formulations of 6-mercaptopurine - The present invention provides enterically coated formulations of 6-mercaptopurine that exhibit a delay in release of the 6-mercaptopurine such that substantial release of 6-mercaptopurine does not occur until after passage through the stomach. Optionally, the formulations also comprise a delay coating in addition to the enteric coating that provides an even further delay such that substantial release of 6-mercaptopurine does not occur until after a certain period of time following passage through the stomach. Such a period of time is preferably at least one hour after passage through the stomach. Following the delay imparted by the enteric coating and optional delay coating, the formulations exhibit better bioavailability and faster dissolution than previous formulations. | 02-12-2009 |
20120207841 | FORMULATIONS OF 6-MERCAPTOPURINE - The present invention provides improved formulations of 6-mercaptopurine that exhibit better bioavailability and faster dissolution than previous formulations. | 08-16-2012 |
20150290133 | FORMULATIONS OF 6-MERCAPTOPURINE - The present invention provides improved formulations of 6-mercaptopurine that exhibit better bioavailability and faster dissolution than previous formulations. | 10-15-2015 |
Ruud Smit, Driehuis NL
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20160030575 | TAXOID - PURIFICATION PRINCIPLE FOR LIQUID EXCIPIENTS - The invention relates to taxoid compositions having improved stability. | 02-04-2016 |
Sebastiaan Smit, Utrecht NL
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20150277242 | SUBSTRATE POSITIONING SYSTEM, LITHOGRAPHIC APPARATUS AND DEVICE MANUFACTURING METHOD - A positioning system for positioning an object in a lithographic apparatus, including: a first and second object tables moveable in an operating area; a first position measurement system to provide an incremental position measurement of the second object table relative to a reference when in the operating area, wherein the first position measurement system is configured to provide an absolute position measurement of the first object table relative to the reference; a second position measurement system to provide an absolute position measurement of the first object table relative to the second object table, and wherein the first position measurement system is further configured to provide an absolute position measurement of the second object table relative to the reference based on the absolute position measurement of the first object table relative to the reference and on the absolute position measurement of the first object table relative to the second object table. | 10-01-2015 |
Theodericus Johannes Henricus Smit, Rijswijk NL
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20140365193 | METHOD TO CONSTRAIN A BASIN MODEL WITH CURIE DEPTH - Methods for constraining basin models to forecast the presence and maturity of hydrocarbon in a basin. The method involves determining a Curie depth at a location at the basin, constraining basin models to match the Curie depth at the location and determining the presence of hydrocarbon in the basin based on the basin models constrained by Curie depth. | 12-11-2014 |
20150090443 | METHODS FOR ESTIMATING RESOURCE DENSITY USING RAMAN SPECTROSCOPY OF INCLUSIONS IN SHALE RESOURCE PLAYS - A method of determining the in situ pressure of a light hydrocarbon in a shale source rock formation comprising: providing an inclusion comprising the light hydrocarbon trapped within the inclusion; using Raman spectroscopy to determine the density and composition of the light hydrocarbon trapped within the inclusion; and calculating a pressure of the light hydrocarbon in the shale source rock formation based upon the density and composition of the light hydrocarbon trapped within the inclusion. | 04-02-2015 |
20150301219 | METHODS FOR ESTIMATING RESOURCE DENSITY BY INTEGRATING SEISMIC METHODS WITH FLUID DENSITY AND PRESSURE IN SHALE RESOURCE PLAYS - A method of evaluating a shale source rock formation comprising: determining in situ partial pressures of a light hydrocarbon utilizing a downhole Raman tool and producing a map of spatial and vertical variations of the in situ partial pressures of the light hydrocarbon in the shale source rock formation. | 10-22-2015 |
Victor Smit, Almere NL
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20100279344 | Integrated cytokine production system - A multi-stage method for producing a cytokine involves expressing the cytokine in an expression system, preferably a | 11-04-2010 |
Wilhelmus Jacobus Maria Smit, Melissant NL
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20120033396 | SYSTEM FOR CONTROLLING ELECTRICAL EQUIPMENT UNITS - System for controlling electrical equipment units on an offshore structure comprising an explosion proof housing closable with a panel door, at least one controller module mountable in the housing, arranged for autonomously controlling an electrical equipment unit, wherein the panel door comprises an operating module arranged for operating the at least one controller module and for providing status indication of the at least one controller module. | 02-09-2012 |