Shi, PA
Bin Shi, Lansdale, PA US
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20100113577 | ISOLATED NUCLEIC ACID MOLECULES CORRESPONDING TO MICRO RNA 145 (MIRNA-145) AND THEIR USE IN TREATING COLON CANCER - Provided herein are isolated nucleic acid molecule corresponding to miR145 that are useful in treating colon cancer. The disclosed miR145 nucleic acids specifically bind the 3′ UTR within endogenous IRS-I such as to suppress or inhibit colon cell proliferation. | 05-06-2010 |
Dongchuan Shi, Collegeville, PA US
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20080255195 | Compounds Which Have Activity at M1 Receptor and Their Uses in Medicine - Compounds of formula (I) and salts are provided: | 10-16-2008 |
20080293770 | Compounds Which Have Activity at M1 Receptor and Their Uses In Medicine - Compounds of formula (I) and salts are provided: | 11-27-2008 |
20080306112 | Benzimidazolones Which Have Activity at M1 Receptor - Compounds of formula (I) and salts are provided: | 12-11-2008 |
20090253908 | NOVEL M3 MUSCARINIC ACETYLCHOINE RECEPTOR ANTAGONISTS - Muscarinic Acetylcholine receptor antagonists and methods of using them are provided. | 10-08-2009 |
20130345120 | PEPTIDE DEFORMYLASE INHIBITORS - The present invention relates to a compound of Formula (I): | 12-26-2013 |
Frank Shi, Dowingtown, PA US
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20100151003 | EGFR BINDING PEPTIDES AND USES THEREOF - Short oligopeptides are provided which are capable of binding to the epidermal growth factor receptor on the surface of human tumor cells. Methods for using the peptides as targeting moieties in more complex compositions, such as conjugates of cytoxins, and/or structures, such as liposomal structures, for the purposes of drug delivery are also provided. | 06-17-2010 |
Frank Shi, Downingtown, PA US
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20100098681 | DIMERIC HIGH AFFINITY EGFR CONSTRUCTS AND USES THEREOF - Polypeptides comprising EGFR extracellular domains I-III capable of forming dimeric EGF-binding proteins are provided. The dimeric construct of the invention is useful in applications where high affinity EGF binding is desired and can be used to select agents capable of binding to native EGFR in the presence of EGF. | 04-22-2010 |
Haibin Shi, Pittsburgh, PA US
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20090061451 | BIOSENSORS AND RELATED METHODS - Provided herein are biosensors that comprise a biological signal source linked to a substrate by a peptide nucleic acid spacer and methods of use of the biosensor. In one embodiment, the biosensor is used to detect prostate-specific antigen. | 03-05-2009 |
Hong Shi, King Of Prussia, PA US
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20090274693 | Method of Treating Cancer using a cMet and AXL Inhibitor and an ErbB Inhibitor - The present invention relates to a method of treating cancer in a patient comprising administering to the patient therapeutically effective amounts of: | 11-05-2009 |
20130142790 | Method of Treating Cancer Using a cMET and AXL Inhibitor and an ErbB Inhibitor - The present invention relates to a method of treating cancer in a patient comprising administering to the patient therapeutically effective amounts of: | 06-06-2013 |
20130150363 | Method of Treating Cancer Using a cMET and AXL Inhibitor and an ErbB Inhibitor - The present invention relates to a method of treating cancer in a patient comprising administering to the patient therapeutically effective amounts of: | 06-13-2013 |
Hongjian Shi, Souderton, PA US
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20110026671 | PANORAMIC DENTAL IMAGING USING SEGMENTATION AND A MASTER ARCH - A method and a system for generating a panoramic x-ray image by obtaining volumetric x-ray image data having a first plurality of slices, segmenting the x-ray image data into a first portion above a vertical threshold and a second portion below the vertical threshold, and separating the second portion into a second plurality of slices. Further, the method and the system include generating a plurality of curves for each slice in the second plurality of slices, generating a master arch for the second plurality of slices, and generating a panoramic image based on the master arch. | 02-03-2011 |
20130094748 | DENTAL IMAGING USING SEGMENTATION AND AN ARCH - A method and a system for generating an image by obtaining x-ray image data, segmenting the x-ray image data into a first portion above a vertical threshold and a second portion below the vertical threshold. Further, the method and the system include generating an arch for the second plurality of slices, and generating an image based on the arch. | 04-18-2013 |
Jianbo Shi, Philadelphia, PA US
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20140160247 | TECHNIQUES FOR WAVELET-BASED IMAGE DISPARITY ESTIMATION - Various embodiments are generally directed to repeated use of wavelet filters with different directional orientations each time to detect distances to edges in different directions in deriving a disparity map from multiple image bitmaps. A method includes subjecting an image bitmap to a first-order wavelet filter a selected number of times, an orientation of the first-order wavelet filter altered each time to create a first set of intermediate maps; and subjecting the first image bitmap to a second-order wavelet filter the selected number of times, an orientation of the second-order wavelet filter altered each time to create a second set of intermediate maps; the first-order and second-order wavelet filters, as well as their orientations, selected to be mathematically related such that the first-order wavelet filter approximates a sine function and the second-order wavelet filter approximates a related cosine function, both masked by a Gaussian. Other embodiments are described and claimed. | 06-12-2014 |
20140232831 | MODULAR CAMERA ARRAY - Devices, systems and methods employing modular camera arrays are described. A two-dimensional array of cameras may be arranged in a non-rectangular array. A first camera, a second camera, and a third camera in the array may be located approximately equidistant from each other, and/or may be arranged approximately in an equilateral triangle, an isosceles triangle, a scalene triangle, and/or a right triangle. | 08-21-2014 |
Jingie Shi, State College, PA US
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20100139377 | PARTICLE FOCUSING WITHIN A MICROFLUIDIC DEVICE USING SURFACE ACOUSTIC WAVES - Examples of the present invention include apparatus and methods for particle focusing, for particles within a fluid sample. An example apparatus, which may be a microfluidic device, comprises a substrate, a channel receiving the fluid sample, and at least one surface acoustic wave (SAW) generator. The SAW generator may comprise electrodes supported by the substrate. In some examples, the channel has a particle focusing region located near a region of the substrate surface in which a SAW is generated. Particles are concentrated within one or more particle focus regions of the sample flow (the particle focus regions being appreciably narrower than the channel dimensions) by the effects of the SAW. As an example, a pair of SAW generators can be used to generate a standing surface acoustic wave (SSAW) that is used for particle focusing. | 06-10-2010 |
Jinjie Shi, Ambler, PA US
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20130084716 | SYSTEM AND CONNECTOR CONFIGURED FOR MACRO MOTION - A connector system is configured for macro motion. Two mating terminals are configured so that during macro motion cycles, the resistance between two terminals does not substantially increase. One terminal can have multiple, somewhat spherical-shaped mating surfaces while a mating surface on the other terminal can be flat. The mating terminals can be configured to provide desirable resistance performance after more than 5000 cycles of macro motion. | 04-04-2013 |
Justin Y. Shi, Wayne, PA US
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20090019258 | FAULT TOLERANT SELF-OPTIMIZING MULTI-PROCESSOR SYSTEM AND METHOD THEREOF - A fault-tolerant self-optimizing multi-processor system is disclosed that includes a plurality of redundant network switching units and a plurality of processors electrically coupled to the network switching units. Each processor comprises a local memory, local storage, multiple network interfaces and a routing agent (RA). The RAs form a unidirectional virtual ring (UVR) network using the redundant network switching units. The UVR network may coordinate all of the processors for data matching, failure detection/recovery and system management functions. Once data is matched via the UVR network, application programs communicate directly via the network switching units, thus fully exploiting the hardware redundancy. Each of the RAs may implement a tuple space daemon responsible for data matching and delivery, forwarding unsatisfied data requests to a downstream processor or dropping expired tuples from UVR circulation. The RAs provide overall system fault tolerance and are responsible for delivering data sources to the matching processors. | 01-15-2009 |
Kebin Shi, State College, PA US
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20100309465 | COHERENT ANTI-STOKES RAMAN HOLOGRAPHY - Apparatus and methods of four wave mixing (FWM) holography are described, including illuminating a sample with a first beam, a second beam, and a third beam, and combining the generated FWM signal with a reference beam at a imaging device to obtain holographic image data. In some examples, the first and second beams may be provided by a single pump-probe beam. The third beam may be a Stokes beam or an anti-Stokes beam. A representative example is coherent anti-Stokes Raman holography (CARS holography), which includes illuminating a sample with a pump/probe beam and a Stokes beam to obtain a CARS signal from the sample; and combining the CARS signal with a reference beam to obtain a CARS hologram. | 12-09-2010 |
Li Shi, Eagleville, PA US
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20090047303 | Method for improving the immunogenicity of plasmodium antigens - The present invention provides a Malaria antigen-carrier conjugate, which comprises a carrier protein and a plurality of | 02-19-2009 |
Michael Shi, Chalfont, PA US
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20130345234 | FGFR AND LIGANDS THEREOF AS BIOMARKERS FOR BREAST CANCER IN HR POSITIVE SUBJECTS - The present invention describes methods for diagnosing, treating and determining the prognosis of breast cancer HR+ patient, the methods including detecting the amplification of one or more biomarkers comprising a FGFR ligand such as FGF3, FGF4, FGF19, and/or a FGFR, such as for example FGFR1 in a subject; determining an FGFR1 inhibitor for treating the subject based on the amplification of the one or more biomarkers in the subject; administering to the subject in need thereof the FGFR1 inhibitor and using the one or more biomarkers to indicate prognosis of the subject treated with the FGFR1 inhibitor. | 12-26-2013 |
20140221389 | USE OF 4-AMINO-5-FLUORO-3-[6-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL- ]-1H-QUINOLIN-2-ONE IN THE TREATMENT OF CANCER IN MODERATE HEPATIC IMPAIRED PATIENTS - The present invention relates to a method of treating a cancer in patient in need thereof by administering 4-amino-5 fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one, or a tautomer thereof, or a salt of any one of them, wherein the patient is a moderate hepatic impaired patient. | 08-07-2014 |
Yan Shi, Flourtown, PA US
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20090030046 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME - Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure | 01-29-2009 |
20100324071 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME - Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure | 12-23-2010 |
20110118211 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME - Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure | 05-19-2011 |
20120142636 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME - Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure | 06-07-2012 |
Yeming Shi, Pittsburgh, PA US
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20100077338 | METHOD AND SYSTEM OF TASKBAR BUTTON INTERFACES - The present invention provides a system or method for displaying rich presentation taskbar buttons for a corresponding application. In one example, the rich presentation taskbar button may receive content from an application through a programming interface. The present invention further relates to a system and method for displaying a rich presentation taskbar button and for displaying and/or dismissing a thumbnail of an application window associated with the rich presentation taskbar button. The present invention may further include a system and method of pinning the thumbnail on a display or dismissing a thumbnail. The present invention also relates to a system and method for displaying multiple taskbar buttons in a taskbar including controlling the size of individual taskbar buttons, consolidating taskbar buttons and placing taskbar buttons into an overflow based on the type of taskbar button in the taskbar. | 03-25-2010 |
20140195962 | METHOD AND SYSTEM OF TASKBAR BUTTON INTERFACES - The present invention provides a system or method for displaying rich presentation taskbar buttons for a corresponding application. In one example, the rich presentation taskbar button may receive content from an application through a programming interface. The present invention further relates to a system and method for displaying a rich presentation taskbar button and for displaying and/or dismissing a thumbnail of an application window associated with the rich presentation taskbar button. The present invention may further include a system and method of pinning the thumbnail on a display or dismissing a thumbnail. The present invention also relates to a system and method for displaying multiple taskbar buttons in a taskbar including controlling the size of individual taskbar buttons, consolidating taskbar buttons and placing taskbar buttons into an overflow based on the type of taskbar button in the taskbar. | 07-10-2014 |
Yi Shi, Boothwyn, PA US
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20080279846 | METHODS OF TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES AND DISORDERS - The present invention provides compostions and methods useful for treating and preventing neurodegenerative disease and neurologically related disorders by inhibition of Lp-PLA2. The compositions and methods are useful for treating and preventing diseases and disorders with abnormal blood brain barrier (BBB) function, for example neurodegenerative diseases with a permeable BBB, such as but not limited to, Alzheimer's Disease, Huntington's Disease, Parkinson's Disease and Vascular Dementia. | 11-13-2008 |
20080280829 | METHODS OF TREATMENT AND PREVENTION OF METABOLIC BONE DISEASES AND DISORDERS - The present invention provides compostions and methods useful for treating and preventing metabolic bone diseases and disorders by inhibition of Lp-PLA | 11-13-2008 |
20130150379 | METHODS OF TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES AND DISORDERS - The present invention provides compostions and methods useful for treating and preventing neurodenerative disease and neurologically related disorders by inhibition of Lp-PLA2. The compositions and methods are useful for treating and preventing diseases and disorders with abnormal blood brain barrier (BBB) function, for example neurodegenerative diseases with a permeable BBB, such as but not limited to, Alzheimer's Disease, Huntington's Disease, Parkinson's Disease and Vascular Dementia. | 06-13-2013 |
Yuguang Shi, Hershey, PA US
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20100146642 | Methods and compositions relating to PBK1 - The invention relates to compositions comprising, and methods utilizing PBK1 protein and DNA, including a method of detecting type 1 diabetes; a mammalian pancreas-derived cell comprising a recombinant nucleic acid encoding a PBK1 protein; a method of identifying a PBK1 modulator; a pharmaceutical composition for treatment of type 2 diabetes in a subject; a method of screening for an agent that treats a metabolic disease; delivery of PBK-1 DNA to a subject to stimulate pancreatic beta cell differentiation and/or regeneration; a method for stimulating cell differentiation and/or regeneration in a pancreatic beta cell; usage of transgenic mice with targeted deletion or overexpression of the PBK-1 gene to test efficacy and specificity of PBK-1 modulator compounds. | 06-10-2010 |
Zhen Shi, Pittsburgh, PA US
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20140087447 | Cell Modeling of Heme Deficiency using Ferrochelatase Mutations - Provided herein, is a means for development of ferrochelatase variants with improved tolerance towards N-methyl protoporphyrin. Also disclosed are cell assay systems utilizing the variants, as the variants would confer resistance to N-methyl protoporphyrin inhibition and thereby keep heme synthesis uninterrupted. The variants contain loop mutations that affect the NMPP-ferrochelatase interaction, and different degrees of NMPP tolerance are obtained with the introduction of loop mutations in wild-type ferrochelatase. Also disclosed is kinetic mechanism of inhibition of ferrochelatase by NMPP, using the disclosed variants whose mutations in the “porphyrin-interacting loop” motif weakened the potency of NMPP as an inhibitor. | 03-27-2014 |