Simon, WA
Anthony J. Simon, Seattle, WA US
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20110316691 | FLAT-HIERARCHY SYSTEM FOR CONDITION-BASED MONITORING OF DISTRIBUTED EQUIPMENT - Systems and methods for monitoring the condition of equipment in a manufacturing plant or other facility. A computing node is attached to each piece of equipment under consideration. Each node gathers relevant information from the machine using sensors and is capable of determining the condition of the machine from a preexisting set of possible conditions, using only the information obtained from the sensors. Each node is thus entirely self-sufficient, in that it requires no interaction with a global controller or with other nodes in order to make a decision about the condition of the equipment, and does not necessarily require any information about the past history of the equipment. The nodes are capable of communicating the condition of their corresponding equipment to key maintenance or other personnel, potentially via a wireless network to a convenient wireless-capable device such as a cellular phone or laptop. | 12-29-2011 |
David E. Simon, Bainbridge Island, WA US
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20090250979 | Health care chair - A health care chair includes a base and a seating portion attached to the base. A lift assist mechanism connects the base and seating portion and assists in moving the seating portion from a first reclined position to a second inclined position without electrical power. The chair also includes moveable arms attached to the seating portion that rotate between a first substantially horizontal position and a second substantially vertical position. | 10-08-2009 |
20100205868 | OFFICE SYSTEM - A free-standing, partition-type furniture system adapted to subdivide an open space of a room, comprising a plurality of first partition panels, each including a first body portion having a pair of side edges, and a first screen member operably coupled to the first partition panel and laterally shiftable with respect to the first partition panel such that the first screen member extends from one of the side edges of the first body portion. The furniture system also includes a plurality of second partition panels each including a second body portion having an upper edge, and a second screen member operably coupled to the second partition panel and vertically shiftable with respect to the second partition panel such that the second screen member extends from the upper edge of the second body portion. The plurality of first and second partition panels are operably coupleable and arrangeable so as to subdivide the open space of a room. | 08-19-2010 |
Ian Simon, Redmond, WA US
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20090064851 | Automatic Accompaniment for Vocal Melodies - A method for generating an accompaniment for a recorded audio melody includes providing a recorded audio melody that includes segments; performing a frequency analysis of the recorded audio melody; summing the total duration of each fundamental frequency within a segment of the melody; based on the summing, computing a probability for each possible chord for each segment; based on the computed probabilities, selecting a set of chords for the segments; and outputting the set of chords as an accompaniment for the recorded audio melody. Various other methods, devices, systems, etc. are also disclosed. | 03-12-2009 |
20100192755 | AUTOMATIC ACCOMPANIMENT FOR VOCAL MELODIES - A graphical user interface for facilitating generation of an accompaniment for a recorded audio melody is described. A Hidden Markov Model, trained with blended chord transition matrices and melody observation matrices, is used for providing the accompaniment for the recorded audio melody. The recorded audio melody includes segments. Frequency analysis of the recorded audio melody is performed. The total duration of each fundamental frequency within a segment of the melody is summed. Based on the summing, a probability for each possible chord for each segment is computed. Based on the computed probabilities, a set of chords are selected for the segments. The chords are displayed on a chord chart of the graphical user interface. The graphical user interface facilitates various manipulations using the chords and/or controls, and generation of a new accompaniment for a recorded audio melody based on the manipulations. | 08-05-2010 |
Ian Simon, Seattle, WA US
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20120296458 | Background Audio Listening for Content Recognition - Various embodiments enable audio data, such as music data, to be captured, by a device, from a background environment and processed to formulate a query that can then be transmitted to a content recognition service. In one or more embodiments, the audio data is captured prior to receiving user input associated with audio data capture, e.g., launch of an application associated with the content recognition service, provision of user input proactively indicating that audio data capture is desired, and the like. Responsive to transmitting the query, displayable information associated with the audio data is returned by the content recognition service and can be consumed by the device. | 11-22-2012 |
20120296938 | Query and Matching for Content Recognition - Various embodiments enable audio data, such as music data, to be captured, by a device, from a background environment and processed to formulate a query that can then be transmitted to a content recognition service. In one or more embodiments, multiple queries are transmitted to the content recognition service. In at least some embodiments, subsequent queries can progressively incorporate previous queries plus additional data that is captured. In one or more embodiments, responsive to receiving the query, the content recognition service can employ a multi-stage matching technique to identify content items responding to the query. This matching technique can be employed as queries are progressively received. | 11-22-2012 |
Julian Simon, Seattle, WA US
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20120252839 | GAIN-OF-FUNCTION BCL-2 INHIBITORS - Compounds are described that are useful for treating an apoptosis-associated disease, which are specifically cytotoxic to tumor cells that are overexpressing Bcl-x | 10-04-2012 |
20140179560 | DRUG DISCOVERY METHODS AND PLATFORMS - Methods and systems for discovering drug candidates are disclosed. Methods and systems can include generating libraries of potential drug candidates (e.g., libraries of peptides) that can be screened to identify sub-libraries of potential drug candidates (e.g., sub-libraries of peptides) having selected pharmacological properties. Methods of making and using peptide libraries are also provided. D-amino acid chlorotoxins and D-amino acid chlorotoxin variants are also provided. | 06-26-2014 |
Julian A. Simon, Seattle, WA US
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20090023751 | COMPOUNDS THAT PROTECT AGAINST SENSORY HAIR CELL DEATH - The present invention provides methods of identifying compounds that protect against ototoxicity induced by one or more noxious stimuli, and methods of treating an individual with compounds identified using the present screening methods. Also provided are compounds demonstrated to have otoprotective effects. | 01-22-2009 |
20090203770 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING Bcl-2 FAMILY MEMBER PROTEINS - The present invention provides agents and compositions for modulating the apoptotic state of a cell. The agents comprise derivatives of antimycins which bind to an anti-apoptotic Bcl-2 family member protein. Further, the agents preferentially induce apoptosis in cells that over-express anti-apoptotic Bcl-2 family member proteins and typically exhibit reduced binding affinity for cytochrome B. Pharmaceutical uses of the agents and compositions include treating apoptosis-associated disease, such as neoplasia and drug resistance, are also disclosed. | 08-13-2009 |
20110135756 | COMPOSITIONS AND METHODS FOR PROTECTING SENSORY HAIR CELLS - The invention provides compounds, compositions and methods that can be used for the attenuation of damage to sensory hair cells and symptoms thereof. More particularly, the invention identifies drugs that can be used to protect sensory hair cells from ototoxic medications, noise-induced damage and age-related loss. | 06-09-2011 |
Julianna C. Simon, Kenmore, WA US
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20120259250 | METHODS OF SOFT TISSUE EMULSIFICATION USING A MECHANISM OF ULTRASONIC ATOMIZATION INSIDE GAS OR VAPOR CAVITIES AND ASSOCIATED SYSTEMS AND DEVICES - The present technology is directed to methods of soft tissue emulsification using a mechanism of ultrasonic atomization inside gas or vapor cavities, and associated systems and devices. In several embodiments, for example, a method of non-invasively treating tissue includes pulsing ultrasound energy from the ultrasound source toward the target site in tissue. The ultrasound source is configured to emit high intensity focused ultrasound (HIFU) waves. The target site comprises a pressure-release interface of a gas or vapor cavity located within the tissue. The method continues by generating shock waves in the tissue to induce a lesion in the tissue at the target site. The method additionally includes characterizing the lesion based on a degree of at least one of a mechanical or thermal ablation of the tissue. | 10-11-2012 |
Luke Simon, Redmond, WA US
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20120143794 | ANSWER MODEL COMPARISON - This patent application pertains to answer model comparison. One implementation can determine a first frequency at which an individual answer category appears in an individual slot on a query results page when utilizing a first model. The method can ascertain a second frequency at which the individual answer category appears in the individual slot on the query results page when utilizing a second model. The method can calibrate the second model so that the second frequency approaches the first frequency. | 06-07-2012 |
20140365454 | ENTITY RELEVANCE FOR SEARCH QUERIES - The relevance of entities to search queries is determined using a triangulation approach. The triangulation approach determines the relevance of entities to documents and the relevance of documents to a search query. The relevance of each entity to the search query is then determined as a function of the relevance of the entities to the documents and the relevance of the documents to the search query. The entity/query relevance determination may be employed when returning a search result experience in response to search queries. | 12-11-2014 |
Luke Evans Simon, Redmond, WA US
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20130132378 | SEARCH MODEL UPDATES - Search model updates are described. In one or more implementations, a search service uses a model to rank items in a search result, the model formed using an initial set of data. An update is generated using a subsequent set of data, which is formed after the initial set of data, that provides feedback describing user interaction with one or more items in the search result formed using the model, the generating of the update performed without use of at least a portion of the initial set of data. The model and the update are employed to rank items in a search result for a subsequent search. | 05-23-2013 |
Sandy A. Simon, Seattle, WA US
Patent application number | Description | Published |
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20080279850 | B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules - The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules. | 11-13-2008 |
20090214539 | B-CELL REDUCTION USING CD37-SPECIFIC AND CD20-SPECIFIC BINDING MOLECULES - The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules. | 08-27-2009 |
20090274692 | CD37 IMMUNOTHERAPEUTIC AND COMBINATION WITH BIFUNCTIONAL CHEMOTHERAPEUTIC THEREOF - The present disclosure provides a humanized anti-CD37 small modular immunopharmaceutical (SMIP) molecule, as well as synergistic combination therapies of CD37-specific binding molecules (such as anti-CD37 SMIP proteins or antibodies) with bifunctional chemotherapeutics (such as bendamustine) that can be administered concurrently or sequentially, for use in treating or preventing B-cell related autoimmune, inflammatory, or hyperproliferative diseases. | 11-05-2009 |
20140086903 | CD37 IMMUNOTHERAPEUTIC AND COMBINATION WITH BIFUNCTIONAL CHEMOTHERAPEUTIC THEREOF - The present disclosure provides a humanized anti-CD37 small modular immunopharmaceutical (SMIP) molecule, as well as synergistic combination therapies of CD37-specific binding molecules (such as anti-CD37 SMIP proteins or antibodies) with bifunctional chemotherapeutics (such as bendamustine) that can be administered concurrently or sequentially, for use in treating or preventing B-cell related autoimmune, inflammatory, or hyperproliferative diseases. | 03-27-2014 |
Sandy Alexander Simon, Seattle, WA US
Patent application number | Description | Published |
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20100330089 | ANTI-CD20 THERAPEUTIC COMPOSITIONS AND METHODS - The present invention provides materials and methods for treatment of diseases involving aberrant B-cell activity, using a CD20-specific binding molecule, in particular, antibodies or antigen binding fragment thereof. The compositions disclosed herein is useful for the treatment and diagnosis of B-cell disorders, such as B-cell malignancies and autoimmune diseases. | 12-30-2010 |
20110171208 | CD37 IMMUNOTHERAPEUTIC AND COMBINATION WITH BIFUNCTIONAL CHEMOTHERAPEUTIC THEREOF - The present disclosure provides a humanized anti-CD37 small modular immunopharmaceutical (SMIP) molecule, as well as synergistic combination therapies of CD37-specific binding molecules (such as anti-CD37 SMIP proteins or antibodies) with bifunctional chemotherapeutics (such as bendamustine) that can be administered concurrently or sequentially, for use in treating or preventing B cell related autoimmune, inflammatory, or hyperproliferative diseases. | 07-14-2011 |
20130195850 | CD3 IMMUNOTHERAPEUTICS AND USES THEREOF - The present disclosure provides a humanized anti-CD37 small modular immunopharmaceutical (SMIP) molecule, as well as synergistic combination therapies of CD37-specific binding molecules (such as anti-CD37 SMIP proteins or antibodies) with bifunctional chemotherapeutics (such as bendamustine) that can be administered concurrently or sequentially, for use in treating or preventing B cell related autoimmune, inflammatory, or hyperproliferative diseases. | 08-01-2013 |
20130266561 | B-CELL REDUCTION USING CD37-SPECIFIC AND CD20-SPECIFIC BINDING MOLECULES - The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules. | 10-10-2013 |
20140004117 | B-CELL REDUCTION USING CD37-SPECIFIC AND CD20-SPECIFIC BINDING MOLECULES | 01-02-2014 |
20140010813 | B-CELL REDUCTION USING CD37-SPECIFIC AND CD20-SPECIFIC BINDING MOLECULES - The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules. | 01-09-2014 |
20140072562 | B-CELL REDUCTION USING CD37-SPECIFIC AND CD20-SPECIFIC BINDING MOLECULES - The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules. | 03-13-2014 |