Patent application number | Description | Published |
20120291848 | SUPPORTING STRUCTURES FOR BUILDING INTEGRABLE PHOTOVOLTAIC MODULES - Building integrable photovoltaic (BIP) modules include photovoltaic inserts for producing electrical power and supporting structures for mechanically attaching and supporting the insert with respect to a building structure, such as roof tops. The supporting structures may include ventilation ribs that form ventilation channels under the photovoltaic insert and, in certain embodiments, under other components of the module. These ribs may be used to provide mechanical support to the entire module. In specific embodiments, ventilation channels of one module are configured to coincide with ventilation channels of one or more other like modules and to form a continuous channel along the roof edge. The supporting structures may be used to form moisture barriers in between two modules, such as side glitters. In certain embodiments, supporting structures are separate components and are attached to the insert to form a module during fabrication or installation of the module on a building structure. | 11-22-2012 |
20130032198 | ATTACHMENT STRUCTURES FOR BUILDING INTEGRABLE PHOTOVOLTAIC MODULES - Provided are novel building integrable photovoltaic (BIP) modules having specially configured attachment structures for securing these modules to building structures and other BIP modules. In certain embodiments, a BIP module includes a base sheet supporting photovoltaic cells and having a rigid polymer portion and a flexible polymer portion. The flexible portion is designed to be penetrated with mechanical fasteners during installation. The flexible portion may include fastening pointers and/or through holes for identifying specific penetration locations. The rigid portion provides necessary structural rigidity and support to the module and more specifically to the photovoltaic cells. In certain other embodiments, a BIP module includes an adhesive bumper strip disposed along one edge of the module and configured for secure this module with respect to another module. During installation, the strip is positioned between a back sealing sheet of one module and a front sealing sheet of another module. | 02-07-2013 |
20130067836 | BUILDING INTEGRABLE INTERCONNECTION STRUCTURES HAVING FIELD-CONFIGURABLE SHAPES - Provided are novel building integrable interconnection structures having field-configurable shapes and methods of installing thereof. An interconnection structure may be cut or otherwise modified in the field during installation to form one or more openings. These openings can then be positioned around various obstacles that are frequently present in building installation areas. Some examples of such obstacles include chimneys, vents, and skylights. In some embodiments, the interconnection structures can be provided as part of a set or configured to be installed in an array with building integrable photovoltaic (BIPV) modules of the same size. This installation configuration allows preserving an offset between adjacent rows of the array. Furthermore, the interconnection structures can have the same perimeter features as the BIPV modules, such as electrical connectors and moisture flaps. These features provide electrical continuity and sealing characteristics in an array of BIPV modules despite the presence of obstacles on building structures. | 03-21-2013 |
20130098420 | INTERCONNECTING STRIPS FOR BUILDING INTEGRABLE PHOTOVOLTAIC MODULES - Provided are novel interconnecting strips for electrically connecting building integrable photovoltaic (BIPV) modules in a photovoltaic array. An interconnecting strip can be provided between a building structure and the BIPV modules, with electrical connections established by lowering the modules onto the strip previously positioned on the structure. The strip can includes two or more terminal groups aligned with different rows of BIPV modules. Each terminal group includes two or more connector terminals for connecting to the modules in that row. The interconnecting strip also includes leads extending between terminal groups and connecting connector terminals of different groups. In certain embodiments, terminal groups are offset with respect to adjacent groups to align with BIPV modules that are similarly offset to provide a moisture barrier. The interconnecting strip may be reconfigured in the field to provide different electrical connection schemes among BIPV modules. | 04-25-2013 |
20130118558 | FLEXIBLE CONNECTORS OF BUILDING INTEGRABLE PHOTOVOLTAIC MODULES FOR ENCLOSED JUMPER ATTACHMENT - Provided are novel Building Integrable Photovoltaic (BIPV) modules having one or more connectors that are movable between extended and retracted positions. Connector adjustment may be performed in the field, for example, during installation of a module. In certain embodiments, a connector includes a connector body and extension body. The extension body flexibly attaches the connector body to the module and allows the connector body to move with respect to the module edge. In an extended position, the connector body is positioned closer to the edge and is configured to make electrical connections to a joiner connector for interconnecting with an adjacent module. In a retracted positioned, the connector body is positioned further from the edge and is configured to make electrical connections to a jumper for interconnecting the conductive elements of the connector. In certain embodiments, a jumper does not protrude beyond the edge when connected to the connector body. | 05-16-2013 |
20130169056 | MULTI-MODULE INVERTERS AND CONVERTERS FOR BUILDING INTEGRABLE PHOTOVOLTAIC MODULES - Provided are multi-module inverters and/or converters for connecting to a set of building integrable photovoltaic (BIPV) modules that are interconnected in series and arranged into photovoltaic arrays on building structures. Outputs from multiple multi-module inverters and/or converters in one array may be combined using parallel connections and then connected to an electrical grid, standalone electrical network, or central inverter. Each set is connected to a different multi-module inverter and/or converter and may have a variable number of BIPV modules. A multi-module inverter and/or converter may be positioned within or integrated into one of the BIPV modules or attached to a building structure supporting the array. In certain embodiments, a multi-module inverter and/or converter is installed in a ventilation channel on the back side of a module. A multi-module inverter and/or converter may be also integrated into an electrical routing structure connected to one of the BIPV modules. | 07-04-2013 |
20130174885 | ELECTRICAL ROUTING STRUCTURES FOR BUILDING INTEGRABLE PHOTOVOLTAIC ARRAYS - Provided are electrical routing structures for installing on buildings and for interconnecting adjacent rows of building integrable photovoltaic (BIPV) modules at the ends of these rows. The electrical routing structures may be also used for sealing interfaces with other building components, such as asphalt shingles. An electrical routing structure may include a base, top flap, side flap, and one or two connectors. After the structure is installed, the base is aligned with photovoltaic portions of BIPV modules in one row and bridges a gap between photovoltaic portions of BIPV modules in two adjacent rows. The connectors may be used to interconnect BIPV modules positioned at the ends of two adjacent rows. | 07-11-2013 |
Patent application number | Description | Published |
20090149397 | TREATMENT OF CANCER WITH COMBINATIONS OF TOPOISOMERASE INHIBITORS AND PARP INHIBITORS - In one aspect, the present invention provides a composition and a kit comprising a combination of topoisomerase inhibitor and PARP inhibitor for treatment of cancer. In another aspect, the invention provides a method of treating cancer comprising administering to a subject a combination of topoisomerase inhibitor and PARP inhibitor. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase and a topoisomerase, as well as providing formulations and modes of administering such compositions. | 06-11-2009 |
20090291924 | Drug design for tubulin inhibitors, compositions, and methods of treatment thereof - The present invention relates to a computer-assisted method of a designing of a tubulin inhibitor comprising: a) determining an interaction between a tubulin protein and a chemical known to bind the tubulin protein by evaluating a binding of the tubulin protein to the chemical known to bind the tubulin protein; b) based on the interaction, designing a candidate tubulin inhibitor; c) determining an interaction between the tubulin protein and the candidate tubulin inhibitor by evaluating a binding of the tubulin protein to the candidate tubulin inhibitor; and d) concluding that the candidate tubulin inhibitor inhibits the tubulin protein wherein the conclusion is based on the interaction of step c). The invention also provides compositions and methods of treatment of diseases with the candidate tubulin inhibitors. | 11-26-2009 |
20120004260 | INHIBITION OF FATTY ACID SYNTHESIS BY IODO-NITROBENZAMIDE COMPOUNDS AND METHODS OF TREATMENT THEREOF - The present invention relates to a method of treating a fatty acid synthesis related disease comprising administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis, wherein the fatty acid synthesis related disease is obesity, diabetes, or cardiovascular disease. The present invention also relates to a method of treating a cancer in a subject comprising: (i) identifying a level of fatty acid in a sample from the subject, and (ii) administering an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis in the subject, wherein the administration is based on the level of fatty acid, thereby treating the cancer in the subject. The present invention further relates to a method of treating Her-2 related cancers by administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis. | 01-05-2012 |
20120238601 | TREATMENT OF CANCER - The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions. | 09-20-2012 |
Patent application number | Description | Published |
20090276912 | Polynucleotides and Polypeptides in Plants - The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed. | 11-05-2009 |
20110078806 | POLYNUCLEOTIDES AND POLYPEPTIDES IN PLANTS - The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed. | 03-31-2011 |
20120144518 | POLYNUCLEOTIDES AND POLYPEPTIDES IN PLANTS - The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed. | 06-07-2012 |
20150059014 | POLYNUCLEOTIDES AND POLYPEPTIDES IN PLANTS - The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed. | 02-26-2015 |
Patent application number | Description | Published |
20120087242 | SYSTEMS AND METHODS FOR THROTTLING A FABRIC LOGIN IN A FIBRE CHANNEL ADAPTER - Systems and methods for throttling a fabric login (FLOGI) in a Fibre Channel (FC) adapter are provided. One system includes a first tracking mechanism, a second tracking mechanism, a switch, and a FC adapter. The FC adapter comprises three or more FLOGIs and a controller configured to perform the below method. One method includes transmitting first and second FLOGI requests to the switch and indicating, via a first tracking mechanism, that a first FLOGI associated with the first FLOGI request and a second FLOGI associated with the second FLOGI request are active. The method further includes queuing a third FLOGI request until the first FLOGI request or the second FLOGI request is processed by the switch and indicating, via a second tracking mechanism, that a third FLOGI associated with the third FLOGI request is queued. Also provided are computer storage mediums including computer code for performing the above method. | 04-12-2012 |
20120096190 | SYSTEMS AND METHODS FOR DETECTING SUPPORTED SMALL FORM-FACTOR PLUGGABLE (SFP) DEVICES - Systems and methods for detecting supported small form-factor pluggable (SFP) devices in an adapter are provided. One system includes multiple ports, each port configured to be coupled to a SFP device, a tracking device configured to store data representing a list of supported SFP devices for the adapter, and a processor coupled to each of the plurality of ports and the tracking device. The processor is configured to scan each port at start-up, determine if any of the ports is coupled to a non-supported SFP device, and disable any ports that are coupled to a non-supported SFP device. One method includes scanning each port at start-up, determining if any of the ports is coupled to a non-supported SFP device, and disabling any ports that are coupled to a non-supported SFP device. Also provided are computer storage mediums including computer code for performing the above method. | 04-19-2012 |
20120096469 | SYSTEMS AND METHODS FOR DYNAMICALLY SCANNING A PLURALITY OF ACTIVE PORTS FOR WORK - Systems and methods for scanning ports for work are provided. One system includes one or more processors, multiple ports, a first tracking mechanism, and a second tracking mechanism for tracking high priority work and low priority work, respectively. The processor(s) is/are configured to perform the below method. One method includes scanning the ports, finding high priority work on a port, and accepting or declining the high priority work. The method further includes changing a designation of the processor to TRUE in the first tracking mechanism if the processor accepts the high priority work such that the processor is allowed to perform the high priority work on the port. Also provided are computer storage mediums including computer code for performing the above method. | 04-19-2012 |
20120110222 | APPARATUS AND METHOD FOR DYNAMICALLY ENABLING AND DISABLING WRITE XFR_RDY - A method for dynamically enabling and disabling use of XFR_RDY is disclosed herein. In one embodiment of the invention, such a method includes receiving a write command at a target and determining whether XFR_RDY is enabled or disabled for the write command. In the event XFR_RDY is disabled, the method determines whether one or more buffers are available at the target. If at least one buffer is available, the method processes the write command by writing data associated with the write command to the one or more buffers. The method then returns information indicating the number of buffers that are still available at the target after completing the write command. A corresponding apparatus and computer program product are also disclosed and claimed herein. | 05-03-2012 |
20120236721 | SYSTEMS AND METHODS FOR THROTTLING A FABRIC LOGIN IN A FIBRE CHANNEL ADAPTER - A fabric login (FLOGI) in a Fibre Channel (FC) adapter is throttled. The system includes a first tracking mechanism, a second tracking mechanism, a switch, and an FC adapter. The FC adapter comprises three or more FLOGIs and a controller. First and second FLOGI requests are transmitted to the switch and indicate, via a first tracking mechanism, that a first FLOGI associated with the first FLOGI request and a second FLOGI associated with the second FLOGI request are active. A third FLOGI request is queued until the first FLOGI request or the second FLOGI request is processed by the switch and indicates, via a second tracking mechanism, that a third FLOGI associated with a third FLOGI request is queued. | 09-20-2012 |
Patent application number | Description | Published |
20090069726 | CPR Device with Counterpulsion Mechanism - A system for performing chest compression and abdominal compression for Cardiopulmonary Resuscitation. The system includes a motor and gearbox including a system of clutches and brakes which allow for controlling and limiting the movement of compressing mechanisms operating on the chest and the abdomen of a patient. | 03-12-2009 |
20090177127 | Chest Compression Device with Electro-Stimulation - A device for performing chest compressions for CPR in coordination with applying electro-stimulus for additional resuscitative actions such as electro-ventilation, electro-counterpulsion, and defibrillation. The device includes a chest compression mechanism, electrodes and power supply for electro-stimulus, and a control system for applying electro-stimulus in coordination with the action of the chest compression mechanism. | 07-09-2009 |
20090204035 | Resuscitation Device and Method - A resuscitation device for automatic compression of victim's chest using a compression belt which exerts force evenly over the entire thoracic cavity. The belt is constricted and relaxed through a motorized spool assembly which repeatedly tightens the belt and relaxes the belt to provide repeated and rapid chest compression. An assembly includes various resuscitation devices including chest compression devices, defibrillation devices, and airway management devices, along with communications devices and senses with initiate communications with emergency medical personnel automatically upon use of the device. | 08-13-2009 |
20100211128 | Public Access CPR and AED Device - A system for resuscitation of a heart attack victim. The system includes CPR device which compresses the victim's chest, a defibrillator which may be used to defibrillate the patient, and an identification system for identifying the person operating the system. Depending on the identity of the operator, the system permits varying degrees of access to components and enablement of the functions of the various subsystems. | 08-19-2010 |
20110282408 | Resuscitation Device with Expert System - A resuscitation device for automatic compression of victim's chest using a compression belt which exerts force evenly over the entire thoracic cavity. The belt is constricted and relaxed through a motorized spool assembly which repeatedly tightens the belt and relaxes the belt to provide repeated and rapid chest compression. An assembly includes various resuscitation devices including chest compression devices, defibrillation devices, and airway management devices, along with communications devices and senses with initiate communications with emergency medical personnel automatically upon use of the device. | 11-17-2011 |
20120191025 | Resuscitation Device and Method - A resuscitation device for automatic compression of victim's chest using a compression belt which exerts force evenly over the entire thoracic cavity. The belt is constricted and relaxed through a motorized spool assembly which repeatedly tightens the belt and relaxes the belt to provide repeated and rapid chest compression. An assembly includes various resuscitation devices including chest compression devices, defibrillation devices, and airway management devices, along with communications devices and senses with initiate communications with emergency medical personnel automatically upon use of the device. | 07-26-2012 |
20120283606 | Resuscitation Device with Expert System - A resuscitation device for automatic compression of victim's chest using a compression belt which exerts force evenly over the entire thoracic cavity. The belt is constricted and relaxed through a motorized spool assembly which repeatedly tightens the belt and relaxes the belt to provide repeated and rapid chest compression. An assembly includes various resuscitation devices including chest compression devices, defibrillation devices, and airway management devices, along with communications devices and senses with initiate communications with emergency medical personnel automatically upon use of the device. | 11-08-2012 |
Patent application number | Description | Published |
20090112135 | Method of Estimating the Actual ECG of a Patient During CPR - A method of processing a raw acceleration signal, measured by an accelerometer-based compression monitor, to produce an accurate and precise estimated actual depth of chest compressions. The raw acceleration signal is filtered during integration and then a moving average of past starting points estimates the actual current starting point. An estimated actual peak of the compression is then determined in a similar fashion. The estimated actual starting point is subtracted from the estimated actual peak to calculate the estimated actual depth of chest compressions. In addition, one or more reference sensors (such as an ECG noise sensor) may be used to help establish the starting points of compressions. The reference sensors may be used, either alone or in combination with other signal processing techniques, to enhance the accuracy and precision of the estimated actual depth of compressions. | 04-30-2009 |
20100241039 | CPR Compression Device and Method - Improved automatic chest compression systems which use constricting belts, repeatedly inflating bladders, or reciprocating pistons to compress the chest. A bladder is placed between the chest and the particular mechanism used to compress the chest during CPR. The bladder maximizes the effectiveness of chest compressions. | 09-23-2010 |
20120004582 | Method of Determining Depth of Chest Compressions During CPR - A method of processing a raw acceleration signal, measured by an accelerometer-based compression monitor, to produce an accurate and precise estimated actual depth of chest compressions. The raw acceleration signal is filtered during integration and then a moving average of past starting points estimates the actual current starting point. An estimated actual peak of the compression is then determined in a similar fashion. The estimated actual starting point is subtracted from the estimated actual peak to calculate the estimated actual depth of chest compressions. In addition, one or more reference sensors (such as an ECG noise sensor) may be used to help establish the starting points of compressions. The reference sensors may be used, either alone or in combination with other signal processing techniques, to enhance the accuracy and precision of the estimated actual depth of compressions. | 01-05-2012 |
Patent application number | Description | Published |
20080202637 | Method for improving adhesion between a shape memory alloy and a polymer - Methods for improving adhesion between a shape memory alloy and a polymeric material include functionalizing a surface of the shape memory polymer with a phosphorous containing compound or an organosilane coupling agent. Other methods include surface texturing the shape memory alloy surface, independently or in combination with the functionalization. | 08-28-2008 |
20100028745 | Chemically modified catalyzed support particles for electrochemical cells - A membrane-electrode assembly in a polymer electrolyte/proton exchange membrane fuel cell includes the electrodes (anode and cathode), with a thin layer of catalyzed conductive support particles bonded to either side of the membrane. Where the polymer membrane comprises pendant chains of fluorinated carbon atoms with mobile proton containing terminal groups, proton conductivity with the catalyst particles is improved by chemically attaching like pendant chains to carbon atoms at surfaces of carbon particles. In certain implementations, an amino aryl perfluorinated sulfonic acid precursor is prepared. This precursor is converted to an aryl diazonium cation in the presence of carbon particles. The diazonium cation is reduced to the aryl radical which reacts with carbon atoms of the carbon substrate. | 02-04-2010 |
20100092238 | ACTIVE MATERIAL ELEMENTS HAVING REINFORCED STRUCTURAL CONNECTORS - An active material assembly for interconnecting with at least one structural member of a structure, sustaining a load over a predetermined period, and selectively effecting a change in the structure, includes at least one active material element, such as a shape memory wire, and a reinforcing connector, such as a ring terminal crimp fixedly secured to the wire, and more preferably including the use of one or more tube or shim intermediate the wire and crimp, wave form imparting configurations, collets, or ferrules. | 04-15-2010 |
20100291416 | STATE OF CHARGE MARKER FOR BATTERY SYSTEMS - An exemplary embodiment includes a battery cell electrode including a first material having a first potential versus state of charge (SOC) relationship; a second material having a second potential versus state of charge (SOC) relationship; wherein the second material becomes active to transfer ions at a selected SOC level to result in a readily observable change in measured potential from the first to the second potential versus SOC relationship. | 11-18-2010 |
20120100403 | ELECTROLYTIC CELL AND METHOD OF ESTIMATING A STATE OF CHARGE THEREOF - A lithium ion battery includes a positive electrode, a negative electrode, and an electrolyte operatively disposed between the positive and negative electrodes. The negative electrode contains a composite material including graphitic carbon and a disordered carbon. | 04-26-2012 |
20140375325 | BATTERY WITH REFERENCE ELECTRODE FOR VOLTAGE MONITORING - A lithium-ion battery structure with a third electrode as reference electrode is disclosed. The reference electrode may be fabricated from lithium metal, lithiated carbon, or a variety of other lithium-containing electrode materials. A porous current collector allows permeation of reference lithium ions from the reference electrode to the cathode or anode, enabling voltage monitoring under actual operation of a lithium-ion battery. The reference electrode therefore does not need to be spatially between the battery anode and cathode, thus avoiding a shielding effect. The battery structure includes an external reference circuit to dynamically display the anode and cathode voltage. The battery structure can result in improved battery monitoring, enhanced battery safety, and extended battery life. | 12-25-2014 |
20150044420 | Coatings, Coating Compositions, and Methods of Delaying Ice Formation - A coating includes at least one coating layer containing first particles, second particles, and third particles distributed throughout a cross-linked, continuous polymer matrix. An outer surface of the coating layer includes surfaces of at least first particles extending outward from a top periphery of the polymer matrix. The outer surface exhibits a property of delaying ice formation compared to the coating layer without the first particles. A method includes applying a coating composition in one application step. The one-step coating composition contains first particles, second particles, and third particles in a base containing a polymer. A coating composition includes first particles, second particles, and third particles distributed in a matrix precursor. | 02-12-2015 |
Patent application number | Description | Published |
20110048575 | VISCOUS MATERIAL NONCONTACT JETTING SYSTEM - A viscous material noncontact jetting system has a jetting dispenser mounted for relative motion with respect to a surface. A control is operable to cause the jetting dispenser to jet a viscous material droplet that is applied to the surface as a viscous material dot. A device, such as a camera or weigh scale, is connected to the control and provides a feedback signal representing a size-related physical characteristic of the dot applied to the surface. The size-related physical characteristics of subsequently applied dots is controlled by heating and cooling, or adjusting a piston stroke in the jetting dispenser, in response to the size-related physical characteristic feedback. Dispensed material volume control and velocity offset compensation are also provided. | 03-03-2011 |
20110184569 | VISCOUS MATERIAL NONCONTACT JETTING SYSTEM - A viscous material noncontact jetting system has a jetting dispenser mounted for relative motion with respect to a surface. A control is operable to cause the jetting dispenser to jet a viscous material droplet that is applied to the surface as a viscous material dot. A device, such as a camera or weigh scale, is connected to the control and provides a feedback signal representing a size-related physical characteristic of the dot applied to the surface. The size-related physical characteristics of subsequently applied dots is controlled by heating and cooling, or adjusting a piston stroke in the jetting dispenser, in response to the size-related physical characteristic feedback. Dispensed material volume control and velocity offset compensation are also provided. | 07-28-2011 |
20120285990 | Viscous Material Noncontact Jetting System - A viscous material noncontact jetting system has a jetting dispenser mounted for relative motion with respect to a surface. A control is operable to cause the jetting dispenser to jet a viscous material droplet that is applied to the surface as a viscous material dot. A device, such as a camera or weigh scale, is connected to the control and provides a feedback signal representing a size-related physical characteristic of the dot applied to the surface. The size-related physical characteristics of subsequently applied dots is controlled by heating and cooling, or adjusting a piston stroke in the jetting dispenser, in response to the size-related physical characteristic feedback. Dispensed material volume control and velocity offset compensation are also provided. | 11-15-2012 |
Patent application number | Description | Published |
20080281322 | RF Energy Delivery System and Method - A radio frequency tissue ablation system with a radio frequency generator, the generator comprising a radio frequency source, at least four independently controllable radio frequency outputs, a user interface and a controller configured to delivery radio frequency energy from the radio frequency source to the radio frequency outputs in one of at least two different output configurations in response to a configuration selection made through the user. | 11-13-2008 |
20090030411 | ABLATION CATHETER - Devices, systems and methods are disclosed for the ablation of tissue. Embodiments include an ablation catheter which has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be constrained within the lumen of a catheter, and deployed to take on an expanded condition. | 01-29-2009 |
20110190755 | PATIENT RETURN ELECTRODE DETECTION FOR ABLATION SYSTEM - A medical device is provided, including an ablation system with a generator, at least one ablation element, a patient return electrode, and a feedback system to verify and monitor the electrical connection between the generator and the patient return electrode, as well as contact of the patient return electrode with the patient. If an electrical connection is absent, intermittent, or of low quality, the medical device may also provide notice, a warning or alarm, and may also automatically cease ablation occurring at that time. | 08-04-2011 |
20120109115 | REACTANCE CHANGES TO IDENTIFY AND EVALUATE CRYO ABLATION LESIONS - A method of assessing lesion quality of an ablated tissue region comprising ablating at least a portion of the tissue region. The reactance of the ablated tissue region is measured. The lesion quality of the ablated tissue region is determined based on the measured reactance. | 05-03-2012 |
20120136346 | System and Method for Adaptive RF Ablation - A medical method, device, and system are provided, including advancing an ablation element of a medical device into contact with tissue to be treated, selecting a power level of energy to ablate the tissue, delivering energy at the selected power level to the ablation element, determining whether the ablation element is in continuous contact with the tissue, and reducing the selected power level when the ablation element ceases to be in continuous contact with the tissue. | 05-31-2012 |
20120136348 | System and Method for Adaptive RF Ablation - A medical method, device, and system are provided, including advancing an ablation element of a medical device into contact with tissue to be treated, selecting a power level of energy to ablate the tissue, delivering energy at the selected power level to the ablation element, determining whether the ablation element is in continuous contact with the tissue, and reducing the selected power level when the ablation element ceases to be in continuous contact with the tissue. | 05-31-2012 |
20120197243 | MULTI FREQUENCY AND MULTI POLARITY COMPLEX IMPEDANCE MEASUREMENTS TO ASSESS ABLATION LESIONS - A method of assessing a tissue ablation treatment, including positioning a medical device adjacent a target tissue; measuring a first impedance magnitude a first frequency with the medical device; measuring a first impedance phase at a second frequency with the medical device; ablating at least a portion of the target tissue with the medical device; measuring at second impedance magnitude at a third frequency with the medical device; measuring a second impedance phase at a fourth frequency with the medical device; comparing at least one of (i) the first and second impedance magnitudes and (ii) the first and second impedance phases; and providing an indication of the efficacy of the ablation treatment based at least in part on the comparison. | 08-02-2012 |
20130138097 | SYSTEM AND METHOD TO DETECT PATIENT RETURN ELECTRODE CONNECTION IN AN RF ABLATION SYSTEM - A medical device is provided, including an ablation system with a generator, at least one ablation element, a patient return electrode, and a feedback system to verify and monitor the electrical connection between the generator and the patient return electrode, as well as contact of the patient return electrode with the patient. The medical system sends a test signal to the patient return electrode prior to the delivery of ablation energy. If the response to the test signal indicates that the connection of the patient return electrode is absent, intermittent, or of low quality, the medical device may also provide notice, a warning or alarm. | 05-30-2013 |
20130289551 | INTERMITTENT SHORT CIRCUIT DETECTION ON A MULTI-ELECTRODE CATHETER - A method and system for detecting a short circuit during a radiofrequency ablation procedure. The method includes measuring an impedance of a pair of electrodes coupled to a treatment assembly of a medical device. Radiofrequency ablation energy is transmitted between the pair of electrodes. The transmission of radiofrequency ablation energy between the pair of electrodes is terminated when after a predetermined period of time the measured impedance in either of the electrodes in the pair of electrodes is below a predetermined threshold impedance value. An alert is generated indicating a short circuit between the pair of electrodes. | 10-31-2013 |
20130296679 | IMPEDANCE DETECTION OF VENOUS PLACEMENT OF MULTI-ELECTRODE CATHETERS - Systems and methods for assessing electrode position, including positioning a plurality of electrodes within a heart and proximate a pulmonary vein; obtaining an impedance measurement from each of the plurality of electrodes; determining whether any of the plurality of electrodes is located within the pulmonary vein based at least in part on the obtained impedance measurements; and generating an indication if at least one of the plurality of electrodes is determined to be located within the pulmonary vein. | 11-07-2013 |
20130296839 | DETECTION OF MICROBUBBLE FORMATION DURING CATHETER ABLATION - A method and system for detecting microbubble formation during a radiofrequency ablation procedure. The method includes measuring an impedance of a pair of electrodes, at least one electrode in the pair of electrodes being coupled to a treatment assembly of a medical device. Radiofrequency ablation energy is transmitted between the pair of electrodes. The transmission of radiofrequency ablation energy between the pair of electrodes is terminated when after a predetermined period of time the measured impedance in either of the electrodes in the pair of electrodes is a predetermined percentage above a measured minimum impedance and a measured power is above a predetermined power threshold. An alert is generated indicating at least one of the formation and release of microbubbles proximate the pair of electrodes. | 11-07-2013 |
20130296840 | SYSTEMS AND METHODS FOR DETECTING TISSUE CONTACT DURING ABLATION - Systems and methods for assessing tissue contact, including positioning an electrode adjacent a tissue region; delivering radiofrequency energy to the electrode, wherein the delivered radiofrequency energy is sufficient to ablate at least a portion of the tissue region; obtaining a plurality of impedance measurements from the electrode during the delivery of the radiofrequency energy; calculating a change in the impedance measurements over a pre-determined time period; and generating an alert if the calculated change is less than a pre-defined value. | 11-07-2013 |
20130331831 | ABLATION CATHETER - Devices, systems and methods are disclosed for the ablation of tissue. Embodiments include an ablation catheter which has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be constrained within the lumen of a catheter, and deployed to take on an expanded condition. | 12-12-2013 |
20140066913 | ABLATION DEVICE AND METHOD FOR ELECTROPORATING TISSUE CELLS - A method and system for producing deep lesions without the production of high heat. The method generally includes ablating target tissue cells with a device in communication with an energy generator programmable to ablate tissue using heat energy, electroporation, or a combination thereof. The system generally includes a medical device having a plurality of electrodes at a distal end, and an energy generator in communication with the plurality of electrodes, the generator programmable to deliver alternating current energy between approximately 100 volts RMS and approximately 2000 volts RMS or greater. The generator is further programmable to deliver energy in unipolar mode, bipolar mode, and a combination thereof. | 03-06-2014 |
20140171942 | USER INTERFACE FOR TISSUE ABLATION SYSTEM - Devices, systems and methods are disclosed for the ablation of tissue. Embodiments include an ablation catheter that has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be constrained within the lumen of a catheter, and deployed to take on an expanded condition. The carrier assembly includes multiple electrodes that are configured to ablate tissue at low power. Systems include an interface unit with a visual display that provides a visual representation of the geometry of the ablation elements and/or provides selection means for selecting an icon provided on the display. | 06-19-2014 |
20140288546 | RF ENERGY DELIVERY SYSTEM - A radio frequency tissue ablation system with a radio frequency generator, the generator comprising a radio frequency source, at least four independently controllable radio frequency outputs, a user interface and a controller configured to delivery radio frequency energy from the radio frequency source to the radio frequency outputs in one of at least two different output configurations in response to a configuration selection made through the user. | 09-25-2014 |
Patent application number | Description | Published |
20100323422 | PEG-Urate Oxidase Conjugates and Use Thereof - A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme. | 12-23-2010 |
20100323423 | PEG-Urate Oxidase Conjugates and Use Thereof - A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme. | 12-23-2010 |
20110287466 | Aggregate-Free Urate Oxidase for Preparation of Non-Immunogenic Polymer Conjugates - A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates. | 11-24-2011 |
20120114742 | Polymer Conjugates with Decreased Antigenicity, Methods of Preparation and Uses Thereof - Methods are provided for the preparation of conjugates of a variety of bioactive components, especially proteins, with water-soluble polymers (e.g., poly(ethylene glycol) and derivatives thereof), which conjugates have reduced antigenicity and immunogenicity compared to similar conjugates prepared using poly(ethylene glycol) containing a methoxyl or another alkoxyl group. The invention also provides conjugates prepared by such methods, compositions comprising such conjugates, kits containing such conjugates or compositions and methods of use of the conjugates and compositions in diagnostic and therapeutic protocols. | 05-10-2012 |
20120149083 | PEG-Urate Oxidase Conjugates and Use Thereof - A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme. | 06-14-2012 |
20130052677 | PEG-Urate Oxidase Conjugates and Use Thereof - A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme. | 02-28-2013 |
20140363414 | Aggregate-Free Urate Oxidase For Preparation of Non-Immunogenic Polymer Conjugates - A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates. | 12-11-2014 |