Patent application number | Description | Published |
20090055131 | AUTOMATIC RECORDING VOLUME MEASUREMENT APPARATUS - Data acquisition apparatus for use with a fluid dispensing device and providing an electronic record of the precise volumes of fluid dispensed from the fluid dispensing device. The fluid dispensing device may be laboratory or clinical apparatus such as an automatic or manual pipette. The apparatus generally includes a fluid volume sensor for detecting the volume of fluid released from the fluid dispensing device and producing electrical signals determined by the volume of fluid released from the device, a data transmission device configured to receive the electrical signals, and a data storage device for storing them. | 02-26-2009 |
20090101491 | METHODS AND APPARATUS FOR RAPID CRYSTALLIZATION OF BIOMOLECULES - The present invention relates to methods and apparatus for promoting rapid formation of biomolecule crystals from a solution of biomolecules, preferably proteins, wherein the protein solution undergoes rapid concentration according to its isoelectric point in an electric field. Protein crystallization according to the methods of the present invention takes place within a period of hours or less. | 04-23-2009 |
20090221985 | SYSTEM FOR IONTOPHORETIC TRANSDERMAL DELIVERY OF POLYMERIC AGENTS AND METHODS OF USE THEREOF - A system for iontophoretic transdermal delivery of a non-peptidic polymeric cosmetic or therapeutic agent or of a polypeptide useful for delivery of high molecular weight cosmetic or therapeutic agents. Particularly, the present invention relates to a system that includes an iontophoresis device and a pharmaceutical composition of a non-peptidic polymeric cosmetic or therapeutic agent together with a peptide, polypeptide or protein and a pharmaceutically acceptable carrier having a pH below or above the isoelectric pH of the peptide, polypeptide or protein. | 09-03-2009 |
20100316697 | METHODS AND COMPOSITIONS FOR DRUG TARGETING - The present invention provides methods and compositions for targeting a drug to a specific desired location, such as an intracellular location in a mammalian cell, by causing said drug to migrate along a pH gradient to the specific location, where the drug preferentially accumulates at a pH range of the specific location. Accordingly, the invention described herein is based on providing a drug which is “pH matched” with that of a particular location, such that the drug preferentially migrates to and accumulates at the pH or pH range at that location. The location may be a type of tissue, a type of cell, a sub-cellular location or an intracellular location, such as an organelle. Without being bound to any theory, the drug migrates along or across a pH gradient, and stops migrating and accumulates at a location of specific pH or range of pH at which the drug is energetically neutral, or where its diffusion potential is at a minimum. | 12-16-2010 |
20110112050 | SEPARATION OF POLYSACCHARIDES BY CHARGE DENSITY GRADIENT - Methods and apparatus for the separation of polysaccharides, particular heparin products, and glycosylated molecules are provided. The separation is based on the molecular weight and charge, by application of an electric field across a low-friction matrix, modified with a charged separation agent comprising charged regions ordered in a monotonous sequence distributed throughout the matrix, to generate a charge density gradient formed when an external electric field is applied. Saccharides of different charges migrate differently across the porous matrix and immobilized by charge neutralization in different charge regions of the matrix. | 05-12-2011 |
20120135060 | COMPOSITIONS AND METHODS FOR CELL KILLING - Provided herein are biocidic compositions including an ion exchange material, wherein when said material is in an environment capable of transporting H | 05-31-2012 |
20130040026 | EXTENDED SHELF-LIFE LIQUIDS AND METHOD THEREOF - A method of producing a liquid substantially free of beverage spoiling microorganisms, characterized in that said method comprises steps of: (a) obtaining a liquid; (b) obtaining a bioactive material that does not affect a predetermined set of organoleptic parameters of said liquid upon contact with said concentrate for a predetermined length of time; and, (c) treating said liquid with said bioactive material until the concentration of beverage-spoiling microorganism falls below a predetermined threshold. | 02-14-2013 |
20150024017 | COMPOSITIONS AND METHODS FOR CELL KILLING - A solid buffer including one or more ion exchange materials, wherein said solid buffer has a volumetric buffering capacity greater than about 20 mM H | 01-22-2015 |
20150079193 | COMPOSITIONS AND METHODS FOR INDUCING ANGIOGENESIS - The present invention relates to compositions and methods of inducing angiogenesis and methods of treating a pathology that would benefit from angiogenesis by use of a composition comprising partially purified intact mitochondria and/or ruptured mitochondria derived therefrom. | 03-19-2015 |