Patent application number | Description | Published |
20080266440 | PREDICTIVE AUTOFOCUSING - A method of autofocusing includes capturing first, second and third images of a sample, at respective first, second and third sample distances and respective first, second and third lateral positions determined with respect to an objective; determining a quantitative characteristic for the first, second and third images; determining a primary sample distance based upon at least the quantitative characteristics for the first, second, and third images; and capturing a primary image of the sample at the primary sample distance and at a primary lateral position that is offset from the first, second and third lateral positions. | 10-30-2008 |
20080266652 | MICROSCOPE WITH DUAL IMAGE SENSORS FOR RAPID AUTOFOCUSING - A digital optical microscope includes a primary image sensor that generates a primary image of a sample at a primary frame rate, an auxiliary image sensor that generates an auxiliary image of the sample at an auxiliary frame rate that is faster than the primary frame rate, and a controller that adjusts a focal distance between an objective lens and the sample along an optical axis in response to the auxiliary image, thereby autofocusing the primary image on the sample. The primary image sensor generates the primary image in response to the autofocusing. | 10-30-2008 |
20090073381 | IRIS IMAGING SYSTEM AND METHOD FOR THE SAME - An iris imaging system is provided. The iris imaging system includes at least one light source configured to illuminate an iris at a spectrum of light. The iris imaging system also includes at least one image capturing device including at least one of an indium-gallium-arsenide, lead sulphide, and lead selenide based detector and configured to capture an image of the iris via light reflected from the iris at the spectrum. The device is further configured to provide a signal representing one or more features of the iris in response to the light reflected from the iris. | 03-19-2009 |
20090195688 | System and Method for Enhanced Predictive Autofocusing - In an imaging device having an objective and a stage for holding a sample to be imaged, a method for autofocusing is presented. The method includes determining a measured focus value corresponding to at least a first of a plurality of logical image segments. Further, the method includes imaging the first logical image segment using the measured focus value. The method also includes determining a predicted focus value for a second of the plurality of logical image segments using the measured focus value and a stored focus variation parameter. In addition, the method includes imaging the second logical image segment using the predicted focus value. | 08-06-2009 |
20090236541 | System and Methods for Optical Imaging - The invention relates to imaging methods and systems. The systems may comprise a white light source configured to generate light in a first wavelength range, an excitation source configured to generate light at one or more wavelengths for exciting a fluorescent substance, a first detector configured to acquire reflectance image data that represents white light reflected from a subject, and a second detector configured to acquire fluorescence image data that represents fluorescence emissions from the subject. At least one of the one or more wavelengths generated by the excitation light source is within the first wavelength range of the white light source. The fluorescent substance may be, for example, a fluorescent dye that is injected into a patient before or during a surgery. The system may also include an image processing engine and a display. The image processing engine may receive the reflectance image data and the fluorescence image data and generate a merged image in which the fluorescence image data is superimposed on the reflectance image data. The display may be used by a surgeon, for example, to more effectively visualize the surgical site during surgery. | 09-24-2009 |
20090242797 | SYSTEM AND METHOD FOR MULTI-MODE OPTICAL IMAGING - A technique is provided for multi-mode optical imaging. The technique includes directing a visible light and an excitation light multiplexed in time towards a specimen. The excitation light is configured to induce luminescence in the specimen. The technique also includes detecting visible light scattered or reflected from the specimen and luminescent light emitted via luminescence via a single detector that is in synchronization with the one or more illumination sources. | 10-01-2009 |
20090244521 | SYSTEM AND METHOD FOR MULTI-MODE OPTICAL IMAGING - A technique is provided for multi-mode optical imaging. The technique includes directing a visible light and an excitation light towards a specimen. The excitation light is configured to induce luminescence in the specimen. The technique also includes detecting visible light scattered or reflected from the specimen and luminescent light emitted via luminescence simultaneously via a single detector. | 10-01-2009 |
20090267703 | DYNAMICALLY ADAPTABLE IMPEDANCE MATCHING CIRCUITRY BETWEEN AN ELECTRO-OPTICAL LOAD AND A DRIVING SOURCE - A system including a driving source that supplies an alternating current (AC) electrical signal is provided. At least one electro-optical device is coupled as an electrical load of the driving source. The system further includes an apparatus configured to provide a dynamically adaptable electrical impedance matching between the driving source and the electro-optical load over a frequency range. | 10-29-2009 |
20090290236 | ENDOSCOPE OBJECTIVE LENS WITH LARGE ENTRANCE PUPIL DIAMETER AND HIGH NUMERICAL APERTURE - An endoscope objective lens for collecting combined bright field (white light) and fluorescence images includes a negative lens group, a stop, and a positive lens group. The lens has a combination of large entrance pupil diameter (≧0.4 mm) for efficiently collecting weak fluorescence light, large ratio between the entrance pupil diameter and the maximum outside diameter (D | 11-26-2009 |
20100110572 | MULTIMODAL OPTICAL IMAGING - Provided herein are devices, systems, and methods for multimodal optical imaging. The devices include a filter assembly that is capable of rotary action during real time image acquisition. The systems include such filter assemblies, which are detachable or integrated in the systems. The methods include techniques for capturing image targets using multiple light sources such as white light and fluorescent light. | 05-06-2010 |
20100220903 | SYSTEM AND METHOD FOR CONTRAST ENHANCEMENT OF TIME-RESOLVED FLUORESCENCE IMAGES - A method of fluorescence imaging is provided. The method provides for simultaneously acquiring image data at a plurality of phases and a plurality of frequencies from a region of interest, identifying at least one desired signal and at least one background signal in the acquired image data associated with the region of interest, constructing a digital filter based upon the at least one desired signal and the at least one background signal, wherein the digital filter is configured to enhance image contrast and applying the digital filter to the acquired image data associated with the region of interest to enhance image contrast in the acquired image data. Systems and computer programs that afford functionality of the type defined by this method are also provided. | 09-02-2010 |
20100312122 | SYSTEMS FOR INTRAOPERATIVE NERVE IMAGING - Disclosed are systems for intraoperative nerve imaging using compact high collection power imaging devices for fluorescence and white light imaging of myelin basic protein (MBP) nerve imaging agents during open and minimally invasive surgery. | 12-09-2010 |
20110043916 | OBJECTIVE FOR OPTICAL IMAGING SYSTEMS - A wide angle hybrid refractive-diffractive endoscope objective is provided. The objective comprises a negative meniscus lens having a first surface and a second surface; a stop adjacent to the negative meniscus lens; a positive lens adjacent to the negative lens and having a first surface and a second surface; and a hybrid refractive-diffractive element adjacent to the positive lens and having a first surface and a second surface, wherein one of the first surface, or the second surface comprises a diffractive surface, wherein the objective has an effective focal length in a range from about 0.8 mm to about 1.6 mm. | 02-24-2011 |
20120128264 | METHODS AND SYSTEMS OF OPTICAL IMAGING FOR TARGET DETECTION IN A SCATTERING MEDIUM - A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames. | 05-24-2012 |
20130052725 | SYSTEM FOR OPTICAL BASED DELIVERY OF EXOGENOUS MOLECULES TO CELLS - A system for delivering exogenous molecules comprises a support for containing cells and exogenous molecules; an infra-red (IR) light source that generates an IR optical beam with an average power density at least greater than 10 | 02-28-2013 |
20130162948 | SYSTEM AND METHOD FOR AUTO-RANGING IN OPTICAL COHERENCE TOMOGRAPHY - A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal. Further, the OCT imaging system includes a controller having logic configured to perform an auto-ranging process to match the reference arm with the sample arm. | 06-27-2013 |
20130162978 | SYSTEM AND METHOD FOR AUTO-FOCUSING IN OPTICAL COHERENCE TOMOGRAPHY - A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal at a detector. Further, the OCT imaging system includes a controller having logic configured to perform an auto-focusing process to determine the optimal position for a lens in the sample arm in order to bring the sample into focus. | 06-27-2013 |
20130261415 | SYSTEM AND METHODS FOR PHYSIOLOGICAL MONITORING - Embodiments of devices, methods, and non-transitory computer readable media for monitoring a subject are presented. The monitoring device includes at least one sensor configured to monitor one or more physiological parameters of a subject and a processing unit operatively coupled to the sensor. The sensor comprises a plurality of radiation sources and detectors disposed on a flexible substrate in a designated physical arrangement. The processing unit is configured to dynamically configure an operational geometry of the sensor by controlling the intensity of one or more of the radiation sources and the gain of one or more of the detectors so as to satisfy at least one quality metric associated with one or more physiological parameters of the subject. | 10-03-2013 |
20130286400 | QUANTITATIVE PHASE MICROSCOPY FOR LABEL-FREE HIGH-CONTRAST CELL IMAGING - Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei. | 10-31-2013 |
20140171764 | SYSTEMS AND METHODS FOR NERVE IMAGING - Systems and methods for imaging are presented. The method includes producing excitation light configured to induce fluorescence in an imaging agent that selectively binds to a target species in a region of interest (ROI) of a subject that also includes a background species. A first and a second spectral region are selected such that a determined difference between fluorescence corresponding to the target and the background species in the first spectral region differs from a corresponding difference in the second spectral region. First and second fluorescence images are generated from the fluorescence corresponding to the first and second spectral regions. Additionally, a fluorescence ratio for the background species in the first and second fluorescence image is determined. The first fluorescence image is then multiplied or divided with the determined ratio to generate an intermediate image that is subtracted from the second fluorescent image to reconstruct a background-subtracted image. | 06-19-2014 |