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Simon, MA
Amy R. Simon, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080207489 | Use of CCN5 for treatment of smooth muscle proliferation disorders - The invention provides methods for treating a smooth muscle cell disorder such as asthma, vascular injury, persistent pulmonary hypertension in the newborn, pulmonary hypertension in adults, megaureter, pyloric stenosis, uterine fibroids, lymphangioleiomyomatosis (LAM), cervical incompetence, or cancer, and methods for assessing smooth muscle tissue remodeling in a mammal by expressing CCN5 in a smooth muscle cell of the mammal, or by contacting the tissue directly with CCN5. | 08-28-2008 |
Andrew Simon, Worcester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110163118 | Metered Dispenser - A dispensing apparatus includes a container having an opening, and a doser coupled with the container about the container opening. The doser includes a housing forming a chamber with an interior wall, an inlet, and an outlet. The inlet is diametrically offset from the outlet, and substantially aligned with the opening of the container. The doser also includes a covering member to alternatively cover and open the inlet and the outlet. The covering member is movable about a range of positions to substantially completely cover at least one of the inlet and outlet at all positions in the range. The covering member covers no more than a portion of the chamber interior wall when the covering member completely opens the outlet. | 07-07-2011 |
| 20130020347 | Strip Dispenser - A strip dispenser ( | 01-24-2013 |
Barry Simon, Sudbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120036519 | CALLING OF LATE BOUND FUNCTIONS FROM AN EXTERNAL PROGRAM ENVIRONMENT - The present invention is directed toward automatically integrating a late bound program language into an external environment. The external environment may be an early bound environment, a late bound environment or some combination thereof. Associated with the late bound program environment is a modular execution engine and an interface mechanism, wherein the interface mechanism is capable of expressing late bound semantics in a format compatible with the external environment. | 02-09-2012 |
Beryl Simon, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080270166 | TRANSCRIPT, COURSE CATALOG AND FINANCIAL AID APPARATUS, SYSTEMS, AND METHODS - In one aspect the invention relates to a method of automating an application process. The method includes the steps of collecting student identification information using a graphic user interface; collecting student transcript and student application data; generating a first secure communication channel to transmit a portion of the student transcript and student application data to a first server in response to a valid request; formatting the transcript data such that it is suitable for use by a first database; generating a second secure communication channel to transmit the portion of the student transcript and student application data to the first database, the first database managed by a higher educational institution, and notifying the first server when the transcript data has been received by the database. In one embodiment, the valid request is verified using student identification information. | 10-30-2008 |
| 20130066798 | TRANSCRIPT, COURSE CATALOG AND FINANCIAL AID APPARATUS, SYSTEMS, AND METHODS - In one aspect the invention relates to a method of automating an application process. The method includes the steps of collecting student identification information using a graphic user interface; collecting student transcript and student application data; generating a first secure communication channel to transmit a portion of the student transcript and student application data to a first server in response to a valid request; formatting the transcript data such that it is suitable for use by a first database; generating a second secure communication channel to transmit the portion of the student transcript and student application data to the first database, the first database managed by a higher educational institution, and notifying the first server when the transcript data has been received by the database. In one embodiment, the valid request is verified using student identification information. | 03-14-2013 |
Brett Simon, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120022338 | APPARATUS, SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM FOR ANALYZING INFORMATION REGARDING CARDIOVASCULAR DISEASES AND FUNCTIONS - According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for determining information regarding a tissue or an object at or within the tissue. For example, with at least one first arrangement which is situated inside a particular organ of the body, it is possible to generate at least one electromagnetic radiation in the tissue, wherein the tissue is different from and outside of the particular organ. The particular signals that are responsive to the at least one electromagnetic radiation can be detected (e.g., possibly with at least one second arrangement), at least one characteristic of the tissue and/or information regarding the object at or in the tissue can be determined (e.g., with the second arrangement(s)). Alternatively or in addition, the tissue can be different from and outside of the particular organ, and the first arrangement(s) can be situated inside a particular organ of the body. To that end, the can include (i) the heart, (ii) major vessels attached to the heart, (iii) coronary artery, and/or (iv) blood therein. | 01-26-2012 |
Christian Simon, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20130064843 | Identification of conserved peptide blocks in homologous polypeptides - Methods for identifying at least one conserved peptide block in three or more homologous polypeptides are provided and compositions comprising conserved peptides are provided. More particularly, methods for selecting conserved peptides in variable viral polypeptides for use in immunogenic compositions are provided. | 03-14-2013 |
Daniel Allen Simon, Gloucester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110265821 | TECHNIQUES FOR MAINTAINING A SUBSTRATE PROCESSING SYSTEM - Techniques and systems for maintaining a plasma processing kit consisting of protection and shielding elements without causing damage are introduced. The elements may be made of aluminium, polysilicon and quartz and may be coated with silicon. The surfaces of the elemants show a specified roughness. Precision cleaning and recovery of the contamined kit components of a plasma doping (PLAD) system is used, to extend the life and reusability of the components. The methods described cover the stages of inspection, pre-cleaning, mechanical processing and texturing, post-cleaning, clean-room class cleaning and packaging of the components consisting of quartz, aluminium and/or silicon. Techniques described employ the combination of a variety of means (primarily chemical and mechanical) to achieve the desired levels of cleanliness. The result obtained by methods that include Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) and Laser Particle Count affirm the efficacy of these techniques. | 11-03-2011 |
Itamar Simon, Brighton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080241822 | GENOME-WIDE LOCATION AND FUNCTION OF DNA BINDING PROTEINS - The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a cell. The genomic DNA to which the DNA binding protein is linked is removed and combined or contacted with DNA comprising a sequence complementary to genomic DNA of the cell under conditions in which hybridization between the identified genomic DNA and the sequence complementary to genomic DNA occurs. Region(s) of hybridization are region(s) of the genome of the cell to which the protein of binds. A method of identifying a set of genes where cell cycle regulator binding correlates with gene expression and of identifying genomic targets of cell cycle transcription activators in living cells is also encompassed. | 10-02-2008 |
Jerome H. Simon, Newton Centre, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090323356 | ILLUMINATING DEVICES USING SMALL PT SOURCES INCLUDING LEDS - In one form, there is a luminaire for providing uniform color and brightness from multiple small light sources, which includes a shallow plate of transparent material having a first surface which is substantially flat, and a second surface which includes patterned planes acutely disposed to the first surface. Each second surface is adjacent to an entry face into which light from the multiple small light sources is projected into the plane. | 12-31-2009 |
| 20100079995 | LUMINAIRES AND OPTICS FOR CONTROL AND DISTRIBUTION OF MULTIPLE QUASI POINT SOURCE LIGHT SOURCES SUCH AS LEDS - A light projection device of a stack of at least 2 LED light projection modules. Each module shares a common optical axis and each includes an LED at least partially surrounded by an off-axis collimating optic and each projects a radially collimated canted beam towards and onto. There is a refracting plate for redirecting and changing the angle in respect to the optical axis of at least one of the radially collimated canted beams. | 04-01-2010 |
Jerome H. Simon, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080285272 | Heat sinks and other thermal management for solid state devices and modular solid state - A luminaire module comprising an LED on an optical axis, thermally mounted to a heat sink, said heat sink comprising openings for which air can circulate; said opening of each portion offset from each other so that light emanating from said LED can pass through the holes from one said portion, said light blocked by the solid area of the other portion. | 11-20-2008 |
| 20090147511 | Lumenairs Having Structurally and Electrically Integrated Arrangements of Quasi Point Light Sources, Such as LEDS - A lumenaire system for providing varied types of illumination having a structural frame with hubs disposed in a spatial configuration and joining members providing structure and stability between said hubs. There are quasi point light sources mounted at specific points on the structural frame for providing a radiant illumination from said lumenaire system and an optical system for distributing the radiant illumination as a specific light pattern. | 06-11-2009 |
| 20090213616 | CO-FUNCTIONAL MULTI-LIGHT SOURCE LUMENAIRES AND COMPONENTS THEREOF - A lumenaire system for providing illumination by distributing and mixing light from multiple sources of illumination which includes a first light source providing Lambertian light radiation and a second light source providing collimated illumination. There is a prismatic light guide structure having at least two functions, the first function being to refract the light radiation from the first light source disposed as to at least partially surround the light source, and the second function is to guide and distribute light from the second light source so as to mix it with light from the first light source. | 08-27-2009 |
| 20100036493 | MAGNETIC CUSHIONING DEVICES - A cushioning device that when implanted provides mobility and wear resisting cushioning to joints within a human body, provides a first component at least in part comprising at least one magnet, a second component at least in part comprising at least one magnet, the magnetic poles of said magnet of said first component, and the magnetic poles of said magnet of said second component, so disposed as to create a repelling force between said first and second components and therefore an opposing movement away from each other, and a third component comprising a magnetically attractable material disposed between said first and second components towards which said corresponding magnets are attracted, said attracting forces balancing and controlling said same repelling force so as to maintain said movement of said first and second components within said predetermined planar degree of freedom. | 02-11-2010 |
| 20100091492 | LUMINAIRES USING MULTIPLE QUASI-POINT SOURCES FOR UNIFIED RADIALLY DISTRIBUTED ILLUMINATION - A luminaire for providing broad uniform surface illumination and sharp cutoff which has at least one quasi point light source, such as an LED, located on an optical axis. There is at least one collimating ring lens which, at least partially surrounds the quasi point light source. The collimating ring projects a radial collimated beam and there is at least one reflective ring, at least partially surrounding the collimating ring lens. The reflecting ring reflects and redirects the collimated radial beam as a canted radial beam through the optical axis. In another embodiment at least one off axis collimating ring lens at least partially surrounds at least one quasi point light source, and projects a canted radial beam away from the optical axis. There is at least one ring reflector which at least partially surrounds the optical axis and is positioned to reflect the canted radial beam toward and through the optical axis. In a further embodiment, at least one linearly collecting reflector at least partially surrounds the quasi point light source and the reflector projects a linear beam onto a substantially conical reflector which redirects the linear beam into a radially directed beam. | 04-15-2010 |
| 20110170291 | EFFICIENT AND UNIFORMLY DISTRIBUTED ILLUMINATION FROM MULTIPLE SOURCE LUMINAIRIES - Light projecting luminaires and devices for integrating the light output from multiple light emitting quasi point sources into unified predetermined light patterns. The multiple light emitting quasi point sources are generally stacked with a common optical axis, each o the light emitting quasi point light sources further surrounded by a ring collimator designed to collect and project a radial beam of light away from the optical axis. The ring collimator can be a canted off axis ring lens that projects a canted radial beam away from the axi A series of individual collimators can form a multibeam collimator surrounding each of the light emitting sources and substituting for the ring collimator forming an array of beams projected away from the optical axis. Either of the systems may use reflecting surfaces to intercept and redirect the radiating collimated light into distribution patterns ranging from focused beams to ambient broad light distribution. | 07-14-2011 |
| 20120033418 | LUMINAIRES USING MULTIPLE QUASI-POINT SOURCES FOR UNIFIED RADIALLY DISTRIBUTED ILLUMINATION - A luminaire for providing broad uniform surface illumination and sharp cutoff which has at least one quasi point light source, such as an LED, located on an optical axis. There is at least one collimating ring lens which, at least partially surrounds the quasi point light source. The collimating ring projects a radial collimated beam and there is at least one reflective ring, at least partially surrounding the collimating ring lens. The reflecting ring reflects and redirects the collimated radial beam as a canted radial beam through the optical axis. In another embodiment at least one off axis collimating ring lens at least partially surrounds at least one quasi point light source, and projects a canted radial beam away from the optical axis. There is at least one ring reflector which at least partially surrounds the optical axis and is positioned to reflect the canted radial beam toward and through the optical axis. In a further embodiment, at least one linearly collecting reflector at least partially surrounds the quasi point light source and the reflector projects a linear beam onto a substantially conical reflector which redirects the linear beam into a radially directed beam. | 02-09-2012 |
Jesse Simon, Jamaica Plain, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090062886 | SYSTEMS AND METHODS FOR DELIVERING ELECTRICAL ENERGY IN THE BODY - Small implantable magnetostrictive-electroactive (ME) device for delivering electrical energy to surrounding tissue. The wireless ME device is activated by a changing magnetic field from an externally applied alternating magnetic field source. The ME device provides a means for stimulating a nerve, tissue or internal organ with direct electrical current, such as relatively low-level direct current for temporary or as needed therapy. The field source (e.g. small coil antenna) may be a hand-held device or affixed to the wearer's skin, clothing or accessories. The ME implant may be configured as pellets which are small enough to be implanted through a surgical needle. In one embodiment, the wireless energy transmission system can be used for stimulating bone growth. | 03-05-2009 |
| 20100015918 | WIRELESS TRANSFER OF INFORMATION USING MAGNETO-ELECTRIC DEVICES - Apparatus and method for wireless near-field magnetic communication (NFMC) of information (e.g., voice or data) over modest distances (centimeters to a few kilometers). The transmission can proceed from an inductive coil transmitter to a magneto-electric (ME) receiving device, or between two ME devices. Electrical power may also be transmitted from and/or received using the same device. In one case, power and data are transmitted from an induction coil to a distant ME device that collects power and transmits data back to the power-transmission coil. In another case, the wireless transfer of data can be carried out between two ME devices. ME devices can be engineered to transmit or receive data and to receive electric power over a variety of frequencies by changing their dimensions, their material makeup and configuration, electrode configurations, and/or their resonance modes (longitudinal, transversal, bending, shear etc). Data rates up to and above several kilo-bits/s are possible using these methods with no limits on the frequency and duration of the communication. | 01-21-2010 |
Jesse M. Simon, Somerville, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110190849 | NEURAL STIMULATION DEVICES AND SYSTEMS FOR TREATMENT OF CHRONIC INFLAMMATION - A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (<10 minutes per week) charge an implanted microstimulator. The external controller may be configured as a prescription pad that controls the dosing and activity of the microstimulator. | 08-04-2011 |
John B. Simon, Springfield, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110089135 | LASER MODIFIED PLASTIC CONTAINER - A polyethylene terephthalate container having a laser-formed area, wherein the laser-formed area is modified in response to radiation energy. In some embodiments, the laser-formed area of the container permitting localized contouring to permit or otherwise generally prevent flexural response to vacuum and/or loading forces. In some embodiments, the laser-formed area of the container comprises visible indicia formed to permit labeless containers. | 04-21-2011 |
| 20110186538 | HOT-FILL CONTAINER HAVING FLAT PANELS - A container may employ an upper portion defining a mouth, a shoulder portion formed with the upper portion and extending away from the upper portion, a bottom portion forming a base, a sidewall extending between and joining the shoulder portion and the bottom portion, and a plurality of smooth surfaced vacuum panels formed in the sidewall, which may be separated by one or more strengthening grooves. The vacuum panels and/or the container in a profile view may form an hourglass shape. The container may also employ a sidewall utilizing three smooth, grooveless, vacuum panels, which may form a triangle in cross-section. The vacuum panels may be concave inward toward a central vertical axis of the container and have an hourglass shape when the container is viewed in a side view. | 08-04-2011 |
John W. Simon, Westborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080293788 | Methods and Compositions for the Treatment of Pulmonary Diseases - This invention related to methods of treating, preventing and managing various pulmonary diseases or disorders using formoterol in combination with calcium activated potassium channel openers. Pharmaceutical compositions comprising formoterol and calcium activated potassium channel openers are also disclosed. | 11-27-2008 |
| 20090035224 | Methods of Using Albuterol and Calcium Activated Potassium Channel Openers - This invention related to methods of treating, preventing and managing various pulmonary or respiratory diseases or disorders using albuterol in combination with calcium activated potassium channel openers. Pharmaceuticals compositions comprising albuterol and calcium activated potassium channel openers are also disclosed. | 02-05-2009 |
Kenneth Simon, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100093980 | Methods of Humanizing Immunoglobulin Variable Regions Through Rational Modification Of Complementarity Determining Residues - The present invention is based, at least in part, on the discovery that strategic modifications of non-human donor antibody CDR residue(s) can be used to humanize antibodies. Such modifications modulate the 3D structural fit between donor antibody CDRs and human acceptor antibody framework regions that comprise the variable domains of a CDR-grafted antibody. Whereas prior art methods of humanization have relied on making framework substitutions (in which selected human framework residues are backmutated to the corresponding amino acid residue present in the non-human donor antibody), the instant invention is based, at least in part, on a method of humanizing antibodies in which selected CDR residues, and optionally adjacent FR residues, are changed in order to accommodate differences in FR amino acid sequences between donor and acceptor antibodies. | 04-15-2010 |
Kenneth J. Simon, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080286269 | Anti-alpha(v)beta(6) antibodies and uses thereof - The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize α | 11-20-2008 |
| 20090186036 | Anti-Alpha V Beta 6 Antibodies - Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having O06-mediated diseases, or to diagnose % Qmediated diseases. | 07-23-2009 |
| 20110305629 | Anti-Alpha v Beta 6 Antibodies and Uses Thereof - The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize α | 12-15-2011 |
| 20120251532 | ANTI-ALPHA V BETA 6 ANTIBODIES - Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Qmediated diseases. | 10-04-2012 |
| 20130022961 | ASSAY FOR JC VIRUS ANTIBODIES - The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject. | 01-24-2013 |
Mark M. Simon, Wilbraham, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120315209 | METHODS AND SYSTEMS FOR TREATING WATER STREAMS - Methods and systems for treating wastewater and process water streams are provided. In some embodiments, the wastewater and/or process water to be treated contains a target chemical (e.g., ammonia and/or ammonium). The methods and systems described herein may include recovering the target chemical from the water stream and/or producing a desired product (e.g., a fertilizer such as an ammonium salt) from the target chemical. In one set of embodiments, a method of treating wastewater and/or process water involves introducing the water stream into a system that includes a combination of two or more of, or all of, a reverse osmosis system, a reaction and separation system (e.g., a vacuum distillation system or other suitable separation system), and a membrane reactor system. | 12-13-2012 |
Matthew Simon, East Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120040857 | ISOLATION OF FACTORS THAT ASSOCIATE DIRECTLY OR INDIRECTLY WITH CHROMATIN - Methods for isolating non-coding nucleic acids that are associated with chromatin at a target genomic locus are provided. The methods comprise the steps of obtaining a sample that comprises a target genomic DNA sequence and one or more non-coding nucleic acids associated with that DNA sequence; contacting the sample with at least one oligonucleotide probe that comprises a sequence that is complimentary to and capable of hybridising with at least a portion of the target DNA sequence, wherein the oligonucleotide probe comprises at least one modified nucleotide analogue and wherein the oligonucleotide probe further comprises at least one affinity label; allowing the at least one oligonucleotide probe and the target DNA sequence to hybridise with each other so as to form a probe-target hybrid; isolating the probe-target hybrid from the sample by immobilizing the probe-target hybrid through a molecule that binds to the at least one affinity label; and eluting the one or more non-coding nucleic acids that are associated with the target genomic DNA sequence. Also provided are probes suitable for use in the methods of the invention. The methods and probes of the invention are suited to identification of non-coding RNAs including microRNAs and snoRNAs that are associated with chromatin remodelling. | 02-16-2012 |
Matthew D. Simon, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080199964 | SITE-SPECIFIC INSTALLATION OF METHYL-LYSINE ANALOGUES INTO RECOMBINANT HISTONES - The present invention provides reagents and methods for the introduction of analogues of methyl or acetyl lysine into histone proteins. | 08-21-2008 |
Thomas D. Simon, Marlborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080266017 | CONTROLLING COUPLING STRENGTH IN ELECTROMAGNETIC BUS COUPLING - A controller sends signals to an electromagnetic coupler associated with a bus. The signals are arranged to set a coupling strength of the coupler. | 10-30-2008 |