Patent application number | Description | Published |
20130164339 | PLATFORM FOR ENGINEERED IMPLANTABLE TISSUES AND ORGANS AND METHODS OF MAKING THE SAME - Disclosed are engineered tissues and organs comprising one or more muscle cell-containing layers, the engineered tissue or organ consisting essentially of cellular material, provided that the engineered tissue or organ is implantable in a vertebrate subject and not a vascular tube. | 06-27-2013 |
20130190210 | ENGINEERED TISSUES FOR IN VITRO RESEARCH USES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME - Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays. | 07-25-2013 |
20130345794 | MULTILAYERED VASCULAR TUBES - Described herein are engineered multilayered vascular tubes comprising at least one layer of differentiated adult fibroblasts, at least one layer of differentiated adult smooth muscle cells, wherein any layer further comprises differentiated adult endothelial cells, wherein said tubes have the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1:99 to about 45:55; (b) the tube is compliant; (c) the internal diameter of the tube is about 6 mm or smaller; (d) the length of the tube is up to about 30 cm; and (e) the thickness of the tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is free of any pre-formed scaffold. Also described herein are methods of forming said tubes and uses for said tubes including methods for treating patients, comprising providing such a tube into to a patient in need thereof. | 12-26-2013 |
Patent application number | Description | Published |
20140099709 | ENGINEERED THREE-DIMENSIONAL CONNECTIVE TISSUE CONSTRUCTS AND METHODS OF MAKING THE SAME - Disclosed are engineered, living, three-dimensional connective tissue constructs comprising connective tissue cells. In some embodiments, the connective tissue cells are derived from multi-potent cells such as mesenchymal stem/stromal cells. In some embodiments, the cells are cohered to one another. In some embodiments, the multi-potent cells have been exposed to one or more differentiation signals to provide a living, three-dimensional connective tissue construct. In some embodiments, the constructs are substantially free of pre-formed scaffold at the time of use. Also disclosed are implants for engraftment, arrays of connective tissue constructs for in vitro experimentation, as well as methods of making the same. | 04-10-2014 |
20140274802 | ENGINEERED LIVER TISSUES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME - Engineered, living, three-dimensional liver tissue constructs comprising: one or more layers, wherein each layer contains one or more liver cell types, the one or more layers cohered to form a living, three-dimensional liver tissue construct. In some embodiments, the constructs are characterized by having at least one of: at least one layer comprising a plurality of cell types, the cell types spatially arranged relative to each other to create a planar geometry; and a plurality of layers, at least one layer compositionally or architecturally distinct from at least one other layer to create a laminar geometry. Also disclosed are arrays and methods of making the same. Also disclosed are engineered, living, three-dimensional liver tissue constructs for use in the augmentation or restoration of one or more liver functions, by in vivo delivery of tissue or utilization of tissue in an extracorporeal device. | 09-18-2014 |
20140287960 | ENGINEERED LIVER TISSUES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME - Engineered, living, three-dimensional liver tissue constructs comprising: one or more layers, wherein each layer contains one or more liver cell types, the one or more layers cohered to form a living, three-dimensional liver tissue construct. In some embodiments, the constructs are characterized by having at least one of: at least one layer comprising a plurality of cell types, the cell types spatially arranged relative to each other to create a planar geometry; and a plurality of layers, at least one layer compositionally or architecturally distinct from at least one other layer to create a laminar geometry. Also disclosed are arrays and methods of making the same. Also disclosed are engineered, living, three-dimensional liver tissue constructs for use in the augmentation or restoration of one or more liver functions, by in vivo delivery of tissue or utilization of tissue in an extracorporeal device. | 09-25-2014 |
Patent application number | Description | Published |
20100036490 | FOLDABLE INTRAOCULAR LENS AND METHOD OF MAKING - A foldable intraocular lens for providing vision contains an optic body that includes an optical zone and a peripheral zone entirely surrounding the optical zone. The optic body has an anterior face, a substantially opposing posterior face, an optic edge, and an optical axis. The anterior face comprises a central face, a peripheral face, and a recessed annular face therebetween that is disposed posterior to the peripheral face. The intraocular lens further comprises at least one haptic that is integrally formed with the peripheral zone. The haptic comprises a distal posterior face, a proximal posterior face, and a step edge disposed at a boundary therebetween. The haptic further comprises a side edge disposed between the optic edge and the step edge. The proximal posterior face and the posterior face of the optic body form a continuous surface. An edge corner is formed by the intersection of the continuous surface with the optic edge, the side edge, and the step edge. | 02-11-2010 |
20110152873 | METHODS AND APPARATUS FOR INSERTING AN INTRAOCULAR LENS INTO AN EYE - Apparatus and methodology for inserting an intraocular lens (IOL) into an eye. The apparatus includes a cartridge for holding an IOL and a handpiece with a body member for receiving the cartridge, an injector rod that is receivable by the body member, and a drive mechanism that longitudinally oscillates the injector rod in the body member when a rotational force is applied about a longitudinal axis in a single direction. In other words, a constant rotation in a single direction of the drive mechanism causes the injector rod to move distally and proximally in discrete increments, with the distal increments being larger than the proximal increments. Accordingly, the injector rod urges an IOL out of the handpiece in a two-steps-forward, one-step-back manner, thereby minimizing or eliminating the chance of the injector rod engaging with the IOL. | 06-23-2011 |
20130231742 | FOLDABLE INTRAOCULAR LENS AND METHOD OF MAKING - A foldable intraocular lens for providing vision contains an optic body that includes an optical zone and a peripheral zone entirely surrounding the optical zone. The optic body has an anterior face, a substantially opposing posterior face, an optic edge, and an optical axis. The anterior face comprises a central face, a peripheral face, and a recessed annular face therebetween that is disposed posterior to the peripheral face. The intraocular lens further comprises at least one haptic that is integrally formed with the peripheral zone. The haptic comprises a distal posterior face, a proximal posterior face, and a step edge disposed at a boundary therebetween. The haptic further comprises a side edge disposed between the optic edge and the step edge. The proximal posterior face and the posterior face of the optic body form a continuous surface. An edge corner is formed by the intersection of the continuous surface with the optic edge, the side edge, and the step edge. | 09-05-2013 |
Patent application number | Description | Published |
20110206578 | Treatment of metal oxide surfaces - Methods for activating and/or reactivating a metal oxide surface for deposition, immobilizing, and/or growing a biological sample (e.g., an oligonucleotide, a polynucleotide, functionalized particle, a polymer, etc.) thereon are disclosed. The metal oxide surface (e.g., zirconium oxide) can be activated and/or reactivated by exposing the metal oxide surface to various activation and/or treatment protocols capable of enhancing a slide's activity relative to the activity of an untreated slide. The activation and/or treatment protocol can include subjecting the slide (or at least the metal oxide layer) to an oxygen plasma treatment and/or a peroxide solution for an amount of time sufficient to activate and/or reactivate the metal oxide surface. Activated sequencing slides capable of incorporation, for example, into various embodiments of a flow cell for use in NGS platforms are also disclosed herein. | 08-25-2011 |
20120000777 | DEVICES AND METHODS FOR FORMING DOUBLE EMULSION DROPLET COMPOSITIONS AND POLYMER PARTICLES - The present invention generally relates to double emulsion droplet compositions, polymer particles that can be formed from such double emulsion droplet compositions, and to methods and apparatuses for making such compositions and particles. A double emulsion generally describes larger droplets that contain smaller droplets therein. These double emulsion droplet compositions can be used to create a variety of materials including polymer particles and polymeric shells and are further useful for encapsulating a variety of species including catalyst compounds and pharmaceutical agents. The double emulsion droplet compositions disclosed herein are readily formed using planar droplet (“digital”) microfluidic devices without channels, and either air or an immiscible liquid as an ambient medium. | 01-05-2012 |
Patent application number | Description | Published |
20140283128 | Specifying Applications to Share in a Shared Access Mode - Some embodiments of the invention provide a mobile device with multiple access modes. The device in some embodiments has at least two access modes, a primary access mode and a secondary access mode, that provide different restrictions for accessing the applications and/or data that are stored on the device. In some embodiments, the primary access mode of the device provides unfettered access to all of the device's applications and/or data that are available to a user, while its secondary access mode provides access to a limited set of applications and/or data that are stored on the device. In some embodiments, the device provides tools to select applications for the secondary access mode. | 09-18-2014 |
20140283135 | Mobile Computing Device with Multiple Access Modes - Some embodiments of the invention provide a mobile device that restricts access to its applications. The mobile device, displays, on the device's touch screen display, a lock screen page for accessing the device in a primary access mode or a secondary access mode. The primary access mode provides access to several of the device's applications, and the secondary access mode provides access to a limited set of the applications. The mobile device receives a touch input on the lock screen page to access the device in the secondary access mode. The mobile device unlocks the device to the secondary access mode by allowing access to the set of applications and restricting access to the remaining applications in the plurality of applications. | 09-18-2014 |
20140283141 | Switching a Mobile Device from Operating in a Primary Access Mode to a Secondary Access Mode - Some embodiments of the invention provide a mobile device with multiple access modes. The device in some embodiments has at least two access modes, a primary access mode and a secondary access mode, that provide different restrictions for accessing the applications and/or data that are stored on the device. In some embodiments, the primary access mode of the device provides unfettered access to all of the device's applications and/or data that are available to a user, while its secondary access mode provides access to a limited set of applications and/or data that are stored on the device. | 09-18-2014 |
20140283142 | Analyzing Applications for Different Access Modes - Some embodiments of the invention provide a mobile device with multiple access modes. The device in some embodiments has at least two access modes, a primary access mode and a secondary access mode, that provide different restrictions for accessing the applications and/or data that are stored on the device. In some embodiments, the mobile device automatically selects applications to share or keep private based metadata associated with the applications. | 09-18-2014 |
20140364104 | Push Notification Initiated Background Updates - In some implementations, a mobile device can be configured to monitor environmental, system and user events. The occurrence of one or more events can trigger adjustments to system settings. In some implementations, the mobile device can be configured to keep frequently invoked applications up to date based on a forecast of predicted invocations by the user. In some implementations, the mobile device can receive push notifications associated with applications that indicate that new content is available for the applications to download. The mobile device can launch the applications associated with the push notifications in the background and download the new content. In some implementations, before running an application or accessing a network interface, the mobile device can be configured to check energy and data budgets and environmental conditions of the mobile device to preserve a high quality user experience. | 12-11-2014 |
20140366042 | Initiating Background Updates Based on User Activity - In some implementations, a mobile device can be configured to monitor environmental, system and user events. The occurrence of one or more events can trigger adjustments to system settings. In some implementations, the mobile device can be configured to keep frequently invoked applications up to date based on a forecast of predicted invocations by the user. In some implementations, the mobile device can receive push notifications associated with applications that indicate that new content is available for the applications to download. The mobile device can launch the applications associated with the push notifications in the background and download the new content. In some implementations, before running an application or accessing a network interface, the mobile device can be configured to check energy and data budgets and environmental conditions of the mobile device to preserve a high quality user experience. | 12-11-2014 |
20150074615 | DEVICE, METHOD, AND GRAPHICAL USER INTERFACE FOR MANIPULATING USER INTERFACES BASED ON FINGERPRINT SENSOR INPUTS - An electronic device with a display and a fingerprint sensor displays a fingerprint enrollment interface and detects, on the fingerprint sensor, a plurality of finger gestures performed with a finger. The device collects fingerprint information from the plurality of finger gestures performed with the finger. After collecting the fingerprint information, the device determines whether the collected fingerprint information is sufficient to enroll a fingerprint of the finger. When the collected fingerprint information for the finger is sufficient to enroll the fingerprint of the finger, the device enrolls the fingerprint of the finger with the device. When the collected fingerprint information for the finger is not sufficient to enroll the fingerprint of the finger, the device displays a message in the fingerprint enrollment interface prompting a user to perform one or more additional finger gestures on the fingerprint sensor with the finger. | 03-12-2015 |
20150146945 | DEVICE, METHOD, AND GRAPHICAL USER INTERFACE FOR MANIPULATING USER INTERFACES BASED ON FINGERPRINT SENSOR INPUTS - An electronic device with a display and a fingerprint sensor displays a fingerprint enrollment interface and detects, on the fingerprint sensor, a plurality of finger gestures performed with a finger. The device collects fingerprint information from the plurality of finger gestures performed with the finger. After collecting the fingerprint information, the device determines whether the collected fingerprint information is sufficient to enroll a fingerprint of the finger. When the collected fingerprint information for the finger is sufficient to enroll the fingerprint of the finger, the device enrolls the fingerprint of the finger with the device. When the collected fingerprint information for the finger is not sufficient to enroll the fingerprint of the finger, the device displays a message in the fingerprint enrollment interface prompting a user to perform one or more additional finger gestures on the fingerprint sensor with the finger. | 05-28-2015 |
Patent application number | Description | Published |
20100213957 | APPARATUS FOR TESTING ELECTRONIC DEVICES - An apparatus is described for burn-in and/or functional testing of microelectronic circuits of unsingulated wafers. A large number of power, ground, and signal connections can be made to a large number of contacts on a wafer. The apparatus has a cartridge that allows for fanning-in of electric paths. A distribution board has a plurality of interfaces that are strategically positioned to provide a dense configuration. The interfaces are connected through flexible attachments to an array of first connector modules. Each one of the first connector modules can be independently connected to a respective one of a plurality of second connector modules, thereby reducing stresses on a frame of the apparatus. Further features include for example a piston that allows for tight control of forces exerted by terminals onto contacts of a wafer. | 08-26-2010 |
20120113556 | APPARATUS FOR TESTING ELECTRONIC DEVICES - An apparatus is described for burn-in and/or functional testing of microelectronic circuits of unsingulated wafers. A large number of power, ground, and signal connections can be made to a large number of contacts on a wafer. The apparatus has a cartridge that allows for fanning-in of electric paths. A distribution board has a plurality of interfaces that are strategically positioned to provide a dense configuration. The interfaces are connected through flexible attachments to an array of first connector modules. Each one of the first connector modules can be independently connected to a respective one of a plurality of second connector modules, thereby reducing stresses on a frame of the apparatus. Further features include for example a piston that allows for tight control of forces exerted by terminals onto contacts of a wafer. | 05-10-2012 |
20130141135 | APPARATUS FOR TESTING ELECTRONIC DEVICES - An apparatus is described for burn-in and/or functional testing of microelectronic circuits of unsingulated wafers. A large number of power, ground, and signal connections can be made to a large number of contacts on a wafer. The apparatus has a cartridge that allows for fanning-in of electric paths. A distribution board has a plurality of interfaces that are strategically positioned to provide a dense configuration. The interfaces are connected through flexible attachments to an array of first connector modules. Each one of the first connector modules can be independently connected to a respective one of a plurality of second connector modules, thereby reducing stresses on a frame of the apparatus. Further features include for example a piston that allows for tight control of forces exerted by terminals onto contacts of a wafer. | 06-06-2013 |
20130304412 | APPARATUS FOR TESTING ELECTRONIC DEVICES - An apparatus is described for burn-in and/or functional testing of microelectronic circuits of unsingulated wafers. A large number of power, ground, and signal connections can be made to a large number of contacts on a wafer. The apparatus has a cartridge that allows for fanning-in of electric paths. A distribution board has a plurality of interfaces that are strategically positioned to provide a dense configuration. The interfaces are connected through flexible attachments to an array of first connector modules. Each one of the first connector modules can be independently connected to a respective one of a plurality of second connector modules, thereby reducing stresses on a frame of the apparatus. Further features include for example a piston that allows for tight control of forces exerted by terminals onto contacts of a wafer. | 11-14-2013 |
20140091810 | APPARATUS FOR TESTING ELECTRONIC DEVICES - An apparatus is described for burn-in and/or functional testing of microelectronic circuits of unsingulated wafers. A large number of power, ground, and signal connections can be made to a large number of contacts on a wafer. The apparatus has a cartridge that allows for fanning-in of electric paths. A distribution board has a plurality of interfaces that are strategically positioned to provide a dense configuration. The interfaces are connected through flexible attachments to an array of first connector modules. Each one of the first connector modules can be independently connected to a respective one of a plurality of second connector modules, thereby reducing stresses on a frame of the apparatus. Further features include for example a piston that allows for tight control of forces exerted by terminals onto contacts of a wafer. | 04-03-2014 |
20140232424 | APPARATUS FOR TESTING ELECTRONIC DEVICES - An apparatus is described for burn-in and/or functional testing of microelectronic circuits of unsingulated wafers. A large number of power, ground, and signal connections can be made to a large number of contacts on a wafer. The apparatus has a cartridge that allows for fanning-in of electric paths. A distribution board has a plurality of interfaces that are strategically positioned to provide a dense configuration. The interfaces are connected through flexible attachments to an array of first connector modules. Each one of the first connector modules can be independently connected to a respective one of a plurality of second connector modules, thereby reducing stresses on a frame of the apparatus. Further features include for example a piston that allows for tight control of forces exerted by terminals onto contacts of a wafer. | 08-21-2014 |
Patent application number | Description | Published |
20120317491 | NETWORK CONNECTIVITY AND SECURITY VISUALIZATION - A method for displaying a graphical user interface for a computing environment including computing resources that are provided to a plurality of organizations over one or more external networks includes displaying representations of the one or more external networks. The method further includes displaying a first node in the graphical user interface that is connected to the representations of at least one of the one or more external networks, where the first node is associated with a first organization; displaying an aggregate node in the graphical user interface that is associated with a plurality of other organizations besides the first organization; receiving a selection to view details of the first organization; and displaying an expanded view of the first organization in the graphical user interface in response to the selection. | 12-13-2012 |
20130055092 | USER INTERFACE FOR NETWORKS INCLUDING VIRTUAL MACHINES - A user interface for a virtual machine infrastructure enables a user to navigate a graph in a tabular format. The user interface simultaneously displays data associated with a selected node from a plurality of applications via view extensions provided by the applications. The user interface shows data associated with a node on which a navigation panel is focused, an anchor node, together with related nodes and edge categories including the edges connecting the related nodes to the anchor node. The user can peek at the data associated with a related node by selecting the node in the user interface and change the displayed data without changing the focus of the navigation panel. The user can also change the focus of the navigation panel to a related node via data displayed in a data panel or related nodes identified in the navigation panel. | 02-28-2013 |
20130055244 | EXTENSIBLE INFRASTRUCTURE FOR REPRESENTING NETWORKS INCLUDING VIRTUAL MACHINES - Embodiments provide a virtual machine infrastructure including an application model and a user interface for displaying data associated with a plurality of nodes. The user interface is arranged in a hierarchy of views. An application is added to the infrastructure by adding an edge category and a view extension to the infrastructure. The user interface simultaneously displays the added view extension together with a view extension provided by another application. | 02-28-2013 |
20140289634 | EXTENSIBLE INFRASTRUCTURE FOR REPRESENTING NETWORKS INCLUDING VIRTUAL MACHINES - One or more embodiments provide an extensible user interface for navigating a graph in a tabular format for which the extensible user interface is arranged in a hierarchy of views. The hierarchy includes an entry point level having at least one extension added by an application, wherein data is displayed when the extensible user interface is initially accessed by the user. The hierarchy further includes an inventory level having at least one extension added by the application, wherein data is displayed when the user selects an extension at the inventory level. Another level of the hierarchy is a category extension level having at least one extension added by an application, wherein data is displayed when the user focuses the extensible user interface on a node displayed by an extension added at the inventory level. | 09-25-2014 |
Patent application number | Description | Published |
20090215667 | Utility of phylloplanins as antibiotics, selective fungicides and for enhancing microbial resistance in plants - The present invention relates to plant proteins produced by a plant's epidermal layer that contribute to the innate pest/disease resistance of the plant (“phylloplanins”), compositions comprising the phylloplanins and methods of using them. In particular the methods relate to inhibiting or preventing microbial, e.g., fungal or bacterial, growth on a subject, organism or surface by administering a phylloplanin. The invention also relates to transformed host cells that produce phylloplanins, and to transgenic plants producing phylloplanins conferring increased resistance to microbial infections/growth. | 08-27-2009 |
20090281038 | Phylloplanins Inhibition of Microbial Growth on Organic Materials - The present invention relates to plant proteins produced by a plant's epidermal layer that contribute to the innate pest/disease resistance of the plant (“phylloplanins’), compositions comprising the phylloplanins and methods of using the them. In particular the methods relate to inhibiting or prevent microbial, e.g., fungal or bacterial, growth on a subject, organism or surface, particularly inhibiting or preventing spoilage of food products due to microbial infection and growth. The invention also relates to transformed host cells that produce the phylloplanins, and to transgenic plants producing phylloplanins conferring increased resistance to microbial infections/growth. | 11-12-2009 |