Silver, MD
Bruce A. Silver, Dunkirk, MD US
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20130109709 | METHODS OF TREATING A BRUTON'S TYROSINE KINASE DISEASE OR DISORDER | 05-02-2013 |
Jason Silver, Ellicott City, MD US
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20120059731 | Method to Facilitate Electronic Commerce Between Buyers and Sellers Using a Buyer-Initiated System - This invention is a method of brokering a relationship between buyers and sellers via electronic means by way of an intermediary facilitating this relationship. Potential buyers of goods or services relay their requirements and desired range of pricing for a good or service to an aggregator. A potential buyer's personal contact information is hidden from any seller that would be interested in selling a buyer the requested good or service. Sellers have the option of searching a list of willing buyers of goods or services or may have this list sent to them electronically. Additionally, the requirements of buyers may be proactively used to search seller websites or databases via a web crawler. A brokerage fee to an aggregator is all that is required for a seller to gain access to a buyer via proxy. This method does not bind buyers to sellers. It allows a buyer to set a pre-determined price range based on his requirements for a good or service and a seller to make an initial connection with a buyer based on these needs. Should a buyer transact with seller, the buyer is incentivized to report the sale to the intermediary such that an additional transaction fee may be charged by the aggregator. | 03-08-2012 |
Jonathan Silver, Bethesda, MD US
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20140329305 | DEVICES, METHODS, AND SYSTEMS FOR NUCLEIC ACID AMPLIFICATION - A microfluidic device comprising a first surface portion and a first sample retaining element, which have differing affinities to a fluid, and a method comprising supplying a sample to such a device. In some embodiments, the differing affinity is a result of plasma, ion embedding, surface charging, chemical, optical, electronic and/or electromagnetic treatment. Also, a microfluidic device comprising at least one microcapillary device having a sample retaining element, at least one surface of which exhibits hydrophobicity, hydrophilicity, electromagnetic force exertion and electrostatic force exertion. Also, a microfluidic device comprising a first element having a hydrophilic pattern comprising at least a first sample retaining element. Also, a method comprising supplying a sample to a channel between a first element and a second element, and inducing in the first element at least one hydrophilic pattern by electrets or by internal or external electrodes to provide a charged surface. | 11-06-2014 |
Jonathan E. Silver, Bethesda, MD US
Patent application number | Description | Published |
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20080213766 | METHOD AND DEVICE FOR DETECTING THE PRESENCE OF A SINGLE TARGET NUCLEIC ACID IN SAMPLES - A method comprising for each individual sample of a plurality of samples, loading at least one sample portion of the individual sample into at least one respective sample chamber of a plurality of sample chambers, subjecting the sample portions to at least a first amplification step; and then determining whether sample portions contain at least one molecule of the target nucleic acid. For each sample portion, if the sample portion contains at least a single molecule of the target nucleic acid, the sample portion would attain a detectable concentration of the target nucleic acid after a single round of amplification. | 09-04-2008 |
20090035759 | METHOD AND DEVICE FOR DETECTING THE PRESENCE OF A SINGLE TARGET NUCLEIC ACID IN A SAMPLE - A method comprises loading a sample portion into a sample chamber which comprises means for minimizing diffusion of the sample portion, subjecting the sample portion to an amplification step, and determining whether the sample portion contains at least one molecule of a target nucleic acid. If the sample portion contains a single molecule of the target nucleic acid, the sample portion would attain a detectable concentration of the target nucleic acid after a single round of amplification. Also, a microfluidic device comprising a sample portion and a sample chamber comprising means for minimizing diffusion of the sample portion. Also, a microfluidic device comprising a sample chamber and an amplification targeting reagent positioned in the first sample chamber. | 02-05-2009 |
20120063972 | DEVICE HAVING REGIONS OF DIFFERING AFFINITIES TO FLUID, METHODS OF MAKING SUCH DEVICES, AND METHODS OF USING SUCH DEVICES - A microfluidic device comprising a first surface portion and a first sample retaining element, which have differing affinities to a fluid, and a method comprising supplying a sample to such a device. In some embodiments, the differing affinity is a result of plasma, ion embedding, surface charging, chemical, optical, electronic and/or electromagnetic treatment. Also, a microfluidic device comprising at least one microcapillary device having a sample retaining element, at least one surface of which exhibits hydrophobicity, hydrophilicity, electromagnetic force exertion and electrostatic force exertion. Also, a microfluidic device comprising a first element having a hydrophilic pattern comprising at least a first sample retaining element. Also, a method comprising supplying a sample to a channel between a first element and a second element, and inducing in the first element at least one hydrophilic pattern by electrets or by internal or external electrodes to provide a charged surface. | 03-15-2012 |
20120301884 | METHOD AND DEVICE FOR DETECTING THE PRESENCE OF A SINGLE TARGET NUCLEIC ACID IN A SAMPLE - A method comprising subjecting one or more sample portion(s) to a single amplification step, thereby amplifying a single molecule in the sample portion to a detectable level, and, in some embodiments, then determining whether the sample portion contains at least one molecule of the target nucleic acid. In some embodiments, the sample portion is in a porous sample structure, or in a sample chamber which comprises means for minimizing diffusion of the sample portion, or in a sample chamber which is inside a microcapillary device, or in a sample retaining means. | 11-29-2012 |
20130143218 | DEVICE FOR AMPLIFYING TARGET NUCLEIC ACID - A device for amplifying a target nucleic acid in a sample containing one or more target nucleic acids may include a substrate assembly comprising a flow channel and an inlet, wherein the inlet is in flow communication with the flow channel and is configured to introduce sample containing one or more target nucleic acids into the flow channel. The device may further include a plurality of moieties disposed at inner surface regions of the flow channel along at least a portion of a length of the flow channel, each of the plurality of moieties being sufficient to respectively hybridize to the one or more target nucleic acids in the sample to facilitate amplification of the one or more target nucleic acids when hybridized. The device is further configured to retain amplified product of the one or more hybridized target nucleic acids at discrete locations proximate the inner surface regions after amplification. | 06-06-2013 |
20150017709 | METHOD FOR DETECTING THE PRESENCE OF A TARGET NUCLEIC ACID SEQUENCE IN A SAMPLE - A method comprises loading a sample portion into a sample chamber which comprises means for minimizing diffusion of the sample portion, subjecting the sample portion to an amplification step, and determining whether the sample portion contains at least one molecule of a target nucleic acid. If the sample portion contains a single molecule of the target nucleic acid, the sample portion would attain a detectable concentration of the target nucleic acid after a single round of amplification. Also, a microfluidic device comprising a sample portion and a sample chamber comprising means for minimizing diffusion of the sample portion. Also, a microfluidic device comprising a sample chamber and an amplification targeting reagent positioned in the first sample chamber. | 01-15-2015 |
Ken Silver, Pikesville, MD US
Patent application number | Description | Published |
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20120136284 | ACTIVE HAND-EXTENSION/FLEXION DEVICE - A hand movement device comprises a glove for positioning about a hand of a user, a first anchor element adapted to be positioned about a base surface of glove, a second anchor element adapted to be positioned at a tip of a finger portion of the glove, an active spring member positioned between the first and second anchor elements, said active spring member being fixedly secured to said first anchor element and moveable through said second anchor element to thereby allow said spring member to bend about a joint of the finger when said finger is flexed, an activating element positioned adjacent the active spring member to heat or cool said active spring member thereby causing the spring member to bend or straighten, and an intermediary support device for housing said spring element and for connecting the first anchor element to said second anchor element. | 05-31-2012 |
Phyllis Silver, Silver Spring, MD US
Patent application number | Description | Published |
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20080199460 | Use of IL-23 and IL-17 antagonists to treat autoimmune ocular inflammatory disease - Novel methods and drug products for treating autoimmune ocular inflammatory disease are disclosed, which involve administration of agents that antagonize one or both of IL-17 and IL-23 activity. | 08-21-2008 |
20100111950 | USE OF IL-23 AND IL-17 ANTAGONISTS TO TREAT AUTOIMMUNE OCULAR INFLAMMATORY DISEASE - Novel methods and drug products for treating autoimmune ocular inflammatory disease are disclosed, which involve administration of agents that antagonize one or both of IL-17 and IL-23 activity. | 05-06-2010 |
20100111954 | USE OF IL-23 AND IL-17 ANTAGONISTS TO TREAT AUTOIMMUNE OCULAR INFLAMMATORY DISEASE - Novel methods and drug products for treating autoimmune ocular inflammatory disease are disclosed, which involve administration of agents that antagonize one or both of IL-17 and IL-23 activity. | 05-06-2010 |
20110142831 | USE OF IL-23 AND IL-17 ANTAGONISTS TO TREAT AUTOIMMUNE OCULAR INFLAMMATORY DISEASE - Novel methods and drug products for treating autoimmune ocular inflammatory disease are disclosed, which involve administration of agents that antagonize one or both of IL-17 and IL-23 activity. | 06-16-2011 |
20130323251 | USE OF IL-23 AND IL-17 ANTAGONISTS TO TREAT AUTOIMMUNE OCULAR INFLAMMATORY DISEASE - Novel methods and drug products for treating autoimmune ocular inflammatory disease are disclosed, which involve administration of agents that antagonize one or both of IL-17 and IL-23 activity. | 12-05-2013 |
20140248279 | USE OF IL-23 AND IL-17 ANTIAGONISTS TO TREAT AUTOIMMUNE OCULAR INFLAMMATORY DISEASE - Novel methods and drug products for treating autoimmune ocular inflammatory disease are disclosed, which involve administration of agents that antagonize one or both of IL-17 and IL-23 activity. | 09-04-2014 |
Richard M. Silver, Derwood, MD US
Patent application number | Description | Published |
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20090109446 | Zeroeth Order Imaging - A method of imaging critical dimensions by measuring the zeroeth order of diffracted light. The method involves providing a target, directing light onto the target so as to cause the target to diffract the light. The zeroeth order of the diffracted light is collected and analyzed to determine structural features of the target. The target can be an article of manufacture, such as a semiconductor device, or a separate target that is provided or fabricated on an article of manufacture. One of at least the wavelength and the angle at which the light is directed onto the target can be scanned. The target can fill all or only a portion of the field of view. | 04-30-2009 |
Scott Silver, Annapolis, MD US
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20090173055 | COMPOSITE COTTON AND POLYESTER YARN AND METHOD FOR MAKING SAME - A composite polyester and cotton yarn is formed by blending polyester fibers with cotton fibers which have been regenerated from waste cotton material such as trimmings and cuttings from the apparel manufacturing industry. The fibers are cleaned and blended, then carded to align the fibers into strands. Depending on the size and texture of the desired yarn, the fibers are stretched and drawn into slivers prior to spinning to join the fibers together. The polyester fibers are preferably recycled polyethylene terephthalate fibers which are up to three time longer than the regenerated cotton fibers, so that the polyethylene terephthalate fibers overlap and braid onto the regenerated cotton fibers during spinning. The resultant yarn is stronger and more absorbent than yarns made solely out of regenerated cotton fibers. The yarn is suitable for producing woven or knit fabric for the production of colorful and functional clothing and home textiles without the need for further bleaching or dyeing. | 07-09-2009 |
Scott H. Silver, Annapolis, MD US
Patent application number | Description | Published |
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20090173054 | COMPOSITE COTTON AND HEMP YARN AND METHOD FOR MAKING THE SAME - A composite hemp and cotton yarn is formed by blending hemp fibers with cotton fibers which have been regenerated from waste cotton material such as trimmings and cuttings from the apparel manufacturing industry. The fibers are cleaned and blended, then carded to align the fibers into strands. Depending on the size and texture of the desired yarn, the fibers are stretched and drawn into slivers prior to spinning to join the fibers together. The hemp fibers are up to three time longer than the regenerated cotton fibers, so that the hemp fibers overlap and braid onto the regenerated cotton fibers during spinning. The resultant yarn is stronger and more absorbent than yarns made solely out of regenerated cotton fibers or a blend of cotton and acrylic or cotton and polyester fibers. | 07-09-2009 |
20090293443 | COMPOSITE REGENERATED COTTON AND BAST FIBER YARN AND METHOD FOR MAKING THE SAME - A composite bast fiber and cotton yarn is formed by blending natural bast fibers with cotton fibers which have been regenerated from waste cotton material such as trimmings and cuttings from the apparel manufacturing industry. The regenerated cotton and bast fibers are cleaned and blended, then carded to align the fibers into strands. Depending on the size and texture of the desired yarn, the fibers are stretched and drawn into slivers prior to spinning to join the fibers together. The natural bast fibers are up to two and one half to three time longer than the regenerated cotton fibers, so that the natural bast fibers overlap and braid onto the regenerated cotton fibers during spinning. The resultant yarn is stronger and more absorbent than yarns made solely out of regenerated cotton fibers, a blend of regenerated cotton and acrylic fibers, or regenerated cotton and polyester fibers currently available. | 12-03-2009 |