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| 20090093703 | Method of Assessing Vascular Reactivity Using Magnetic Resonance Imaging, Applications Program and Media Embodying Same - Featured are methods for non-invasive assessment of vascular reactivity. The methods of the invention use phase contrast magnetic resonance imaging angiography and use the image data thereby acquired to measure shear rate, radius of the vasculature and flow through the vasculature. According to one aspect, such acquisition of image data occurs before and during, an arterial occlusion and according to another aspect such acquisition of image data occurs before during and after arterial occlusion. The disclosed methods of the invention allow for reproducible, non-invasive diagnosis of early stage indicators of atherosclerosis. | 04-09-2009 |
| 20110245691 | NON-INVASIVE METHODS AND SYSTEMS FOR ASSESSING CARDIAC FILING PRESSURE - Featured are methods and systems for assessing cardiac filing pressure non-invasively. Such methods include, inter alia, arranging a photoplethysmography (PPG) transducer on a finger of a patient and fluidly coupling a pressure transducer to the patient's mouth so that the pressure transducer measures expiratory pressure. The PPG transducer provides an output of a pulse volume signal of cardiac circulatory flow. Such methods also including determining a pulse amplitude ratio, using the pulse volume near the end of the expiratory effort and a baseline pulse volume, and assessing the pulse amplitude ratio so as to determine a filing pressure condition for the heart of the patient. | 10-06-2011 |
| 20120123240 | Method of Assessing Central Arterial Stiffness Using Mri, Method of Assessing Vascular Function Including Arterial Stiffness, Applications Program and Media Embodying Same - Featured are methods for non-invasive assessment of a vascular physiological parameter including but not limited to central arterial stiffness, vascular reactivity and/or local arterial stiffness. The methods of the invention use any one of a number of magnetic resonance imaging techniques known in the art to acquire image data so as to arrive at these vascular physiological parameters. Also such methods include locating the detector or imaging coil proximal to a single artery and external to the body/specimen. According to one aspect, the methodology determines the central arterial stiffness from image data acquired at the single arterial location. In another aspect, image data is acquired so that one or more of central arterial stiffness, vascular reactivity and/or local arterial stiffness can be determined from the acquired image data alone or in combination with other acquired data/information. The disclosed methods of the invention allow for reproducible, non-invasive diagnosis of early stage indicators of atherosclerosis. | 05-17-2012 |
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| 20090043893 | Multiple Resource Control-Advisor for Management of Distributed or Web-Based Systems - A system and method are provided for autonomic system management in a computing system containing system resources including network resources and multiple resource demands, or processes. The computing system may be a stream-processing system or other real-time computer management system, such as workload management, or a virtualization engine. The system and method enables achieving a better level of performance than would occur in the computing system using only existing mechanism. It permits, with very low computational overhead, achieving or driving the system closer to a user-defined system performance objective. To do so, a system performance equation is defined to determine a level of performance of the system as a function of the allocation of two or more system resources among a plurality of system resource demands or processes. From this system performance equation, a plurality of resource-specific change equations is derived. Each resource-specific change equation is capable of calculating changes in the level of performance of the system attributable to changes in the allocation of one of the system resources. The resource-specific change equation yielding the greatest change in the level of system performance at a given allocation of all of the system resources and the system resource associated with the identified resource-specific change equation are identified. The allocation of the identified associated system resource to at least one system resource demand to provide the largest increase in the level of performance of the system, and allocations for all system resources are adjusted in accordance with the modified allocation of the identified associated system resource. | 02-12-2009 |
| 20110016108 | SEARCH RESULT PLUSBOX INCLUDING RESTRICTED RESULTS - Systems, methods and computer program products for generating initial search results based on a search query and additional search results using a control element are described. The control element, when activated by a user of a client device, may execute a call to a server which fetches the additional results to the client device. Alternatively, the additional results may be pre-populated and displayed only when the control element is activated. In some implementations, the additional results may include results that are from the same source as the initial search results. | 01-20-2011 |
| 20110137933 | RESOURCE SEARCH OPERATIONS - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for identifying query-relevant content in a resource identified by a search result in response to the query. In one aspect, a method includes identifying resource search tidbits for a resource, each resource search tidbit being eligible for a resource search operation for the resource. The resource search tidbits are provided with search results to a client device. In response to a user selecting a resource identified by a search result, the client device identifies text in the resource matching the query-relevant text of the resource search tidbit and performs a resource search operation on the resource if the identified text meets a search operation threshold condition. | 06-09-2011 |
| 20110276562 | VISUALIZING SITE STRUCTURE AND ENABLING SITE NAVIGATION FOR A SEARCH RESULT OR LINKED PAGE - Methods, systems, and apparatus, including computer program products, for attaching a visual representation of hierarchical data associated with a resource identified by a search system to the resource. The resource and hierarchical data can be presented to a user as a search result. In some implementations, breadcrumbs that describe a traversal path toward a starting or entry page associated with the resource can represent the hierarchical data. | 11-10-2011 |
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| 20080239947 | METHOD AND APPARATUS FOR FAILURE RESILIENT FORWARDING OF DATA OVER A COMPUTER NETWORK - In one embodiment, the present invention is a method and an apparatus for failure-resilient forwarding of data over a computer network. In one embodiment, a marker is introduced into the data stream, e.g., at the sending node, and allows, in turn, forwarding nodes and/or receivers to efficiently track data stream reception. The marker functions as a checkpoint for the data transport process, and is identified and indexed at each forwarding node and receiver. Each receiver saves the marker prior to delivering data to an application, thereby designating a point in the data stream at which all preceding data is confirmed to have been delivered to the application. Thus, if a forwarding node fails, the receiver may request stream data from an alternate forwarding node by specifying to the alternate forwarding node to provide data starting from the marker. | 10-02-2008 |
| 20090175164 | METHOD AND APPARATUS FOR FAILURE RESILIENT FORWARDING OF DATA OVER A COMPUTER NETWORK - In one embodiment, the present invention is a method and an apparatus for failure-resilient forwarding of data over a computer network. In one embodiment, a marker is introduced into the data stream, e.g., at the sending node, and allows, in turn, forwarding nodes and/or receivers to efficiently track data stream reception. The marker functions as a checkpoint for the data transport process, and is identified and indexed at each forwarding node and receiver. Each receiver saves the marker prior to delivering data to an application, thereby designating a point in the data stream at which all preceding data is confirmed to have been delivered to the application. Thus, if a forwarding node fails, the receiver may request stream data from an alternate forwarding node by specifying to the alternate forwarding node to provide data starting from the marker. | 07-09-2009 |
| 20090313400 | DYNAMIC STABILIZATION FOR A STREAM PROCESSING SYSTEM - Disclosed are a method, upstream processing node, and computer readable medium for dynamically stabilizing a stream processing system. The method includes receiving at least one computing resource allocation target. The method further includes determining that an input data flow rate of at least one upstream processing element varies. The computing resource is dynamically allocated to the upstream processing element in response to the input rate of the upstream processing element varying. Data flow is dynamically controlled between the upstream processing element and at least one downstream processing element. | 12-17-2009 |
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| 20080274535 | Hepatocyte Bioreactor System For Long Term Culture of Functional Hepatocyte Spheroids - A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate-metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible. | 11-06-2008 |
| 20080286759 | Hepatocyte Bioreactor System For Long Term Culture of Functional Hepatocyte Spheroids - A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible. | 11-20-2008 |
| 20100035298 | Hepatocyte Bioreactor System For Long Term Culture of Functional Hepatocyte Spheroids - A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible. | 02-11-2010 |
