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Shigeru Tokita
Shigeru Tokita, Tsukuba-Shi JP
| Patent application number | Description | Published |
|---|---|---|
| 20090203710 | Novel piperidine derivative - Provided are a histamine-H3 receptor antagonist; and a preventive and/or a remedy for metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout, fatty liver, circulatory system diseases, for example, stenocardia, acute/congestive cardiac insufficiency, cardiac infarction, coronary arteriosclerosis, hypertension, nephropathy, sleep disorder and various diseases accompanied by sleep disorder such as idiopathic hypersomnia repetitive hypersomnia, true hypersomnia, narcolepsy, sleep periodic acromotion disorder, sleep apnea syndrome, circadian rhythm disorder, chronic fatigue syndrome, REM sleep disorder, senile insomnia, night worker sleep insanitation, idiopathic insomnia, repetitive insomnia, true insomnia, electrolyte metabolism disorder; and central and peripheral nervous system diseases such as bulimia, emotional disorder, melancholia, anxiety, epilepsy, delirium, dementia, shinzophrenia, attention deficit/hyperactivity disorder, memory disorder, Alzheimer's disease, Parkinson's disease, sleep disorder, recognition disorder, motion disorder, paresthesia, dysosmia, epilepsy, morphine resistance, narcotic dependency, alcoholic dependency. The histamine-H3 receptor antagonist comprises a piperidine derivative compound of formula (I) [wherein X | 08-13-2009 |
| 20090209562 | Fused ring 4-oxopyrimidine derivative - The present invention provides a compound represented by formula (I) below, or a pharmaceutically acceptable salt thereof, which, having histamine H3 receptor antagonist or inverse agonist activity, is useful in the prophylaxis or therapy of metabolic diseases, circulatory diseases, or nervous system diseases. | 08-20-2009 |
| 20100210637 | HETEROARYLOXY NITROGENOUS SATURATED HETEROCYCLIC DERIVATIVE - Provided are compounds of a formula (I) and their pharmaceutically-acceptable salts: | 08-19-2010 |
Shigeru Tokita, Ibaraki JP
| Patent application number | Description | Published |
|---|---|---|
| 20080269287 | Substituted Pyridone Derivative - Compounds of a formula (I) | 10-30-2008 |
| 20080275069 | Quinazoline Derivative - This invention provides a compound or its pharmaceutically-acceptable salt of formula (I) | 11-06-2008 |
| 20090023163 | Method of Measuring Enzyme Activity and Method of Evaluating Compound - It is intended to provide a method of measuring an activity, which is a method of measuring an activity of an enzymatic reaction in which a lipid-soluble reaction product is formed by catalyzing an addition reaction of two or more kinds of substrates, characterized by comprising a labeling step in which any one of the substrates is labeled, a reaction step in which an enzymatic reaction is carried out in the presence of an enzyme, all substrates and an acceptor, and a detection step in which the reaction product is detected by bringing the labeled molecule and a molecule to be detected close to each other via the acceptor and transferring an energy generated by the labeled molecule to the molecule to be detected, and a method of evaluating a compound utilizing the method of measuring an activity. By the methods of the invention, it is possible to perform a treatment from the enzymatic reaction to the measurement of an enzyme activity with the simple steps and it is possible to provide a method of measuring an enzyme activity which can be applied to an HTS evaluation system. | 01-22-2009 |
| 20090137576 | Novel Piperidine Derivative - Disclosed is a substance having an antagonistic effect on the binding of histamine to a histamine H3 receptor or an inhibitory effect on the activity which a histamine H3 receptor constantly exhibits. A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof; (I) | 05-28-2009 |
| 20100137391 | Histamine H3 Agonist for use as Therapeutic Agent for a Lipid/Glucose Metabolic Disorder - Disclosed are: novel use of an agonist histamine receptor H3 (e.g., Imetit) for prevention of obesity or the reduction of food intake; a method for evaluation of a compound for use as a therapeutic agent targeted to histamine receptor HR protein; and a compound provided by the method. | 06-03-2010 |
Shigeru Tokita, Yokohama JP
| Patent application number | Description | Published |
|---|---|---|
| 20090016742 | Optical Transmission Module, Optical Transmission Apparatus, and Structure for Fixing Member - An optical transmission module mounted pluggably to a cage having an opening. The optical transmission module comprises a gasket on at least a part of an outer periphery of the module. The gasket is deformed depending on temperature change. The gasket is deformed according to temperature rise in a direction toward an inner wall of the cage to push the inner wall and deformed according to temperature drop in an opposite direction to the direction. | 01-15-2009 |
| 20090039503 | SEMICONDUCTOR DEVICE - The invention provides a heat radiating structure which reduces a mechanical stress applied to an electronic part mounted on a printed circuit board including a semiconductor package. The heat radiating structure is constructed by a semiconductor package mounted on a printed circuit board, a thermal conduction sheet arranged on an upper surface of the semiconductor package, and a metal case provided with a heat radiating fin for receiving a heat transmitted form the thermal conduction sheet so as to discharge to an atmospheric air, and the metal case is provided with a concavo-convex structure in a contact portion with the thermal conduction sheet. | 02-12-2009 |
| 20090245812 | OPTICAL TRANSMISSION CIRCUIT - Provided is an optical transmission circuit capable of realizing a high-quality optical signal waveform with low power consumption. An optical transmission circuit ( | 10-01-2009 |
| 20090317086 | OPTICAL TRANSCEIVER MODULE AND METHOD OF CONTROLLING OPTICAL TRANSCEIVER MODULE - An optical transceiver module for transmitting and receiving an optical signal with a plurality of channels includes timing generator for sequentially generating timing instructions defining different start-up time points, and powering controller for effecting a control such that power supply to at least a portion of circuit components associated with the respective channels is sequentially started in accordance with the timing instructions generated by the timing generator. Current to be instantaneously necessitated when a power switch is turned on or when a power restoration is made from power saving operation modes can be suppressed. | 12-24-2009 |
Shigeru Tokita, Tokyo JP
| Patent application number | Description | Published |
|---|---|---|
| 20110237791 | 2-PYRIDONE COMPOUNDS - A 2-pyridone compound represented by the formula [1]: | 09-29-2011 |