Siena
Emilio Siena, Colle Val D'Elsa IT
Patent application number | Description | Published |
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20120070457 | Polypeptides from neisseria meningitidis - Polypeptides comprising | 03-22-2012 |
Matthew J. Siena, Portland, CT US
Patent application number | Description | Published |
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20100212079 | Universal flush valve kit and method of using - An adapter cup for use in a multi-piece valve assembly, a universal flush valve assembly kit and a method of installing in a flush tank with a discharge hole. The kit has a first adapter cup, an additional adapter cup and a main body valve fitting. The adapter cups have substantially identical upper rims that are configured for attachment to the main body valve fitting. Each adapter cup has a lower cylindrical portion with a different outer diameter than that of the other adapter cup. The lower portion of one of the adapter cups is inserted into a discharge hole of like or substantially similar diameter. The main body fitting with an inlet and outlet is attached to the rim of the inserted adapter cup. A flapper is swingable relative to the main body fitting from a closed position abutting the outlet to an open position raised from the inlet. A single flush tank valve assembly can be installed into toilet tanks with different sized discharge holes. | 08-26-2010 |
20110126348 | SINGLE-PIECE HIGH RATE FLUSH VALVE ASSEMBLY - A single-piece flush valve assembly for increasing the flush rate out of a discharge hole in a tank. The kit has an upper portion with an upper cylindrical wall defining an upper bore and a lower portion with a lower cylindrical wall defining a lower bore. The lower bore is smaller than the upper bore. The upper portion defines an inlet and the lower portion defines an outlet. The upper and lower bores are fluidly connected and collectively define a discharge conduit that extends from the inlet to the outlet. The lower portion is inserted into a discharge hole of like or substantially similar diameter. A flapper is swingable relative to the valve assembly from a closed position abutting the inlet to an open position raised from the inlet. The upper bore of greater relative diameter to the lower bore increases the rate of flow out the discharge hole. | 06-02-2011 |
20110138527 | UNIVERSAL DRAIN STOPPING DEVICE WITH ENLARGED STOPPER - A universal drain stopping device with enlarged stopper is installable in drains having different sized central threaded bores. A stopping assembly with a stopper and hollow shaft is removably engageable with a reversible stem. The stopping assembly and stem are axially reciprocable relative to each other when engaged. The reversible stem has opposite threaded ends having different sizes. The device is installable into a drain by threaded mating of one end of the stem with the central threaded bore of the drain. The stem can be axially reversed for installation into another drain with a different sized threaded bore. The stopper has a diameter that is greater than the outer diameter of the drain in which the device is installed. | 06-16-2011 |
Salvatore Siena, Mailand IT
Patent application number | Description | Published |
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20090269344 | Anti-EGFR antibody therapy based on an increased copy number of the EGFR gene in tumor tissues - The invention relates to an indidualized and personalized diagnosis and therapy of cancer based on specific molecular alterations which occur in specific tumor tissue of specific tumor patient populations. The therapy and diagnostic is based on the findings that proliferation and tumor growth of specific EGFR bearing tumor tissue expressing an amplified EGFR gene copy number may be abolished by anti-EGFR antibodies, while other individual molecular alterations such as mutations occurring in tumor tissues are unaffected by the same anti-EGFR antibody treatment. | 10-29-2009 |
Salvatore Siena, Milan IT
Patent application number | Description | Published |
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20090075267 | K-ras and B-raf mutations and anti-EGFr antibody therapy - The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to B-raf mutations, to polynucleotides encoding mutant B-raf polypeptides, to vectors containing those polynucleotides, and to methods of identifying B-raf mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors. | 03-19-2009 |
20110212456 | K-ras and B-raf mutations and anti-EGFr antibody therapy - The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to B-raf mutations, to polynucleotides encoding mutant B-raf polypeptides, to vectors containing those polynucleotides, and to methods of identifying B-raf mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors. | 09-01-2011 |
20140134158 | KRAS MUTATIONS AND RESISTANCE TO ANTI-EGFR TREATMENT - The disclosure provides compositions and methods for detecting and predicting acquired resistance to anti-EGFR treatment in colorectal cancers. Also provided are compositions and methods of preventing, reversing or delaying the acquired resistance. The present disclosure also provides kits for use in the methods described herein. | 05-15-2014 |