Sirven
Aride Sirven, Paris FR
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20120122204 | LENTIVIRAL TRIPLEX DNA, AND VECTORS AND RECOMBINANT CELLS CONTAINING LENTIVIRAL TRIPLEX DNA - The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1 reverse transcription at the center of HIV-1 linear DNA genomes. These triplex structures can act as a cis-determinant of HIV-1 DNA nuclear import, allowing infection of non-dividing target cells. In one aspect, the presence of the DNA triplex sequence in an HIV vector strongly stimulates gene transfer in hematopoietic stem cells. The invention also provides methods of using these triplex structures for making recombinant cells, as well as methods of using the recombinant cells to express proteins of interest both in vitro and in vivo. | 05-17-2012 |
20120122963 | LENTIVIRAL TRIPLEX DNA, AND VECTORS AND RECOMBINANT CELLS CONTAINING LENTIVIRAL TRIPLEX DNA - The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1 reverse transcription at the center of HIV-1 linear DNA genomes. These triplex structures can act as a cis-determinant of HIV-1 DNA nuclear import, allowing infection of non-dividing target cells. In one aspect, the presence of the DNA triplex sequence in an HIV vector strongly stimulates gene transfer in hematopoietic stem cells. The invention also provides methods of using these triplex structures for making recombinant cells, as well as methods of using the recombinant cells to express proteins of interest both in vitro and in vivo. | 05-17-2012 |
Aude Sirven, Paris FR
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20150191745 | LENTIVIRAL TRIPLEX DNA, AND VECTORS AND RECOMBINANT CELLS CONTAINING LENTIVIRAL TRIPLEX DNA - The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1 reverse transcription at the center of HIV-1 linear DNA genomes. These triplex structures can act as a cis-determinant of HIV-1 DNA nuclear import, allowing infection of non-dividing target cells. In one aspect, the presence of the DNA triplex sequence in an HIV vector strongly stimulates gene transfer in hematopoietic stem cells. The invention also provides methods of using these triplex structures for making recombinant cells, as well as methods of using the recombinant cells to express proteins of interest both in vitro and in vivo. | 07-09-2015 |
Catherine Sirven, Langenfeld DE
Patent application number | Description | Published |
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20110183978 | Phenylpyri(mi)dinylazoles - Phenylpyri(mi)dinylazoles of the formula [I-a] and [I-b], | 07-28-2011 |
20130281455 | Phenylpyri(mi)dinylazoles - Phenylpyri(mi)dinylazoles of the formula [I-a] and [I-b], | 10-24-2013 |
Catherine Sirven, Langendeld DE
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20110237588 | Thienylpyri(mi)dinylazole - Thienylpyri(mi)dinylazole of the formula (I) | 09-29-2011 |
Jean-Baptiste Sirven, Paris FR
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20130280132 | SMOKE ANALYSIS CHARACTERIZATION CELL - The invention relates to a smoke analysis characterization cell employing optical spectroscopy, which comprises: a reaction chamber, an inlet orifice for injecting smoke into the reaction chamber; an outlet orifice for discharging the smoke from the reaction chamber; and an analysis window for the entry of a laser beam intended to form the plasma inside the reaction chamber, which cell is characterized in that the system further includes a blower for blowing an inert gas close to the analysis window; and a shielding gas injector for the shielded injection of the smoke into the reaction chamber, the shielding being provided by a jet of inert gas around the smoke. | 10-24-2013 |
Philemon Sirven, Poissy FR
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20130337085 | USE OF IDE AS A BIOMARKER FOR A SCALP CONDITION - The subject matter of the present invention is in particular the use of an amino acid sequence of IDE, or of an analogue or fragment thereof, or of at least one nucleic acid sequence encoding this sequence, as a biomarker, or as an active agent, with regard to a dandruff condition of the scalp. | 12-19-2013 |