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Shiffman, US

Carl A. Shiffman, Waban, MA US

Patent application numberDescriptionPublished
20100292603Electrical Impedance Myography - Electrical impedance myography (EIM) can be used for the assessment and diagnosis of muscular disorders. EIM includes applying an electrical signal to a region of tissue and measuring a resulting signal. A characteristic of the region of tissue is determined based on the measurement. Performing EIM at different frequencies and/or different angular orientations with respect to a muscle can aid in the assessment and diagnosis. Devices are described that facilitate assessment and diagnosis using EIM.11-18-2010

Daniel M. Shiffman, Palo Alto, CA US

Patent application numberDescriptionPublished
20080306942On the Role of Market Economics in Ranking Search Results - The invention presents a method of and service for searching computerized networks, such as the internet, that first performs a search based on a user query to produce results that are ranked. The results comprise references to entities (addresses on the network, such as web sites). Before reporting the results to the user, the invention provides that the search entity contacts the entities listed in the search results to determine whether entities listed in the search results desire to change their rank when compared to other entities listed in the results. If some entities do desire to change their rank, the invention charges fees to entities that increase their rank and credits (pays fees) to entities that decrease their rank. A portion of the amount charged to entities that increase their rank can be paid to the entity performing the search (helping to support the high quality search engines), and a portion will go to the entities that voluntarily decrease their rank within the search results (helping to support high-content web sites).12-11-2008

Dov Shiffman, Palo Alto, CA US

Patent application numberDescriptionPublished
20080248476Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof - The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.10-09-2008
20090004187POLYMORPHISM IN THE APO(A) GENE PREDICT RESPONSIVENESS TO ACETYLSALICYLIC ACID TREATMENT (RIDKER) - This invention relates to nucleotide polymorphisms in the human Apo(a) gene and to the use of Apo(a) nucleotide polymorphisms in identifying whether a human subject will respond or not to treatment with acetylsalicylic acid.01-01-2009
20090264453GENETIC POLYMORPHISMS ASSOCIATED WITH CORONARY HEART DISEASE, METHODS OF DETECTION AND USES THEREOF - The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease, and in particular MI, and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.10-22-2009
20090312410Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof - The present invention is based on the discovery of genetic polymorphisms that are associated with coronary heart disease, specifically MI and including early-onset MI, and response to drug treatment. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.12-17-2009
20100035983GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF - The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.02-11-2010

Patent applications by Dov Shiffman, Palo Alto, CA US

Rhett M. Shiffman, Laguna Beach, CA US

Patent application numberDescriptionPublished
20110021595KETOROLAC TROMETHAMINE COMPOSITIONS FOR TREATING OR PREVENTING OCULAR PAIN - The present invention provides an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises mixtures of carboxymethyl cellulose in an aqueous solution wherein said concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye and improve visual acuity of the users.01-27-2011

Saul Shiffman, Pittsburgh, PA US

Patent application numberDescriptionPublished
20110082827Operation and Method for Prediction and Management of the Validity of Subject Reported Data - A system for developing and implementing empirically derived algorithms to generate decision rules to predict invalidity of subject reported data and fraud with research protocols in surveys allows for the identification of complex patterns of variables that detect or predict subject invalidity of subject reported data and fraud with the research protocol in the survey. The present invention may also be used to monitor invalidity of subject reported data within a research protocol to determine preferred actions to be performed. Optionally, the invention may provide a spectrum of invalidity, from minor invalidity needing only corrective feedback, to significant invalidity requiring subject removal from the survey. The algorithms and decision rules can also be domain-specific, such as detecting invalidity or fraud among subjects in a workplace satisfaction survey, or demographically specific, such as taking into account gender or age. The algorithms and decision rules may be optimized for the specific sample of subjects being studied.04-07-2011

Patent applications by Saul Shiffman, Pittsburgh, PA US