Patent application number | Description | Published |
20090253899 | RECONSTITUTED POLYPEPTIDES - The present invention provides modified fibronectin type III (Fn3) molecules, and nucleic acid molecules encoding the modified Fn3 molecules. Also provided are methods of preparing these molecules, and kits to perform the methods. | 10-08-2009 |
20090326200 | Altered ospa of borrelia burgdorferi - Provided herein are OspA polypeptides from Lyme Disease-causing | 12-31-2009 |
20110045604 | MOLECULAR AFFINITY CLAMP TECHNOLOGY AND USES THEREOF - The invention provides a molecular affinity clamp. The architecture of the affinity clamp is modular with two biorecognition modules, each capable of binding a target motif. The first biorecognition module has a recognition domain that possesses inherent or natural specificity for the target motif. The second biorecognition module also has a recognition domain that binds the motif. The two biorecognition modules are tethered together either directly, e.g., via a peptide bond between the two modules, or indirectly, e.g., via a linker moiety or linker. The invention further provides a novel affinity ligand which is specifically bound by the molecular affinity clamps of the invention. | 02-24-2011 |
20110143963 | MOLECULAR AFFINITY CLAMP TECHNOLOGY AND USES THEREOF - The invention provides a molecular affinity clamp. The architecture of the affinity clamp is modular with two biorecognition modules, each capable of binding a target motif. The first biorecognition module has a recognition domain that possesses inherent or natural specificity for the target motif. The second biorecognition module also has a recognition domain that binds the motif. The two biorecognition modules are tethered together either directly, e.g., via a peptide bond between the two modules, or indirectly, e.g., via a linker moiety or linker. | 06-16-2011 |
20130237684 | RECONSTITUTED POLYPEPTIDES - The present invention provides modified fibronectin type III (Fn3) molecules, and nucleic acid molecules encoding the modified Fn3 molecules. Also provided are methods of preparing these molecules, and kits to perform the methods. | 09-12-2013 |
20140030285 | Altered OSPA of Borrelia Burgdorferi - Provided herein are OspA polypeptides from Lyme Disease-causing | 01-30-2014 |
20140057807 | FIBRONECTIN CRADLE MOLECULES AND LIBRARIES THEREOF - The here described invention discloses a combination of a top and bottom loop binder library using the CD and the FG loops of a number of FnIII domains (FnIII) (e.g., FnIII | 02-27-2014 |
20160024191 | RECONSTITUTED POLYPEPTIDES - The present invention provides modified fibronectin type III (Fn3) molecules, and nucleic acid molecules encoding the modified Fn3 molecules. Also provided are methods of preparing these molecules, and kits to perform the methods. | 01-28-2016 |
Patent application number | Description | Published |
20090270597 | ARTIFICIAL ANTIBODY POLYPEPTIDES - A fibronectin type III (Fn3) polypeptide monobody, a nucleic acid molecule encoding said monobody, and a variegated nucleic acid library encoding said monobody, are provided by the invention. Also provided are methods of preparing a Fn3 polypeptide monobody, and kits to perform said methods. Further provided is a method of identifying the amino acid sequence of a polypeptide molecule capable of binding to a specific binding partner (SBP) so as to form a polypeptide:SSP complex, and a method of identifying the amino acid sequence of a polypeptide molecule capable of catalyzing a chemical reaction with a catalyzed rate constant, k | 10-29-2009 |
20100099168 | Artificial antibody polypeptides - A fibronectin type III (Fn3) polypeptide monobody, a nucleic acid molecule encoding said monobody, and a variegated nucleic acid library encoding said monobody, are provided by the invention. Also provided are methods of preparing a Fn3 polypeptide monobody, and kits to perform said methods. Further provided is a method of identifying the amino acid sequence of a polypeptide molecule capable of binding to a specific binding partner (SBP) so as to form a polypeptide:SSP complex, and a method of identifying the amino acid sequence of a polypeptide molecule capable of catalyzing a chemical reaction with a catalyzed rate constant, k | 04-22-2010 |
20120135516 | ARTIFICIAL ANTIBODY POLYPEPTIDES - A fibronectin type III (Fn3) polypeptide monobody, a nucleic acid molecule encoding said monobody, and a variegated nucleic acid library encoding said monobody, are provided by the invention. Also provided are methods of preparing a Fn3 polypeptide monobody, and kits to perform said methods. Further provided is a method of identifying the amino acid sequence of a polypeptide molecule capable of binding to a specific binding partner (SBP) so as to form a polypeptide:SSP complex, and a method of identifying the amino acid sequence of a polypeptide molecule capable of catalyzing a chemical reaction with a catalyzed rate constant, k | 05-31-2012 |
20130267676 | ARTIFICIAL ANTIBODY POLYPEPTIDES - The present invention provides a fibronectin type III (Fn3) molecule, wherein the Fn3 contains a stabilizing mutation. The present invention also provides Fn3 polypeptide monobodies, nucleic acid molecules encoding monobodies, and variegated nucleic acid libraries encoding such monobodies. Also provided are methods of preparing a Fn3 polypeptide monobody, and kits to perform the methods. | 10-10-2013 |
Patent application number | Description | Published |
20090141092 | PIEZOELECTRIC ACTUATOR - A piezoelectric actuator includes a vibration plate, a first piezoelectric layer formed on one surface of the vibration plate, a second piezoelectric layer stacked on a surface of the first piezoelectric layer, a plurality of individual electrodes arranged on a surface of the second piezoelectric layer in a predetermined direction, a first common electrode having a plurality of first electrodes formed between the first piezoelectric layer and the second piezoelectric layer, and which are arranged in the predetermined direction to face the individual electrodes respectively, and a first wire electrically connecting all of the first electrodes, and a second common electrode having a plurality of second electrodes formed between the vibration plate and the first piezoelectric layer, and which are arranged in the predetermined direction to face the individual electrodes respectively, and a second wire electrically connecting all of the second electrodes. | 06-04-2009 |
20090244129 | LIQUID DROPLET JETTING APPARATUS - In a liquid droplet jetting mode of jetting liquid droplets, a controller controls a piezoelectric actuator to perform a liquid droplet jetting operation in which volume of a pressure chamber is decreased to a decreased volume smaller than a predetermined volume, and then the volume of the pressure chamber is increased to an increased volume greater than the predetermined volume, and the volume of the pressure chamber is again decreased to the decreased volume. On the other hand, in a warm-up mode of heating the liquid in the pressure chamber, the controller controls the piezoelectric actuator to perform at least one of a first warm-up operation in which the volume of the pressure chamber is changed repeatedly between the predetermined volume and the increased volume, and a second warm-up operation in which the volume of the pressure chamber is changed repeatedly between the predetermined volume and the decreased volume. | 10-01-2009 |
20090322821 | Image-Forming Apparatus - An image-forming apparatus is capable of performing a non-margin recording operation without a margin on a recording medium and providing a waiting time between a moment of termination of a movement of a carriage in one of opposite directions and a moment of initiation of a subsequent movement of the carriage in the other direction, if the non-margin recording operation is performed during the movement of the carriage in the above-indicated one direction. The carriage is moved in the other direction (returned) at a speed lower than that of the movement in the above-indicated one direction, so that the back surface of an edge portion (e.g., leading end portion) of the recording medium is protected from contamination with an ink mist produced from the ink droplets. The waiting time and the return speed of the carriage can be manually selected or changed by using an operator's control panel, so that the non-margin recording operation can be performed in a desired manner (in a high-image-quality mode or a high-speed mode). | 12-31-2009 |
20120229552 | LIQUID DROPLET JETTING APPARATUS AND LIQUID DROPLET JETTING STATE INSPECTION UNIT - A liquid droplet jetting apparatus includes: a liquid droplet jetting head which has a liquid droplet jetting surface on which a plurality of nozzles are open and aligned in a row in a first direction; and a liquid droplet jetting state inspection unit which inspects liquid droplet jetting state of each of the nozzles, including: a liquid droplet landing body which has a landing surface facing the liquid droplet jetting surface and on which the liquid droplets jetted from each of the nozzles land, and which is configured to be relatively movable, with respect to the liquid droplet jetting head, in a second direction which is parallel to the liquid droplet jetting surface and intersects the first direction; and a landing detection mechanism which detects whether or not the liquid droplets have landed on a predetermined detection area provided on the landing surface of the liquid droplet landing body. | 09-13-2012 |
20120247816 | FLEXIBLE WIRING SUBSTRATE, METHOD FOR ASSEMBLING FLEXIBLE WIRING SUBSTRATE, AND METHOD FOR MANUFACTURING LIQUID JETTING APPARATUS - A flexible wiring substrate includes: a flexible base material; a wire provided on the base material; and an inspection wire provided on the base material, having an inspection segment which breaks up under a condition that the inspection segment is folded with not less than a predetermined curvature and a non-inspection segment which does not break up under a condition that the non-inspection segment is folded with not less than the predetermined curvature. | 10-04-2012 |
20120249670 | LIQUID DROPLET JETTING APPARATUS - There is provided a liquid droplet jetting apparatus, including: a liquid droplet jetting head in which a plurality of nozzles and a plurality of individual channels are formed; a purge mechanism; a judgment mechanism which judges whether or not a defective nozzle in which a jetting failure occurs is included in purge target nozzles; a heating mechanism which heats a liquid in the plurality of individual channels; and a controller which controls the purge mechanism and the heating mechanism. In a case that the judgment mechanism judges that the defective nozzle is included in the purge target nozzles, the controller controls the heating mechanism and the purge mechanism to heat the liquid in a part of the plurality of individual channels, which include an individual channel communicating with the defective nozzle, and to execute the purge operation for the purge target nozzles. | 10-04-2012 |
20120249681 | LIQUID DROPLET DISCHARGE APPARATUS, PIEZOELECTRIC ACTUATOR, AND METHOD FOR PRODUCING LIQUID DROPLET DISCHARGE APPARATUS - A liquid droplet discharge apparatus, which discharges liquid droplets of a liquid, includes: a flow passage unit which is formed with a plurality of nozzles for discharging the liquid droplets of the liquid and a plurality of liquid flow passages including a plurality of pressure chambers communicated with the plurality of nozzles respectively; an actuator which has a sealing plate joined to the flow passage unit for defining the plurality of pressure chambers and which applies a pressure to the liquid contained in each of the plurality of pressure chambers by changing a volume of each of the plurality of pressure chambers by deforming the sealing plate; and a deformation adjusting member which adjusts a deformation amount of the sealing plate. | 10-04-2012 |
20130076818 | LIQUID JETTING APPARATUS - A liquid jetting apparatus includes: a head unit including a liquid jetting head, a regulating member arranged to sandwich the head unit from a nozzle array direction, a restriction mechanism configured to restrict the head unit from displacement in an orthogonal direction perpendicular to the nozzle array direction, and a landing position correction mechanism configured to correct position of landing the liquid jetted from the plurality of nozzles onto the medium in the orthogonal direction. The restriction mechanism restricts a portion of the head unit inside of outmost nozzle arrays in the orthogonal direction. | 03-28-2013 |
20130257993 | LIQUID DROPLET DISCHARGE HEAD - A liquid droplet discharge head includes a plurality of discharge unit parts, each of which extends in a first direction. The discharge unit parts are arranged in a second direction intersecting with the first direction. Each of the discharge unit parts includes: a nozzle column configured by a plurality of nozzles; a liquid droplet discharge surface; a common flow path; a plurality of pressure chambers; a damper chamber extending in the first direction; a damper wall arranged between the damper chamber and the common flow path; and a pillar part connecting the damper wall and a separate wall that is different from the damper wall in the damper chamber. A position of the pillar part of at least one discharge unit part of the discharge unit parts in the first direction is deviated from a position of the pillar part in the other discharge unit part. | 10-03-2013 |
20130286106 | LIQUID DROPLET JETTING APPARATUS AND PIEZOELECTRIC ACTUATOR - A liquid droplet jetting apparatus includes a flow passage structural body having a nozzle and a pressure chamber communicated with the nozzle, and a piezoelectric actuator provided on the flow passage structural body to apply jetting energy to a liquid inside the pressure chamber. The piezoelectric actuator has a piezoelectric layer arranged to face the pressure chamber, a low-potential electrode provided on the piezoelectric layer, and a high-potential electrode provided on the piezoelectric layer and to which a higher potential is applied than to the low-potential electrode. The high-potential electrode has a first electrode layer arranged to contact with the piezoelectric layer and formed of gold, and a second electrode layer stacked on the first electrode layer to extend in a predetermined direction, having a width shorter than that of the first electrode layer, and formed of a conductive material more likely to cause migration than gold. | 10-31-2013 |
20140292869 | LIQUID JETTING APPARATUS - There is provided a liquid jetting apparatus including: a liquid jetting head including a pressure generating element and a plurality of nozzles arranged in rows in a nozzle-row direction; and a controller. The controller is configured to: determine a basic flushing amount for each nozzle; make the liquid jetting head carry out flushing with the basic flushing amount for inner-side nozzles positioned at an inner side in the nozzle-row direction; and make the liquid jetting head carry out flushing with a flushing amount larger than the basic flushing amount, for outer-side nozzles positioned at an outer side in the nozzle-row direction, of the inner-side nozzles. | 10-02-2014 |
20150049143 | LIQUID JETTING APPARATUS - A liquid jetting apparatus includes: a liquid jetting section having a liquid jetting surface in which a plurality of nozzles are formed, and configured to jet a liquid from the plurality of nozzles; and a liquid supply section provided on the liquid jetting section on a side opposite to the liquid jetting surface with respect to a direction intersecting the liquid jetting surface, and configured to supply the liquid to the liquid jetting section. The liquid jetting section includes: two nozzle groups arranged apart in a predetermined scanning direction, each nozzle group including a plurality of nozzles aligned in a nozzle arrangement direction which intersects the scanning direction; and two common liquid chambers arranged apart in the scanning direction, each common liquid chamber extending in the nozzle arrangement direction and communicating with one of the two nozzle groups. | 02-19-2015 |
20150158294 | INK JET HEAD AND INK JET PRINTER - A channel-structure has first to third nozzle-rows for first-ink, and first and second nozzle-rows for second-ink. Between the first nozzle-row for the first-ink and the first nozzle-row for the second-ink, and between the second nozzle-row for the first-ink and the second nozzle-row for the second-ink, each nozzle is located in the same position. The third nozzle-row for the first-ink is located in a different position with respect to the first and second nozzle-rows. Either the first and the second nozzle-rows for the second-ink are arranged between the first and second nozzle-rows for the first-ink, or the first and second nozzle-rows for the first-ink are arranged between the first and second nozzle-rows for the second-ink. A distance between the first nozzle-row for the first-ink and the first nozzle-row for the second-ink is equal to a distance between the second nozzle-row for the first-ink and the second nozzle-row for the second-ink. | 06-11-2015 |